Proteins and bioactive peptides from algae: insights into antioxidant, anti-hypertensive, anti-diabetic and anti-cancer activities

A systematic review on consumer acceptance of alternative proteins: Pulses, algae, insects, plant-based meat alternatives, and cultured meat

Onwezen, M. C., Bouwman, E. P., Reinders, M. J., & Dagevos, H. (2020) · Appetite · doi:10.1016/j.appet.2020.105058 · Cited by 1,093 · see citing works

Algal Proteins: Extraction, Application, and Challenges Concerning Production

Bleakley, S., & Hayes, M. (2017) · Foods · doi:10.3390/foods6050033 · Cited by 1,092 · see citing works

Antioxidant properties of a new antioxidative peptide from algae protein waste hydrolysate in different oxidation systems

Sheih, I., Wu, T., & Fang, T. J. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.02.014 · Cited by 397 · see citing works

Extraction of Proteins from Two Marine Macroalgae, Ulva Sp. and Gracilaria Sp., for Food Application, and Evaluating Digestibility, Amino Acid Composition and Antioxidant Properties of the Protein Concentrates

Kazir, M., Abuhassira, Y., Robin, A., Nahor, O., Luo, J., Israel, A., Golberg, A., & Livney, Y. D. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.07.047 · Cited by 269 · see citing works

Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats

Suetsuna, K., Maekawa, K., & Chen, J.-R. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.11.004 · Cited by 249 · see citing works

Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)

Suetsuna, K., & Nakano, T. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00110-8 · Cited by 243 · see citing works

Anticancer and Antioxidant Activities of the Peptide Fraction from Algae Protein Waste

Sheih, I., Fang, T. J., Wu, T., & Lin, P.-H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903089m · Cited by 242 · see citing works

Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp. 1

Hamann, M. T., Otto, C. S., Scheuer, P. J., & Dunbar, D. C. (1996) · The Journal of Organic Chemistry · doi:10.1021/jo960877+ · Cited by 240 · see citing works

Kahalalide F: a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp

Hamann, M. T., & Scheuer, P. J. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00066a061 · Cited by 237 · see citing works

The Potential and Challenge of Microalgae as Promising Future Food Sources

Chen, C., Tang, T., Shi, Q., Zhou, Z., & Fan, J. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.06.016 · Cited by 229 · see citing works

Purification and identification of dipeptidyl peptidase (DPP) IV inhibitory peptides from the macroalga Palmaria palmata

Harnedy, P. A., O’Keeffe, M. B., & Fitzgerald, R. J. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.09.083 · Cited by 204 · see citing works

Prospects of microalgae proteins in producing peptide-based functional foods for promoting cardiovascular health

Ejike, C. E. C. C., Collins, S. A., Balasuriya, N., Swanson, A. K., Mason, B., & Udenigwe, C. C. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.10.026 · Cited by 193 · see citing works

Bioactive properties of peptides obtained by enzymatic hydrolysis from protein byproducts of Porphyra columbina

Cian, R. E., Martínez‐Augustin, O., & Drago, S. R. (2012) · Food Research International · doi:10.1016/j.foodres.2012.07.003 · Cited by 191 · see citing works

Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.

Suárez, Y., González, L. E., Cuadrado, A., Berciano, M., Lafarga, M., & Múñoz, A. (2003) · PubMed · Cited by 190 · see citing works

Identification of Bioactive Peptides with α-Amylase Inhibitory Potential from Enzymatic Protein Hydrolysates of Red Seaweed (Porphyra spp)

Admassu, H., Gasmalla, M. A. A., Yang, R., & Zhao, W. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00960 · Cited by 178 · see citing works

Identification of anti-diabetes peptides from Spirulina platensis

Hu, S., Fan, X., Qi, P., & Zhang, X. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.03.024 · Cited by 150 · see citing works

In vitro assessment of the cardioprotective, anti-diabetic and antioxidant potential of Palmaria palmata protein hydrolysates

Harnedy, P., & Fitzgerald, R. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-0017-4 · Cited by 149 · see citing works

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

Echave, J., Otero, P., Garcia‐Oliveira, P., Munekata, P. E. S., Pateiro, M., Lorenzo, J. M., Simal‐Gándara, J., & Prieto, M. A. (2022) · Antioxidants · doi:10.3390/antiox11010176 · Cited by 143 · see citing works

Preparation and Identification of ACE Inhibitory Peptides from the Marine Macroalga Ulva intestinalis

Sun, S., Xu, X., Sun, X., Zhang, X., Chen, X., & Xu, N. (2019) · Marine Drugs · doi:10.3390/md17030179 · Cited by 140 · see citing works

Current knowledge on the extraction, purification, identification, and validation of bioactive peptides from seaweed

Cermeño, M., Kleekayai, T., Amigo‐Benavent, M., Harnedy‐Rothwell, P. A., & Fitzgerald, R. J. (2020) · Electrophoresis · doi:10.1002/elps.202000153 · Cited by 139 · see citing works

Separation, antitumor activities, and encapsulation of polypeptide from Chlorella pyrenoidosa

Wang, X., & Zhang, X. (2013) · Biotechnology Progress · doi:10.1002/btpr.1725 · Cited by 133 · see citing works

A multi-national comparison of meat eaters' attitudes and expectations for burgers containing beef, pea or algae protein

Michel, F., Knaapila, A., Hartmann, C., & Siegrist, M. (2021) · Food Quality and Preference · doi:10.1016/j.foodqual.2021.104195 · Cited by 127 · see citing works

Enhancement of Protein and Pigment Content in Two Chlorella Species Cultivated on Industrial Process Water

Safafar, H., Nørregaard, P. U., Ljubić, A., Møller, P., Holdt, S. L., & Jacobsen, C. (2016) · Journal of Marine Science and Engineering · doi:10.3390/jmse4040084 · Cited by 122 · see citing works

Antihypertensive Effects, Molecular Docking Study, and Isothermal Titration Calorimetry Assay of Angiotensin I-Converting Enzyme Inhibitory Peptides from <i>Chlorella vulgaris</i>

Xie, J., Chen, X., Wu, J., Zhang, Y., Zhou, Y., Zhang, L., Tang, Y.-J., & Wei, D. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04294 · Cited by 118 · see citing works

Peptide identification from a Porphyra dioica protein hydrolysate with antioxidant, angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory activities

Cermeño, M., Stack, J., Tobin, P. R., O’Keeffe, M. B., Harnedy, P. A., Stengel, D. B., & Fitzgerald, R. J. (2019) · Food & Function · doi:10.1039/c9fo00680j · Cited by 118 · see citing works

Purification and identification of novel angiotensin-I converting enzyme (ACE) inhibitory peptides from cultured marine microalgae (Nannochloropsis oculata) protein hydrolysate

Samarakoon, K. W., O-Nam, K., Ko, J.-Y., Lee, J.-H., Kang, M.-C., Kim, D., Lee, J. B., Lee, J.-S., & Jeon, Y.-J. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9994-6 · Cited by 116 · see citing works

Purification and characterisation of a novel angiotensin-I converting enzyme (ACE)-inhibitory peptide derived from the enzymatic hydrolysate of Enteromorpha clathrata protein

Pan, S., Wang, S., Jing, L., & Yao, D. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.087 · Cited by 110 · see citing works

Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity, Antioxidant Properties, Phenolic Content and Amino Acid Profiles of Fucus spiralis L. Protein Hydrolysate Fractions

Paiva, L. S., Lima, E., Neto, A. I., & Baptista, J. (2017) · Marine Drugs · doi:10.3390/md15100311 · Cited by 106 · see citing works

Isolation and identification of anti‐proliferative peptides from Spirulina platensis using three‐step hydrolysis

Wang, Z., & Zhang, X. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7815 · Cited by 92 · see citing works

Phycobiliproteins from algae: Current updates in sustainable production and applications in food and health

Ji, L., Qiu, S., Wang, Z., Zhao, C., Tang, B. H. J., Gao, Z., & Fan, J. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112737 · Cited by 88 · see citing works

Bioactive Peptides from Algae: Traditional and Novel Generation Strategies, Structure-Function Relationships, and Bioinformatics as Predictive Tools for Bioactivity

O’Connor, J., Garcia-Vaquero, M., Meaney, S., & Tiwari, B. K. (2022) · Marine Drugs · doi:10.3390/md20050317 · Cited by 81 · see citing works

Preparation and identification of antioxidant peptides from protein hydrolysate of marine alga Gracilariopsis lemaneiformis

Zhang, X., Cao, D., Sun, X., Sun, S., & Xu, N. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-1746-9 · Cited by 79 · see citing works

Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity

Li, Y., Aiello, G., Bollati, C., Bartolomei, M., Arnoldi, A., & Lammi, C. (2020) · Nutrients · doi:10.3390/nu12030794 · Cited by 79 · see citing works

Evaluation of the in vitro biological activity of protein hydrolysates of the edible red alga, Palmaria palmata (dulse) harvested from the Gaspe coast and cultivated in tanks

Beaulieu, L., Sirois, M., & Tamigneaux, É. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0850-3 · Cited by 77 · see citing works

Isolation and characterization of angiotensin I-converting enzyme (ACE) inhibitory peptides from Ulva rigida C. Agardh protein hydrolysate

Paiva, L., Lima, E., Isabel, A., & Baptista, J. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.07.006 · Cited by 76 · see citing works

Protein nutritional quality, amino acid profile, anti-amylase and anti-glucosidase properties of microalgae: Inhibition and mechanisms of action through in vitro and in silico studies

Siahbalaei, R., Kavoosi, G., & Noroozi, M. (2021) · LWT · doi:10.1016/j.lwt.2021.112023 · Cited by 76 · see citing works

Prediction of Bioactive Peptides from Chlorella sorokiniana Proteins Using Proteomic Techniques in Combination with Bioinformatics Analyses

Tejano, L. A., Peralta, J. P., Yap, E. E. S., Panjaitan, F. C. A., & Chang, Y.-W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071786 · Cited by 75 · see citing works

Design and characterization of a novel Arthrospira platensis glutathione oxido-reductase-derived antioxidant peptide GM15 and its potent anti-cancer activity via caspase-9 mediated apoptosis in oral cancer cells

Sannasimuthu, A., Kumaresan, V., Anilkumar, S., Pasupuleti, M., Munuswamy‐Ramanujam, G., Mala, K., Paray, B. A., Al‐Sadoon, M. K., Albeshr, M. F., & Arockiaraj, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.03.006 · Cited by 74 · see citing works

Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells

Chaves, R. P., da Silva, S. R., Neto, L. G. D. N., Carneiro, R. F., da Silva, A. L. C., Sampaio, A. H., de Sousa, B. L., Cabral, M. G., Videira, P. A., Teixeira, E. H., et al. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.09.116 · Cited by 68 · see citing works

Further studies and biological activities of macromolecular protein R-Phycoerythrin from Portieria hornemannii

Senthilkumar, N., Kurinjimalar, C., Thangam, R., Veeraperumal, S., Kavitha, G., Gunasekaran, P., & Rengasamy, R. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.08.004 · Cited by 67 · see citing works

Mechanism Analysis of a Novel Angiotensin-I-Converting Enzyme Inhibitory Peptide from Isochrysis zhanjiangensis Microalgae for Suppressing Vascular Injury in Human Umbilical Vein Endothelial Cells

Chen, J., Tan, L., Li, C., Zhou, C., Hong, P., Sun, S., & Qian, Z. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00925 · Cited by 65 · see citing works

Antiproliferative and Antioxidant Activities and Mycosporine-Like Amino Acid Profiles of Wild-Harvested and Cultivated Edible Canadian Marine Red Macroalgae

Athukorala, Y., Trang, S., Kwok, C., & Yuan, Y. (2016) · Molecules · doi:10.3390/molecules21010119 · Cited by 63 · see citing works

Chemical and biological characterization of spirulina protein hydrolysates: Focus on ACE and DPP-IV activities modulation

Aiello, G., Li, Y., Boschin, G., Bollati, C., Arnoldi, A., & Lammi, C. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103592 · Cited by 63 · see citing works

Induction of ROS-Dependent Mitochondria-Mediated Intrinsic Apoptosis in MDA-MB-231 Cells by Glycoprotein from Codium decorticatum

Thangam, R., Senthilkumar, D., Veeraperumal, S., Sathuvan, M., Sivasubramanian, S., Pazhanichamy, K., Gorlagunta, P. K., Kannan, S., Gunasekaran, P., Rengasamy, R., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405329e · Cited by 61 · see citing works

Investigation of Chlorella pyrenoidosa Protein as a Source of Novel Angiotensin I-Converting Enzyme (ACE) and Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides

Li, Y., Aiello, G., Fassi, E. M. A., Boschin, G., Bartolomei, M., Bollati, C., Roda, G., Arnoldi, A., Grazioso, G., & Lammi, C. (2021) · Nutrients · doi:10.3390/nu13051624 · Cited by 59 · see citing works

Novel peptides with anti-proliferation activity from the Porphyra haitanesis hydrolysate

Fan, X., Bai, L., Mao, X., & Zhang, X. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2017.05.018 · Cited by 58 · see citing works

Purification and Identification of Angiotensin I-Converting Enzyme Inhibitory Peptides and the Antihypertensive Effect of Chlorella sorokiniana Protein Hydrolysates

Lin, Y.-H., Chen, G.-W., Yeh, C., Song, H., & Tsai, J.-S. (2018) · Nutrients · doi:10.3390/nu10101397 · Cited by 57 · see citing works

Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth

Wang, Z., & Zhang, X. (2015) · Food & Function · doi:10.1039/c5fo01186h · Cited by 56 · see citing works

Antihyperglycemic and antioxidant activities of a lectin from the marine red algae, Bryothamnion seaforthii, in rats with streptozotocin-induced diabetes

Alves, M. F. D. A., Barreto, F. K. D. A., de Vasconcelos, M. A., Neto, L. G. D. N., Carneiro, R. F., da Silva, L. T., Nagano, C. S., Sampaio, A. H., & Teixeira, E. H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.238 · Cited by 55 · see citing works

Identification and in silico study of a novel dipeptidyl peptidase IV inhibitory peptide derived from green seaweed Ulva spp. hydrolysates

Cian, R. E., Nardo, A. E., Garzón, A. G., Añón, M. C., & Drago, S. R. (2021) · LWT · doi:10.1016/j.lwt.2021.112738 · Cited by 53 · see citing works

