Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis
Abstract
Exposure to particulate silica (most crystalline polymorphs) causes a persistent inflammation sustained by the release of oxidants in the alveolar space. Reactive oxygen species (ROS), which include hydroxyl radical, superoxide anion, hydrogen peroxide, and singlet oxygen, are generated not only at the particle surface, but also by phagocytic cells attempting to digest the silica particle. Two distinct kinds of surface centers-silica-based surface radicals and poorly coordinated iron ions-generate O(2)(*)(-) and HO(*) in aqueous solution via different mechanisms. Crystalline silica is also a potent stimulant of the respiratory burst in phagocytic cells with increased oxygen consumption and production of O(*)(-), H(2)O(2), and NO leading to acute inflammation and HO(*) generation in the lung. Oxidative stress elicited by crystalline silica is also evidenced by increased expression of antioxidant enzymes such as manganese superoxide dismutase (Mn-SOD) and glutathione peroxidase, and the enzyme inducible nitric oxide synthase (iNOS). Generation of oxidants by crystalline silica particles and by silica-activated cells results in cell and lung injury, activation of cell signaling pathways to include MAPK/ERK kinase (MEK), and extracellular signal-regulated kinase (ERK) phosphorylation, increased expression of inflammatory cytokines (e.g., tumor necrosis factoralpha [TNFalpha], interleukin-1 [IL-1]), and activation of specific transcription factors (e.g., NFkappaB, AP-1). Silica can also initiate apoptosis in response to oxygen- and nitrogen-based free radicals, leading to mitochondrial dysfunction, increased gene expression of death receptors, and/or their ligands (TNFalpha, Fas ligand [FasL]).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Freshly-fractured quartz is more toxic than aged quartz.
“Freshly-fractured quartz is more toxic than aged quartz”
From Toxicity of lunar dust (2012) · cites this paper as Fubini and Hubbard, 2003
The leading explanation for freshly-fractured quartz being more toxic than aged quartz is mechanochemical activation: mechanical disruption of quartz results in homolytic and heterolytic rupture of silicon-oxygen bonds.
“the leading explanation for this observation is the concept that mechanical disruption of quartz results in the homolytic and heterolytic rupture of the silicon-oxygen bonds ('mechanochemical activation') (Fubini and Hubbard, 2003).”
From Toxicity of lunar dust (2012) · cites this paper as Fubini and Hubbard, 2003
Silica, asbestos and ATP have all been associated with ROS production, and ROS inhibition in vitro resulted in impairment of caspase 1 activation and IL-1β production by these stimuli.
“Silica58,68, asbestos57 and ATP69 have all been associated with ROS production, and ROS inhibition in vitro resulted in impairment of caspase 1 activation and IL-1β production by these stimuli57,58,69.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [68]
Cites
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,816 · see citing works
The surface properties of silicas
Legrand, A. P. (1998) · Medical Entomology and Zoology · Cited by 610 · see citing works
Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution
Blough, N. V., & Zafiriou, O. C. (1985) · Inorganic Chemistry · doi:10.1021/ic00216a003 · Cited by 525 · see citing works
Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages
Freire-de-Lima, C. G., Nascimento, D. O., Soares, M. B. P., Bozza, P. T., Castro-Faria-Neto, H. C., Mello, F. G. D., DosReis, G. A., & Lopes, M. F. (2000) · Nature · doi:10.1038/35003208 · Cited by 455 · see citing works
Schmidt, K. N., Amstad, P., Cerutti, P., & Baeuerle, P. A. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90076-4 · Cited by 454 · see citing works
Papírer, E. (2000) · CRC Press eBooks · doi:10.1201/9781482269703 · Cited by 391 · see citing works
Vallyathan, V., Shi, X., Dalal, N. S., Irr, W., & Castranova, V. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.5.1213 · Cited by 327 · see citing works
Regulation of the transcription factors NF-κB and AP-1 by redox changes
