Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies
Abstract
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.
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In a study by Mollace et al., bergamot showed dose-dependent lipid-lowering action: in groups A and B, LDL-C decreased by 24.1% and 30.6%, triglycerides by 28.2% and 37.9%, and HDL-C increased by 22.3% and 40.1%, respectively, compared with baseline.
“The results showed dose-dependent lipid-lowering action of bergamot (groups A and B LDL-C: À24.1% and À30.6%, TG: À28.2% and À37.9%, and HDL-C: þ22.3% and þ40.1%, respectively; p < 0.001 for all) compared with baseline.”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
In that study, group C receiving placebo did not show significant reductions in serum cholesterol.
“Group C (placebo) did not show significant reductions in serum cholesterol”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
Some nutraceuticals can enhance or potentially replace statin action.
“some nutraceuticals are then able to enhance (126,127,135-137,145-147) or potentially replace the action of statins (63-66,50-52,58,168,169).”
From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [135]
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The Role of Nutraceutical Supplements in the Treatment of Dyslipidemia
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Probiotics for the treatment of hyperlipidemia: Focus on gut-liver axis and lipid metabolism
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Nutraceuticals: A New Challenge against Cadmium-Induced Testicular Injury
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Effect of bergamot on lipid profile in humans: A systematic review
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Recovery of phenolic compounds from bergamot juice by nanofiltration membranes
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MediterrAsian Diet Products That Could Raise HDL-Cholesterol: A Systematic Review
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Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review
Mollace, V., Rosano, G. M. C., Anker, S. D., Coats, A. J. S., Seferovic, P. M., Mollace, R., Tavernese, A., Gliozzi, M., Musolino, V., Carresi, C., et al. (2021) · Nutrients · doi:10.3390/nu13010257 · Cited by 34 · see citing works
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Recent Pharmacological Options in Type 2 Diabetes and Synergic Mechanism in Cardiovascular Disease
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Bergamot Polyphenol Extract Reduces Hepatocyte Neutral Fat by Increasing Beta-Oxidation
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Role of Nutraceuticals in Hypolipidemic Therapy
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Re-assessing the mechanism of action of n−3 PUFAs
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Mollace, R., Macrì, R., Tavernese, A., Gliozzi, M., Musolino, V., Carresi, C., Maiuolo, J., Fini, M., Volterrani, M., & Mollace, V. (2022) · Nutrients · doi:10.3390/nu14030477 · Cited by 26 · see citing works
- Authors
- Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., & Romeo, F.
- Affiliations
- Magna Graecia University (IT)
- Agenzia Regionale per la Protezione dell'Ambiente della Calabria (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Mollace, Vincenzo
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 82
- Issue
- 3
- Pages
- 309-316
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W2073068954
- Cited by
- 246
- References
- 29
- Citations by year
- 2026: 16 · 2025: 9 · 2024: 23 · 2023: 25 · 2022: 19 · 2021: 15 · 2020: 18 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 12 · 2013: 8 · 2012: 6
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- Citrus aurantium, hypolipidemic activity, hypoglycemic activity, hyperlipidemia, hyperglycemia, LDL cholesterol, HDL cholesterol, triglycerides, HMG-CoA reductase inhibition, herbal medicine, diet-induced hyperlipidemia
- MeSH terms
- Adult, Aged, Animals, Hypolipidemic Agents, Blood Glucose, Citrus, Double-Blind Method, Female, Humans, Hydroxymethylglutaryl CoA Reductases, Hyperglycemia, Hyperlipidemias, Hypoglycemic Agents, Lipids, Male, Phytotherapy, Middle Aged, Plant Extracts, Vasodilation, Rats, Wistar, Rats
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