Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain

Principles and procedures of statistics.

Steel, R. G. D., & Torrie, J. H. (1960) · Cited by 24,135

Principles and Procedures of Statistics

Robinson, H. F. (1961) · Agronomy Journal · doi:10.2134/agronj1961.00021962005300050002x · Cited by 17,727

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

Production of Reactive Oxygen Species by Mitochondria

Chen, Q., Vazquez, E. J., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304854200 · Cited by 1,616

Complete Structure of the 11-Subunit Bovine Mitochondrial Cytochrome bc 1 Complex

Iwata, S., Lee, J. W., Okada, K., Lee, J. K., Iwata, M., Rasmussen, B., Link, T. A., Ramaswamy, S., & Jap, B. K. (1998) · Science · doi:10.1126/science.281.5373.64 · Cited by 1,253

Cytochrome c release from mitochondria proceeds by a two-step process

Ott, M., Robertson, J. D., Gogvadze, V. G., Zhivotovsky, B., & Orrenius, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241655498 · Cited by 955

Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle

Palmer, J. W., Tandler, B., & Hoppel, C. L. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75283-1 · Cited by 830

Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure

Lesnefsky, E. J., Moghaddas, S., Tandler, B., Kerner, J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1378 · Cited by 719

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol

Han, D., Antunes, F., Canali, R., Rettori, D., & Cadenas, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210269200 · Cited by 711

New concepts in reactive oxygen species and cardiovascular reperfusion physiology

Becker, L. C. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.025 · Cited by 703

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation–reduction state

Kushnareva, Y., Murphy, A. N., & Andreyev, A. Y. (2002) · Biochemical Journal · doi:10.1042/bj20021121 · Cited by 696

The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex.

Trumpower, B. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38410-8 · Cited by 598

Cardiolipins and biomembrane function

Hoch, F. L. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(92)90035-9 · Cited by 596

Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.

Ambrosio, G., Zweier, J. L., Duilio, C., Kuppusamy, P., Santoro, G., Elia, P. P., Tritto, I., Cirillo, P. L., Condorelli, M., & Chiariello, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46660-9 · Cited by 515

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

Ricci, J.-E., Gottlieb, R. A., & Green, D. R. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208089 · Cited by 504

Generation of superoxide in cardiomyocytes during ischemia before reperfusion

Becker, L. B., Hoek, T. L. V., Shao, Z., Li, C., & Schumacker, P. T. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.6.h2240 · Cited by 413

Cardiolipin requirement for electron transfer in complex I and III of the mitochondrial respiratory chain.

Fry, M., & Green, D. E. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69888-1 · Cited by 405

Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine

Kagan, V. E., Borisenko, G. G., Tyurina, Y. Y., Tyurin, V. A., Jiang, J., Potapovich, A. I., Kini, V., Amoscato, A. A., & Fujii, Y. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.016 · Cited by 344

Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion

Kevin, L. G., Camara, A. K. S., Riess, M. L., Novalija, E., & Stowe, D. F. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00711.2002 · Cited by 272

Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase

Kadenbach, B., Hüttemann, M., Arnold, S., Lee, I., & Bender, E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00305-1 · Cited by 268

Cardiolipin and apoptosis

McMillin, J. B., & Dowhan, W. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00329-3 · Cited by 266

Evidence for two distinct acidic phospholipid-binding sites in cytochrome c.

Rytömaa, M., & Kinnunen, P. K. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42094-1 · Cited by 254

Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation

Shidoji, Y., Hayashi, K., KOMURA, S., Ohishi, N., & Yagi, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1410 · Cited by 251

Blockade of Electron Transport during Ischemia Protects Cardiac Mitochondria

Lesnefsky, E. J., Chen, Q., Moghaddas, S., Hassan, M. O., Tandler, B., & Hoppel, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409720200 · Cited by 236

The cardiolipin–cytochrome c interaction and the mitochondrial regulation of apoptosis

Iverson, S. L., & Orrenius, S. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.002 · Cited by 235

Cardiolipin requirement by cytochrome oxidase and the catalytic role of phospholipid

Fry, M., & Green, D. E. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)90622-1 · Cited by 230

Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria

Lesnefsky, E. J., Tandler, B., Ye, J., Slabe, T. J., Turkaly, J. S., & Hoppel, C. L. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.3.h1544 · Cited by 229

Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia

Borutaitė, V. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00005-1 · Cited by 203

Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria

Lesnefsky, E. J., Slabe, T. J., Stoll, M. S. K., Minkler, P. E., & Hoppel, C. L. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2770 · Cited by 194

