Production of enzymatic hydrolysates with in vitro antioxidant, antihypertensive, and antidiabetic properties from proteins derived from Arthrospira platensis
Abstract
The microalga Arthrospira platensis BEA 005B was produced using 80 m 2 (9 m 3) raceway photobioreactors achieving a biomass productivity of 28.2 g·m-2·day-1 when operating the reactors in semi-continuous mode (0.33 day-1). The produced biomass was rich in proteins (58.1 g·100 g-1) and carbohydrates (25.6 g·100 g-1); the content of phycocyanins and allophycocyanins was 115.4 and 36.9 mg·g-1, respectively. Ultrasounds and high-pressure homogenisation allowed recovering approximately 90% of the initial protein content of the biomass; however, the energetic requirements of the former (∼100 kJ·kg-1) were significantly lower than those of high-pressure homogenisation (∼200 kJ·kg-1). An in silico analysis revealed that papain and ficin would allow releasing a large number of bioactive peptides with antioxidant, antihypertensive (ACE-I and renin), and antidiabetic (DPP-IV, α-amylase, and α-glucosidase) properties. Both were assessed in vitro together with Alcalase and pepsin leading to the generation of enzymatic hydrolysates with in vitro bioactivity.
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Peptides from Limnospira platensis, Ulva lactuca, Dunaliella salina, and Gracilaria bursa-pastoris reduce α-amylase and/or α-glucosidase activity and consequently lower blood glucose levels.
“For example, peptides from Limnospira platensis [90], Ulva lactuca [91], Dunaliella salina [92], and Gracilaria bursa-pastoris (Rhodophyta) [93] have been shown to reduce enzyme activity and consequently lower blood glucose levels.”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [90]
Peptides obtained from Limnospira platensis have shown DPP-IV inhibitory potential.
“Peptides obtained from Limnospira platensis have also shown their DPP-IV inhibitory potential [90].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [90]
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Self-citation
- Authors
- Villaró, S., Jiménez-Márquez, S., Musari, E., Bermejo, R., & Lafarga, T.
- Affiliations
- Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (ES)
- University of Almería (ES)
- Marche Polytechnic University (IT)
- Universidad de Jaén (ES)
- Corresponding author
- Lafarga, Tomás
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2023-01
- Volume
- 163
- Pages
- 112270
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W4310816953
- Cited by
- 50
- References
- 48
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 17 · 2023: 8
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundación BBVA (IN[20]_IN_ING_0051)
- European Regional Development Fund (UAL2020-AGR-A1945)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Keywords
- Spirulina platensis, enzymatic hydrolysate, proteolysis, antioxidant activity, antihypertensive effect, antidiabetic activity, bioactive peptides, phycocyanin, allophycocyanin, raceway photobioreactor, ultrasound-assisted extraction, high-pressure homogenization, papain, ficin, alcalase, pepsin, DPP-4 inhibition, α-glucosidase inhibition, α-amylase inhibition, angiotensin-converting enzyme inhibition, renin inhibition
- MeSH terms
- Antihypertensive Agents, Antioxidants, Hypoglycemic Agents, Protein Hydrolysates, Spirulina, Dipeptidyl-Peptidase IV Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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