Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain

Principles and procedures of statistics.

Steel, R. G. D., & Torrie, J. H. (1960) · Cited by 24,135

Principles and Procedures of Statistics

Robinson, H. F. (1961) · Agronomy Journal · doi:10.2134/agronj1961.00021962005300050002x · Cited by 17,727

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

Production of Reactive Oxygen Species by Mitochondria

Chen, Q., Vazquez, E. J., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304854200 · Cited by 1,616

Complete Structure of the 11-Subunit Bovine Mitochondrial Cytochrome bc 1 Complex

Iwata, S., Lee, J. W., Okada, K., Lee, J. K., Iwata, M., Rasmussen, B., Link, T. A., Ramaswamy, S., & Jap, B. K. (1998) · Science · doi:10.1126/science.281.5373.64 · Cited by 1,253

Cytochrome c release from mitochondria proceeds by a two-step process

Ott, M., Robertson, J. D., Gogvadze, V. G., Zhivotovsky, B., & Orrenius, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241655498 · Cited by 955

Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle

Palmer, J. W., Tandler, B., & Hoppel, C. L. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75283-1 · Cited by 830

Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure

Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 719

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol

Han, D., Antunes, F., Canali, R., Rettori, D., & Cadenas, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210269200 · Cited by 711

New concepts in reactive oxygen species and cardiovascular reperfusion physiology

Becker, L. C. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.025 · Cited by 703

Reactive oxygen species, cellular redox systems, and apoptosis

Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340

ROS signalling in the biology of cancer

Moloney, J. N., & Cotter, T. G. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.023 · Cited by 2,030

Mechanisms of Cell Death in Oxidative Stress

Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., & Choi, A. M. K. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.49 · Cited by 1,286

Three Distinct Mechanisms Generate Oxygen Free Radicals in Neurons and Contribute to Cell Death during Anoxia and Reoxygenation

Abramov, A. Y., Scorziello, A., & Duchen, M. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4468-06.2007 · Cited by 686

Oxidative Stress in Cancer Cell Metabolism

Arfin, S., Jha, N. K., Jha, S. K., Kesari, K. K., Ruokolainen, J., Roychoudhury, S., Rathi, B., & Kumar, D. (2021) · Antioxidants · doi:10.3390/antiox10050642 · Cited by 721

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

Radi, E., Formichi, P., Battisti, C., & Federico, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132738 · Cited by 641

Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling

Radak, Z. O., Zhao, Z., Koltai, E., Ohno, H., & Atalay, M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4498 · Cited by 643

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555

Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471

Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies

Lesnefsky, E. J., Chen, Q., Tandler, B., & Hoppel, C. L. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103335 · Cited by 447

Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process

den Hengst, W. A., Gielis, J. F., Lin, J. Y., Schil, P. E. V., Windt, L. J. D., & Moens, A. L. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00251.2010 · Cited by 411

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion

Raedschelders, K., Ansley, D. M., & Chen, D. D. Y. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.004 · Cited by 393

Cytochrome c oxidase dysfunction in oxidative stress

Srinivasan, S., & Avadhani, N. G. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.021 · Cited by 392

Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System

Branca, J. J. V., Fiorillo, C., Carrino, D., Paternostro, F., Taddei, N., Gulisano, M., Pacini, A., & Becatti, M. (2020) · Antioxidants · doi:10.3390/antiox9060492 · Cited by 327

Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria

Chen, Q., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00211.2007 · Cited by 299

Mitochondria-Targeted Cytoprotective Peptides for Ischemia–Reperfusion Injury

Szeto, H. H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1892 · Cited by 274

Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion

Chen, Q., Camara, A. K. S., Stowe, D. F., Hoppel, C. L., & Lesnefsky, E. J. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00270.2006 · Cited by 271

Role of Oxidative Stress in Pancreatic Inflammation

Leung, P. S., & Chan, Y. C. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2109 · Cited by 267

NF-κB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes

Mariappan, N., Elks, C. M., Sriramula, S., Guggilam, A., Liu, Z., Borkhsenious, O. N., & Francis, J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp305 · Cited by 248

Reversible Blockade of Electron Transport during Ischemia Protects Mitochondria and Decreases Myocardial Injury following Reperfusion

Chen, Q., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.110262 · Cited by 215

Potential Therapeutic Benefits of Strategies Directed to Mitochondria

Camara, A. K. S., Lesnefsky, E. J., & Stowe, D. F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2788 · Cited by 199

