Cited by 553Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathways

The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.

Linking oxidative stress to inflammation: Toll-like receptors

Open access

Gill, Roop, Tsung, Allan, Billiar, Timothy·2010·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2010.01.006PMC PMC3423196

Open this paper in CoChat — free account

Abstract

Injury caused by oxidative stress occurs in many clinical scenarios involving ischemia and reperfusion such as organ transplantation, hemorrhagic shock (HS), myocardial infarction, and cerebral vascular accidents. Activation of the immune system as a result of disturbances in the redox state of cells seems to contribute to tissue and organ damage in these conditions. The link between oxidative stress and inflammatory pathways is poorly understood. Recently, Toll-like receptors (TLRs) have been shown to mediate the inflammatory response seen in experimental ischemia and reperfusion (I/R). The TLR family of receptors involved in alerting the innate immune system of danger seems to be activated by damage-associated molecular pattern molecules (DAMPs) that are released during conditions of oxidative stress. In this review, we examine the role of TLRs in various experimental models of oxidative stress such as HS and I/R. We also report on potential DAMPs that may interact with TLRs in mediating injury. Finally, potential mechanisms by which reactive oxygen species from NADPH oxidase can signal the commencement of inflammatory pathways through TLRs are explored.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2010.01.006

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,996
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125

Show all 134 references

Sorted by citations

Items 401–500 of 553

Protecting the aging eye with hydrogen sulfide
George, A. K., Homme, R. P., Stanišić, D., Tyagi, S. C., & Singh, M. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0216 · Cited by 10
Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis and poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targets
Mavian, C. N., Ramirez-Mata, A. S., Dollar, J. J., Nolan, D. J., Cash, M. N., White, K., Rich, S. N., Magalis, B. R., Marini, S., Prosperi, M., et al. (2021) · Journal of NeuroVirology · doi:10.1007/s13365-020-00927-z · Cited by 10
The Potential of Lisosan G as a Possible Treatment for Glaucoma
Amato, R., Rossino, M. G., Cammalleri, M., Timperio, A. M., Fanelli, G., Monte, M. D., Pucci, L., & Casini, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.719951 · Cited by 10
Non-Essential Role for TLR2 and Its Signaling Adaptor Mal/TIRAP in Preserving Normal Lung Architecture in Mice
Ruwanpura, S. M., McLeod, L., Lilja, A. R., Brooks, G. D., Dousha, L. F., Seow, H. J., Bozinovski, S., Vlahos, R., Hertzog, P. J., Anderson, G. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078095 · Cited by 10
Caffeine alleviate lipopolysaccharide-induced neuroinflammation and depression through regulating p-AKT and NF-κB
Zhang, R., Zhang, L., Du, W., Tang, J., Yang, L., Geng, D., & Cheng, Y. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137923 · Cited by 9
Air pollution: an emerging risk factor for autism spectrum disorder
Ojha, S. K., & Amal, H. (2024) · Brain medicine : · doi:10.61373/bm024e.0115 · Cited by 9
Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration
Liu, J., Copland, D. A., Clare, A. J., Gorski, M., Richards, B. T., Scott, L. M., Theodoropoulou, S., Greferath, U., Cox, K. H. M., Shi, G., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adi4125 · Cited by 9
Identification and characterisation of the anti-oxidative stress properties of the lamprey prohibitin 2 gene
Tie-song, L., Wang, Y., Gao, Y., & Li, Q. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.11.016 · Cited by 9
Genome‑wide DNA methylation profiling in a rat model with vascular dementia
Park, J., Kim, Y. J., Song, M. K., Lee, J., & Kim, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8990 · Cited by 9
Neuroprotective Effect of Huperzine A on d -Galactose-Induced Hearing Dysfunction
Li, C., & Shi, S. (2019) · Ear Nose & Throat Journal · doi:10.1177/0145561319864570 · Cited by 9
Revelation of the sciences of traditional foods
Jia, Z., Zhang, B., Sharma, A., Kim, N. S., Purohit, S., Green, M. M., Roche, M. R., Holliday, E. G., & Chen, H. (2022) · Food Control · doi:10.1016/j.foodcont.2022.109392 · Cited by 10
Hydroethanolic Extract of Morus nigra L. Leaves: A Dual PPAR-α/γ Agonist with Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7
Carneiro, A. D. A., Sinoti, S. B. P., de Freitas, M. M., Simeoni, L. A., Fagg, C. W., Magalhães, P. O., Silveira, D., & Fonseca-Bazzo, Y. M. (2022) · Plants · doi:10.3390/plants11223147 · Cited by 11
Toll-like Receptor 2-Melatonin Feedback Loop Regulates the Activation of Spinal NLRP3 Inflammasome in Morphine-Tolerant Rats
Peng, X., Wang, J., Li, Z., Jia, X., Zhang, A., Ju, J., Eulenburg, V., & Gao, F. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03998-6 · Cited by 11
Postconditioning: “Toll-erating” mesenteric ischemia-reperfusion injury?
