Ageing, age-related diseases and oxidative stress: What to do next?

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Sequence and organization of the human mitochondrial genome

Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,640 · see citing works

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works

Oxidative Stress

Sies, H., Berndt, C., & Jones, D. P. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045037 · Cited by 3,520 · see citing works

Protein Oxidation in Aging, Disease, and Oxidative Stress

Berlett, B. S., & Stadtman, E. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20313 · Cited by 3,339 · see citing works

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works

Oxidative stress: a concept in redox biology and medicine

Sies, H. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.002 · Cited by 3,015 · see citing works

Mitochondrial free radical generation, oxidative stress, and aging

Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010 · see citing works

Advanced glycation end-products: A review

Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597 · see citing works

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577 · see citing works

Oxidative stress shortens telomeres

von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524 · see citing works

Reconciling the chemistry and biology of reactive oxygen species

Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504 · see citing works

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,335 · see citing works

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185 · see citing works

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148 · see citing works

Cellular mechanisms and physiological consequences of redox-dependent signalling

Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093 · see citing works

Vitamin E Consumption and the Risk of Coronary Disease in Women

Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282003 · Cited by 2,085 · see citing works

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039 · see citing works

The Biologic Clock: The Mitochondria?

Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 1,991 · see citing works

Ros and ros-mediated cellular signaling

Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4350965 · Cited by 1,980 · see citing works

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins

Stadtman, E. R., & Levine, R. L. (2003) · Amino Acids · doi:10.1007/s00726-003-0011-2 · Cited by 1,968 · see citing works

Free Radical Lipid Peroxidation: Mechanisms and Analysis

Yin, H., Xu, L., & Porter, N. A. (2011) · Chemical Reviews · doi:10.1021/cr200084z · Cited by 1,952 · see citing works

Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Klein, E. A., Thompson, I. M., Tangen, C. M., Crowley, J. J., Lucia, M. S., Goodman, P. J., Minasian, L. M., Ford, L. G., Parnes, H. L., Gaziano, J. M., et al. (2011) · JAMA · doi:10.1001/jama.2011.1437 · Cited by 1,787 · see citing works

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596 · see citing works

Vitamin E: function and metabolism

Brigelius‐Flohé, R., & Traber, M. G. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1145 · Cited by 1,592 · see citing works

Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis

Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519 · see citing works

The role of oxidative stress in neurodegenerative diseases

Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355 · see citing works

Mitochondrial metabolism of reactive oxygen species

Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336 · see citing works

Oxidative Stress in Atherosclerosis

Kattoor, A. J., Pothineni, N. V. K., Palagiri, D. R., & Mehta, J. L. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0678-6 · Cited by 1,276 · see citing works

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

Burdon, R. H. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00198-s · Cited by 1,166 · see citing works

Ageing, neurodegeneration and brain rejuvenation

Wyss-Coray, T. (2016) · Nature · doi:10.1038/nature20411 · Cited by 1,147 · see citing works

Dietary Intake of Antioxidants and Risk of Alzheimer Disease

Engelhart, M. J. (2002) · JAMA · doi:10.1001/jama.287.24.3223 · Cited by 1,080 · see citing works

Protein oxidation and aging

Stadtman, E. R. (2006) · Free Radical Research · doi:10.1080/10715760600918142 · Cited by 1,056 · see citing works

Trends in oxidative aging theories

Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

Stewart, J. B., & Chinnery, P. F. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3966 · Cited by 1,041 · see citing works

Reactions of oxyl radicals with DNA

Breen, A. P., & Murphy, J. A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00209-3 · Cited by 1,038 · see citing works

Oxidative Stress, Mitochondrial Dysfunction, and Aging

Cui, H., Kong, Y., & Zhang, H. (2011) · Journal of Signal Transduction · doi:10.1155/2012/646354 · Cited by 1,036 · see citing works

Reactive oxygen species, cell signaling, and cell injury

Hensley, K., Robinson, K. A., Gabbita, S. P., Salsman, S., & Floyd, R. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00252-5 · Cited by 1,021 · see citing works

Measurement of F2-isoprostanes as an index of oxidative stress in vivo

Roberts, L. J., & Morrow, J. D. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00264-6 · Cited by 1,000 · see citing works

Oxidative Stress: Introductory Remarks

Sies, H. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-642760-8.50005-3 · Cited by 989 · see citing works

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

Islam, M. T. (2016) · Neurological Research · doi:10.1080/01616412.2016.1251711 · Cited by 989 · see citing works

The common biology of cancer and ageing

Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988 · see citing works

Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial

Heilbronn, L. K., de Jonge, L., Frisard, M. I., DeLany, J. P., Larson-Meyer, D. E., Rood, J., Nguyen, T., Martin, C. K., Volaufova, J., Most, M. M., et al. (2006) · JAMA · doi:10.1001/jama.295.13.1539 · Cited by 969 · see citing works

Free radical-induced damage to DNA: mechanisms and measurement

Dizdaroglu, M., Jaruga, P., Birincioglu, M., & Rodriguez, H. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00826-2 · Cited by 953 · see citing works

Protein oxidation and peroxidation

Davies, M. J. (2016) · Biochemical Journal · doi:10.1042/bj20151227 · Cited by 952 · see citing works

The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review)

Siti, H. N., Kamisah, Y., & Jaarin, K. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.03.005 · Cited by 898 · see citing works

Advanced Oxidation Protein Products as Novel Mediators of Inflammation and Monocyte Activation in Chronic Renal Failure,

Witko‐Sarsat, V., Friedlander, M. A., Nguyen‐Khoa, T., Capeillère‐Blandin, C., Nguyen, A., Canteloup, S., Dayer, J., Jungers, P., Drüeke, T. B., & Descamps‐Latscha, B. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.5.2524 · Cited by 879 · see citing works

Oxidative stress and Parkinson’s disease

Blesa, J., Trigo-Damas, I., Quiroga-Varela, A., & Jackson-Lewis, V. R. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00091 · Cited by 878 · see citing works

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855 · see citing works

ROS-dependent signal transduction

Reczek, C. R., & Chandel, N. S. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.010 · Cited by 850 · see citing works

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.010 · Cited by 836 · see citing works

The Role of Sirtuins in Antioxidant and Redox Signaling

Singh, C. K., Chhabra, G., Ndiaye, M. A., Garcia‐Peterson, L. M., Mack, N. J., & Ahmad, N. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7290 · Cited by 812 · see citing works

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., & Zuo, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2525967 · Cited by 810 · see citing works

Mutagenesis by 8-oxoguanine: an enemy within

Grollman, A. P., & Moriya, M. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90089-z · Cited by 807 · see citing works

Oxidative Stress in Neurodegenerative Diseases

Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800 · see citing works

Reactive oxygen species and the free radical theory of aging

Liochev, S. I. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.011 · Cited by 768 · see citing works

Isoprostanes: markers and mediators of oxidative stress

Montuschi, P., Barnes, P. J., & Roberts, L. J. (2004) · The FASEB Journal · doi:10.1096/fj.04-2330rev · Cited by 747 · see citing works

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734 · see citing works

Calorie restriction and aging: review of the literature and implications for studies in humans

Heilbronn, L. K., & Ravussin, E. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.361 · Cited by 701 · see citing works

Oxidative damage to DNA: formation, measurement and biochemical features

Cadet, J., Douki, T., Gasparutto, D., & Ravanat, J. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.09.001 · Cited by 698 · see citing works

Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

Mariani, E., Polidori, M. C., Cherubini, A., & Mecocci, P. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.04.023 · Cited by 682 · see citing works

Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study

Morris, M. C. (2002) · JAMA · doi:10.1001/jama.287.24.3230 · Cited by 678 · see citing works

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

Moskovitz, J., Barnoy, S., Williams, W. M., Requena, J. R., Berlett, B. S., & Stadtman, E. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231472998 · Cited by 677 · see citing works

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and DiseasePreprint

Dc, W., & Chalkia, D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021220 · Cited by 656 · see citing works

Trends in dietary supplement use among US adults from 1999-2012.

