The DOI matches its Crossref record; 220 of the 220 references it cites were found in a registry or an index.
Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?
Open accessAbstract
The oxidative stress theory of aging predicts that manipulations that alter oxidative stress/damage will alter aging. The gold standard for determining whether aging is altered is lifespan, i.e., does altering oxidative stress/damage change lifespan? Mice with genetic manipulations in the antioxidant defense system designed to directly address this prediction have, with few exceptions, shown no change in lifespan. However, when these transgenic/knockout mice are tested using models that develop various types of age-related pathology, they show alterations in progression and/or severity of pathology as predicted by the oxidative stress theory; increased oxidative stress accelerates pathology and reduced oxidative stress retards pathology. These contradictory observations might mean a) oxidative stress plays a very limited, if any, role in aging but a major role in healthspan; and/or b) the role that oxidative stress plays in aging depends on environment. In environments with minimal stress, as expected under optimal husbandry, oxidative damage plays little role in aging. However, under chronic stress, including pathological phenotypes that diminish optimal health, oxidative stress/damage plays a major role in aging. Under these conditions, enhanced antioxidant defenses exert an “anti-aging” action, leading to changes in lifespan, age-related pathology, and physiological function as predicted by the oxidative stress theory of aging.
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Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
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“With respect to induced genetic alternations, antioxidants-related transgenic lower models have been frequently used, which have altered antioxidant capacity or a disrupted oxidative-related signaling pathway, leading to either a reduced or extended lifespan (Chen et al., 2010; Liang et al., 2003; Liao and Kennedy, 20…”
Background
Metadata
- Authors
- Salmon, A. B., Richardson, A., & Pérez, V. I.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 48
- Issue
- 5
- Pages
- 642-655
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1968406679
- Cited by
- 446
- References
- 220
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Salmon, A. B., Richardson, A., & Pérez, V. I. (2010). Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging? Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2009.12.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