Bioassay-guided fractionation approach for determination of protein precursors of proteolytic bioactive metabolites from macroalgae

Bondu, S., Bonnet, C., Gaubert, J., Deslandes, É., Turgeon, S. L., & Beaulieu, L. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0425-0 · Cited by 52 · see citing works

Production of enzymatic hydrolysates with in vitro antioxidant, antihypertensive, and antidiabetic properties from proteins derived from Arthrospira platensis

Villaró, S., Jiménez-Márquez, S., Musari, E., Bermejo, R., & Lafarga, T. (2023) · Food Research International · doi:10.1016/j.foodres.2022.112270 · Cited by 50 · see citing works

A Systemic Review on Microalgal Peptides: Bioprocess and Sustainable Applications

Sathya, R., MubarakAli, D., MohamedSaalis, J., & Kim, J.-W. (2021) · Sustainability · doi:10.3390/su13063262 · Cited by 48 · see citing works

Macroalgal protein hydrolysates from Palmaria palmata influence the ‘incretin effect’ in vitro via DPP-4 inhibition and upregulation of insulin, GLP-1 and GIP secretion

McLaughlin, C. M., Harnedy-Rothwell, P. A., Lafferty, R. A., Sharkey, S., Parthsarathy, V., Allsopp, P. J., McSorley, E. M., FitzGerald, R. J., & O’Harte, F. P. M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02583-3 · Cited by 45 · see citing works

An ACE inhibitory peptide from Isochrysis zhanjiangensis exhibits antihypertensive effect via anti-inflammation and anti-apoptosis in HUVEC and hypertensive rats

Pei, Y., Cai, S., Ryu, B., Zhou, C., Hong, P., & Qian, Z. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105061 · Cited by 45 · see citing works

Characterization of ACE Inhibitory Peptides Prepared from Pyropia pseudolinearis Protein

Kumagai, Y., Toji, K., Katsukura, S., Morikawa, R., Uji, T., Yasui, H., Shimizu, T., & Kishimura, H. (2021) · Marine Drugs · doi:10.3390/md19040200 · Cited by 42 · see citing works

Influence of Seasonal Variation on Chemical Composition and Nutritional Profiles of Macro‐ and Microalgae

Kumar, K. S., Kumari, S., Singh, K., & Kushwaha, P. (2021) · Wiley eBooks · doi:10.1002/9781119542650.ch2 · Cited by 41 · see citing works

Insights into the Regulation of Algal Proteins and Bioactive Peptides Using Proteomic and Transcriptomic Approaches

Beaulieu, L. (2019) · Molecules · doi:10.3390/molecules24091708 · Cited by 40 · see citing works

Characterisation of Bioactive Peptides from Red Alga Gracilariopsis chorda

Mune, M. A. M., Miyabe, Y., Shimizu, T., Matsui, W., Kumagai, Y., & Kishimura, H. (2023) · Marine Drugs · doi:10.3390/md21010049 · Cited by 40 · see citing works

Biochemical characterization and application of a novel lectin from the cyanobacterium Lyngabya confervoides MK012409 as an antiviral and anticancer agent

El‐Fakharany, E. M., Saad, M. H., Salem, M. S., & Sidkey, N. M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.046 · Cited by 37 · see citing works

Identification of ACE inhibitory peptides from red alga Mazzaella japonica

Kumagai, Y., Kitade, Y., Kobayashi, M., Watanabe, K., Kurita, H., Takeda, H., Yasui, H., & Kishimura, H. (2020) · European Food Research and Technology · doi:10.1007/s00217-020-03567-z · Cited by 37 · see citing works

Dipeptidyl peptidase IV inhibitory peptides from Chlorella vulgaris: in silico gastrointestinal hydrolysis and molecular mechanism

Zhu, Q., Chen, X., Wu, J., Zhou, Y., Yang, Q., Fang, M., Xie, J., & Wei, D. (2017) · European Food Research and Technology · doi:10.1007/s00217-017-2879-1 · Cited by 36 · see citing works

In Silico Analysis of Relationship between Proteins from Plastid Genome of Red Alga Palmaria sp. (Japan) and Angiotensin I Converting Enzyme Inhibitory Peptides

Kumagai, Y., Miyabe, Y., Takeda, T., Adachi, K., Yasui, H., & Kishimura, H. (2019) · Marine Drugs · doi:10.3390/md17030190 · Cited by 36 · see citing works

Structure and anticancer activity of a new lectin from the cultivated red alga, Kappaphycus striatus

Hưng, L. Đ., & Trinh, P. T. H. (2020) · Journal of Natural Medicines · doi:10.1007/s11418-020-01455-0 · Cited by 36 · see citing works

In silico and in vitro assessment of bioactive peptides from Arthrospira platensis phycobiliproteins for DPP-IV inhibitory activity, ACE inhibitory activity, and antioxidant activity

Liu, J., Bai, X., & Fu, P. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02732-z · Cited by 36 · see citing works

Recent Advances in Micro and Macroalgal Processing

(2021) · Wiley eBooks · doi:10.1002/9781119542650 · Cited by 36 · see citing works

Identification of Bioactive Peptides from a Laminaria digitata Protein Hydrolysate Using In Silico and In Vitro Methods to Identify Angiotensin-1-Converting Enzyme (ACE-1) Inhibitory Peptides

Purcell, D., Packer, M. A., & Hayes, M. (2023) · Marine Drugs · doi:10.3390/md21020090 · Cited by 36 · see citing works

Anti-proliferation peptides from protein hydrolysates of Pyropia haitanensis

Mao, X., Bai, L., Fan, X., & Zhang, X. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-1037-7 · Cited by 34 · see citing works

Pressurized extraction of phycobiliproteins from Arthrospira platensis and evaluation of its effect on antioxidant and anticancer activities of these biomolecules

Carlos, T. A. V., Cavalcante, K. M. D. S. P., de Oliveira, F. D. C. E., Pessoa, C., de Sant’Ana, H. B., Feitosa, F. X., & Rocha, M. V. P. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-020-02358-z · Cited by 33 · see citing works

Consumers’ willingness-to-buy pasta with microalgae proteins–which label can promote sales?

