Lysosomal cell death mechanisms in aging

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Autophagy is required to maintain muscle mass.

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Lysosomal acidification mechanisms

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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Lysosomal Physiology

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Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

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Pathogenic Lysosomal Depletion in Parkinson's Disease

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

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Lysosomal cell death at a glance

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Age-related decline in chaperone-mediated autophagy

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Autophagy failure in Alzheimer's disease—locating the primary defect

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Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

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The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

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Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

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Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

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Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

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Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion

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Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

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Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

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Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

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Sphingosine-induced apoptosis is dependent on lysosomal proteases

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Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

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Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species

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The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium

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Sphingosine-induced apoptosis is dependent on lysosomal proteases

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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

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Effective Tumor Cell Death by σ-2 Receptor Ligand Siramesine Involves Lysosomal Leakage and Oxidative Stress

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Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

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Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

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Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

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Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

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Lysosome membrane lipid microdomains: novel regulators of chaperone‐mediated autophagy

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Vincristine Induces Dramatic Lysosomal Changes and Sensitizes Cancer Cells to Lysosome-Destabilizing Siramesine

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V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

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