Kantor, E. D., Rehm, C. D., Du, M., White, E., & Giovannucci, E. L. (2016) · JAMA · doi:10.1001/jama.2016.14403 · Cited by 644 · see citing works

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

Yang, W., & Hekimi, S. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000556 · Cited by 630 · see citing works

Impact of Oxidative Stress on the Heart and Vasculature

Münzel, T. F., Camici, G. G., Maack, C., Bonetti, N. R., Fuster, V., & Kovacic, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.035 · Cited by 623 · see citing works

Taking a good look at free radicals in the aging process

Hekimi, S., Lapointe, J., & Wen, Y. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.008 · Cited by 606 · see citing works

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

Jiang, T., Sun, Q., & Chen, S. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.005 · Cited by 594 · see citing works

Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance

Dalleau, S., Baradat, M., Guéraud, F., & Huc, L. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.138 · Cited by 580 · see citing works

The GH/IGF-1 axis in ageing and longevity

Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.67 · Cited by 574 · see citing works

Oxy radicals, lipid peroxidation and DNA damage

Marnett, L. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00448-1 · Cited by 563 · see citing works

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

Coskun, P. E., Beal, M. F., & Wallace, D. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403649101 · Cited by 556 · see citing works

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534 · see citing works

Calorie restriction in humans: An update

Most, J., Tosti, V., Redman, L. M., & Fontana, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.005 · Cited by 530 · see citing works

Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein

Fornai, F., Schlüter, O. M., Lenzi, P., Gesi, M., Ruffoli, R., Ferrucci, M., Lazzeri, G., Busceti, C. L., Pontarelli, F., Battaglia, G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409713102 · Cited by 526 · see citing works

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

Guarente, L. (2008) · Cell · doi:10.1016/j.cell.2008.01.007 · Cited by 513 · see citing works

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

Van Raamsdonk, J. M., & Hekimi, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000361 · Cited by 511 · see citing works

Sirtuins, Aging, and Medicine

Guarente, L. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100831 · Cited by 510 · see citing works

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegansPreprint

Doonan, R., McElwee, J., Matthijssens, F., Walker, G. A., Houthoofd, K., Back, P., Matscheski, A., Vanfleteren, J. R., & Gems, D. (2008) · Genes & Development · doi:10.1101/gad.504808 · Cited by 480 · see citing works

Mitochondrial Dysfunction and Reactive Oxygen Species in Excitotoxicity and Apoptosis: Implications for the Pathogenesis of Neurodegenerative Diseases

Rego, A. C., & Oliveira, C. R. (2003) · Neurochemical Research · doi:10.1023/a:1025682611389 · Cited by 472 · see citing works

Sirtuins, a promising target in slowing down the ageing process

Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470 · see citing works

Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials

Myung, S.-K., Ju, W., Cho, B., Oh, S.-W., Park, S. M., Koo, B.-K., Park, B.-J., & for the Korean Meta-Analysis (KORMA) Study Group (2013) · BMJ · doi:10.1136/bmj.f10 · Cited by 467 · see citing works

Calorie restriction and sirtuins revisited

Guarente, L. (2013) · Genes & Development · doi:10.1101/gad.227439.113 · Cited by 464 · see citing works

Vitamin E: Emerging aspects and new directions

Galli, F., Azzi, A., Birringer, M., Cook‐Mills, J. M., Eggersdorfer, M. L., Frank, J., Cruciani, G., Stefan Lorkowski, A., & Özer, N. K. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.017 · Cited by 455 · see citing works

Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence

von Zglinicki, T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06639.x · Cited by 445 · see citing works

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.024 · Cited by 445 · see citing works

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

Salmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 444 · see citing works

Why Have Antioxidants Failed in Clinical Trials?

Steinhubl, S. R. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.003 · Cited by 424 · see citing works

Vitamin E for Alzheimer's dementia and mild cognitive impairment

Farina, N., Llewellyn, D. J., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub5 · Cited by 421 · see citing works

Antioxidant Vitamin Intake and Risk of Alzheimer Disease

Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.203 · Cited by 414 · see citing works

Vitamin E: action, metabolism and perspectives

Herrera, E., & Barbas, C. (2001) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179812 · Cited by 403 · see citing works

It takes two to tango: NAD(+) and sirtuins in aging/longevity control

Imai, S.-I., & Guarente, L. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.17 · Cited by 394 · see citing works

Mitochondrial decay in aging

Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00024-x · Cited by 391 · see citing works

Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.

Halliwell, B. B. (1989) · PubMed · Cited by 368 · see citing works

The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

Yee, C., Yang, W., & Hekimi, S. (2014) · Cell · doi:10.1016/j.cell.2014.02.055 · Cited by 356 · see citing works

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00449.x · Cited by 353 · see citing works

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

Daiber, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.032 · Cited by 347 · see citing works

A mitochondrial bioenergetic etiology of disease

Wallace, D. C. (2013) · Journal of Clinical Investigation · doi:10.1172/jci61398 · Cited by 342 · see citing works

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

Yang, W., Nagasawa, K., Münch, C., Xu, Y., Satterstrom, F. K., Jeong, S., Hayes, S., Jedrychowski, M. P., Vyas, F. S., Zaganjor, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.016 · Cited by 341 · see citing works

Vaccines, new opportunities for a new society

Rappuoli, R., Pizza, M., Giudice, G. D., & Gregorio, E. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402981111 · Cited by 337 · see citing works

Vitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer Disease

Morris, M. C., Beckett, L. A., Scherr, P. A., Hebert, L. E., Bennett, D. A., Field, T. S., & Evans, D. A. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00001 · Cited by 332 · see citing works

Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases

Trpković, A., Resanović, I., Stanimirović, J., Radak, D. J., Mousa, S. A., Cenic-Milosevic, D., Jevremović, D., & Isenović, E. R. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.992063 · Cited by 322 · see citing works

Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta‐analysis

da Silva, S. L., Vellas, B. J., Elemans, S., Luchsinger, J. A., Kamphuis, P. J. G. H., Yaffe, K. S., Sijben, J., Groenendijk, M., & Stijnen, T. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.1771 · Cited by 313 · see citing works

F 2 -Isoprostanes as markers of oxidative stress in vivo : An overview

Milne, G. L., Musiek, E. S., & Morrow, J. D. (2005) · Biomarkers · doi:10.1080/13547500500216546 · Cited by 313 · see citing works

Association of Mitochondrial DNA Copy Number With Cardiovascular Disease

Ashar, F. N., Zhang, Y., Longchamps, R. J., Lane, J., Moes, A., Grove, M. L., Mychaleckyj, J. C., Taylor, K. D., Coresh, J., Rotter, J. I., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.3683 · Cited by 299 · see citing works

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

Butterfield, D. A., Lange, M. L. B., & Rukhsana Sultana, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.005 · Cited by 298 · see citing works