Ischemia, rather than reperfusion, inhibits respiration through cytochrome oxidase in the isolated, perfused rabbit heart: role of cardiolipin

Lesnefsky, E. J., Chen, Q., Slabe, T. J., Stoll, M. S. K., Minkler, P. E., Hassan, M. O., Tandler, B., & Hoppel, C. L. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00348.2003 · Cited by 135

Lipid requirements for cytochrome c oxidase activity

Vik, S. B., & Capaldi, R. (1977) · Biochemistry · doi:10.1021/bi00645a016 · Cited by 130

Aging defect at the QO site of complex III augments oxyradical production in rat heart interfibrillar mitochondria

Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00166-8 · Cited by 120

The Ubiquinol/bc1 Redox Couple Regulates Mitochondrial Oxygen Radical Formation

Gille, L., & Nohl, H. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2257 · Cited by 107

Role of Oxalacetate in the Regulation of Mammalian Succinate Dehydrogenase

Ackrell, B. A. C., Kearney, E. B., & Mayr, M. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42790-7 · Cited by 102

A concerted, alternating sites mechanism of ubiquinol oxidation by the dimeric cytochrome bc1 complex

Trumpower, B. L. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00273-6 · Cited by 98

Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by myocardial ischaemia

Borutaitė, V., Jekabsone, A., Morkūnienė, R., & Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00062-x · Cited by 97

The role of cytochrome c diffusion in mitochondrial electron transport.

Gupte, S. S., & Hackenbrock, C. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60707-0 · Cited by 88

Activation of beef-heart cytochrome c oxidase by cardiolipin and analogues of cardiolipin

Abramovitch, D. A., Marsh, D., & Powell, G. L. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90090-q · Cited by 77

Spin-label studies on the specificity of interaction of cardiolipin with beef heart cytochrome oxidase

Powell, G. L., Knowles, P. F., & Marsh, D. (1987) · Biochemistry · doi:10.1021/bi00399a018 · Cited by 76

A Possible Role of Slips in Cytochrome C Oxidase in the Antioxygen Defense System of the Cell

Papa, S., GUERRIERI, F., & Capitanio, N. (1997) · Bioscience Reports · doi:10.1023/a:1027331116866 · Cited by 49

Effect of membrane environment on succinate dehydrogenase activity.

Ackrell, B. A. C., Kearney, E. B., & Singer, T. P. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40590-4 · Cited by 23

Studies on the nucleotide specificity of mitochondrial inner membrane particles

Hoppel, C. L., & Cooper, C. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90529-3 · Cited by 21

Reactive oxygen species, cellular redox systems, and apoptosis

Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340

ROS signalling in the biology of cancer

Moloney, J. N., & Cotter, T. G. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.023 · Cited by 2,030

Mechanisms of Cell Death in Oxidative Stress

Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., & Choi, A. M. K. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.49 · Cited by 1,286

Three Distinct Mechanisms Generate Oxygen Free Radicals in Neurons and Contribute to Cell Death during Anoxia and Reoxygenation

Abramov, A. Y., Scorziello, A., & Duchen, M. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4468-06.2007 · Cited by 686

Oxidative Stress in Cancer Cell Metabolism

Arfin, S., Jha, N. K., Jha, S. K., Kesari, K. K., Ruokolainen, J., Roychoudhury, S., Rathi, B., & Kumar, D. (2021) · Antioxidants · doi:10.3390/antiox10050642 · Cited by 721

Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria

Chen, Q., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00211.2007 · Cited by 299

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

Pasdois, P., Parker, J. E., Griffiths, E. J., & Halestrap, A. P. (2011) · Biochemical Journal · doi:10.1042/bj20101957 · Cited by 127

Electron flow into cytochrome c coupled with reactive oxygen species from the electron transport chain converts cytochrome c to a cardiolipin peroxidase: role during ischemia–reperfusion

Aluri, H. S., Simpson, D. C., Allegood, J. C., Hu, Y., Szczepanek, K., Gronert, S., Chen, Q., & Lesnefsky, E. J. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.07.017 · Cited by 38

Blockade of Electron Transport during Ischemia Protects Cardiac Mitochondria

Lesnefsky, E. J., Chen, Q., Moghaddas, S., Hassan, M. O., Tandler, B., & Hoppel, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409720200 · Cited by 236

Ischemia, rather than reperfusion, inhibits respiration through cytochrome oxidase in the isolated, perfused rabbit heart: role of cardiolipin

Lesnefsky, E. J., Chen, Q., Slabe, T. J., Stoll, M. S. K., Minkler, P. E., Hassan, M. O., Tandler, B., & Hoppel, C. L. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00348.2003 · Cited by 135