Oxidative phosphorylation and aging

Lesnefsky, E. J., & Hoppel, C. L. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.001 · Cited by 197

Formation and Regulation of Mitochondrial Membranes

Schenkel, L. C., & Bakovic, M. (2014) · International Journal of Cell Biology · doi:10.1155/2014/709828 · Cited by 180

Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria

Boengler, K., Stahlhofen, S., van de Sand, A., Gres, P., Ruiz‐Meana, M., David Garcia-dorado, A., Heusch, G., & Schulz, R. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0007-5 · Cited by 172

Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

Yang, L., Zhao, K., Calingasan, N. Y., Luo, G., Szeto, H. H., & Beal, M. F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2445 · Cited by 168

Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies

Hollander, J. M., Thapa, D., & Shepherd, D. L. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00747.2013 · Cited by 171

Effect of gold nanoparticles on glutathione depletion-induced hydrogen peroxide generation and apoptosis in HL7702 cells

Gao, W. Z., Xu, K., Ji, L., & Tang, B. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.05.1018 · Cited by 136

Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology?

Koopman, W. J. H., Verkaart, S., Visch, H.-J., Vries, S. E. V. E., Nijtmans, L. G. J., Smeitink, J. A. M., & Willems, P. H. G. M. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00194.2006 · Cited by 134

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

Pasdois, P., Parker, J. E., Griffiths, E. J., & Halestrap, A. P. (2011) · Biochemical Journal · doi:10.1042/bj20101957 · Cited by 127

Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3

Szczepanek, K., Chen, Q., Larner, A. C., & Lesnefsky, E. J. (2012) · Mitochondrion · doi:10.1016/j.mito.2011.08.011 · Cited by 117

Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle

Sahlin, K., Shabalina, I. G., Mattsson, C. M., Bakkman, L., Fernström, M., Rozhdestvenskaya, Z., Enqvist, J. K., Nedergaard, J., Ekblom, B. T., & Tonkonogi, M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2009 · Cited by 112

Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

Lee, W.-J., Hsiao, M., Chang, J.-L., Yang, S., Tseng, T., Cheng, C., Chow, J., Lin, K.-H., Lin, Y.-W., Liu, C.-C., et al. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1300-0 · Cited by 108

Mitochondrial Respiratory Dysfunction in Familiar Parkinsonism Associated with PINK1 Mutation

Piccoli, C., Sardanelli, A. M., Scrima, R., Ripoli, M. C., Quarato, G., D’Aprile, A., Bellomo, F., Scacco, S., Michele, G. D., Filla, A., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9729-2 · Cited by 109

Development of Mitochondria‐targeted Aromatic‐cationic Peptides for Neurodegenerative Diseases

Szeto, H. H. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.013 · Cited by 100

Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions

Monteiro, J. P., Oliveira, P. J., & Jurado, A. S. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.06.002 · Cited by 102

Exercise Protects Cardiac Mitochondria against Ischemia–Reperfusion Injury

Lee, Y., Min, K., Talbert, E. E., Kavazis, A. N., Smuder, A. J., Willis, W. T., & Powers, S. K. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318231c037 · Cited by 98

A radical approach to beating hypoxia: depressed free radical release from heart fibres of the hypoxia-tolerant epaulette shark (Hemiscyllum ocellatum)

Hickey, A. J., Renshaw, G. M. C., Speers‐Roesch, B., Richards, J. G., Wang, Y., Farrell, A. P., & Brauner, C. J. (2011) · Journal of Comparative Physiology B · doi:10.1007/s00360-011-0599-6 · Cited by 90

Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia

Birk, A. V., Chao, W. M., Liu, S., Soong, Y., & Szeto, H. H. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.06.006 · Cited by 65

Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore

Chen, Q., & Lesnefsky, E. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.029 · Cited by 64

Critical role of complex III in the early metabolic changes following myocardial infarction

Heather, L. C., Carr, C. A., Stuckey, D. J., Pope, S. A. S., Morten, K., Carter, E. E., Edwards, L. M., & Clarke, K. J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp276 · Cited by 61

Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis

Kolli, V. K., Natarajan, K., Isaac, B. T. J., Selvakumar, D., & Abraham, P. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113515503 · Cited by 57

Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1

Jian, B., Yang, S., Chaudry, I. H., & Raju, R. P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00365 · Cited by 57

Mitigation of NADH: Ubiquinone oxidoreductase deficiency by chronic Trolox treatment

Koopman, W. J. H., Verkaart, S., Vries, S. E. V. E., Grefte, S., Smeitink, J. A. M., Nijtmans, L. G. J., & Willems, P. H. G. M. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.028 · Cited by 58