Effect of Antioxidants Supplementation on Aging and Longevity

Sadowska‐Bartosz, I., & Bartosz, G. (2014) · BioMed Research International · doi:10.1155/2014/404680 · Cited by 298 · see citing works

Haptoglobin: Basic and Clinical Aspects

Levy, A. P., Asleh, R., Blum, S., Levy, N. S., Miller‐Lotan, R., Kalet-Litman, S., Anbinder, Y., Lache, O., Nakhoul, F. M., Asaf, R., et al. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2793 · Cited by 294 · see citing works

Calorie restriction as an intervention in ageing

López‐Lluch, G., & Navas, P. (2015) · The Journal of Physiology · doi:10.1113/jp270543 · Cited by 291 · see citing works

Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease

Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybyłowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G., & Channon, K. M. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000196651.64776.51 · Cited by 278 · see citing works

Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function

Daiber, A., Lisa, F. D., Oelze, M. W., Kröller‐Schön, S., Steven, S., Schulz, E., & Münzel, T. F. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13403 · Cited by 271 · see citing works

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

Mecocci, P., & Polidori, M. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.006 · Cited by 270 · see citing works

The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis

Spickett, C. M. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.007 · Cited by 269 · see citing works

The relationship between dose of vitamin E and suppression of oxidative stress in humans

Roberts, L. J., Oates, J. A., Linton, M. F., Fazio, S., Meador, B. P., Gross, M., Shyr, Y., & Morrow, J. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.019 · Cited by 263 · see citing works

A Long Journey into Aging, Brain Aging, and Alzheimer’s Disease Following the Oxidative Stress Tracks

Mecocci, P., Boccardi, V., Cecchetti, R., Bastiani, P., Scamosci, M., Ruggiero, C., & Baroni, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170732 · Cited by 255 · see citing works

Oxidative Stress Signaling to Chromatin in Health and Disease

Kreuz, S., & Fischle, W. (2016) · Epigenomics · doi:10.2217/epi-2016-0002 · Cited by 254 · see citing works

Urinary biomarkers of oxidative status

Il’yasova, D., Scarbrough, P. M., & Spasojević, I. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.06.012 · Cited by 252 · see citing works

Mitochondrial DNA repair pathways

Croteau, D. L., Stierum, R. H., & Bohr, V. A. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00025-7 · Cited by 240 · see citing works

Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk

Zhang, S., Hernán, M. Á., Chen, H., Spiegelman, D. L., Willett, W. C., & Ascherio, A. (2002) · Neurology · doi:10.1212/01.wnl.0000028688.75881.12 · Cited by 240 · see citing works

Mitochondrial Metabolism, Sirtuins, and AgingPreprint

Sack, M. N., & Finkel, T. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013102 · Cited by 237 · see citing works

Genetic mouse models of extended lifespan

Liang, H., Masoro, E. J., Nelson, J. F., Strong, R., McMahan, C. A., & Richardson, A. G. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.019 · Cited by 236 · see citing works

Reduced risk of colon cancer with high intake of vitamin E : the Iowa Women's Health Study.

Bostick, Potter, J. D., McKenzie, M., & Sellers (1993) · Cancer Research · Cited by 234 · see citing works

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

Fessel, J. P., Porter, N. A., Moore, K. P., Sheller, J. R., & Roberts, L. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252649099 · Cited by 219 · see citing works

Mitochondrial DNA repair in aging and disease

Druzhyna, N., Wilson, G. L., & LeDoux, S. P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.002 · Cited by 217 · see citing works

Antioxidant and prooxidant activity of alpha-tocopherol in human plasma and low density lipoprotein.

Kontush, A., Finckh, B., Karten, B., Kohlschütter, A., & Beisiegel†, U. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39128-8 · Cited by 216 · see citing works

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

Zhang, Y., Ikeno, Y., Qi, W., Chaudhuri, A., Li, Y., Bokov, A., Thorpe, S. R., Baynes, J., Epstein, C. J., Richardson, A. G., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp132 · Cited by 206 · see citing works

Sirtuins, Aging, and MetabolismPreprint

Guarente, L. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010629 · Cited by 205 · see citing works

DNA damage in neurodegenerative diseases

Coppedè, F., & Migliore, L. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.11.010 · Cited by 204 · see citing works

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

Jang, Y. C., Pérez, V., Song, W. J., Lustgarten, M. S., Salmon, A. B., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A. R., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp100 · Cited by 201 · see citing works

Many tocopherols, one vitamin E

Azzi, A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.004 · Cited by 201 · see citing works

The brain, sirtuins, and ageing

Satoh, A., Imai, S., & Guarente, L. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.42 · Cited by 198 · see citing works

Lifespan-regulating genes in C. elegans

Uno, M., & Nishida, E. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.10 · Cited by 192 · see citing works

Antioxidants: Scientific Literature Landscape Analysis

Yeung, A. W. K., Tzvetkov, N. T., El-Tawil, O. S., BUNGAU, S. G., Abdel‐Daim, M. M., & Atanasov, A. G. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8278454 · Cited by 190 · see citing works

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans

Hwang, A. B., Ryu, E.-A., Artan, M., Chang, H., Kabir, M. H., Nam, H.-J., Lee, D.-Y., Yang, J., Kim, S., Mair, W. B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411199111 · Cited by 189 · see citing works

Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study.

Bostick, R. M., Potter, J. D., McKenzie, D. R., Sellers, T. A., Kushi, L. H., Steinmetz, K. A., & Folsom, A. R. (1993) · PubMed · Cited by 180 · see citing works

Classifying oxidative stress by F2-isoprostane levels across human diseases: A meta-analysis

Erve, T. J. V. ‘., Kadiiska, M. B., London, S. J., & Mason, R. P. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.024 · Cited by 174 · see citing works

Dietary Intakes of Vitamin E, Vitamin C, and β-Carotene and Risk of Alzheimer's Disease: A Meta-Analysis

Li, F.-J., Shen, L., & Ji, H. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120349 · Cited by 173 · see citing works

Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds

Sousa, B. C., Pitt, A. R., & Spickett, C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.003 · Cited by 172 · see citing works

A Measurable Increase in Oxidative Damage Due to Reduction in Superoxide Detoxification Fails to Shorten the Life Span of Long-Lived Mitochondrial Mutants of Caenorhabditis elegans

Yang, W., Li, J., & Hekimi, S. (2007) · Genetics · doi:10.1534/genetics.107.080788 · Cited by 171 · see citing works

The New Demographic Transition: Most Gains in Life Expectancy Now Realized Late in Life

Eggleston, K. N., & Fuchs, V. R. (2012) · The Journal of Economic Perspectives · doi:10.1257/jep.26.3.137 · Cited by 167 · see citing works

A therapeutic role for sirtuins in diseases of aging?

