Cited by 246Natural Products and Biological ResearchNatural Antidiabetic Agents StudiesPhytochemicals and Antioxidant Activities

Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies

Mollace, Vincenzo, Sacco, Iolanda, Janda, Elzbieta, Malara, Claudio, Ventrice, Domenica, Colica, Carmen, Visalli, Valeria, Muscoli, Saverio +4 more·2011·Fitoterapia

Abstract

Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.

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Crossref · 10.1016/j.fitote.2010.10.014

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  • In a study by Mollace et al., bergamot showed dose-dependent lipid-lowering action: in groups A and B, LDL-C decreased by 24.1% and 30.6%, triglycerides by 28.2% and 37.9%, and HDL-C increased by 22.3% and 40.1%, respectively, compared with baseline.

    “The results showed dose-dependent lipid-lowering action of bergamot (groups A and B LDL-C: À24.1% and À30.6%, TG: À28.2% and À37.9%, and HDL-C: þ22.3% and þ40.1%, respectively; p < 0.001 for all) compared with baseline.”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]

  • In that study, group C receiving placebo did not show significant reductions in serum cholesterol.

    “Group C (placebo) did not show significant reductions in serum cholesterol”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]

  • Some nutraceuticals can enhance or potentially replace statin action.

    “some nutraceuticals are then able to enhance (126,127,135-137,145-147) or potentially replace the action of statins (63-66,50-52,58,168,169).”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]

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Authors
Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., & Romeo, F.
Affiliations
  • Magna Graecia University (IT)
  • Agenzia Regionale per la Protezione dell'Ambiente della Calabria (IT)
  • University of Rome Tor Vergata (IT)
Corresponding author
Mollace, Vincenzo
Venue
Fitoterapia
Publisher
Elsevier BV
Published
2011-04
Volume
82
Issue
3
Pages
309-316
ISSN
0367-326X (ISSN-L)
OpenAlex
W2073068954
Cited by
246
References
29
Citations by year
2026: 16 · 2025: 9 · 2024: 23 · 2023: 25 · 2022: 19 · 2021: 15 · 2020: 18 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 12 · 2013: 8 · 2012: 6
FWCI
5.41
Type
journal article
Language
en
Open access
closed
Locations
  • Fitoterapia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
Citrus aurantium, hypolipidemic activity, hypoglycemic activity, hyperlipidemia, hyperglycemia, LDL cholesterol, HDL cholesterol, triglycerides, HMG-CoA reductase inhibition, herbal medicine, diet-induced hyperlipidemia
MeSH terms
Adult, Aged, Animals, Hypolipidemic Agents, Blood Glucose, Citrus, Double-Blind Method, Female, Humans, Hydroxymethylglutaryl CoA Reductases, Hyperglycemia, Hyperlipidemias, Hypoglycemic Agents, Lipids, Male, Phytotherapy, Middle Aged, Plant Extracts, Vasodilation, Rats, Wistar, Rats

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