Rosero, O., Ónody, P., Kovács, T., Molnár, D., Fulop, A. K., Lotz, G., Harsányi, L., & Szíjártó, A. (2016) · Surgery · doi:10.1016/j.surg.2016.09.031 · Cited by 9
Polyscias scutellaria: An emerging source of natural antioxidants and anti-inflammatory compounds for health
Muhar, A. M., Velaro, A. J., Prananda, A. T., Nugraha, S. E., Çamlık, G., Wasnik, S., abidin, S. Z., Sjofjan, O., Harahap, M. A. Y., Syahrian, M. F., et al. (2023) · Pharmacia · doi:10.3897/pharmacia.70.e112502 · Cited by 8
The role of bile acid in regulating head-kidney, spleen and skin immune function of on-growing grass carp (Ctenopharyngodon idella)
Zhao, F., Peng, X.-R., Jiang, W., Wu, P., Liu, Y., Feng, L., & Zhou, X. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741611 · Cited by 8
Fattening with formulated diets improves the immune response and lipid accumulation in the gonads of male Chinese mitten crab (Eriocheir sinensis)
Chen, J., Xu, P., Xu, G., Xue, M., Wang, Q., He, J., He, C., Kong, C., Li, X., Wang, H., et al. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741945 · Cited by 8
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges
Francavilla, F., Intranuovo, F., Spada, G. L., Lacivita, E., Catto, M., Graps, E. A., & Altomare, C. (2024) · ChemMedChem · doi:10.1002/cmdc.202400672 · Cited by 13
Oxidative Stress as a Regulatory Checkpoint in the Production of Antiphospholipid Autoantibodies: The Protective Role of NRF2 Pathway
Sorice, M., Profumo, E., Capozzi, A., Recalchi, S., Riitano, G., Veroli, B. D., Saso, L., & Buttari, B. (2023) · Biomolecules · doi:10.3390/biom13081221 · Cited by 10
The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation
Gu, X., Li, L., Chen, B., Zhang, Y., Zhou, Y., Liu, K., Xia, W., Li, X., Zhang, Z., Shi, H., et al. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2304087 · Cited by 8
Novel Therapeutic Targets for Major Depressive Disorder
Lazar, M. A., & McIntyre, R. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00034-2 · Cited by 9
Hemorrhagic Shock and the Microvasculature
Filho, I. P. T. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00005.x · Cited by 8
Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation
Wang, Q., Yang, H., Liu, H.-Z., Mi, S., Zhang, X., Yan, H., Ma, Y., Wang, X., & Hu, Z. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.67 · Cited by 8
Effect of orexin-A on phagocytic activity of peritoneal macrophage in starved rats
Izgut-Uysal, V. N., Gemici, B., & Tan, R. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.06.005 · Cited by 8
Role of Toll-like receptor 4/oxidant-coupled activation in regulating the biosynthesis of omega-3 polyunsaturated fatty acid derivative resolvin D1 in primary murine peritoneal macrophage
Zhang, Y., & Igwe, O. J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.021 · Cited by 8
Extracorporeal shock wave therapy effectively protects brain against chronic cerebral hypo-perfusion-induced neuropathological changes.
