Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions
Abstract
Previous studies have provided compelling evidence for the presence of oxidized proteins and lipids in advanced human atherosclerotic lesions. The catalyst responsible for such oxidation is unknown and controversial. We have previously provided evidence for elevated levels of iron in lesions. In this study we hypothesized that if iron ions catalyzed protein and lipid oxidation in the artery wall, then there should be a positive correlation between these parameters. Iron concentrations in ex vivo healthy human arteries and advanced carotid lesions were quantified by electron paramagnetic resonance spectroscopy. Four specific side-chain oxidation products of proteins, and the lipid oxidation products 7-ketocholesterol and cholesterol ester alcohols and hydroperoxides, were quantified by HPLC in the same samples used for the iron measurements. Parent amino acids, cholesterol, and cholesterol esters were also quantified. Statistically elevated levels of iron, cholesterol, cholesterol esters, 7-ketocholesterol, and cholesterol ester alcohols and hydroperoxides were detected in advanced lesions compared with healthy control tissue. Iron levels correlated positively and strongly with all four markers of protein oxidation, but not with either marker of lipid oxidation. These data support the hypothesis that elevated levels of iron contribute to the extent of protein, but not lipid, oxidation in advanced human lesions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Iron and oxidised lipids are both found in atherosclerotic lesions.
“Iron and oxidised lipids are both found in atherosclerotic lesions [141,765-777]”
Iron levels in atherosclerotic plaques correlate with the amount of oxidised proteins therein.
“Iron levels in plaques correlate with the amount of oxidised proteins therein”
Cites
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425 · see citing works
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Circulation · doi:10.1161/01.cir.92.5.1355 · Cited by 3,506 · see citing works
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works
The role of lipid peroxidation and antioxidants in oxidative modification of LDL
Esterbauer, H., Gebicki, J. M., Puhl, H., & Jürgens, G. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90181-f · Cited by 2,307 · see citing works
Daugherty, A., Dunn, J. L., Rateri, D. L., & Heinecke, J. W. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117342 · Cited by 1,269 · see citing works
Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry
Beckman, J. S., Ye, Y. Z., Anderson, P. G., Chen, J., Accavitti, M. A., Tarpey, M. M., & White, C. R. (1994) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1994.375.2.81 · Cited by 1,122 · see citing works
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969 · see citing works
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.9.1512 · Cited by 959 · see citing works
Oxysterols and atherosclerosis
Brown, A. J., & Jessup, W. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00196-8 · Cited by 921 · see citing works
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842 · see citing works
Generation and propagation of radical reactions on proteins
Hawkins, C. L., & Davies, M. J. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00252-8 · Cited by 753 · see citing works
Self-citationPresence of hypochlorite-modified proteins in human atherosclerotic lesions.
Hazell, L. J., Arnold, L., Flowers, D., Waeg, G., Malle, E., & Stocker, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118576 · Cited by 592 · see citing works
Heinecke, J. W., Rosen, H., & Chait, A. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111609 · Cited by 536 · see citing works
Ferritin and superoxide-dependent lipid peroxidation.
Thomas, C. E., Morehouse, L. A., & Aust, S. D. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83617-7 · Cited by 530 · see citing works
Heinecke, J. W., Li, W., Daehnke, H. L., & Goldstein, J. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53581-x · Cited by 485 · see citing works
Leeuwenburgh, C., Hardy, M. M., Hazen, S. L., Wagner, P. D., Oh‐ishi, S., Steinbrecher, U. P., & Heinecke, J. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1433 · Cited by 461 · see citing works
Stable markers of oxidant damage to proteins and their application in the study of human disease
Davies, M. J., Fu, S., Wang, H., & Dean, R. T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00206-3 · Cited by 461 · see citing works
Self-citationSmith, C., Mitchinson, M. J., Aruoma, O. I., & Halliwell, B. (1992) · Biochemical Journal · doi:10.1042/bj2860901 · Cited by 455 · see citing works
Ylä‐Herttuala, S., Rosenfeld, M. E., Parthasarathy, S., Glass, C. K., Sigal, E., Witztum, J. L., & Steinberg, D. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.18.6959 · Cited by 424 · see citing works
Suarna, C., Dean, R. T., May, J. M., & Stocker, R. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.10.1616 · Cited by 356 · see citing works
Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins.