Meyer, M., Pahl, H. L., & Baeuerle, P. A. (1994) · Chemico-Biological Interactions · doi:10.1016/0009-2797(94)90029-9 · Cited by 310 · see citing works
Oxidative Stress Activates Metal-responsive Transcription Factor-1 Binding Activity
Dalton, T. P., Li, Q., Bittel, D., Liang, L., & Andrews, G. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26233 · Cited by 237 · see citing works
The quartz hazard: a variable entity
Donaldson, K. (1998) · The Annals of Occupational Hygiene · doi:10.1016/s0003-4878(98)00044-1 · Cited by 222 · see citing works
Schins, R. P. F., Duffin, R., Höhr, D., Knaapen, A. M., Shi, T., Weishaupt, C., Stone, V., Donaldson, K., & Borm, P. J. A. (2002) · Chemical Research in Toxicology · doi:10.1021/tx025558u · Cited by 198 · see citing works
Role of Reactive Oxygen Intermediates in Activation-induced CD95 (APO-1/Fas) Ligand Expression
Bauer, M. K. A., Vogt, M., Łoś, M., Siegel, J., Wesselborg, S., & Schulze‐Osthoff, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8048 · Cited by 186 · see citing works
Surface Chemistry and Quartz Hazard
Fubini, B. (1998) · The Annals of Occupational Hygiene · doi:10.1016/s0003-4878(98)00066-0 · Cited by 182 · see citing works
Self-citationEnhanced Generation of Free Radicals from Phagocytes Induced by Mineral Dusts
Vallyathan, V., Mega, J. F., Shi, X., & Dalal, N. S. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.4.404 · Cited by 180 · see citing works
Vallyathan, V., Castranova, V., Pack, D., Leonard, S. S., Shumaker, J. M., Hubbs, A. F., Shoemaker, D. A., Ramsey, D. M., Pretty, J. R., & McLaurin, J. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.3.7663775 · Cited by 168 · see citing works
Silica-Induced Apoptosis Mediated via Scavenger Receptor in Human Alveolar Macrophages
IYER, R., Hamilton, R. F., LI, L., & Holian, A. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0263 · Cited by 165 · see citing works
Gossart, S., Cambon, C., Orfila, C., Séguélas, M., Lepert, J., RAMI, J., Carré, P., & Pipy, B. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.4.1540 · Cited by 163 · see citing works
Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica.
Janssen-Heininger, Y. M. W., Marsh, J. P., Absher, M. P., Hemenway, D. R., Vacek, P. M., Leslie, K. O., Borm, P. J. A., & Mossman, B. T. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50063-1 · Cited by 157 · see citing works
Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages
Iyer, R. S., Hamilton, R. F., Li, L., et al. (1996) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(96)80012-3 · Cited by 145 · see citing works
Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates
Ghio, A. J., Kennedy, T. P., Whorton, A. R., Crumbliss, A. L., Hatch, G. E., & Hoidal, J. R. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.263.5.l511 · Cited by 132 · see citing works
Silica and Silica-Induced Lung Diseases
Castranova, V., Vallyathan, V., & Wallace, W. E. (1995) · Medical Entomology and Zoology · Cited by 131 · see citing works
Chen, F., Kuhn, D. C., Sun, S. C., Gaydos, L. J., & Demers, L. M. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2363 · Cited by 130 · see citing works
Srivastava, K. D., Rom, W. N., Jagirdar, J. S., Yie, T.-A., Gordon, T., & Tchou-Wong, K.-M. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.4.2106009 · Cited by 127 · see citing works
Fubini, B., Giamello, E., Volante, M., & Bolis, V. (1990) · Toxicology and Industrial Health · doi:10.1177/074823379000600604 · Cited by 117 · see citing works
Self-citationDuffin, R., Gilmour, P. S., Schins, R. P. F., Clouter, A., Guy, K., Brown, D. M., MacNee, W., Borm, P. J. A., Donaldson, K., & Stone, V. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9268 · Cited by 115 · see citing works
FAS Ligand Triggers Pulmonary Silicosis
Borges, V. M., Falcão, H., Leite-Júnior, J. H., Alvim, L., Teixeira, G. P., Russo, M., Nóbrega, A., Lopes, M. F., Rocco, P. R. M., Davidson, W. F., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.2.155 · Cited by 115 · see citing works
Blackford, J. A., Antonini, J. M., Castranova, V., & Dey, R. D. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.11.4.7522485 · Cited by 113 · see citing works