Westphal, C. H., Dipp, M., & Guarente, L. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.09.008 · Cited by 167 · see citing works

Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models

Gugliandolo, A., Bramanti, P., & Mazzon, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122504 · Cited by 167 · see citing works

Haptoglobin

Andersen, C. B. F., Stødkilde, K., Sæderup, K. L., Kuhlee, A., Raunser, S., Graversen, J. H., & Moestrup, S. K. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6793 · Cited by 167 · see citing works

Dietary supplements and risk of cause-specific death, cardiovascular disease, and cancer: a systematic review and meta-analysis of primary prevention trials

Schwingshackl, L., Boeing, H., Stelmach-Mardas, M., Gottschald, M., Dietrich, S., Hoffmann, G., & Chaimani, A. (2017) · Advances in Nutrition · doi:10.3945/an.116.013516 · Cited by 165 · see citing works

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life

Rutjes, A. W., Denton, D. A., Di Nisio, M., Chong, L.-Y., Abraham, R. P., Al-Assaf, A. S., Anderson, J. L., Malik, M. A., Vernooij, R. W., Martínez, G., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011906.pub2 · Cited by 164 · see citing works

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment

McCleery, J., Abraham, R. P., Denton, D. A., Rutjes, A. W., Chong, L.-Y., Al-Assaf, A. S., Griffith, D. J., Rafeeq, S., Yaman, H., Malik, M. A., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011905.pub2 · Cited by 162 · see citing works

Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases

Bartoli, M. L. E., Novelli, F., Costa, F., Malagrinò, L., Melosini, L., Bacci, E., Cianchetti, S., Dente, F. L., Franco, A. D., Vagaggini, B., et al. (2011) · Mediators of Inflammation · doi:10.1155/2011/891752 · Cited by 161 · see citing works

Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

Wright, M. E., Lawson, K. A., Weinstein, S. J., Pietinen, P., Taylor, P. R., Virtamo, J. R. K., & Albanes, D. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1200 · Cited by 151 · see citing works

Antioxidants as therapies: can we improve on nature?

Murphy, M. P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.010 · Cited by 148 · see citing works

Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity

Testa, G., Biasi, F., Poli, G., & Chiarpotto, E. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660699 · Cited by 148 · see citing works

Impact of antioxidants, zinc, and copper on cognition in the elderly

Age-Related Eye Disease Study Research Group (2004) · Neurology · doi:10.1212/01.wnl.0000142969.19465.8f · Cited by 147 · see citing works

Oxidative stress biomarkers as predictors of cardiovascular disease

Strobel, N., Fassett, R. G., Marsh, S. A., & Coombes, J. S. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.08.008 · Cited by 145 · see citing works

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C. C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.12.001 · Cited by 145 · see citing works

Anti‐atherosclerotic effects of vitamin E – myth or reality?

Vlad, A., Zingg, J.-M., & Azzi, A. (2004) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2004.tb00260.x · Cited by 144 · see citing works

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus

Olsson, L. M., Johansson, Å. C. M., Gullstrand, B., Jönsen, A., Saevarsdóttir, S., Rönnblom, L., Leonard, D., Wetterö, J., Sjöwall, C., Svenungsson, E., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211287 · Cited by 142 · see citing works

Synthetic as compared with natural vitamin E is preferentially excreted as α‐CEHC in human urine: studies using deuterated α‐tocopheryl acetates

Traber, M. G., Elsner, A., & Brigelius‐Flohé, R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01210-1 · Cited by 138 · see citing works

Lower brain and blood nutrient status in Alzheimer's disease: Results from meta‐analyses

de Wilde, M. C., Vellas, B. J., Girault, E. M., Cetinyurek‐Yavuz, A., & Sijben, J. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.06.002 · Cited by 138 · see citing works

Biological ageing and cardiovascular disease

Samani, N. J., & van der Harst, P. (2008) · Heart · doi:10.1136/hrt.2007.136010 · Cited by 136 · see citing works

Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature

Kelkka, T., Kienhöfer, D., Hoffmann, M. H., Linja, M., Wing, K., Sareila, O., Hultqvist, M. H., Laajala, E., Chen, Z. J., Vasconcelos, J. H. L., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5828 · Cited by 135 · see citing works

Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span

Salmon, A. B., Pérez, V., Bokov, A. F., Jernigan, A., Kim, G., Zhao, H., Levine, R. L., & Richardson, A. (2009) · The FASEB Journal · doi:10.1096/fj.08-127415 · Cited by 131 · see citing works

Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies

Ye, Z., & Song, H. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f11f95 · Cited by 131 · see citing works

Protein tyrosine nitration in hydrophilic and hydrophobic environments

Bartesaghi, S., Ferrer‐Sueta, G., Peluffo, G., Valez, V., Zhang, H., Kalyanaraman, B., & Radí, R. (2006) · Amino Acids · doi:10.1007/s00726-006-0425-8 · Cited by 130 · see citing works

Pathophysiological importance of aggregated damaged proteins

Höhn, A., Jung, T., & Grune, T. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.028 · Cited by 126 · see citing works

Oxidative stress and endothelial dysfunction: Therapeutic implications

Gori, T., & Münzel, T. F. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.543920 · Cited by 124 · see citing works

Calorie restriction in rodents: Caveats to consider

Ingram, D. K., & de Cabo, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.008 · Cited by 122 · see citing works

Peripheral artery disease, redox signaling, oxidative stress – Basic and clinical aspects

Steven, S., Daiber, A., Dopheide, J. F., Münzel, T. F., & Espinola–Klein, C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.017 · Cited by 109 · see citing works

Evidence for beneficial effects of vitamin E

Niki, E. (2015) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2015.30.5.571 · Cited by 108 · see citing works

Plasma and Dietary Vitamin E in Relation to Incidence of Type 2 Diabetes

Mayer‐Davis, E. J., Costacou, T., King, I. B., Zaccaro, D. J., & Bell, R. A. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2172 · Cited by 107 · see citing works

A Mitochondrial Etiology of Neurodegenerative Diseases: Evidence from Parkinson's Disease

Хуснутдинова, Э. К., Gilyazova, I. R., Ruiz‐Pesini, E., Derbeneva, O. A., Khusainova, R. I., Khidiyatova, I. M., Magzhanov, R. V., & Wallace, D. C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.001 · Cited by 105 · see citing works

Coexistence of Oxidized Lipids and α-Tocopherol in All Lipoprotein Density Fractions Isolated From Advanced Human Atherosclerotic Plaques

Niu, X., Zammit, V. C., Upston, J. M., Dean, R. T., & Stocker, R. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.7.1708 · Cited by 105 · see citing works

DNA mismatch repair (MMR) mediates 6-thioguanine genotoxicity by introducing single-strand breaks to signal a G2-M arrest in MMR-proficient RKO cells.

Yan, T., Berry, S. E., Desai, A. B., & Kinsella, T. J. (2003) · PubMed · Cited by 104 · see citing works

Vitamin E for Alzheimer's dementia and mild cognitive impairment

Farina, N., Llewellyn, D., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub4 · Cited by 104 · see citing works

Vitamin E: absorption, plasma transport and cell uptake

Hacquebard, M., & Carpentier, Y. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200503000-00005 · Cited by 102 · see citing works

Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan?