Chai, H., Chen, K., Wallace, C. G., Chen, C., Sung, P., Chen, Y., Yuen, C.-M., Shao, P., Sun, C., Chang, H., et al. (2017) · Europe PMC (PubMed Central) · Cited by 8
Role of necroptosis in pulpitis: integration of bacterial infection, immune imbalance, and oxidative stress
Wang, X., Wang, Y., Pang, Z., Gong, P., Ma, X., Qiu, Y., Li, J., Peng, L., & Liu, Z. (2025) · PeerJ · doi:10.7717/peerj.20209 · Cited by 7
Decreased leukocyte exhaustion is associated with decreased IFN-β and increased α-defensin-1 levels in type-2 diabetes
Shruthi, S., Sibi, J. M., Mohan, V., Babu, S., Nirmaladevi, V., & Aravindhan, V. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155918 · Cited by 6
Dual roles of CD11b+CD33+HLA-DR-/lowCD14- myeloid-derived suppressor cells with a granulocytic morphology following allogeneic hematopoietic stem cell transplantation: from inflammation promoters to immune suppressors within 90 days
Ni, M., Cui, J. Z., Yang, X., Ding, Y., Zhao, P., Hu, T., Zhan, Y., Kang, Q., Hu, X., Zhao, J., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1403272 · Cited by 7
Streptozotocin activates inflammation-associated signalling and antioxidant response in the lobster cockroach; Nauphoeta cinerea (Blattodea: Blaberidae)
Olagoke, O. C., Segatto, A. L. A., Afolabi, B. A., & da Rocha, J. B. T. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109563 · Cited by 7
Renal denervation ameliorates post-infarction cardiac remodeling in rats through dual regulation of oxidative stress in the heart and brain
Jiang, W., Huo, J.-Y., Chen, C., Chen, R., Ge, T., Chang, Q., Hu, J., Geng, J., Jiang, Z., & Shan, Q. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109243 · Cited by 7
High and fluctuating glucose levels increase the expression and secretion of interleukin-18 in mouse peritoneal macrophages
Zhang, C., Bi, Y., Jin, G., Gan, H., & Yu, L. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3753 · Cited by 7
In vivo evaluation of efficacy and safety of Coagulansin-A in treating arthritis
Naz, S., Mazhar, M. U., Faiz, S., Malik, M., Khan, J., Haq, I. U., Zhu, L., & Tipu, M. K. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117008 · Cited by 6
Pyraclostrobin-induced toxic effects in the gills of common carp (Cyprinus carpio L.): Mechanisms unveiled through biochemical, molecular, and metabolomic analyses
Zhao, H., Ma, Q., Lu, S., Liu, S., Feng, Y., Liu, Y., & Zhang, B. (2025) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2025.101443 · Cited by 6
Exploring the toxicity of thiamethoxam on aquatic ecosystems: an overarching assessment of biochemical parameters, genotoxicity, fish flesh residues and histological alterations in Nile tilapia
Mansour, A., Nossair, M. A., Ibrahim, E., Abd-elaziz, R. A., Althobaiti, F., Alotaibi, K. S., Albattal, S. B., Marzouk, M., Soliman, M. M., & Abdelmaksoud, E. M. (2025) · Environmental Pollutants and Bioavailability · doi:10.1080/26395940.2025.2493050 · Cited by 6
Water-soluble polysaccharides derived from Poria cocos protect against LPS-induced renal injury through inhibiting the NF-κB-NOX4 signaling pathway
Yu, D., Ge, K., Chen, N., Wang, Y., & Xu, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146626 · Cited by 6
Green Synthesis of Sulfur Nanoparticles Using Flavour and Fragrance‐Relevant Phytochemicals Rich Mukia maderaspatana Extract: Functional Antimicrobial and Anti‐Inflammatory Properties
Sivasuriyan, K. S., Namasivayam, S. K. R., Subbulakshmi, A. V. G., & Rajendran, S. (2026) · Flavour and Fragrance Journal · doi:10.1002/ffj.70119 · Cited by 7