Program, B. S. P. (1998) · Journal of Toxicology and Environmental Health · doi:10.1080/009841098158601 · Cited by 109 · see citing works
Activation of NF-κB-dependent gene expression by silica in lungs of luciferase reporter mice
Hubbard, A. K., Timblin, C. R., Shukla, A., Rincón, M., & Mossman, B. T. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00327.2001 · Cited by 107 · see citing works
Self-citationKnaapen, A. M. (2002) · Carcinogenesis · doi:10.1093/carcin/23.7.1111 · Cited by 107 · see citing works
Essential Role of NF-κB Activation in Silica-Induced Inflammatory Mediator Production in Macrophages
Chen, F., Sun, S., Kuh, D. C., Gaydos, L. J., & Demers, L. M. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2383 · Cited by 100 · see citing works
Ding, M., Shi, X., Dong, Z., Chen, F., Lu, Y., Castranova, V., & Vallyathan, V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30611 · Cited by 100 · see citing works
Fubini, B., Zanetti, G., Altilia, S., Tiozzo, R., Lison, D., & Saffiotti, U. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980261a · Cited by 94 · see citing works
Self-citationCastranova, V., Vallyathan, V., Ramsey, D. M., McLaurin, J., Pack, D., Leonard, S. S., Barger, M. W., Ma, J. Y., Dalal, N. S., & TEASS, A. W. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51319 · Cited by 91 · see citing works
Barrett, E. G., Johnston, C. J., Oberdörster, G., & Finkelstein, J. N. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8716 · Cited by 91 · see citing works
Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica
Porter, D. W., Millecchia, L., Robinson, V. A., Hubbs, A. F., Willard, P. A., Pack, D., Ramsey, D. M., McLaurin, J., Khan, A., Landsittel, D. P., et al. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00427.2001 · Cited by 86 · see citing works
Barrett, E. G., Johnston, C. J., Oberdörster, G., & Finkelstein, J. N. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.276.6.l979 · Cited by 85 · see citing works
Fenoglio, I., Prandi, L., Tomatis, M., & Fubini, B. (2001) · Redox Report · doi:10.1179/135100001101536382 · Cited by 84 · see citing works
Self-citationShukla, A., Timblin, C. R., Hubbard, A. K., Bravman, J., & Mossman, B. T. (2001) · PubMed · Cited by 82 · see citing works
Self-citationThe role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-κB
Shi, X., Dong, Z., Huang, C., Shi, X., Ma, W., Liu, K., Chen, F., Leonard, S. S., Ding, M., Castranova, V., et al. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006904904514 · Cited by 82 · see citing works
The Quartz Hazard: A Variable Entity
Donaldson, K., & Borm, P. J. A. (1998) · The Annals of Occupational Hygiene · doi:10.1093/annhyg/42.5.287 · Cited by 81 · see citing works
Apoptosis Underlies Immunopathogenic Mechanisms in Acute Silicosis
Borges, V. M., Lopes, M. F., Falcão, H., Leite-Júnior, J. H., Rocco, P. R. M., Davidson, W. F., Linden, R., Zin, W. A., & DosReis, G. A. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.1.4717 · Cited by 72 · see citing works
Silica induces apoptosis in macrophages and the release of interleukin-1 α and interleukin-1β
Sarih, M., Souvannavong, V., Brown, S., & Adam, A. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.5.407 · Cited by 72 · see citing works
Eliáš, Z., Poirot, O., Danière, M. C., Terzetti, F., Marande, A. M., Dźwigaj, S., Pezerat, H., Fenoglio, I., & Fubini, B. (2000) · Toxicology in Vitro · doi:10.1016/s0887-2333(00)00039-4 · Cited by 69 · see citing works
Self-citationHolley, J. A., Janssen-Heininger, Y. M. W., Mossman, B. T., & Taatjes, D. J. (1992) · PubMed Central · Cited by 68 · see citing works
The surface chemistry of crushed quartz dust in relation to its pathogenicity
Fubini, B., Bolis, V., & Giamello, E. (1987) · Inorganica Chimica Acta · doi:10.1016/s0020-1693(00)81222-0 · Cited by 67 · see citing works
Self-citationSchapira, R. M., Ghio, A. J., Effros, R. M., Morrisey, J. F., Almagro, U. A., DAWSON, C. A., & Hacker, A. (1995) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.12.2.7865220 · Cited by 66 · see citing works
Silica-induced apoptosis in alveolar and granulomatous cells in vivo.