Sanz, A. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.03.018 · Cited by 101 · see citing works

Vitamin E in Humans: An Explanation of Clinical Trial Failure

Robinson, I., de Serna, D. G., Gutierrez, A., & Schade, D. S. (2006) · Endocrine Practice · doi:10.4158/ep.12.5.576 · Cited by 100 · see citing works

Structure of a hydroxyl radical-induced DNA-protein crosslink involving thymine and tyrosine in nucleohistone

Dizdaroğlu, M., Gajewski, E., Reddy, P., & Margolis, S. A. (1989) · Biochemistry · doi:10.1021/bi00434a071 · Cited by 99 · see citing works

Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians’ Health Study II randomized trial , , ,

Wang, L., Sesso, H. D., Glynn, R. J., Christen, W. G., Bubes, V. Y., Manson, J. E., Buring, J. E., & Gaziano, J. M. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.085480 · Cited by 99 · see citing works

Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection

Vardi, M., Levy, N. S., & Levy, A. P. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r026641 · Cited by 98 · cited 1× · see citing works

Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

Desjardins, D., Cacho‐Valadez, B., Liu, J., Wang, Y., Yee, C. S., Bernard, K., Khaki, A., Breton, L., & Hekimi, S. (2016) · Aging Cell · doi:10.1111/acel.12528 · Cited by 94 · see citing works

The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials

Zhu, Z., Sun, M.-X., Zhang, W., Wang, W., Jin, Y.-M., & Xie, C. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2757-9 · Cited by 88 · see citing works

The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial

El‐Aal, A. A., Abdelghffar, E. A. R., Ghali, A. S. A., Zughbur, M. R., & Sirdah, M. M. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.03.013 · Cited by 85 · see citing works

Measurement of plasma F2-isoprostanes as an index of lipid peroxidation does not appear to be confounded by diet

Gopaul, N. K., Halliwell, B. B., & Änggård, E. (2000) · Free Radical Research · doi:10.1080/10715760000300671 · Cited by 83 · see citing works

Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice

Pérez, V., Cortez, L. A., Lew, C. M., Rodriguez, M., Webb, C. R., Remmen, H. V., Chaudhuri, A. R., Qi, W., Lee, S., Bokov, A., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr125 · Cited by 80 · see citing works

Coenzyme Q10 for Patients with Parkinson';s Disease: A Systematic Review and Meta-Analysis

Negida, A., Menshawy, A., Ashal, G. E., Elfouly, Y., Hani, Y., Hegazy, Y., ghonimy, S. E., Fouda, S., & Rashad, Y. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150821103306 · Cited by 77 · see citing works

Vitamin E family: Role in the pathogenesis and treatment of Alzheimer's disease

Boccardi, V., Baroni, M., Mangialasche, F., & Mecocci, P. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.08.002 · Cited by 73 · see citing works

Mammalian models of extended healthy lifespan

Selman, C., & Withers, D. J. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0243 · Cited by 71 · see citing works

Antioxidant Clinical Trials in Mild Cognitive Impairment and Alzheimer’s disease – Challenges and Perspectives

Polidori, M., & Nelles, G. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660706 · Cited by 69 · cited 1× · see citing works

Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle

Zullo, A., Simone, E., Grimaldi, M., Musto, V., & Mancini, F. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040928 · Cited by 66 · see citing works

Inter- and intra-individual variation in plasma and red blood cell vitamin E after supplementation

Roxborough, H. E., Burton, G. W., & Kelly, F. J. (2000) · Free Radical Research · doi:10.1080/10715760000300971 · Cited by 65 · see citing works

Mitochondrial-Targeted Catalase

Dai, D., Chiao, Y. A., Martin, G. M., Marcinek, D. J., Basisty, N., Quarles, E. K., & Rabinovitch, P. S. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.015 · Cited by 62 · see citing works

Circulating vitamin E levels and Alzheimer's disease: a Mendelian randomization study

Liu, G., Zhao, Y., Jin, S., Hu, Y., Wang, T., Tian, R., Han, Z., Xu, D., & Jiang, Q. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.08.008 · Cited by 62 · see citing works

Enhanced expression of thioredoxin‐interacting‐protein regulates oxidative DNA damage and aging

Oberacker, T., Bajorat, J., Ziola, S., Schroeder, A., Röth, D., Kastl, L., Edgar, B. A., Wagner, W., Gülow, K., & Krammer, P. H. (2018) · FEBS Letters · doi:10.1002/1873-3468.13156 · Cited by 61 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Oxidative Stress and Inflammation in Osteoarthritis Pathogenesis: Role of Polyphenols

Ansari, M. Y., Ahmad, N., & Haqqi, T. (2020) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2020.110452 · Cited by 665 · see citing works

Gut microbiota and dysbiosis in Alzheimer's disease: Implications for pathogenesis and treatment

Liu, S., Gao, J., Zhu, M., Liu, K., & Zhang, H.-L. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02073-3 · Cited by 516 · see citing works

Health Benefits of Quercetin in Age-Related Diseases

Deepika, & Maurya, P. K. (2022) · Molecules · doi:10.3390/molecules27082498 · Cited by 453 · see citing works

Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

Cordiano, R., Gioacchino, M. D., Mangifesta, R., Panzera, C., Gangemi, S., & Minciullo, P. L. (2023) · Molecules · doi:10.3390/molecules28165979 · Cited by 490 · see citing works

Use of Alcalase in the production of bioactive peptides: A review

Tacias-Pascacio, V. G., Morellon‐Sterling, R., Siar, E.-H., Tavano, O. L., Berenguer‐Murcia, Á., & Fernández‐Lafuente, R. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.060 · Cited by 418 · see citing works

Pathological mechanisms and therapeutic strategies for Alzheimer’s disease

Tam, K. Y., & Ju, Y. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320970 · Cited by 416 · see citing works

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

El Assar, M., Álvarez-Bustos, A., Sosa, P., Angulo, J., & Rodríguez-Mañas, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158713 · Cited by 371 · see citing works

Mitochondrial dysfunction in aging

Guo, Y., Guan, T., Shafiq, K., Yu, Q., Jiao, X., Na, D., Li, M., Zhang, G., & Kong, J. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101955 · Cited by 351 · see citing works

Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

Xiang, D., Liu, Y., Zhou, S.-J., Zhou, E., & Wang, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5523516 · Cited by 262 · see citing works

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276 · see citing works

Uric acid in health and disease: From physiological functions to pathogenic mechanisms

Wen, S., Arakawa, H., & Tamai, I. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108615 · Cited by 246 · see citing works

Cytotoxic effects of polystyrene nanoplastics with different surface functionalization on human HepG2 cells

He, Y., Li, J., Chen, J., Miao, X., Li, G., He, Q., Xu, H., Li, H., & Wei, Y. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138180 · Cited by 223 · see citing works

Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota

Wu, M., Luo, Q., Nie, R., Yang, X., Tang, Z., & Chen, H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1773390 · Cited by 207 · see citing works

Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022) · Theranostics · doi:10.7150/thno.71360 · Cited by 197 · see citing works

Preparation, characterization and antioxidant activity of protocatechuic acid grafted carboxymethyl chitosan and its hydrogel

Xu, C., Guan, S., Xu, J., Gong, W., Liu, T., Ma, X., & Sun, C. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117210 · Cited by 188 · see citing works

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Ji, S., Xiong, M., Chen, H., Liu, Y., Zhou, L., Hong, Y., Wang, M., Wang, C., Fu, X., & Sun, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01343-5 · Cited by 166 · see citing works

Comparison of In Vitro and In Vivo Antioxidant Activities of Six Flavonoids with Similar Structures

Zeng, Y., Song, J., Zhang, M., Wang, H., Zhang, Y., & Suo, H. (2020) · Antioxidants · doi:10.3390/antiox9080732 · Cited by 159 · see citing works

Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

Li, Y., Peng, Y., Shen, Y., Zhang, Y., Liu, L., & Yang, X. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2076064 · Cited by 156 · see citing works

Biomarkers and Mechanisms of Oxidative Stress—Last 20 Years of Research with an Emphasis on Kidney Damage and Renal Transplantation