Van der Stricht, H., Profeta, A., Hung, Y., & Verbeke, W. (2023) · Food Quality and Preference · doi:10.1016/j.foodqual.2023.104948 · Cited by 33 · see citing works

Free Radical Scavenging Properties and Induction of Apoptotic Effects of FA Fraction Obtained after Proteolysis of Bioactive Peptides from Microalgae Synechococcus sp. VDW

Suttisuwan, R., Phunpruch, S., Saisavoey, T., Sangtanoo, P., Thongchul, N., & Karnchanatat, A. (2019) · Food Technology and Biotechnology · doi:10.17113/ftb.57.03.19.6028 · Cited by 32 · see citing works

Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles

McLaughlin, C. M., Sharkey, S. J., Harnedy‐Rothwell, P. A., Parthsarathy, V., Allsopp, P. J., McSorley, E. M., Fitzgerald, R. J., & O'Harte, F. P. M. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104101 · Cited by 32 · see citing works

OPTIMIZATION OF A NEW CULTURE MEDIUM FOR THE LARGE‐SCALE PRODUCTION OF PROTEIN‐RICH ARTHROSPIRA PLATENSIS (OSCILLATORIALES, CYANOPHYCEAE)

Gómez-Serrano, C., Guzmán, A., Lafarga, T., & Acién‐Fernández, F. G. (2020) · Journal of Phycology · doi:10.1111/jpy.13111 · Cited by 30 · see citing works

Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813

Purcell, D., Packer, M. A., & Hayes, M. (2022) · Foods · doi:10.3390/foods11121792 · Cited by 30 · see citing works

Taurine, homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae

Terriente-Palacios, C., Rubiño, S., Hortos, M., Peteiro, C., & Castellari, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-25130-4 · Cited by 29 · see citing works

Preparation and Characterization of an Anticancer Peptide from Oriental Tonic Food Enteromorpha prolifera

Lin, X., Dong, L., Yan, Q., Dong, Y., Wang, L., & Wang, F. (2022) · Foods · doi:10.3390/foods11213507 · Cited by 26 · see citing works

In Silico Analysis of ACE Inhibitory Peptides from Chloroplast Proteins of Red Alga Grateloupia asiatica

Sumikawa, K., Takei, K., Kumagai, Y., Shimizu, T., Yasui, H., & Kishimura, H. (2020) · Marine Biotechnology · doi:10.1007/s10126-020-09959-2 · Cited by 25 · see citing works

In vitro assessment of dual (antiviral and antitumor) activity of a novel lectin produced by the newly cyanobacterium isolate, Oscillatoria acuminate MHM-632 MK014210.1

Saad, M. H., El‐Fakharany, E. M., Salem, M. S., & Sidkey, N. M. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1848632 · Cited by 25 · see citing works

Induction of apoptosis by a peptide from Porphyra yezoensis: Regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells

Park, S., RYU, J., Kim, I., Choi, Y., & Nam, T. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2509 · Cited by 23 · see citing works

Hypoglycemic peptide‐enriched hydrolysates of <scp><i>Corbicula fluminea</i></scp> and <scp><i>Chlorella sorokiniana</i></scp> possess synergistic hypoglycemic activity through inhibiting α‐glucosidase and dipeptidyl peptidase‐4 activity

Huang, T., Liu, P., Lin, Y., & Tsai, J. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11402 · Cited by 23 · see citing works

First Report of Screening of Novel Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from the Red Alga Acrochaetium sp.

Windarto, S., Lee, M., Nursyam, H., & Hsu, J. (2022) · Marine Biotechnology · doi:10.1007/s10126-022-10152-w · Cited by 20 · see citing works

Characterization and antitumor activity of protein hydrolysates from Arthrospira platensis (Spirulina platensis) using two-step hydrolysis

Wang, Z., & Zhang, X. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0881-9 · Cited by 19 · see citing works

Anticancer Activity of Mannose-Specific Lectin, BPL2, from Marine Green Alga Bryopsis plumosa

Lee, J. H., Lee, S. B., Kim, H., Shin, J. M., Yoon, M., An, H. S., & Han, J. W. (2022) · Marine Drugs · doi:10.3390/md20120776 · Cited by 19 · see citing works

Effects of phycoerythrin from Gracilaria lemaneiformis in proliferation and apoptosis of SW480 cells

Li, P., Ying, J., Chang, Q., Zhu, W., Yang, G., Xu, T., Yi, H., Pan, R., Zhang, E., Zeng, X., et al. (2016) · Oncology Reports · doi:10.3892/or.2016.5162 · Cited by 17 · see citing works

ACE-inhibitory peptides from Laminaria japonica and their potential anti-hypertensive mechanism

Wang, J., Ye, X., Su, Z., Zou, P., Pang, J., & Chen, J. (2021) · CyTA - Journal of Food · doi:10.1080/19476337.2021.1900923 · Cited by 17 · see citing works

Phycocyanobilin from Arthrospira platensis: A potential photodynamic anticancer agent

Xiao, S., Lu, Z.-H., Yang, J., Shi, X., & Zheng, Y. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111516 · Cited by 16 · see citing works

Peridinin-chlorophyll-protein complex industry from algae: A critical review of the current advancements, hurdles, and biotechnological potential

Qiu, S., Yuan, Y., Li, X., Zhao, C., He, Y., Tang, B., Wang, W., & Fan, J. (2023) · Algal Research · doi:10.1016/j.algal.2023.103118 · Cited by 12 · see citing works

Characterization and exploration of biological properties of phycobiliproteins purified from Thai karstic cave cyanobacterium Nostoc sp. SW02

Suphan, S., Limrujiwat, K., Kula, K., Maneeruttanarungroj, C., Raksajit, W., & Khetkorn, W. (2023) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2023.102826 · Cited by 11 · see citing works

Antioxidant activities of purified glycoprotein extracted from Codium decorticatum

Senthilkumar, D., & Jayanthi, S. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.501217 · Cited by 8 · see citing works

Exploring Metabolites Of Green Algae Caulerpa Spp. To Discover Putative Inhibitors Of Dpp-4, A New Antidiabetic Target Protein: Molecular Docking Compounds from Marine Green Algae

Balansa, W. (2023) · Jurnal Ilmiah PLATAX · doi:10.35800/jip.v11i2.48061 · Cited by 7 · see citing works

Bioactivity of Marine-Derived Peptides and Proteins: A Review

Shahidi, F., & Saeid, A. (2025) · Marine Drugs · doi:10.3390/md23040157 · Cited by 112 · see citing works

Bioactive Compounds from Marine Macroalgae: A Natural Defense Against Oxidative Stress-Related Diseases

Monroy-García, I. N., Torres-Romero, S., Castro-Ochoa, D., Mendoza-Acosta, A., Viveros‐Valdez, E., & Ayala-Zavala, J. F. (2025) · Stresses · doi:10.3390/stresses5010022 · Cited by 61 · see citing works

Recent biotechnological applications of value-added bioactive compounds from microalgae and seaweeds

Eladl, S. N., Elnabawy, A. M., & Eltanahy, E. (2024) · Botanical studies · doi:10.1186/s40529-024-00434-y · Cited by 60 · see citing works

A review on anti-inflammatory and antioxidant peptides derived from marine organisms: Mechanism of action and therapeutic applications

Jegani, K. T., Balde, A., & Nazeer, R. A. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105745 · Cited by 40 · see citing works

From Sea to Lab: Angiotensin I-Converting Enzyme Inhibition by Marine Peptides—Mechanisms and Applications

Jo, D., Khan, F., Park, S., Ko, S., Kim, K. W., Yang, D., Kim, J.-Y., Oh, G., Choi, G., Lee, D.-S., et al. (2024) · Marine Drugs · doi:10.3390/md22100449 · Cited by 38 · see citing works

Nutritional Composition and Functional Properties of A. platensis-Derived Peptides: A Green and Sustainable Protein-Rich Supplement

Begum, N., Qi, F., Yang, F., Khan, Q. U., Faizan, Fu, Q., Li, J., Xiu, W., Wang, X., Wang, J., et al. (2024) · Processes · doi:10.3390/pr12112608 · Cited by 38 · see citing works

The future of algal proteins: Innovations in extraction and modifications, functional properties, and sustainable food applications