Leigh, J., Wang, H., Bonin, A., Peters, M. J., & Ruan, X. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51241 · Cited by 62 · see citing works
Fenoglio, I., Croce, M. A., Renzo, F. D., Tiozzo, R., & Fubini, B. (2000) · Chemical Research in Toxicology · doi:10.1021/tx990169u · Cited by 62 · see citing works
Self-citationGilmour, P. S., Beswick, P. H., Brown, D. M., & Donaldson, K. (1995) · Carcinogenesis · doi:10.1093/carcin/16.12.2973 · Cited by 62 · see citing works
Deshpande, A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/67.2.275 · Cited by 59 · see citing works
Shen, H., Zhang, Z., Zhang, Q., & Ong, C. N. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.1.l10 · Cited by 59 · see citing works
Fenoglio, I., Martra, G., Coluccia, S., & Fubini, B. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000125h · Cited by 54 · see citing works
Self-citationChao, S., Hamilton, R. F., Pfau, J. C., & Holian, A. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9190 · Cited by 54 · see citing works
Zhang, Z., Shen, H., Zhang, Q.-F., & Ong, C. N. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.4.l743 · Cited by 53 · see citing works
Mitochondrial-Derived Oxidants and Quartz Activation of Chemokine Gene Expression
Driscoll, K. E., Howard, B. W., Carter, J. M., et al. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0667-6_74 · Cited by 51 · see citing works
Sacks, M., Gordon, J., Bylander, J. E., Porter, D. W., Shi, X., Castranova, V., Kaczmarczyk, W., Dyke, K. V., & Reasor, M. J. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9763 · Cited by 49 · see citing works
Generation of Reactive Oxygen Species by Quartz Particles and Its Implication for Cellular Damage
Shi, X., Mao, Y., Danie, L. N., Saffiotti, U., Dalal, N. S., & Vallyathan, V. (1995) · Applied Occupational and Environmental Hygiene · doi:10.1080/1047322x.1995.10389108 · Cited by 47 · see citing works
Cho, Y.-J., Seo, M. S., Kim, J. K., Lim, Y., Chae, G., Ha, K., & Lee, K.-H. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1274 · Cited by 43 · see citing works
Silica-induced apoptosis in vitro and in vivo
Lim, Y. (1999) · Toxicology Letters · doi:10.1016/s0378-4274(99)00107-1 · Cited by 42 · see citing works
Inhibition of Stimulant-Induced Activation of Phagocytic Cells With Tetrandrine
Castranova, V., Kang, J.-H., Moore, M. D., Pailes, W. H., Frazer, D. G., & Schwegler‐Berry, D. (1991) · Journal of Leukocyte Biology · doi:10.1002/jlb.50.4.412 · Cited by 40 · see citing works
Giamello, E., Fubini, B., Volante, M., & Costa, D. (1990) · Colloids and Surfaces · doi:10.1016/0166-6622(90)80019-z · Cited by 36 · see citing works
Self-citationKonečný, R., Leonard, S. S., Shi, X., Robinson, V. A., & Castranova, V. (2001) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.v20.isuppl.1.110 · Cited by 32 · see citing works
Castranova, V., Vallyathan, V., Ramsey, D. M., et al. (1997) · Environmental Health Perspectives · doi:10.2307/3433554 · Cited by 27 · see citing works
Kaw, J. L., Beck, E. G., & Bruch, J. (1975) · Environmental Research · doi:10.1016/0013-9351(75)90011-0 · Cited by 26 · see citing works
Costa, D., Fubini, B., Giamello, E., et al. (1991) · Canadian Journal of Chemistry · doi:10.1139/v91-211 · Cited by 23 · see citing works
Self-citationThe role of mechanochemistry in the pulmonary toxicity caused by particulate minerals
Fenoglio, I., Martra, G., Prandi, L., Tomatis, M., Coluccia, S., & Fubini, B. (2000) · Journal of Materials Synthesis and Processing · doi:10.1023/a:1011303924468 · Cited by 20 · see citing works
Self-citationModulation of Silica Pathogenicity by Surface Processes
Fubini, B., & Wallace, W. E. (2000) · CRC Press eBooks · doi:10.1201/9781482269703-46 · Cited by 19 · see citing works
Self-citationProtective Effects of Silanol Group Binding Agents on Quartz Toxicity to Rat Lung Alveolar Cells
Mao, Y., Daniel, L. N., Knapton, A. D., Shi, X., & Saffiotti, U. (1995) · Applied Occupational and Environmental Hygiene · doi:10.1080/1047322x.1995.10389107 · Cited by 18 · see citing works
Silica-Induced Apoptosis in Alveolar and Granulomatous Cells in Vivo
Leigh, J., Wang, H., Bonin, A. M., et al. (1997) · Environmental Health Perspectives · doi:10.2307/3433540 · Cited by 16 · see citing works
Hubbard, A. K., Timblin, C. R., Rincón, M., & Mossman, B. T. (2001) · CHEST Journal · doi:10.1378/chest.120.1_suppl.s24 · Cited by 14 · see citing works
Self-citationInfluence of mode of disintegration on the fibrogenetic power of quartz particles.