Heinecke, J. W., Li, W., Francis, G. A., & Goldstein, J. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116531 · Cited by 354 · see citing works
Stadler, N., Lindner, R. A., & Davies, M. J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000124892.90999.cb · Cited by 310 · see citing works
Self-citationHawkins, C. L., & Davies, M. J. (1998) · Biochemical Journal · doi:10.1042/bj3320617 · Cited by 305 · see citing works
Self-citationMechanisms of copper- and iron-dependent oxidative modification of human low density lipoprotein
Lynch, S. M., & Frei, B. B. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35737-0 · Cited by 285 · see citing works
Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis
Heinecke, J. W. (1997) · Current Opinion in Lipidology · doi:10.1097/00041433-199710000-00005 · Cited by 275 · see citing works
Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque
Fu, S., Davies, M. J., Stocker, R., & Dean, R. T. (1998) · Biochemical Journal · doi:10.1042/bj3330519 · Cited by 256 · see citing works
Self-citationLipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques.
Folcik, V. A., Nivar-Aristy, R. A., Krajewski, L. P., & Cathcart, M. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118062 · Cited by 252 · see citing works
Iron, Atherosclerosis, and Ischemic Heart Disease
de Valk, B., & Marx, J. J. M. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.14.1542 · Cited by 250 · see citing works
Brown, A. J., Leong, S., Dean, R. T., & Jessup, W. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37148-0 · Cited by 242 · see citing works
Coronary Heart Disease and Iron Status: Meta-Analyses of Prospective Studies
Danesh, J., & Appleby, P. (1999) · Circulation · doi:10.1161/01.cir.99.7.852 · Cited by 226 · see citing works
Radical-Mediated Protein Oxidation: From Chemistry to Medicine
Davies, M. J., & Dean, R. T. (1998) · Medical Entomology and Zoology · Cited by 218 · see citing works
Self-citationKockx, M. M., Cromheeke, K. M. C., Knaapen, M., Bosmans, J. M., Meyer, G. R. Y. D., Herman, A. G., & Bult, H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000057807.28754.7f · Cited by 218 · see citing works
Low density lipoprotein is saturable by pro‐oxidant copper
Gieseg, S. P., & Esterbauer, H. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80553-9 · Cited by 206 · see citing works
Heinecke, J. W. (1999) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(99)90061-6 · Cited by 150 · see citing works
Upston, J. M., Niu, X., Brown, A. J., Mashima, R., Wang, H., Senthilmohan, R., Kettle, A. J., Dean, R. T., & Stocker, R. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64890-0 · Cited by 143 · see citing works
Swain, J., & Gutteridge, J. M. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00726-p · Cited by 136 · see citing works
Chemical and biochemical aspects of electron-spin resonance spectroscopy
Symons, M. C. R. (1978) · Medical Entomology and Zoology · Cited by 134 · see citing works
Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis
Yuan, X., Li, W., OLSSON, A. G., & Brunk, U. T. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05817-0 · Cited by 118 · see citing works
Woods, A. A., Linton, S. M., & Davies, M. J. (2003) · Biochemical Journal · doi:10.1042/bj20021710 · Cited by 111 · see citing works
Self-citationDietary and pharmacological antioxidants in atherosclerosis
Stocker, R. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199912000-00014 · Cited by 104 · see citing works
Minqin, R., Rajendran, R., Pan, N., Kwong-Huat Tan, B., Ong, W.-Y., Watt, F., & Halliwell, B. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.008 · Cited by 100 · see citing works
Iron-mediated cardiovascular injury
Horwitz, L. D., & Rosenthal, E. A. (1999) · Vascular Medicine · doi:10.1177/1358836x9900400207 · Cited by 98 · see citing works
Colocalization of iron and ceroid in human atherosclerotic lesions
Lee, F.-Y., Lee, T., Pan, C., Huang, A.-L., & Chau, L. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00033-1 · Cited by 91 · see citing works
Davies, M. J., & Slater, T. F. (1986) · Biochemical Journal · doi:10.1042/bj2400789 · Cited by 90 · see citing works
Self-citationLamb, D. J., Mitchinson, M. J., & Leake, D. S. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01068-p · Cited by 87 · see citing works
Chemical and biochemical aspects of electron spin resonance spectroscopy
Jones, R. W. L. (1979) · Biochemical Education · doi:10.1016/0307-4412(79)90086-4 · Cited by 79 · see citing works
Evans, P., Smith, C., Mitchinson, M. J., & Halliwell, B. B. (1995) · Free Radical Research · doi:10.3109/10715769509065267 · Cited by 73 · see citing works
Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein
Lamb, D. J., & Leake, D. S. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00903-1 · Cited by 64 · see citing works
Hunter, G., Dubick, M. A., Keen, C. L., & Cd, E. (1991) · Experimental Biology and Medicine · doi:10.3181/00379727-196-43188 · Cited by 49 · see citing works
Superoxide radicals can act synergistically with hypochlorite to induce damage to proteins
Hawkins, C. L., Rees, M. D., & Davies, M. J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03226-4 · Cited by 48 · see citing works
Self-citationElemental changes in atherosclerotic lesions using nuclear microscopy.