Pipliya, S., Kumar, S., Gupta, R. K., Das, R. S., Meena, D., Srivastav, P. P., Tiwari, B. K., & García‐Vaquero, M. (2025) · Future Foods · doi:10.1016/j.fufo.2025.100549 · Cited by 37 · see citing works

Microalgae-Derived Peptides: Exploring Bioactivities and Functional Food Innovations

Ashraf, A., Guo, Y., Yang, T., ud Din, A. S., Ahmad, K., Li, W., & Hou, H. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06800 · Cited by 32 · see citing works

Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy

Tamzi, N. N., Rahman, M. M., & Das, S. (2024) · International Journal of Translational Medicine · doi:10.3390/ijtm4040051 · Cited by 28 · see citing works

Microalgae biomass–A source of sustainable dietary bioactive compounds towards improved health and well-being

Silva, M., Geada, P., Pereira, R. N., & Teixeira, J. A. (2025) · Food Chemistry Advances · doi:10.1016/j.focha.2025.100926 · Cited by 28 · see citing works

Bio-Active Peptides from Marine Sources: Mechanistic Insights into Immune Regulation, Microbiota Modulation, and Intestinal Barrier Protection

Ali, F., Li, D., Su, Y., Chen, L., Cheng, X., Zheng, X., & Mao, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110508 · Cited by 24 · see citing works

Enhanced antioxidant peptide extraction from zein using optimized ultrasound-assisted dual-enzyme methods hydrolysis

Ding, X., Zhao, Y., Zheng, R., Cai, J., Peng, X., & Li, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142938 · Cited by 23 · see citing works

Application research and progress of microalgae as a novel protein resource in the future

Ma, S. L., Sun, S., Li, T. Z., Yan, Y. J., & Wang, Z. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2431208 · Cited by 20 · see citing works

Exploring the Potential and Challenges of Fermentation in Creating Foods: A Spotlight on Microalgae

Bürck, M., Lemes, A. C., Egea, M. B., & Braga, A. R. C. (2024) · Fermentation · doi:10.3390/fermentation10120649 · Cited by 19 · see citing works

Identification of novel ACE inhibitory peptides from Nannochloropsis oculata through peptidomics, in silico screening and molecular docking

Lin, L., Yuan, W., Xiao, J., Jia, J., Xie, Y., Cai, Q., Dai, C., Li, Q., & Wang, B. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145073 · Cited by 18 · see citing works

Characterization of the physicochemical property, antioxidant activity and hypoglycemic potential of quinoa protein hydrolysates

Gan, J., Ji, Y., Sheng, Q., Wang, C., & Shen, X. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106685 · Cited by 16 · see citing works

Chitosan-Coated Nanoliposomes: Exploring the Impact on Physicochemical Properties, Stability, Antioxidant Activity, and Molecular Characterization of Chlorella-Peptide Fractions

Gharehbeglou, P., Sarabandi, K., & Akbarbaglu, Z. (2024) · Journal of Polymers and the Environment · doi:10.1007/s10924-024-03313-6 · Cited by 15 · see citing works

Stress-induced enhancement of microalgal biochemical composition for sustainable biorefineries

Gupta, S., Chelak, P., Das, M., Jha, M. K., & Das, A. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-07545-6 · Cited by 14 · see citing works

Pharmacoinformatics and cellular studies of algal peptides as functional molecules to modulate type-2 diabetes markers

Kurniawan, R., Taslim, N. A., Hardinsyah, H., Syauki, A. Y., Idris, I., Aman, A. M., Permatasari, H. K., Wiyarta, E., Surya, R., Mayulu, N., et al. (2024) · Future Foods · doi:10.1016/j.fufo.2024.100354 · Cited by 14 · see citing works

Algal protein: Structural functionality, advanced extraction technologies, and challenges for applications in food nutrition security

Li, X., Wang, K., Bai, F., Ge, P., & Tan, M. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.143572 · Cited by 14 · see citing works

Freshwater microalgae biomasses are a source of bioaccessible bioactive compounds and have antioxidant, antihypertensive, and antidiabetic activity

Silva, F. A., Santos, R. L. D., Barão, C. E., de Medeiros, V. P. B., Silva, T. O., Sassi, C. F. D. C., Feihrmann, A. C., Lima, M. D. S., Pimentel, T. C., & Magnani, M. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116259 · Cited by 15 · see citing works

Marine Algae‐Derived Bioactives: A Sustainable Resource for the Food and Agriculture Industries

Chadorshabi, S., Mohammadi, M., Shamloo, E., & Mahmoudzadeh, M. (2025) · Food Frontiers · doi:10.1002/fft2.70082 · Cited by 14 · see citing works

Seaweed (G. gracilis) Protein Hydrolyzates: A Valuable Source of Short- and Medium-Chain Peptides with Multifunctional Properties

Taglioni, E., Aita, S. E., Bollati, C., Boschin, G., Cavaliere, C., d’Adduzio, L., Montone, C. M., Laganà, A., Lammi, C., & Capriotti, A. L. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c03547 · Cited by 13 · see citing works

Peptide-based co-assembling materials: bridging fundamental science and versatile applications

Su, X., Yang, B., Chen, L., Liu, Q., Liu, A., Tan, M., & Ji, W. (2025) · Progress in Materials Science · doi:10.1016/j.pmatsci.2025.101562 · Cited by 12 · see citing works

Exploring the Modern Bioactive Peptides ( BAPs ) Universe: Doors to the Future

Patil, P. J. (2024) · Peptide Science · doi:10.1002/pep2.24366 · Cited by 12 · see citing works

Upcycling shrimp processing by-products into dual-functional peptides: Insights into bioactivity and flavor

Chen, J., Lv, H., Lì, J., Zhang, Q., Benjakul, S., Zhang, Y., & Fu, Y. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145917 · Cited by 11 · see citing works

Purification, Identification, and In Silico Analysis of Anti-Obesity and Antidiabetic Peptides from the Red Seaweed Palmaria palmata

Ghelichi, S., Hajfathalian, M., Helalat, S. H., Svensson, B., & Jacobsen, C. (2025) · Marine Drugs · doi:10.3390/md23100392 · Cited by 13 · see citing works

Capsicum in Clinical Biochemistry: Insights into its Role in Health and Disease

Faisal, A. F., & Mustafa, Y. F. (2025) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-025-01317-0 · Cited by 10 · see citing works

Improving Activity of ACE Inhibitory Peptide by Sequence‐Based Rational Design: Properties, Function on Endothelial Cells, and Potential Antihypertensive Mechanism

Liang, Q., Liu, Z., Xiao, M., Zhou, W. J., Yu, D., Liu, J., Wang, L., & Mou, H. (2025) · Food Frontiers · doi:10.1002/fft2.70076 · Cited by 10 · see citing works

In Vitro Antitumor, Antioxidant, and Hemolytic Activities of Chlorella sorokiniana Methanol Extracts and Collective Fractions

Domínguez-Gámez, M., Romo-Sáenz, C. I., Gomez‐Flores, R., González-Ochoa, G., García-Romero, A., Orozco-Flores, A. A., Rodrı́guez-Padilla, C., & Tamez‐Guerra, P. (2024) · Applied Sciences · doi:10.3390/app14209613 · Cited by 9 · see citing works