Cj, G., LidstroM, L. J., & SWENSSON, A. (1972) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789 · see citing works
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works
Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., et al. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-8 · Cited by 2,134 · see citing works
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859 · see citing works
Chong, Z. Z., Li, F., & Maiese, K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.004 · Cited by 536 · see citing works
de Kok, T. M. C. M., Driece, H. A. L., Hogervorst, J. G. F., & Briedé, J. J. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2006.07.001 · Cited by 489 · see citing works
Silica binding and toxicity in alveolar macrophages
Hamilton, R. F., Thakur, S. A., & Holian, A. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.027 · Cited by 415 · see citing works
Immune mechanisms in pulmonary fibrosis
Kolahian, S., Fernandez, I. E., Eickelberg, O., & Hartl, D. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0121tr · Cited by 349 · see citing works
Basic pathogenetic mechanisms in silicosis: current understanding
Rimal, B., Greenberg, A. K., & Rom, W. N. (2005) · Current Opinion in Pulmonary Medicine · doi:10.1097/01.mcp.0000152998.11335.24 · Cited by 326 · see citing works
Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells
Muller, J., Decordier, I., Hoet, P. H., Lombaert, N., Thomassen, L., Huaux, F., Lison, D., & Kirsch-Volders, M. (2008) · Carcinogenesis · doi:10.1093/carcin/bgm243 · Cited by 298 · see citing works
Muller, J., Huaux, F., Fonseca, A., Nagy, J. B., Moreau, N., Delos, M., Raymundo-Piñero, E., Béguin, F., Kirsch-Volders, M., Fenoglio, I., et al. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800101p · Cited by 261 · see citing works
Self-citationMolecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma
Carbone, M., & Yang, H. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2259 · Cited by 229 · see citing works
Multiple aspects of the interaction of biomacromolecules with inorganic surfaces
Fenoglio, I., Fubini, B., Ghibaudi, E. M., & Turci, F. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.08.001 · Cited by 176 · see citing works
Self-citationToxic Potential of Mineral Dusts
Fubini, B., & Fenoglio, I. (2007) · Elements · doi:10.2113/gselements.3.6.407 · Cited by 166 · see citing works
Self-citationTurci, F., Pavan, C., Leinardi, R., Tomatis, M., Pastero, L., Garry, D., Anguissola, S., Lison, D., & Fubini, B. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0136-6 · Cited by 114 · see citing works
Self-citationHorwell, C. J., Fenoglio, I., Vala Ragnarsdottir, K., Sparks, R. S. J., & Fubini, B. (2003) · Environmental Research · doi:10.1016/s0013-9351(03)00044-6 · Cited by 101 · see citing works
Self-citationProduction of hydrogen peroxide in Martian and lunar soils
Hurowitz, J. A., Tosca, N. J., McLennan, S. M., & Schoonen, M. A. A. (2007) · Earth and Planetary Science Letters · doi:10.1016/j.epsl.2006.12.004 · Cited by 98 · see citing works
Linnarsson, D., Carpenter, J., Fubini, B., Gerde, P., Karlsson, L. L., Loftus, D. J., Prisk, G. K., Staufer, U., Tranfield, E. M., & van Westrenen, W. (2012) · Planetary and Space Science · doi:10.1016/j.pss.2012.05.023 · Cited by 95 · see citing works