Scutellariae Radix and Citri Reticulatae Pericarpium Mixture Regulate PPARγ/RXR Signaling in Reflux Esophagitis
Lee, J. A., Shin, M.-R., Park, H.-J., & Roh, S. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6969241 · Cited by 6
PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory Response and Cardiac Function
Wen, J. J., DeJesus, J. E., Radhakrishnan, G. L., & Radhakrishnan, R. S. (2023) · Journal of the American College of Surgeons · doi:10.1097/xcs.0000000000000546 · Cited by 6
The influence of physical occupational factors on the immune system
Kuzmina, L. P., Izmerova, N. I., Khotuleva, A. G., Tsidilkovskaya, E. S., Kisljakova, A. A., & Mili, H. (2023) · Russian Journal of Occupational Health and Industrial Ecology · doi:10.31089/1026-9428-2023-63-11-694-701 · Cited by 6
Reduction of oxidative stress response and protection of liver and renal cell functions by reduced glutathione in lower limb arterial ischemia–reperfusion in New Zealand white rabbits with high triglyceride levels
Wang, X., Sun, H., Cheng, G., & Ge, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33258 · Cited by 6
Novel thiazole–pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol‐induced myocardial infarction
You, H., Su, X., & Su, G. (2020) · Archiv der Pharmazie · doi:10.1002/ardp.202000140 · Cited by 6
Disengaging the COVID-19 Clutch as a Discerning Eye Over the Inflammatory Circuit During SARS-CoV-2 Infection
Anwar, M. M., Sah, R., Shrestha, S., Ozaki, A., Roy, N., Fathah, Z., & Rodriguez-Morales, A. J. (2022) · Inflammation · doi:10.1007/s10753-022-01674-5 · Cited by 6
New stilbenes and phenolic constituents from the rhizomes of Belamcanda chinensis
Liu, K.-D., Yang, W., Dai, M.-Z., Sun, S., Fu, J., & Qu, J. (2022) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2022.2112573 · Cited by 6
Impact of age on cardiovascular function, inflammation, and oxidative stress in experimental asphyxial cardiac arrest
Secher, N., Østergaard, L., Tønnesen, E., Hansen, F. B., & Granfeldt, A. (2017) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13014 · Cited by 6
Intestinal inflammation and microbiota modulation impact cochlear function: emerging insights in gut-ear axis
Pisani, A., Petito, V., Paciello, F., Emoli, V., Masi, L., Hizam, V. M., Puca, P., Montuoro, R., CHIERICO, F. D., Putignani, L., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02338-1 · Cited by 5
Kaempferol suppresses TLR-2 and TLR-4 coactivation by attenuation of LPS/LTA-induced inflammation and cellular stress
Haroon, M., & Kang, S. C. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10989-z · Cited by 6
Gut-Derived Lactobacillus rhamnosus GG Alleviates Intestinal Inflammation in Laying Hens via Microbiota Remodeling and Tryptophan Metabolic Reprogramming
Zhao, M., Amevor, F. K., Liu, L. Z., Dong, S., Chen, D., Zou, R., Liu, A., Liu, L., & Cui, Z. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c11552 · Cited by 5
Innate immune responses following myocardial ischemia and reperfusion: Evidence, mechanisms, and translational challenges
Zhang, S., Du, P., Zhang, C., Jie, W., Shi, G.-P., & Guo, J. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109026 · Cited by 5
Conditioned place avoidance is associated with a distinct hippocampal phenotype, partly preserved pattern separation, and reduced reactive oxygen species production after stress
Kelley, D. P., Albrechet‐Souza, L., Cruise, S. C., Maiya, R., Destouni, A., Sakamuri, S. S. V. P., Duplooy, A., Hibicke, M., Nichols, C. D., Katakam, P. V. G., et al. (2023) · Genes Brain & Behavior · doi:10.1111/gbb.12840 · Cited by 5