Tejchman, K., Kotfis, K., & Sieńko, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158010 · Cited by 153 · see citing works

Evaluation of The Antioxidant Capacity of Food Products: Methods, Applications and Limitations

Sadowska‐Bartosz, I., & Bartosz, G. (2022) · Processes · doi:10.3390/pr10102031 · Cited by 149 · see citing works

Calycosin: a Review of its Pharmacological Effects and Application Prospects

Deng, M., Chen, H., Long, J., Song, J., Xie, L., & Li, X. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2021.1863145 · Cited by 139 · see citing works

The Influence of Lifestyle and Treatment on Oxidative Stress and Inflammation in Diabetes

Wronka, M., Krzemińska, J., Młynarska, E., Rysz, J., & Franczyk, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415743 · Cited by 135 · see citing works

Novel insights into ferroptosis: Implications for age-related diseases

Zhou, R., Chen, Y., Wei, X., Yu, B., Xiong, Z., Lu, C., & Hu, W. M. (2020) · Theranostics · doi:10.7150/thno.50663 · Cited by 132 · see citing works

Flavonoids—Natural Gifts to Promote Health and Longevity

Fan, X., Fan, Z., Yang, Z., Huang, T., Tong, Y., Yang, D., Mao, X., & Yang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042176 · Cited by 127 · see citing works

Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences

Andrés, C. M. C., de la Lastra, J. M. P., Andrés, C., Plou, F. J., & Pérez‐Lebeña, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052600 · Cited by 138 · see citing works

Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Dai, Y., Guo, Y., Tang, W., Chen, D., Xue, L., Chen, Y., Guo, Y., Wei, S., Wu, M., Dai, J., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02501-9 · Cited by 116 · see citing works

A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions

Iakovou, E., & Kourti, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.827900 · Cited by 113 · see citing works

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

Tarek, B., Soleti, R., Panaro, M. A., Torre, M. E. L., Monda, V., Messina, G., & Porro, C. (2021) · Molecules · doi:10.3390/molecules26164794 · Cited by 100 · see citing works

Fucoidan-Derived Functional Oligosaccharides: Recent Developments, Preparation, and Potential Applications

Wang, M., Veeraperumal, S., Zhong, S., & Cheong, K. (2023) · Foods · doi:10.3390/foods12040878 · Cited by 98 · see citing works

Defensing against oxidative stress in Caenorhabditis elegans of a polysaccharide LFP-05S from Lycii fructus

Zhang, F., Zhang, X., Liang, X., Wu, K., Cao, Y. K., Ma, T., Guo, S., Chen, P., Yu, S., Ruan, Q., et al. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119433 · Cited by 96 · see citing works

Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies

Hadziahmetovic, M., & Malek, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.612812 · Cited by 91 · see citing works

Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation

Kumar, P., Osahon, O. W., Vides, D. B., Hanania, N. A., Minard, C. G., & Sekhar, R. V. (2021) · Antioxidants · doi:10.3390/antiox11010050 · Cited by 90 · see citing works

Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties

Es-Sai, B., Wahnou, H., Benayad, S., Rabbaa, S., Laaziouez, Y., Kebbaj, R. E., Limami, Y., & Duval, R. E. (2025) · Molecules · doi:10.3390/molecules30030653 · Cited by 90 · see citing works

Progress in chitin/chitosan and their derivatives for biomedical applications: Where we stand

Mu, L., Wu, L., Wu, S., Ye, Q., & Zhong, Z. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122233 · Cited by 90 · see citing works

Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol?

Meulmeester, F. L., Luo, J. M., Martens, L. G., Mills, K. A., van Heemst, D., & Noordam, R. (2022) · Antioxidants · doi:10.3390/antiox11122322 · Cited by 95 · see citing works

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage

Kumar, P., Osahon, O. W., & Sekhar, R. V. (2022) · Nutrients · doi:10.3390/nu14051114 · Cited by 83 · see citing works

Reactive Oxygen Species and Oxidative Stress in Vascular‐Related Diseases

Cheng, X., Hu, Y., Yang, T., Wu, N., & Wang, X.-N. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7906091 · Cited by 81 · see citing works

Role of phase angle in older adults with focus on the geriatric syndromes sarcopenia and frailty

Norman, K., Herpich, C., & Müller‐Werdan, U. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09772-3 · Cited by 79 · see citing works

Role of mitophagy in mitochondrial quality control: Mechanisms and potential implications for neurodegenerative diseases

Wang, X., Feng, S., Wang, Z., Chen, N., & Zhang, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105433 · Cited by 76 · see citing works

Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014)

Wu, D., Wang, H., Wang, W., Qing, C., Zhang, W., Gao, X., Shi, Y., Li, Y., & Zheng, Z. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1147869 · Cited by 77 · see citing works

Western Dietary Pattern Antioxidant Intakes and Oxidative Stress: Importance During the SARS-CoV-2/COVID-19 Pandemic

Trujillo‐Mayol, I., Guerra‐Valle, M., Casas‐Forero, N., Sobral, M. M. C., Viegas, O., Alarcón, J., Ferreira, I. M. P. L. V. O., & Pinho, O. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa171 · Cited by 74 · see citing works

Physical Activity and Oxidative Stress in Aging

Militello, R., Luti, S., Gamberi, T., Pellegrino, A., Modesti, A., & Modesti, P. A. (2024) · Antioxidants · doi:10.3390/antiox13050557 · Cited by 73 · see citing works

Physical Activity and Oxidative Stress in Aging

Militello, R., Luti, S., Gamberi, T., Pellegrino, A., Modesti, A., & Modesti, P. A. (2024) · doi:10.20944/preprints202404.0293.v1 · Cited by 73 · see citing works

Spotlight on the Mechanism of Action of Semaglutide

Papakonstantinou, I. P., Tsioufis, K. P., & Katsi, V. K. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46120872 · Cited by 80 · see citing works

Oxidative stress and antioxidant defenses in mild cognitive impairment: A systematic review and meta-analysis

Nantachai, G., Vasupanrajit, A., Tunvirachaisakul, C., Solmi, M., & Maes, M. H. J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101639 · Cited by 71 · see citing works

Oxidation Stress as a Mechanism of Aging in Human Erythrocytes: Protective Effect of Quercetin

Remigante, A., Spinelli, S., Basile, N., Caruso, D., Falliti, G., Dossena, S., Marino, A., & Morabito, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147781 · Cited by 71 · see citing works

Fasting: From Physiology to Pathology

Tang, D., Tang, Q., Huang, W., Zhang, Y., Tian, Y., & Fu, X. (2023) · Advanced Science · doi:10.1002/advs.202204487 · Cited by 71 · see citing works

Single-atom catalysts: promotors of highly sensitive and selective sensors

Li, Z., Tian, E., Wang, S., Ye, M., Li, S., Wang, Z., Ma, Z., Jiang, G., Tang, C., Liu, K., et al. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00191h · Cited by 70 · see citing works

Polysaccharides with antioxidant activity: Extraction, beneficial roles, biological mechanisms, structure-function relationships, and future perspectives: A review

Liu, X., Huang, L., Zhang, X., & Xu, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140221 · Cited by 69 · see citing works

Supplementation with γ-glutamylcysteine (γ-GC) lessens oxidative stress, brain inflammation and amyloid pathology and improves spatial memory in a murine model of AD