Self-citationOverview of lunar dust toxicity risk
Pohlen, M., Carroll, D., Prisk, G. K., & Sawyer, A. J. (2022) · npj Microgravity · doi:10.1038/s41526-022-00244-1 · Cited by 72 · see citing works
Iron-induced hydroxyl radical generation from basaltic volcanic ash
Horwell, C. J., Fenoglio, I., & Fubini, B. (2007) · Earth and Planetary Science Letters · doi:10.1016/j.epsl.2007.07.032 · Cited by 71 · see citing works
Self-citationP2X7 Receptor Modulates Inflammatory and Functional Pulmonary Changes Induced by Silica
Monção-Ribeiro, L. C., Faffe, D. S., Santana, P. T., Vieira, F. S., da Graça, C. L. A. L., Marques-da-Silva, C., Machado, M. N., Caruso-Neves, C., Zin, W. A., Borojevic, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110185 · Cited by 71 · see citing works
Masmoudi-Kouki, O., Douiri, S., Hamdi, Y., Kaddour, H., Bahdoudi, S., Vaudry, D., Basille, M., Leprince, J., Fournier, A., Vaudry, H., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07185.x · Cited by 66 · see citing works
Favero-Longo, S. E., Turci, F., Tomatis, M., Castelli, D., Bonfante, P., Hochella, M. F., Piervittori, R., & Fubini, B. (2005) · Journal of Environmental Monitoring · doi:10.1039/b507569f · Cited by 62 · see citing works
Self-citationFenoglio, I., Fonsato, S., & Fubini, B. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00398-8 · Cited by 38 · see citing works
Self-citationA physico-chemical assessment of the health hazard of Mt. Vesuvius volcanic ash
Horwell, C. J., Stannett, G. W., Andronico, D., Bertagnini, A., Fenoglio, I., Fubini, B., Le Blond, J. S., & Williamson, B. J. (2010) · Journal of Volcanology and Geothermal Research · doi:10.1016/j.jvolgeores.2010.01.014 · Cited by 37 · see citing works
Self-citationBai, J., Zheng, Y., Dong, L., Cai, X., Wang, G., & Liu, P. (2015) · Graefe's Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-015-3090-3 · Cited by 17 · see citing works
Oxidative stress in lung cancer
Mousapasandi, A., Loke, W. S. J., Herbert, C. A., & Thomas, P. S. (2021) · Cancer · doi:10.1016/b978-0-12-819547-5.00003-1 · Cited by 5 · see citing works
- Authors
- Fubini, B., & Hubbard, A.
- Affiliations
- University of Turin (IT)
- University of Connecticut (US)
- Corresponding author
- Fubini, Bice
- ORCID
- Fubini, Bice
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 34
- Issue
- 12
- Pages
- 1507-1516
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2044708698
- Semantic Scholar
- dc65c4fe8f83933f24c52f85aa2dcf7960a250d1
- Cited by
- 935
- References
- 72
- Citations by year
- 2026: 25 · 2025: 34 · 2024: 41 · 2023: 44 · 2022: 58 · 2021: 55 · 2020: 50 · 2019: 42 · 2018: 36 · 2017: 48 · 2016: 47 · 2015: 51 · 2014: 56 · 2013: 44 · 2012: 37
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- crystalline silica, reactive oxygen species, reactive nitrogen species, pulmonary fibrosis, oxidative stress, hydroxyl radicals, superoxide, singlet oxygen, hydrogen peroxide, respiratory burst, phagocytes, manganese superoxide dismutase, glutathione peroxidase, inducible nitric oxide synthase, MEK/ERK signaling, NF-κB, AP-1, apoptosis, mitochondrial dysfunction, death receptors
- MeSH terms
- Animals, Humans, Lung, Pneumonia, Pulmonary Fibrosis, Silicon Dioxide, Silicosis, Reactive Oxygen Species, Reactive Nitrogen Species
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