Current status and future prospects of Chlorella as raw materials in cosmeceuticals: cultivation, extraction, and commercial applications

Hidhayati, N., Purba, L. D. A., Firman, N., Admirasari, R., Rahman, D. Y., Agustini, N. W. S., Maryati, L., Anam, K., & Prayitno, J. (2024) · Journal of Applied Phycology · doi:10.1007/s10811-024-03372-1 · Cited by 9 · see citing works

Enzymatic hydrolysis of cassava leaf proteins unlocks antioxidant and therapeutic peptides: Alcalase-derived bioactives target oxidative stress pathways

Zhang, J., Fang, Y., Zhang, Z., Yu, H., Lin, L., Wang, Q., Zhang, Z., & Song, Y. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145280 · Cited by 8 · see citing works

Challenges Associated with Membrane Separation of Polypeptides and Relevant Solution Strategies

Yang, Y. Z., Duan, L., & Wu, H. (2025) · Separations · doi:10.3390/separations12090238 · Cited by 8 · see citing works

Microalgae-Derived Peptides Targeting Lifestyle-Related Diseases: Discovery, Mechanisms, Structure–Activity Relationships, and Structural Modifications

Qoms, M. S., Wong, S. K., Fauzi, N. M., Husain, K., Makpol, S., & Tan, J. K. (2025) · Antioxidants · doi:10.3390/antiox14101170 · Cited by 8 · see citing works

Unraveling the differential mechanism of casein phosphopeptide- quercetin covalent/non-covalent complexes: structural characterization and dynamic binding behavior

Guo, D., Wei, S., Song, M., Yang, Y., Cai, Y., Wang, H., Yang, Y., & Xu, W. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.147503 · Cited by 8 · see citing works

Algal proteins and bioactive peptides: Sustainable nutrition for human health

Meng, T., Wen, J., Liu, H., Guo, Y., Tong, A., Chu, Y., Du, B., He, X., & Zhao, C. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140760 · Cited by 7 · see citing works

Mussels as sustainable marine resources for bioactive peptides for health and the food industry

Suryaningtyas, I. T., Jasmadi, Dayarathne, L. A., Marasinghe, C. K., & Je, J. (2025) · Food & Function · doi:10.1039/d4fo05397d · Cited by 7 · see citing works

Investigation of Anticancer Peptides Derived from Arca Species Using In Silico Analysis

Wu, J., Zhang, X., Jin, Y., Zhang, M., Yu, R., Song, L., Liu, F., & Zhu, J. (2025) · Molecules · doi:10.3390/molecules30071640 · Cited by 7 · see citing works

Dual-Functional Antioxidant CIRAKLC Peptide Discovery: A Biomaterial-Integrated Strategy for ROS Scavenging and Enzyme Modulation in Oxidative Stress Therapeutics

Liu, X., Wu, H., Ren, Z., Wang, Y., Yang, G., Cong, H., & Yu, B. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c05089 · Cited by 7 · see citing works

Functional Properties of Enzymatic Food Protein Hydrolysates

Kadam, D., & Aluko, R. E. (2025) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-053124-013151 · Cited by 7 · see citing works

Recent advances in antidiabetic marine-derived bioactive peptides: production, therapeutic targets, structure–function relationship, and bioavailability

Fang, Y., Alahyaribeik, S., Hazaveh, M. N., Keung, P. C. C., Nie, L., Grootaert, C., Camp, J. V., & Mirzaei, M. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2599498 · Cited by 7 · see citing works

Inhibition of myeloperoxidase by food-derived peptides: A review of current research and future prospects

Wong, F., Chow, Y., Tan, S.-A. S. W., Tian, L., Bai, W., & Chai, T. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104458 · Cited by 6 · see citing works

Defatted Nannochloropsis oculata biomass – Waste or resource?

Sousa, S. C., Machado, M., Coscueta, E. R., Ferreira, A. S., Nunes, C., Coimbra, M. A., Freitas, A. C., CARVALHO, A. P. F. D., & Gomes, A. (2024) · Algal Research · doi:10.1016/j.algal.2024.103695 · Cited by 6 · see citing works

Enhanced antihypertensive chicken by-product hydrolysate fraction after its separation by electrodialysis with ultrafiltration membrane (EDUF)

Adaile-Pérez, V. M., Thibodeau, J., Ortiz‐Basurto, R. I., García‐Magaña, M. D. L., & Bazinet, L. (2025) · Food Research International · doi:10.1016/j.foodres.2024.115595 · Cited by 6 · see citing works

Preparation and Efficacy Evaluation of Antihyperuricemic Peptides from Marine Sources

Qiao, K., Huang, Q., Sun, T., Chen, B., Huang, W., Su, Y., Lin, H., & Liu, Z. (2024) · Nutrients · doi:10.3390/nu16244301 · Cited by 6 · see citing works

Research progress and latest application of ultrasonic treatment on protein extraction and modification

Zhang, J., Ji, S., Liang, J., Chen, Y., Tang, W., & Lyu, F. (2024) · International Journal of Food Science & Technology · doi:10.1111/ijfs.17196 · Cited by 5 · see citing works

Exploring food-derived bioactive peptides: Efficacy, mechanisms, and clinical implications in ferroptosis regulation

Gao, C., Zhang, L., Ma, J., Zhang, H., Pang, Y., Xue, C., Li, D., Zhao, X., Gantumur, M., Hui, M., et al. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105014 · Cited by 5 · see citing works

Discovery and molecular mechanism of a novel antihypertensive peptide from Chlamydomonas reinhardtii based on molecular docking, molecular dynamics simulation, in vitro, and in vivo analysis

Suo, Q., Yue, Y., Wang, J., Wu, N., Geng, L., & Zhang, Q. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118477 · Cited by 6 · see citing works

Emerging methods to extract bioactive compounds from brown algae: a comprehensive review of performance, readiness, and sustainability

Fonseca‐Barahona, I., Shahbaz, K., & Baroutian, S. (2026) · Separation and Purification Technology · doi:10.1016/j.seppur.2026.137731 · Cited by 5 · see citing works

Navigating the potential of algal peptides: health effects, market applications, and scientific challenges

Khaliq, M., Noor, Z., Moazzam, M., Saeed, F., Tul-Zohra, K., Tariq, E., Muhammad Shahbaz, H., & Khaliq, K. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2637282 · Cited by 4 · see citing works

From sea to supplement: Algal protein extraction methods and functional benefits

Chaudhary, S., Singh, R., Mishra, S., Talwar, B., & Balhara, K. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147750 · Cited by 5 · see citing works

Growth and iota-carrageenan from the red seaweed Solieria filiformis (Rhodophyta, Solieriaceae) cultivated in the Ceara State coast, Brazil

Holanda, T. D. B. L., Bessa, É. F., Lima, F. E. D. S., Lopes, F. L. D. S., Martins, J. R. P., Benevídes, N. M. B., & Araújo, M. L. H. (2025) · Aquaculture International · doi:10.1007/s10499-025-01864-6 · Cited by 4 · see citing works

Analysis of Flavor Differences Between Undaria pinnatifida Produced Using Different Processing Methods and from Different Origins Based on GC-IMS

Che, X., Cao, F., Yan, T., Liu, X., Cai, Q., Liu, S., Ma, Y., Ren, D., Zhou, H., Wang, Q., et al. (2025) · Foods · doi:10.3390/foods14122107 · Cited by 4 · see citing works