Thong, P. S. P., Selley, M. L., & Watt, F. (1996) · PubMed · Cited by 41 · see citing works
Lipoxygenase treatment render low-density lipoprotein susceptible to Cu2+-catalysed oxidation
Lass, A., Belkner, J., Esterbauer, H., & Kühn, H. (1996) · Biochemical Journal · doi:10.1042/bj3140577 · Cited by 37 · see citing works
Knott, H. M., Baoutina, A., Davies, M. J., & Dean, R. T. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00018-8 · Cited by 28 · see citing works
Self-citationApplications in medicine using the new Lund microprobe
Pallon, J., Knox, J. M., Forslind, B., Werner-Linde, Y., & Pinheiro, T. (1993) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/0168-583x(93)95557-l · Cited by 20 · see citing works
Abdalla, D. S. P., Costa-Rosa, L. F. B. P., Monteiro, H. P., Čampa, A., & Curi, R. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90017-5 · Cited by 15 · see citing works
Nuclear microprobe applied to the study of coronary artery walls--a distinct look at atherogenesis.
Pinheiro, T., Pallon, J., Fernandes, R., Mj, H., Homman, P., & Malmqvist, K. K. (1996) · PubMed · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works
Oxidative damage to extracellular matrix and its role in human pathologies
Rees, M. D., Kennett, E. C., Whitelock, J. M., & Davies, M. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.016 · Cited by 206 · see citing works
Self-citationIron in arterial plaque: A modifiable risk factor for atherosclerosis
Sullivan, J. L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.06.005 · Cited by 176 · see citing works
Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability
Sullivan, J. L. (2007) · Experimental Biology and Medicine · doi:10.3181/0703-mr-54 · Cited by 143 · see citing works
Kell, D. B., & Pretorius, E. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12407 · Cited by 113 · see citing works
Reactive Oxygen Species in Pathogenesis of Atherosclerosis
Goncharov, N. V., Avdonin, P. V., Nadeev, A. D., Zharkikh, I. L., & Jenkins, R. O. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141014142557 · Cited by 97 · see citing works
Zhu, L.-H., Wang, L., Wang, D., Jiang, H., Tang, Q., Yan, L., Bian, Z., Wang, X.-A., & Li, H. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.040 · Cited by 85 · see citing works
Vaziri, N. D. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.10.027 · Cited by 82 · see citing works
Dalsgaard, T. K., Nielsen, J. H., Brown, B. E., Stadler, N., & Davies, M. J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200277r · Cited by 79 · see citing works
Self-citationIron toxicity: relevance for dialysis patients
Fishbane, S., Mathew, A. T., & Vaziri, N. D. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft269 · Cited by 75 · see citing works
Madrigal‐Matute, J., Martínez-Pinna, R., Ramos‐Mozo, P., Blanco‐Colio, L. M., Moreno, J. A., Tarín, C., Burillo, E., Fernandez‐Garcia, C. E., Egido, J., Meilhac, O., et al. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-04-0248 · Cited by 74 · see citing works
Safety concerns about intravenous iron therapy in patients with chronic kidney disease
Vecchio, L. D., Longhi, S., & Locatelli, F. (2016) · Clinical Kidney Journal · doi:10.1093/ckj/sfv142 · Cited by 70 · see citing works
Mechanisms and consequences of oxidative damage to extracellular matrix
Kennett, E. C., Chuang, C. Y., Degendorfer, G., Whitelock, J. M., & Davies, M. J. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391279 · Cited by 61 · see citing works
Self-citationOxidation and modification of extracellular matrix and its role in disease
Chuang, C. Y., Degendorfer, G., & Davies, M. J. (2014) · Free Radical Research · doi:10.3109/10715762.2014.920087 · Cited by 57 · see citing works
Self-citationIron in Cardiovascular Disease: Challenges and Potentials
Li, S., & Zhang, X. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.707138 · Cited by 57 · see citing works
Hepcidin: another culprit for complications in patients with chronic kidney disease?