The alleviatory effects of koumine on MSU‐induced gouty arthritis via the TLR4/NF‐κB/NLRP3 pathway
Lin, S., Chen, S., Zhan, Y., Guo, X., Wu, W., Lin, Y., Yu, C., & Yang, J. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14037 · Cited by 5
Oxidative stress in intensive care unit patients: a review of glutathione linked metabolism and lipid peroxidation
Meda, S., Singh, S. P., Palade, P., Tonk, S. S., & Awasthi, S. (2019) · The Southwest Respiratory and Critical Care Chronicles · doi:10.12746/swrccc.v7i27.511 · Cited by 5
The Role of Oxidative Stress and Inflammation in Cardiometabolic Health of Children During Cancer Treatment and Potential Impact of Key Nutrients
Bélanger, V., Benmoussa, A., Napartuk, M., Warin, A., Laverdière, C., Marcoux, S., Levy, E. H., & Marcil, V. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8143 · Cited by 6
Evaluating protective effects of botanicals under inflammation and oxidative stress in chicken apical-out enteroids
Ghiselli, F., Yu, L.-E., Piva, A., Grilli, E., & Li, Y. (2023) · Poultry Science · doi:10.1016/j.psj.2023.102821 · Cited by 5
The effect of Balinese Purple Sweet Potato (Ipomoea batatas L.) tuber ethanolic extract on renal Nox4 level in mice with a high purine diet
Mahendra, A. N., & Dewi, N. W. S. (2020) · Bali Medical Journal · doi:10.15562/bmj.v9i3.1787 · Cited by 5
Regulation of Key Immune-Related Genes in the Heart Following Burn Injury
Wen, J. J., Mobli, K., Radhakrishnan, G. L., & Radhakrishnan, R. S. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12061007 · Cited by 5
Age-associated differences in gene expression in response to delayed anesthetic preconditioning
Zhong, C., Fleming, N., Lu, X., Moore, P., & Liu, H. (2011) · AGE · doi:10.1007/s11357-011-9322-5 · Cited by 5
Zinc-loaded montmorillonite alleviates avian pathogenic Escherichia coli -induced intestinal barrier damage in broiler chickens
Zha, P., Liu, X., Qin, Z., Xue, Y., Tan, Z., Chen, Y., & Zhou, Y. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf327 · Cited by 4
The lifespan continuum of brain disorders: investigating links between neurodevelopmental and neurodegenerative disease—chicken or egg?
Sian‐Hülsmann, J., Knudsen, L. V., Sheldrick, A. J., Riederer, P., & Michel, T. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-025-03078-9 · Cited by 5
Reactive oxygen species in skin diseases: pathogenic mechanisms and nanomaterial-based therapeutic strategies
Yan, Q., Zheng, Y., Chen, L., Ma, H., Ding, C., Pang, X., Xia, T., Wei, J., Zhang, Y., & Xu, G. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1797044 · Cited by 4
Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial
Fernández-Garrido, J., Martin, E., Saez-Berlanga, Á., Gargallo, P., Gené‐Morales, J., Alix‐Fages, C., Jiménez‐Martínez, P., Caballero, O., Palmer, R. S., & Colado, J. C. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113122 · Cited by 7
Cinnamomum japonicum Siebold Branch Extracts Attenuate NO and ROS Production via the Inhibition of p38 and JNK Phosphorylation
Kim, J. M., Choi, M., & Yang, J. H. (2023) · Molecules · doi:10.3390/molecules28041974 · Cited by 4
Folate Targeting Peptide Conjugates for Inflammatory Response Suppression
Ruff, E., & Poh, S. (2023) · Current Drug Metabolism · doi:10.2174/1389200224666230419090052 · Cited by 4
Quercetin in Sports and Exercise: A review
Kurtz, J. A., VanDusseldorp, T. A., Uken, B., & Otis, J. S. (2023) · International journal of exercise science · doi:10.70252/gqok2958 · Cited by 6