Proteomics and bioinformatics guided discovery of microalgal multifunctional peptides for novel nutraceutical applications

Romdhani, M., Dhaouafi, J., Deracinois, B., Flahaut, C., Nedjar, N., & Balti, R. (2025) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-025-03192-8 · Cited by 4 · see citing works

Design and experimental verification of novel angiotensin‐converting enzyme and dipeptidyl peptidase IV inhibitory peptides from Ziziphus jujuba peptide KALVAP

Wen, H., Lan, J., Dang, K., Wang, Y., Pan, D., Gao, X., & Dang, Y. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70156 · Cited by 3 · see citing works

Chlorella sp. as a promising natural antioxidant source: Research trends, bioactive components, and future perspectives

Badrunanto, B., Purba, L. D. A., Wikantyasning, E. R., Maryati, M., Prayitno, J., Hidhayati, N., Agustini, N. W. S., Munawaroh, H. S. H., Susanti, H., Kusumawaty, D., et al. (2025) · Algal Research · doi:10.1016/j.algal.2025.104341 · Cited by 3 · see citing works

The latest progress of food protein as a source of antidiabetic peptides: Insights from emerging proteins

Zhang, Q., Liu, J., Li, S., Huang, Z. J., Pang, L., Guo, L., Yang, X., & Qu, B. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149118 · Cited by 3 · see citing works

Marine Biodiversity as a Reservoir of Innovative Biomaterials for Regenerative Medicine

Darshinii, B. D., Anbarasu, K., & Devarajan, Y. (2025) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00507-9 · Cited by 3 · see citing works

Algae-Derived Peptides as Functional Food Ingredients: Bioactivities, Processing Challenges, and Computational Design Strategies

Su, K., Ma, J., Li, Q., ZHANG, X., & Cheng, L. (2026) · Foods · doi:10.3390/foods15050811 · Cited by 3 · see citing works

Photosensitization optimization in Chlorella: Driving the acclimation-enhanced degradation of sulfonamide antibiotics

Chen, J., Lin, S., Ruan, C., Liu, L., & Yang, S. (2025) · Chemical Engineering and Processing - Process Intensification · doi:10.1016/j.cep.2025.110196 · Cited by 3 · see citing works

Identification of peptides derived from ripened Mihalic cheese and promising properties: in silico and in vitro approaches

Altuntas, S., & Altuntaş, V. (2025) · European Food Research and Technology · doi:10.1007/s00217-025-04785-z · Cited by 2 · see citing works

Composition, structural features, and multifunctional properties of extracellular polysaccharides from the non-toxic green alga Parachlorella sp.

Uejima, Y., Yamane, R., Ishida, R., Sasaki, D., Igari, N., Nakamura, A., & Asayama, M. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123996 · Cited by 2 · see citing works

Deep learning-derived optimal annotation strategies to power the systematic mapping of peptide space

Yue, L., Jia, W., & Zhang, R. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145437 · Cited by 2 · see citing works

Selective release of antioxidant peptides and minerals from fermented SC-CO2-defatted Spirulina

Liu, Y., Pallarés, N., Ferrer, E., Martínez‐Culebras, P. V., Roig, P., Castagnini, J. M., Berrada, H., & Barba, F. J. (2026) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2026.104445 · Cited by 2 · see citing works

Algal-derived oligopeptides: overcoming extraction, and purification barriers for sustainable nutraceuticals innovation

Perumal, P. K., Dubey, S., Wani, H. M. U. D., Singhania, R. R., Bhatia, S. K., & Patel, A. K. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2617462 · Cited by 2 · see citing works

Application, Challenges, and Prospects of Non‐Thermal Processing Technologies for Seaweed Protein Extraction—A Review

Mahmud, R., Hasan, M. F. A., Roy, S., & Ahmed, T. (2026) · Food Chemistry International · doi:10.1002/fci2.70064 · Cited by 3 · see citing works

Chlorella vulgaris as a functional food and nutraceutical: bioactive composition, health-promoting mechanisms, applications, and current challenges

Shah, M. A. R., Gao, F., Zhu, F., Hu, X., Kayani, S., AL-Farga, A., Srinuanpan, S., & Huo, S. (2026) · Food & Function · doi:10.1039/d6fo00663a · Cited by 2 · see citing works

Proteins from blue foods to meet the demand in the food sector: Editorial

Fu, Y., Zhang, N., & Zhang, Y. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104722 · Cited by 3 · see citing works

Layer-by-layer assembly mechanism of particulate-continuous phase for sandwich-like nanoparticles in oral colon-targeted protein delivery

Hu, W.-X., Jin, C.-S., Li, S., Fu, J., Liao, L.-S., Yu, X., & Du, S. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145398 · Cited by 2 · see citing works

Characterization and Function of a Novel Extracellular Polysaccharide from a Green Alga Parachlorella sp. AMI5

Yamane, R., Ishida, R., Uejima, Y., Takagi, A., Nakamura, A., & Asayama, M. (2025) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-025-05276-3 · Cited by 1 · see citing works

A highly efficient method for screening dual-target inhibitory peptides against angiotensin I-converting enzyme and α-amylase from Chlorella using an enzyme-immobilized affinity membrane

Yu, C., Zu, X., Liang, Y., Zhao, X., Li, Y., Wang, C., & Wang, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148954 · Cited by 1 · see citing works

Botryocladia leptopoda Extracts Promote Wound Healing Ability via Antioxidant and Anti-Inflammatory Activities and Regulation of MMP/TIMP Expression

Lin, S., Yi, T.-K., Kao, Y.-F., Tu, M.-C., Hsieh, C., Chou, Y.-C., Lu, J.-J., Santoso, S. P., Chai, H., & Cheng, K. (2025) · Marine Drugs · doi:10.3390/md23110444 · Cited by 1 · see citing works

Marine octapeptide DLTAGLLE lowers blood pressure via endothelium-RAS-microbiota axis

Hu, X., Jiang, Y., Dai, Z., Luo, Y., & Zhao, C. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.102890 · Cited by 1 · see citing works

Mechanisms and Production of Hypoglycaemic Peptides: Exploring the Potential of Chlamydomonas reinhardtii

Li, Q., Su, K., Yang, C., Sun, X., Huang, J., Zhong, S., & Cheng, L. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71790 · Cited by 1 · see citing works

Next-generation bioactive peptides from edible microorganisms: From AI-driven discovery to sustainable bio-manufacturing

Chen, M., Li, D., Zeng, W., Mu, J., Wang, S. L., & Liang, Y. (2026) · Journal of Future Foods · doi:10.1016/j.jfutfo.2026.07.001 · Cited by 1 · see citing works

An overview of the use of proteomics and peptidomics to characterize alternative protein foods

Banerjee, R., Nanda, P. K., Alessandroni, L., & Das, A. K. (2026) · Journal of Proteomics · doi:10.1016/j.jprot.2026.105720 · Cited by 1 · see citing works

Healing from the Ocean: Targeting Shared Mechanisms in Autism and Epilepsy Using Algae-Derived Compounds

Avni, D., Weissberg, O., Pintel, N., & Izraelov, L. (2026) · Marine Drugs · doi:10.3390/md24080277 · Cited by 1 · see citing works

