Coronary Heart Disease and Iron Status: Meta-Analyses of Prospective Studies
Abstract
BACKGROUND: Studies of iron status and coronary heart disease (CHD) have yielded conflicting results. In a systematic review ("meta-analysis"), we quantitatively assessed epidemiological associations reported in prospective studies. METHODS AND RESULTS: Studies were identified by computer-assisted searches of the published literature, scanning of relevant reference lists, hand searching of relevant journals, and discussions with relevant authors. The following was abstracted: size and type of cohort, mean age, mean duration of follow-up, assay methods, degree of adjustment for confounders, and relationship of CHD risk to the baseline assay results. Twelve studies were identified, involving a total of 7800 CHD cases, with several reporting on >1 marker of iron status. For serum ferritin, with 570 CHD cases in 5 studies, comparison of individuals with baseline values >/=200 versus <200 microg/L yielded a combined risk ratio of 1.0 (95% CI, 0.8 to 1.3). For transferrin saturation, with 6194 CHD cases in 5 studies, comparison of individuals in the top third with those in the bottom third of the baseline measurements yielded a combined risk ratio of 0.9 (95% CI, 0.7 to 1.1). Comparisons of individuals in top and bottom thirds of baseline measurements also yielded nonsignificant risk ratios in combined analyses of studies involving total iron-binding capacity (combined risk ratio, 1.0; 95% CI, 0.7 to 1.5), serum iron (0.8; 95% CI, 0.7 to 1.0), and total dietary iron (0.8; 95% CI, 0.7 to 1.1). CONCLUSIONS: Published prospective studies do not provide good evidence to support the existence of strong epidemiological associations between iron status and CHD.
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Randomised controlled trials show that supplementation with different quantities of soya protein did not affect CRP, IL-6, IL-18, sICAM-1, sVCAM-1 or sE-selectin.
“Several randomised controlled intervention trials have shown that supplementation with different quantities of soya protein did not affect markers of inflammation (CRP, IL-6, IL-18, sICAM-1, sVCAM-1 and sE-selectin) (Table 7) (345,347 -364) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [347]
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- Authors
- Danesh, J., & Appleby, P.
- Affiliations
- University of Oxford (GB)
- ORCID
- Danesh, John
- Venue
- Circulation
- Published
- 1999-02-23
- Volume
- 99
- Issue
- 7
- Pages
- 852-854
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2072848251
- Cited by
- 226
- References
- 19
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- coronary artery disease, iron status, serum ferritin, transferrin saturation, total iron binding capacity, serum iron, dietary iron, cardiovascular risk factors, prospective cohort
- MeSH terms
- Coronary Disease, Diet, Ferritins, Humans, Iron, Prospective Studies, Transferrin
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