Liu, Y., Chen, Z., Li, B., Yao, H., Zarka, M., Welch, J., Sachdev, P., Bridge, W., & Braidy, N. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2020.104931 · Cited by 69 · see citing works

Oxidative Stress Factors Mediate the Association Between Life’s Essential 8 and Accelerated Phenotypic Aging: NHANES 2005–2018

Liu, W., Wang, J., Wang, M., Hou, H., Ding, X., Ma, L., & Liu, M. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad240 · Cited by 68 · see citing works

Air pollution exposure, accelerated biological aging, and increased thyroid dysfunction risk: Evidence from a nationwide prospective study

Liang, R., Fan, L., Lai, X., Shi, D., Wang, H., Shi, W., Liu, W., Yu, L., Song, J., & Wang, B. (2024) · Environment International · doi:10.1016/j.envint.2024.108773 · Cited by 66 · see citing works

Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging

Xu, W., Luo, Y., Yin, J., Huang, M., & Luo, F. (2022) · Food & Function · doi:10.1039/d2fo02688k · Cited by 69 · see citing works

A Narrative Review: The Effect and Importance of Carotenoids on Aging and Aging-Related Diseases

Bakac, E. R., Percin, E., Bayır, A. G., & Dadak, A. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015199 · Cited by 65 · see citing works

Potential Effects of Akkermansia Muciniphila in Aging and Aging-Related Diseases: Current Evidence and Perspectives

Zeng, S.-Y., Liu, Y., Liu, J., Zeng, Z., Xie, H., & Liu, J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0325 · Cited by 63 · see citing works

Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration

Terao, R., Ahmed, T., Suzumura, A., & Terasaki, H. (2022) · Antioxidants · doi:10.3390/antiox11112189 · Cited by 59 · see citing works

A new discovery of polystyrene microplastics toxicity: The injury difference on bladder epithelium of mice is correlated with the size of exposed particles

Wang, Y., Wang, S., Xu, T., Cui, W., Xu, S., & Xu, S. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153413 · Cited by 58 · see citing works

Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial

Rondanelli, M., Gasparri, C., Barrile, G. C., Battaglia, S., Cavioni, A., Giusti, R., Mansueto, F., Moroni, A., Nannipieri, F., Patelli, Z., et al. (2022) · Nutrients · doi:10.3390/nu14214566 · Cited by 61 · see citing works

Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes

Paplou, V. G., Schubert, N. M. A., & Pyott, S. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.680856 · Cited by 59 · see citing works

Cross‐Talk between Oxidative Stress and m6A RNA Methylation in Cancer

Yang, B., & Chen, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6545728 · Cited by 60 · see citing works

Antioxidant peptides from plants: a review

César, A., Lopes, F. E. S., Azevedo, F. F. N., Pinto, Y. O., Andrade, C. R., Mesquita, F. P., da Silva, G. O., Freitas, C. D. T., & Souza, P. F. N. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-023-09875-y · Cited by 58 · see citing works

Bioadaptation of implants to In vitro and In vivo oxidative stress pathological conditions via nanotopography-induced FoxO1 signaling pathways to enhance Osteoimmunal regeneration

Huang, J., Li, R., Yang, J., Cai, M., Lee, Y., Wang, A., Cheng, B., & Wang, Y. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.02.023 · Cited by 56 · see citing works

Autophagy facilitates age-related cell apoptosis—a new insight from senile cataract

Huang, J., Yu, W., He, Q., He, X., Yang, M. W., Chen, W., & Han, W. (2022) · Cell Death and Disease · doi:10.1038/s41419-021-04489-8 · Cited by 57 · see citing works

Oxidative stress and aging: synergies for age related diseases

Santos, D. F., Simão, S., Nóbrega, C., Bragança, J., Castelo‐Branco, P., & Araújo, I. M. (2024) · FEBS Letters · doi:10.1002/1873-3468.14995 · Cited by 63 · see citing works

A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

Livshits, G., & Kalinkovich, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101852 · Cited by 55 · see citing works

Age-related testosterone decline: mechanisms and intervention strategies

Cheng, H., Zhang, X., Li, Y., Cao, D., Luo, C., Zhang, Q., Zhang, S., & Jiao, Y. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-024-01316-5 · Cited by 61 · see citing works

RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8

Imanishi, T., Unno, M., Yoneda, N., Motomura, Y., Mochizuki, M., Sasaki, T., Pasparakis, M., & Saito, T. (2023) · Science Advances · doi:10.1126/sciadv.add6097 · Cited by 52 · see citing works

The role of redox-mediated lysosomal dysfunction and therapeutic strategies

He, X., Li, X., Tian, W., Li, C., Li, P., Zhao, J., Yang, S., & Li, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115121 · Cited by 53 · see citing works

SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart

Zhang, J., Ren, D., Fedorova, J., He, Z., & Li, J. (2020) · Antioxidants · doi:10.3390/antiox9090858 · Cited by 50 · see citing works

Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders

Salehi, B., Quispe, C., Sharifi‐Rad, J., Giri, L., Suyal, R., Jugran, A. K., Zucca, P., Rescigno, A., Peddio, S., Bobiş, O., et al. (2021) · Phytotherapy Research · doi:10.1002/ptr.7045 · Cited by 49 · see citing works

Dietary methionine restriction improves gut microbiota composition and prevents cognitive impairment in d -galactose-induced aging mice

Xu, Y., Yang, Y., Li, B., Xie, Y., Shi, Y., & Le, G. (2022) · Food & Function · doi:10.1039/d2fo03366f · Cited by 49 · see citing works

A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation

Zhang, Y., Teng, H. W., Gao, Y., Afzal, M. W., Tian, J., Chen, X., Tang, H., James, T. D., & Guo, Y. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.03.020 · Cited by 49 · see citing works

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration

Wang, J., Xia, D., Lin, Y., Xu, W., Wu, Y., Chen, J., Chu, J., Shen, P., Weng, S., Wang, X., et al. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00732-0 · Cited by 48 · see citing works

A Comprehensive Evaluation of Effects on Water-Level Deficits on Tomato Polyphenol Composition, Nutritional Quality and Antioxidant Capacity

Jin, N., Li, J., Wang, S., Meng, X., Ma, X., He, X., Zhang, G., Luo, S., Lyu, J., & Yu, J. (2022) · Antioxidants · doi:10.3390/antiox11081585 · Cited by 48 · see citing works

Antioxidant and Anti-inflammatory Effects of α-Lipoic Acid on Lipopolysaccharide-induced Oxidative Stress in Rat Kidney

Skibska, B., Kochan, E., Stańczak, A., Lipert, A., & Skibska, A. (2023) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-023-00682-z · Cited by 48 · see citing works

Antioxidant action of vitamin E<i>in vivo</i>as assessed from its reaction products with multiple biological oxidants

Niki, E., & Noguchi, N. (2021) · Free Radical Research · doi:10.1080/10715762.2020.1866181 · Cited by 47 · see citing works

Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases

Remigante, A., & Morabito, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148017 · Cited by 47 · see citing works

A Statistically Supported Antioxidant Activity DFT Benchmark—The Effects of Hartree–Fock Exchange and Basis Set Selection on Accuracy and Resources Uptake

Spiegel, M., Gamian, A., & Sroka, Z. (2021) · Molecules · doi:10.3390/molecules26165058 · Cited by 46 · see citing works