Rational module substitution strategy to enhance ACE-inhibitory peptide activity

Liang, Q., Peng, S., Liu, Z., Wang, J., Tang, L., Zhu, C., Zhu, L., Yang, M., Li, D., & Mou, H. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.146191 · Cited by 1 · see citing works

An Overview of the Phytochemical and Therapeutic Potential of Wrightia tinctoria

Jurel, P., Bahadur, S., & Bajpai, M. (2024) · Current Bioactive Compounds · doi:10.2174/0115734072347358240920082453

Biological activities and health benefits of fish protein hydrolysate

Liu, Y., Sebastià, A., Calleja-Gómez, M., Castagnini, J. M., Salgado-Ramos, M., Martí-Quijal, F. J., Barba, F. J., & Pallarés, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21654-1.00009-4

From Sea to Cell: Marine Peptides as Key Players in siRNA-Mediated Cancer Therapy

Alfaray, R. I., Amalia, N., Ali, M., Supranoto, Y. T. N., Darmawan, H. E., Purnomo, A. F., Pramono, A., Taslim, N. A., Tjandrawinata, R. R., Tallei, T. E., et al. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_490

References

Fleurence, J. (2025) · Wiley eBooks · doi:10.1002/9781394361427.refs

Characteristics of hydroxyapatite/lignocellulose composites as stationary phase for the purification applications of phycobiliprotein from red algae

Kausar, R. A., Garcia, S., Anisa, D. N., & Setiawan, A. (2025) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6262/adb560

Discovery and Validation of a Novel Antioxidant Peptide from Lotus Root Via in Silico, in Vitro, and in Vivo ApproachesPreprint

Mao, M., Yu, X., Tian, G., Zhang, L., Huang, H., & Chu, Q. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5247444

The Emergence of Bioactive Peptides as Anti-diabetic Agents: A Review

Prajapati, R., Singh, R. M., Singh, V., & Katrolia, A. (2025) · Current Protein and Peptide Science · doi:10.2174/0113892037386831250806112604

Reshaping Meat Consumption: Meat Substitutes in a Sustainability Perspective

Wang, C., Yang, Z., Lin, M., Miao, S., & Guo, Z. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2577168

Antidiabetic efficiency of mangrove microbiome

Vijayalakshmi, A., & Hemalatha, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26771-0.00023-0

An integrated, eco-friendly analytical platform for exploratory assessment of biomass composition and antioxidant potential in Euglena gracilis (Euglenophyceae)

Leal, V. L., Rathke, C. R., Ortolan, S. A., Ferrão, M. F., Schneider, R. D. C. D. S., & Corbellini, V. A. (2025) · Algal Research · doi:10.1016/j.algal.2025.104435

Marine algae as a source of bioactive compounds: unlocking anticancer potential

Najwa, H., Rachid, R., Ahnyne, R., Abdelouahid, E., Badr, H., Errhif, A., & Ennaji, M. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30225-1.00019-1

Whitening Efficacy of Bird's Nest Filtrate Fermented With Bacillus subtilis FZU‐S10: In Vitro and In Vivo Studies

Liu, W., Chen, Q., Lian, J., Chen, X., Yu, A., Chen, S., Zhang, W., Han, J., Han, J., & Liu, W. (2025) · Journal of Food Science · doi:10.1111/1750-3841.70798

Antimicrobial Potential of Algae and Their Metabolites

Garuba, T. (2026) · Reference series in phytochemistry · doi:10.1007/978-3-031-80866-1_25-1

Aquatic biopeptides in flavor and metabolic regulation: A convergence of biochemistry and artificial intelligence

Sun, H., Yu, T., Zhang, Y., Wang, B., Zhang, Y., Qiu, W., Zhao, G., & Wang, Y. (2026) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2026.105644

Algal peptides: diversity, roles, relation to plant peptide science, and applications in crop improvement

Bakku, R. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-15652-6.00002-3

Secondary Metabolites from Macroalgae: Chemistry, Classification, and Applications

Carpena, M., Silva, A., Barciela, P., Jorge, A. O. S., Perez-Vazquez, A., Pereira, A. G., Nogueira‐Marques, R., Oliveira, M. B. P. P., & Prieto, M. A. (2026) · Springer eBooks · doi:10.1007/978-3-642-36202-6_281-1

Peptide GCSTVLC derived from Sipunculus nudus alleviates diabetic nephropathy partialy through NF-κB pathway regulation

Chen, L., Yan, S., Shen, X., Peng, Z., Qi, Y., Hong, H., Wang, Z., & Ouyang, Q. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107332

Algae as a Sustainable Source of High-Value Nutritional Ingredients: Regulatory Framework and Health Benefits

El‐Saadony, M. T., Saad, A. M., Sitohy, M. Z., Mohammed, D. M., Salem, H. M., Alkafaas, S. S., Choudhary, M., Ghosh, S., Fahmy, M. A., Mosa, W. F. A., et al. (2026) · Springer eBooks · doi:10.1007/978-3-032-22521-4_19

Algae in Functional Foods: Enhancing Health Benefits Through Bioactive Components

Fatima, N. (2026) · Springer eBooks · doi:10.1007/978-3-032-22521-4_3

Natural algal products as potential pancreatic lipase inhibitors for obesity treatment: screening and mechanisms of action

Oliyaei, N., Awlqadr, F. H., & Abedi, E. (2026) · European Food Research and Technology · doi:10.1007/s00217-026-05172-y

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Xu, Y., Li, F., Zhao, R., Shu, T., Min, W., & Zhu, B. (2026) · Advanced Science · doi:10.1002/advs.76666

Algal Proteins, Peptide Hydrolysates, and Temperate Phyconomy

Hayes, M. (2026) · Developments in applied phycology. · doi:10.1007/978-3-032-28281-1_20

Bio-functionalities of proteins derived from marine algae — A review

Samarakoon, K. W., & Jeon, Y. (2012) · Food Research International · doi:10.1016/j.foodres.2012.03.013 · Cited by 289 · see citing works

Bioactive Peptides from Algae: Traditional and Novel Generation Strategies, Structure-Function Relationships, and Bioinformatics as Predictive Tools for Bioactivity

O’Connor, J., Garcia-Vaquero, M., Meaney, S., & Tiwari, B. K. (2022) · Marine Drugs · doi:10.3390/md20050317 · Cited by 81 · see citing works

Bioactive Proteins and Peptides from Microalgae

Stack, J., Gouic, A. V. L., & Fitzgerald, R. J. (2020) · Encyclopedia of Marine Biotechnology · doi:10.1002/9781119143802.ch61 · Cited by 18 · see citing works

Algae-Derived Peptides as Functional Food Ingredients: Bioactivities, Processing Challenges, and Computational Design Strategies

Su, K., Ma, J., Li, Q., ZHANG, X., & Cheng, L. (2026) · Foods · doi:10.3390/foods15050811 · Cited by 3 · see citing works

Navigating the potential of algal peptides: health effects, market applications, and scientific challenges

Khaliq, M., Noor, Z., Moazzam, M., Saeed, F., Tul-Zohra, K., Tariq, E., Muhammad Shahbaz, H., & Khaliq, K. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2637282 · Cited by 4 · see citing works