Metabolic Adaptation to a Disruption in Oxygen Supply during Myocardial Ischemia and Reperfusion Is Underpinned by Temporal and Quantitative Changes in the Cardiac Proteome

Li, X., Arslan, F., Ren, Y., Adav, S. S., Poh, K. K., Sorokin, V. A., Lee, C. N., de Kleijn, D. P. V., Lim, S. K., & Sze, S. K. (2012) · Journal of Proteome Research · doi:10.1021/pr201025m · Cited by 56

Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer

Han, C., Wang, Z., Xu, Y., Chen, S., Han, Y., Li, L., Wang, M., & Xun-bo, J. (2020) · BioMed Research International · doi:10.1155/2020/1269624 · Cited by 57

Short Term Exercise Induces PGC-1α, Ameliorates Inflammation and Increases Mitochondrial Membrane Proteins but Fails to Increase Respiratory Enzymes in Aging Diabetic Hearts

Botta, A. M., Laher, I., Beam, J., DeCoffe, D., Brown, K., Halder, S., Devlin, A. M., Gibson, D. L., & Ghosh, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070248 · Cited by 56

Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia/reperfusion injury

Brown, D. A., Sabbah, H. N., & Shaikh, S. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.005 · Cited by 52

Look into brain energy crisis and membrane pathophysiology in ischemia and reperfusion

Chomová, M., & Žitňanová, I. (2016) · Stress · doi:10.1080/10253890.2016.1174848 · Cited by 53

Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats

Chen, M., Wang, M., Yang, Q., Wang, M., Wang, Z., Zhu, Y., Zhang, Y., Wang, C., Jia, Y., Li, Y., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2571 · Cited by 49

Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia

Sepuri, N. B. V., Angireddy, R., Srinivasan, S., Guha, M., Spear, J. F., Lü, B., Anandatheerthavarada, H. K., Suzuki, C. K., & Avadhani, N. G. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.04.003 · Cited by 49

Oxidative stress-induced formation of a positive-feedback loop for the sustained activation of p38 MAPK leading to the loss of cell division in cardiomyocytes soon after birth

Matsuyama, D., & Kawahara, K. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0178-8 · Cited by 46

Phenazine-1-carboxamide (PCN) from Pseudomonas sp. strain PUP6 selectively induced apoptosis in lung (A549) and breast (MDA MB-231) cancer cells by inhibition of antiapoptotic Bcl-2 family proteins

Kennedy, R. K., Veena, V., Naik, P. R., Lakshmi, P., Krishna, R., Sudharani, S., & Sakthivel, N. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1118-0 · Cited by 47

Ischemia‐reperfusion and cardioprotection: A delicate balance between reactive oxygen species generation and redox homeostasis

Goswami, S. K., Maulik, N., & Das, D. K. (2007) · Annals of Medicine · doi:10.1080/07853890701374677 · Cited by 47

Postconditioning Modulates Ischemia-damaged Mitochondria During Reperfusion

Chen, Q., Paillard, M., Gomez, L., Li, H., Hu, Y., & Lesnefsky, E. J. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31823827cc · Cited by 46

Reverse electron flow-mediated ROS generation in ischemia-damaged mitochondria: Role of complex I inhibition vs. depolarization of inner mitochondrial membrane

Ross, T., Szczepanek, K., Bowler, E., Hu, Y., Larner, A. C., Lesnefsky, E. J., & Chen, Q. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.035 · Cited by 48

Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury

Yang, T., Mao, Y., Liu, S., Hou, J., Cai, Z.-Y., Hu, J., Ni, X., Deng, X., & Zhu, X. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.12.025 · Cited by 43

A Sphingosine Kinase Form 2 Knockout Sensitizes Mouse Myocardium to Ischemia/Reoxygenation Injury and Diminishes Responsiveness to Ischemic Preconditioning

Vessey, D. A., Li, L., Jin, Z.-Q., Kelley, M., Honbo, N. Y., Zhang, J., & Karliner, J. S. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/961059 · Cited by 46

Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat

Zhang, H., Chen, Y., Chen, Y., Jia, P., Ji, S., Xu, J., Li, Y., & Wang, T. Z. (2020) · Food & Function · doi:10.1039/d0fo00732c · Cited by 44

In vivo hyperoxic preconditioning protects against rat-heart ischemia/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c release

Petrosillo, G., Venosa, N. D., Moro, N., Colantuono, G., Paradies, V., Tiravanti, E., Federici, A., Ruggiero, F. M., & Paradies, G. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.030 · Cited by 42