A mitochondria-specific fluorescent probe based on triazolopyridine formation for visualizing endogenous hypochlorous acid in living cells and zebrafish

Teng, H. W., Tian, J., Sun, D., Xiu, M.-X., Zhang, Y., Qiang, X., Tang, H., & Guo, Y. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128288 · Cited by 45 · see citing works

Digital Anti-Aging Healthcare: An Overview of the Applications of Digital Technologies in Diet Management

Armand, T. P. T., Kim, H., & Kim, J.-I. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14030254 · Cited by 50 · see citing works

Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2

Buttari, B., Tramutola, A., Rojo, A. I., Chondrogianni, N., Saha, S., Berry, A., Giona, L., Miranda, J. P., Profumo, E., Davinelli, S., et al. (2025) · Biomolecules · doi:10.3390/biom15010113 · Cited by 47 · see citing works

Current views in chronic obstructive pulmonary disease pathogenesis and management

Alfahad, A. J., Alzaydi, M. M., Aldossary, A. M., Alshehri, A. A., Almughem, F. A., Zaidan, N. M., & Tawfik, E. A. (2021) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2021.10.008 · Cited by 46 · see citing works

The Dual Role of Oxidative-Stress-Induced Autophagy in Cellular Senescence: Comprehension and Therapeutic Approaches

Pantelis, P., Theocharous, G., Lаgopati, N., Veroutis, D., Thanos, D.-F., Lampoglou, G.-P., Pippa, Ν., Gatou, Μ.-A., Tremi, I., Papaspyropoulos, A., et al. (2023) · Antioxidants · doi:10.3390/antiox12010169 · Cited by 41 · see citing works

GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging

Sekhar, R. V. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab309 · Cited by 42 · see citing works

An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway

Ning, B., Hang, S.-Q., Zhang, W., Mao, C.-W., & Li, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1232241 · Cited by 37 · see citing works

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Anghinoni, J. M., Birmann, P. T., da Rocha, M. J., Gomes, C. S., Davies, M. J., Brüning, C. A., Savegnago, L., & Lenardao, E. J. (2023) · Molecules · doi:10.3390/molecules28217349 · Cited by 40 · see citing works

Antioxidant Effects of Caffeic Acid Lead to Protection of Drosophila Intestinal Stem Cell Aging

Sheng, X., Zhu, Y., Zhou, J., Yan, L., Du, G., Liu, Z., & Chen, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.735483 · Cited by 40 · see citing works

The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease

Leisegang, K., Roychoudhury, S., Sláma, P., & Finelli, R. (2021) · Antioxidants · doi:10.3390/antiox10111834 · Cited by 40 · see citing works

Structural characterization, antioxidant, and anti-inflammatory activity of polysaccharides from Plumula Nelumbinis

Zheng, Q., Chen, J., Yuan, Y., Zhang, X., Li, L., Zhai, Y., Gong, X., & Li, B. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.05.097 · Cited by 40 · see citing works

The Effectiveness of Supplementation with Key Vitamins, Minerals, Antioxidants and Specific Nutritional Supplements in COPD—A Review

Fekete, M., Csípő, T., Fazekas‐Pongor, V., Fehér, Á., Szarvas, Z., Kaposvári, C., Horváth, K., Lehoczki, A., Tarantini, S., & Varga, J. T. (2023) · Nutrients · doi:10.3390/nu15122741 · Cited by 39 · see citing works

Sensitive and Selective Dual‐Mode Responses to Reactive Oxygen Species by Chiral Manganese Dioxide Nanoparticles for Antiaging Skin

Qu, A., Chen, Q., Sun, M., Xu, L., Hao, C., Xu, C., & Kuang, H. (2023) · Advanced Materials · doi:10.1002/adma.202308469 · Cited by 39 · see citing works

Probiotic potential of lactic acid bacteria with antioxidant properties in modulating health: Mechanisms, applications, and future directions

Gao, Y., Liang, Q., Sun, J., Wu, X., Song, Y., Xu, Y., Nie, H., HUANG, J. C., & Mu, G. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106181 · Cited by 39 · see citing works

Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging

Zhou, N.-J., Bao, W.-Q., Zhang, C., Jiang, M., Liang, T.-L., Ma, G.-Y., Liu, L., Pan, H., & Li, R.-Z. (2025) · npj Aging · doi:10.1038/s41514-025-00250-z · Cited by 44 · see citing works

Effects of Water Deficit Irrigation on Phenolic Composition and Antioxidant Activity of Monastrell Grapes under Semiarid Conditions

Pérez‐Álvarez, E. P., Intrigliolo, D. S., Almajano, M. P., Rubio‐Bretón, P., & Garde‐Cerdán, T. (2021) · Antioxidants · doi:10.3390/antiox10081301 · Cited by 39 · see citing works

Açaì (Euterpe oleracea) Extract Protects Human Erythrocytes from Age-Related Oxidative Stress

Remigante, A., Spinelli, S., Straface, E., Gambardella, L., Caruso, D., Falliti, G., Dossena, S., Marino, A., & Morabito, R. (2022) · Cells · doi:10.3390/cells11152391 · Cited by 39 · see citing works

Sirtuin 3 Plays a Critical Role in the Antidepressant- and Anxiolytic-like Effects of Kaempferol

Li, H., Wang, J., Liang, L., Shen, S.-Y., Li, W., Chen, X., Li, B., Zhang, Y., & Yu, J. M. (2022) · Antioxidants · doi:10.3390/antiox11101886 · Cited by 38 · see citing works

Gut microbiota metabolism of branched‐chain amino acids and their metabolites can improve the physiological function of aging mice

Wang, H., Feng, L., Pei, Z., Zhao, J., Lu, S., & Lu, W. (2024) · Aging Cell · doi:10.1111/acel.14434 · Cited by 38 · see citing works

The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications

Bouhadana, D., Pagé, M.-H. G., Montjean, D., Bélanger, M., Benkhalifa, M., Miron, P., & Petrella, F. (2025) · Antioxidants · doi:10.3390/antiox14081013 · Cited by 38 · see citing works

Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway

Yu, H., Jiang, X., Dong, F., Zhang, F., Ji, X., Xue, M., Yang, F., Chen, J., Hu, X., & Bao, Z. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112689 · Cited by 38 · see citing works

Oxidative stress related biomarkers in aged-related human studies on vitamin intervention and healthy aging cohorts

Jansen, E. H. J. M., Beekhof, P., Cremers, J. W. J. M., & Tamošiūnas, A. (2012) · Lithuanian University of Health Sciences

Markers of oxidant stress that are clinically relevant in aging and age-related disease

Jacob, K. D., Hooten, N. N., Trzeciak, A. R., & Evans, M. K. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.02.008 · Cited by 233 · see citing works

Exploring the potential of oxidative stress-related biomarkers of ageing in a population-based study of the very old

Wiley, L. (2014) · Cited by 1 · see citing works

Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here

Vassalle, C., Maltinti, M., & Sabatino, L. (2020) · Molecules · doi:10.3390/molecules25112653 · Cited by 77 · see citing works

Oxidative damage to DNA and antioxidant status in aging and age-related diseases.

Oliński, R., Siomek, A., Różalski, R., Gackowski, D., Foksiński, M., Guz, J., Dziaman, T., Szpila, A., & Tudek, B. (2007) · Acta Biochimica Polonica · doi:10.18388/abp.2007_3265 · Cited by 102 · see citing works