Interplay between Pro-inflammatory Mediators and Oxidative Stressinvolved Recurrent Chronic Heart Failure in Elderly Patients with Coronary Stents
Li, X., Zhao, Y. J., Zhou, H., Hu, Y., Chen, Y., & Guo, D. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673309995240829060533 · Cited by 4
Common Signal Transduction Molecules Activated by Bacterial Entry into a Host Cell and by Reactive Oxygen Species
Bonavita, R., & Laukkanen, M. O. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7968 · Cited by 4
Apocynin promotes neural function recovery and suppresses neuronal apoptosis by inhibiting Tlr4/NF-κB signaling pathway in a rat model of cerebral infarction
Pan, L., & Qian, S. (2018) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738418817700 · Cited by 4
Immune neutralization of the receptor for advanced glycation end products reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide
Ribeiro, C. T., Gasparotto, J., Teixeira, A. A., Portela, L. V., Louzada-Flores, V. N., Moreira, J. C. F., & Gelain, D. P. (2018) · The Journal of Biochemistry · doi:10.1093/jb/mvy013 · Cited by 4
Gut-ovary axis mediated synergistic reproductive toxicity of polystyrene nanoplastics and perfluorobutanoic acid co-exposure: pyroptotic signaling and probiotic mitigation
Huang, J., Zhang, Y., Nie, P., Luo, Q., Hu, R., Zhang, R., Zhao, Y. M., Yu, M., & Xu, H. (2026) · Particle and Fibre Toxicology · doi:10.1186/s12989-026-00667-8 · Cited by 3
Zearalenone causes ovarian damage and abnormal estradiol secretion in meat rabbits by inducing oxidative stress and inflammatory responses
Wu, F., Wang, F., Tang, Z., Yang, X., Liu, Y., Zhao, M., Liu, S., Han, S., & Chen, B. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1566284 · Cited by 3
Cardiopulmonary bypass in the newborn: effects of circulatory cell-free hemoglobin and hyperoxia evaluated in a novel rat pup model
Jungner, Å., Vallius, S., Bruschettini, M., Romantsik, O., Gram, M., & Ley, D. (2017) · Intensive Care Medicine Experimental · doi:10.1186/s40635-017-0153-2 · Cited by 4
Effect of Leu-Ile-Lys tripeptide on the activity of free radical oxidation and expression of сyclooxygenase-1 and -2 in gastric mucosa in experimental indomethacin-induced ulcer in rats
Эльшадовна, Л. С., Mazko, E. N., Макарова, О. Г., Zharikov, A. Y., Korenovskiy, Y. V., & Васильевна, А. О. (2019) · Kazan medical journal · doi:10.17816/kmj2019-439 · Cited by 3
Optimum Reaction Conditions for the Synthesis of Selenized Ornithogalum caudatum Ait. (Liliaceae) Polysaccharides and Measurement of Their Antioxidant Activity In Vivo
Sun, R., Qu, Z., Ji, C., Yang, X., Zhang, Y., & Zou, X. (2023) · Molecules · doi:10.3390/molecules28155929 · Cited by 3
Anemonin suppresses sepsis‐induced acute lung injury by inactivation of nuclear factor‐kappa B and activation of nuclear factor erythroid 2‐related factor‐2/heme oxygenase‐1 pathway
Xia, Q., Liu, G., Zhang, L., Xie, B., & Deng, L. (2025) · The FASEB Journal · doi:10.1096/fj.202401987rr · Cited by 3
Antiinflammatory Activity of Wheat Grass Fortified with Cow Urine Distillate
Killari, K. N., Prasad, K., Talluri, M. R., Bokam, Y. K., Nadiminti, S. R., & Kommavari, C. S. (2019) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.538 · Cited by 3
Evaluation of the Anti-Inflammatory/Immunomodulatory Effect of Teucrium montanum L. Extract in Collagen-Induced Arthritis in Rats
Bufan, B., Marčetić, M. D., Djuretić, J., Ćuruvija, I., Blagojević, V., Božić, D. D., Milutinović, V. M., Janković, R., Sopta, J. P., Kotur‐Stevuljević, J., et al. (2024) · Biology · doi:10.3390/biology13100818 · Cited by 2