Nakanishi, T., Hasuike, Y., Otaki, Y., Kida, A., Nonoguchi, H., & Kuragano, T. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr410 · Cited by 53 · see citing works
Characterization of Oxidative Changes in Salted Herring (Clupea harengus) During Ripening
Andersen, E., Andersen, M. L., & Baron, C. P. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071369b · Cited by 53 · see citing works
Pazos, M., da Rocha, A. P., Roepstorff, P., & Rogowska-Wrzesińska, A. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201080t · Cited by 52 · see citing works
Xiao, L., Luo, G., Guo, X., Jiang, C., Zeng, H., Zhou, F., Li, Y., Yu, J., & Yao, P. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158531 · Cited by 50 · see citing works
Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases
Wang, Z., Wu, C., Yin, D., & Dou, K. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02614-x · Cited by 50 · see citing works
Cai, H., Chuang, C. Y., Hawkins, C. L., & Davies, M. J. (2020) · Scientific Reports · doi:10.1038/s41598-019-57299-6 · Cited by 45 · see citing works
Self-citationSouza, C. E. A., Maitra, D., Saed, G. M., Diamond, M. P., Moura, A. A., Pennathur, S., & Abu‐Soud, H. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027641 · Cited by 43 · see citing works
Stadler, N., Stanley, N., Heeneman, S., Vacata, V., Daemen, M. J. A. P., Bannon, P. G., Waltenberger, J. L., & Davies, M. J. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.162735 · Cited by 41 · see citing works
Self-citationDegradation of extracellular matrix and its components by hypobromous acid
Rees, M. D., McNiven, T. N., & Davies, M. J. (2006) · Biochemical Journal · doi:10.1042/bj20061236 · Cited by 41 · see citing works
Self-citationChuang, C. Y., Degendorfer, G., Hammer, A., Whitelock, J. M., Malle, E., & Davies, M. J. (2014) · Biochemical Journal · doi:10.1042/bj20131471 · Cited by 39 · see citing works
Self-citationJung, S., Song, S., Lee, S., Kim, S. H., Ann, S.-J., Cheon, E. J., Yi, G., Choi, E., Lee, S. H., Joo, H., et al. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.11.034 · Cited by 29 · see citing works
Fe(III) distribution varies substantially within and between atherosclerotic plaques
Gustafsson, H., Hallbeck, M., Norell, M., Lindgren, M., Engström, M., Rosén, A., & Zachrisson, H. (2013) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24687 · Cited by 19 · see citing works
Frizzell, N., & Baynes, J. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0881 · Cited by 17 · see citing works
Kopriva, D., Kisheev, A., Meena, D. K., Pelle, S., Karnitsky, M., Lavoie, A., & Buttigieg, J. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143138 · Cited by 18 · see citing works
Kamp, F., & Donangelo, C. M. (2008) · Journal of Nutrition · doi:10.3945/jn.108.093260 · Cited by 16 · see citing works
Bonomo, L., Silva, M., Oliveira, R. D. P., Silva, M. E., & Pedrosa, M. L. (2012) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21410 · Cited by 15 · see citing works
Stadler, N., Heeneman, S., Vöö, S. A., Stanley, N., Giles, G. I., Gang, B. P., Croft, K. D., Mori, T. A., Vacata, V., Daemen, M. J. A. P., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.03.015 · Cited by 14 · see citing works
Self-citationKovacic, P., & Somanathan, R. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799890903582578 · Cited by 13 · see citing works
Dalsgaard, T. K., Bakman, M., Hammershøj, M., Sørensen, J., Nebel, C., ALBRECHTSEN, R., Vognsen, L., & Nielsen, J. H. (2011) · International Journal of Dairy Technology · doi:10.1111/j.1471-0307.2011.00736.x · Cited by 11 · see citing works
Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis
Tasić, N., Tasić, D., Veselinović, M., Jakovljevic, V. L., Djuric, D. M., & Radak, D. J. (2015) · Acta Physiologica Hungarica · doi:10.1556/036.102.2015.2.5 · Cited by 9 · see citing works
Iron-catalyzed oxidation of Trp residues in low-density lipoprotein
Chen, H., Chen, C., Chow, L., Chen, C., Lee, Y., Smith, C. V., & Yang, C. (2011) · Biological Chemistry · doi:10.1515/bc.2011.173 · Cited by 9 · see citing works
Talib, J., & Davies, M. J. (2016) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-016-1340-4 · Cited by 9 · see citing works
Self-citationIron and atherosclerosis: Lessons learned from rabbits relevant to human disease
Halliwell, B. B., Watt, F., & Minqin, R. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.10.383 · Cited by 6 · see citing works
Arterial Iron Content Is Increased in Patients with High Plasma Ferritin Levels
Madsen, J. B., Pedersen, L., Kidholm, C. L., & Rasmussen, L. M. (2016) · Journal of Vascular Research · doi:10.1159/000452799 · Cited by 5 · see citing works
[Increased iron store and its relationship with cardiovascular disease].
Meroño, T., Sorroche, P. B., & Brites, F. D. (2011) · PubMed · Cited by 5 · see citing works
Spatial localisation of oxidative and inflammatory markers within advanced atherosclerotic plaques
Crone, E. M. (2008) · UC Research Repository (University of Canterbury) · doi:10.26021/6121 · Cited by 2 · see citing works
Zaitsev, S. Y., Stepanova, M. V., & Sotnikova, L. F. (2024) · Animal Diseases · doi:10.1186/s44149-024-00143-w · Cited by 1 · see citing works
(2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.10.295 · Cited by 1 · see citing works
Lynch, S. M. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.05.010
Ferritin: A risk factor in ischemic heart disease?
López, E. N. F., de la Torre, D. L. A., García-Padilla, E., & Nolasco, R. (2015) · Medicina Interna de México
Saad-El-Din, A. A., Mazhar, A., & Khalil, W. A. (2020) · Journal of Radiation Research and Applied Sciences · doi:10.1080/16878507.2020.1756186
Shida, N., Tsuchiya, Y. S., & Yamakura, F. (2012) · 微量栄養素研究
Alves, A. S. P. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/jfza-8483
Bories, G. F. P. (2011) · theses.fr (ABES) · doi:10.70675/81757398zf42fz45dcz8424z3f14e050bfb4
Proteomic analysis of oxidative modifications in human atherosclerotic plaques and control arteries
Yang-Jensen, K. C., Lorentzen, L. G., Yeung, K., López‐Alarcón, C., Eiberg, J., & Davies, M. J. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104417
Self-citation
- Authors
- Stanley, N., Stadler, N., Woods, A. A., Bannon, P. G., & Davies, M. J.
- Affiliations
- The Heart Research Institute (AU)
- Baird Institute (AU)
- The University of Sydney (AU)
- Corresponding author
- Davies, Michael J.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 40
- Issue
- 9
- Pages
- 1636-1643
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2043155113
- Cited by
- 51
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- iron, atherosclerosis, protein oxidation, lipid oxidation, carotid artery lesions, 7-ketocholesterol, hydroperoxides, iron-catalyzed oxidation, advanced atherosclerotic lesions, human atherosclerotic plaque
- MeSH terms
- Arteries, Chromatography, High Pressure Liquid, Dihydroxyphenylalanine, Electron Spin Resonance Spectroscopy, Humans, Iron, Oxidation-Reduction, Proteins, Lipid Peroxidation, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review