Oxidative injury induces selective rather than global inhibition of proteasomal activity

Gurusamy, N., Goswami, S. K., Malik, G., & Das, D. K. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.10.005 · Cited by 40

Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model

Jian, B., Yang, S., Chaudry, I. H., & Raju, R. P. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00077 · Cited by 38

HYPOXIA-INDUCED ALTERATION OF MITOCHONDRIAL GENES IN CARDIOMYOCYTES

Jian, B., Wang, D., Chen, D., Voss, J. G., Chaudry, I. H., & Raju, R. P. (2010) · Shock · doi:10.1097/shk.0b013e3181cffe7d · Cited by 38

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Mulligan, C. M., Le, C. H., deMooy, A. B., Nelson, C. B., & Chicco, A. J. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt209 · Cited by 37

Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning☆

Matsuzaki, S., Szweda, P. A., Szweda, L. I., & Humphries, K. M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.008 · Cited by 37

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Chen, Q., Yin, G., Stewart, S., Hu, Y., & Lesnefsky, E. J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.137 · Cited by 34

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Jian, B., Yang, S., Chen, D., Zou, L., Chatham, J. C., Chaudry, I. H., & Raju, R. P. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00195 · Cited by 33

Impaired mitochondrial function in chronically ischemic human heart

Stride, N. O., Larsen, S., Hey‐Mogensen, M., HANSEN, C. N., Prats, C., Steinbrüchel, D. A., Køber, L., & Dela, F. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00991.2012 · Cited by 30

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Thompson, J., Maceyka, M. W., & Chen, Q. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111380 · Cited by 30

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Rohrbach, S., Aslam, M., Niemann, B., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12650 · Cited by 31

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Wang, B., & Xu, A. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.12.004 · Cited by 30

Delta Protein Kinase C Interacts with the d Subunit of the F1F0 ATPase in Neonatal Cardiac Myocytes Exposed to Hypoxia or Phorbol Ester

Nguyen, T. T. M., Ogbi, M., & Johnson, J. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801642200 · Cited by 29

Reactive Oxygen Species and Apoptosis

Azad, N., & Iyer, A. K. V. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_15 · Cited by 27

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Hu, H., Doll, D. N., Sun, J., Lewis, S. E., Wimsatt, J., Kessler, M. J., Simpkins, J. W., & Ren, X. S. (2016) · Aging and Disease · doi:10.14336/ad.2015.0906 · Cited by 24

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Zhang, D., Chen, C., Wang, H., Niu, E., Zhao, P., Fang, S., Zhu, G., Shang, X., & Guo, W. (2020) · Genetics · doi:10.1093/genetics/iyaa017 · Cited by 24

Optical spectroscopy in turbid media using an integrating sphere: Mitochondrial chromophore analysis during metabolic transitions

Chess, D. J., Billings, E. M., Covián, R., Glancy, B. C., French, S. A., Taylor, J. F., Bari, H. D., Murphy, E., & Balaban, R. S. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.04.017 · Cited by 24

Oxidative complexity: The role of ROS in the tumor environment and therapeutic implications

Shen, T., Wang, Y., Cheng, L., Bode, A. M., Gao, Y., Zhang, S., Chen, X., & Luo, X. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118241 · Cited by 24

Arousal from Torpor Increases Oxidative Damage in the Hibernating Thirteen-Lined Ground Squirrel (Ictidomys tridecemlineatus)

Duffy, B. M., & Staples, J. F. (2022) · Physiological and Biochemical Zoology · doi:10.1086/719931 · Cited by 23

Coenzyme Q10 and nicotinamide nucleotide transhydrogenase: Sentinels for mitochondrial hydrogen peroxide signaling

Grayson, C., & Mailloux, R. J. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.08.015 · Cited by 23

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Raffaghello, L., & Longo, V. D. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.01.003 · Cited by 19

Mitochondria as a target of cardioprotection in models of preconditioning

Jasova, M., Kancirová, I., Waczulı́ková, I., & Ferko, M. (2017) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-017-9720-1 · Cited by 17

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Pennington, E. R., Sullivan, E. M., Fix, A., Dadoo, S., Zeczycki, T. N., DeSantis, A., Schlattner, U., Coleman, R., Chicco, A. J., Brown, D. A., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004948 · Cited by 16

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Reid, C., & Finnerty, N. J. (2017) · Sensors · doi:10.3390/s17071596 · Cited by 6

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