Hyperoxia-induced oxidative stress enhances TMEM106B to impair ULK1–mediated autophagy via TLR3/JNK signaling
Xu, M., Jiang, X., Peng, C., Jiang, J., Qin, T., Qin, H., Zeng, C., Cheng, Y.-L., Xing, Y., Wu, S., et al. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf112 · Cited by 2
Mechanistic insights into the anti-benign prostatic hyperplasia effect of dihydromyricetin via suppression of the 5-AR/TGF-β1/Smad2 axis
el-hameed, S. A., Matouk, A. I., Ibrahim, A. R. N., & El‐Daly, M. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-04998-3 · Cited by 2
NEC-Associated Bronchopulmonary Dysplasia and the Gut–Lung Axis in Preterm Infants
Jawale, N., Shenberger, J. S., Shetty, A. K., Gunasekaran, V., & Garg, P. M. (2026) · American Journal of Perinatology · doi:10.1055/a-2821-3458 · Cited by 2
Dauricine ameliorates intestinal inflammation and oxidative stress in DSS-induced colitis through TLR4/NLRP3/GSDMD-mediated pyroptosis and Nrf2 pathway
Wang, L., Liu, J., Wang, J., Xie, Y., Gao, Y., Xu, D., Li, J., Dong, J., Li, B., Cao, Y., et al. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05218-8 · Cited by 2
Antioxidants in pediatric sepsis
Zicca, A., & Tissières, P. (2012) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e31822f12cc · Cited by 2
Ameliorative Effect of Exercise Training on Age-Related Vascular and Biochemical Changes in Rats
HASSAN, M. D. O. A. M. H., & EL-GIZAWY, M. D. S. R. E. I. (2019) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2019.53511 · Cited by 2
Phytochemical Analysis and Assessment of In vitro Antioxidant Potential of Polyherbal Formulation
Rana, N., Singh, V., & Ali, S. (2023) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2023.00477 · Cited by 2
Potent phytoceuticals cocktail exhibits anti-inflammatory and antioxidant activity on LPS-triggered RAW264.7 macrophages in vitro
Rubis, G. D., Paudel, K. R., Kokkinis, S., Sherkawi, T. E., Datsyuk, J. K., Salunke, P., Gerlach, J., & Dua, K. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155770 · Cited by 2
Effects of propolis intake on endurance exercise and molecular signaling related to inflammation and oxidative stress
Xu, X., Hu, B., & Qu, X. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1539701 · Cited by 3
High glucose heightens vulnerability to Leishmania braziliensis infection in human macrophages by hampering the production of reactive oxygen species through TLR2 and TLR4
Bonyek-Silva, Í., Bastos, R., Nunes, S., Tibúrcio, R., Lago, A. S., Silva, J., Carvalho, L. P., Khouri, R., Arruda, S. M., Barral, A. M. P., et al. (2025) · Emerging Microbes & Infections · doi:10.1080/22221751.2025.2475824 · Cited by 2
Polymerised placenta haemoglobin attenuates cold ischaemia/reperfusion injury in isolated rat heart
Li, W., Wu, R. B., Yang, C. M., Zheng, S., & Yu, X. (2011) · Microvascular Research · doi:10.1016/j.mvr.2011.08.010 · Cited by 2
Cancer Biology: Severe Cumulative Delayed Type Hypersensitivity Reactions
Khatami, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-66475-0_6 · Cited by 2
Protective effect of casticin in myocardial ischemia/reperfusion injury in rats via attenuation of oxidative stress and inflammation
Ji, L., Tian, Z., Liu, Y., & Liu, M. (2021) · Archives of Medical Science · doi:10.5114/aoms/127588 · Cited by 2
Discovery of novel ketamine‐inspired derivatives as a protective agent against renal ischemic/reperfusion injury in Wistar rats
Zhu, L., & Zhang, Y. (2021) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14011 · Cited by 2
Immunomodulatory properties of algae
Diego-González, L., & Simón‐Vázquez, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98819-3.00011-0 · Cited by 2
Pathogenesis of the crosstalk between reproductive function and stress in animals – part 2: Prolactin, thyroid, inflammation and oxidative stress
Jaillardon, L., & Kaiser, M. (2023) · Reproduction in Domestic Animals · doi:10.1111/rda.14445 · Cited by 2
Neurochemical Aspects of Dementia
Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00001-5 · Cited by 3
TRPM2 deficiency protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophagesPreprint
Zong, P., Feng, J., Yue, Z., Yu, A. S., Mori, Y., & Yue, L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.29.454234 · Cited by 2
Regulation of neuroinflammation, resolution, and neuroprotection by aerobic exercise, yoga, and Tai Chi
Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-88460-0.00016-3 · Cited by 1
Anemarrhenae asphodeloides Polysaccharide Extraction Process Optimization and its Monosaccharide Composition and Antioxidant Activity of Correlation Analysis
Bai, H., Zhang, Z., Wang, P., He, Y., Zeng, Y., Sun, Y., Wang, Q., & Kuang, H. (2025) · Pharmacognosy Magazine · doi:10.1177/09731296251351369 · Cited by 1
Craibiodendron stellatum (Pierre) WW Sm. Extract Suppresses Lipopolysaccharide-Induced Acute Lung Injury by Regulating Macrophage-Mediated Inflammation In Vivo and In Vitro
Gu, D. H., Kim, M. J., Fauziah, A. N., & Jung, S. K. (2025) · Journal of Medicinal Food · doi:10.1177/1096620x251360148 · Cited by 1
Oxidative stress-induced proinflammatory secretion from retinal pigment epithelium disrupts NAD+ metabolism via CD38 on macrophages leading to immune microenvironment dysregulation
Lin, R., Liang, F., Hu, C., Jiang, L., Wan, Z., Xu, Z., Luo, Y., Ma, J., Wu, Y., Cai, W., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.11.041 · Cited by 1
Deciphering the TLR-mediated immunotoxic adverse outcome pathway of pentachlorophenol in marine medaka (Oryzias melastigma)
Zhang, Y., Chu, J., Cui, S., Kong, Q., Cui, L., Zhou, Y., Yao, S., Zhang, Y., & Zhang, H. (2025) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2025.11.039 · Cited by 1
Transcriptional regulation of Toll-like Receptors in Pinna nobilis: Insights into immune response under varying pathogen loads and effect of individual variation
Lattos, A., Coupé, S., Papadopoulos, D. K., & Giantsis, I. (2026) · Gene Reports · doi:10.1016/j.genrep.2025.102415 · Cited by 1

Authors: Gill, R., Tsung, A., & Billiar, T.
Affiliations: University of Pittsburgh (US)
Corresponding author: Gill, Roop
ORCID: Tsung, Allan
Billiar, Timothy
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2010-05
Volume: 48
Issue: 9
Pages: 1121-1132
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2010.01.006
PMC: PMC3423196
OpenAlex: W2013742341
Cited by: 553
References: 134
Citations by year: 2026: 21 · 2025: 37 · 2024: 26 · 2023: 41 · 2022: 34 · 2021: 50 · 2020: 42 · 2019: 39 · 2018: 38 · 2017: 33 · 2016: 28 · 2015: 31 · 2014: 35 · 2013: 33 · 2012: 18
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM050441)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: oxidative stress, Toll-like receptors, inflammation, ischemia-reperfusion injury, hemorrhagic shock, damage-associated molecular patterns, reactive oxygen species, NADPH oxidase, innate immunity, organ transplantation, myocardial infarction, stroke
MeSH terms: Animals, Humans, Inflammation, Reperfusion Injury, Oxidative Stress, Toll-Like Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Linking oxidative stress to inflammation: Toll-like receptors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks