Billiar, Timothy R.

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences

Animal testing and alternativesImmune Response and Inflammation

Cited by 3,005

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M. P., Lotze, M. T., Yang, H., Li, J., Tracey, K. J., Geller, D. A., et al. (2005) · The Journal of Experimental Medicine

Advanced Glycation End Products researchOrgan Transplantation Techniques and Outcomes

Cited by 1,113

HMGB1 in health and disease

Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine

Advanced Glycation End Products researchImmune Response and Inflammation

Cited by 956

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., et al. (2017) · Cell Reports

Ferroptosis and cancer prognosisCancer-related Molecular Pathways

Cited by 952

Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms

Kim, Y.-M., Talanian, R. V., & Billiar, T. R. (1997) · Journal of Biological Chemistry

Cell death mechanisms and regulationNitric Oxide and Endothelin Effects

Cited by 887

HMGB1: Endogenous Danger Signaling

Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R., & Tsung, A. (2008) · Molecular Medicine

Advanced Glycation End Products researchImmune Response and Inflammation

Cited by 762

Nitrogen oxide levels in patients after trauma and during sepsis

OCHOA, J. B., UDEKWU, A. O., BILLIAR, T. R., CURRAN, R. D., CERRA, F. B., SIMMONS, R. L., & PEITZMAN, A. B. (1991) · Annals of Surgery

Sepsis Diagnosis and TreatmentNitric Oxide and Endothelin Effects

Cited by 599

Linking oxidative stress to inflammation: Toll-like receptors

Gill, R., Tsung, A., & Billiar, T. (2010) · Free Radical Biology and Medicine

Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 553

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin

Nussler, A. K., Di Silvio, M., Billiar, T. R., Hoffman, R. A., Geller, D. A., Selby, R., Madariaga, J., & Simmons, R. L. (1992) · The Journal of Experimental Medicine

Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 420

Nitric oxide and wound repair: role of cytokines?

Schwentker, A., Vodovotz, Y., Weller, R., & Billiar, T. R. (2002) · Nitric Oxide

Wound Healing and TreatmentsNitric Oxide and Endothelin Effects

Cited by 386

Masquerader: High Mobility Group Box-1 and Cancer

Ellerman, J. E., Brown, C. K., de Vera, M., Zeh, H. J., Billiar, T., Rubartelli, A., & Lotze, M. T. (2007) · Clinical Cancer Research

Advanced Glycation End Products researchS100 Proteins and Annexins

Cited by 355

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

Billiar, T. R., Curran, R. D., Harbrecht, B. G., Stuehr, D. J., Demetris, A. J., & Simmons, R. L. (1990) · Journal of Leukocyte Biology

Nitric Oxide and Endothelin EffectsDrug-Induced Hepatotoxicity and Protection

Cited by 335

Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

Zuckerbraun, B. S., Chin, B. Y., Bilban, M., d'Avila, J. D. C., Rao, J., Billiar, T. R., & Otterbein, L. E. (2007) · The FASEB Journal

Heme Oxygenase-1 and Carbon MonoxideNitric Oxide and Endothelin Effects

Cited by 323

Role of Toll-Like Receptors in Changes in Gene Expression and NF-κB Activation in Mouse Hepatocytes Stimulated with Lipopolysaccharide

Liu, S., Gallo, D. J., Green, A. M., Williams, D. L., Gong, X., Shapiro, R. A., Gambotto, A. A., Humphris, E. L., Vodovotz, Y., & Billiar, T. R. (2002) · Infection and Immunity

Immune Response and InflammationNF-κB Signaling Pathways

Cited by 246

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

Xu, J., Jiang, Y., Wang, J., Shi, X., Liu, Q., Liu, Z., Li, Y., Scott, M. J., Xiao, G., Li, S., et al. (2014) · Cell Death & Differentiation

Inflammasome and immune disordersAdvanced Glycation End Products research

Cited by 239

Inflammasome and Autophagy Regulation: A Two-way Street

Sun, Q., Fan, J., Billiar, T. R., & Scott, M. J. (2017) · Molecular Medicine

Inflammasome and immune disordersAutophagy in Disease and Therapy

Cited by 203

IV. Determinants of nitric oxide protection and toxicity in liver

Li, J., & Billiar, T. R. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Nitric Oxide and Endothelin EffectsDrug-Induced Hepatotoxicity and Protection

Cited by 195

Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis‐Induced Liver Injury by Granisetron Generation in Mice

Gong, S., Yan, Z., Liu, Z., Niu, M., Fang, H., Li, N., Huang, C., Li, L., Chen, G., Luo, H., et al. (2019) · Hepatology

Sepsis Diagnosis and TreatmentGut microbiota and health

Cited by 188

High‐mobility group box‐1 in sterile inflammation

Tsung, A., Tohme, S., & Billiar, T. R. (2014) · Journal of Internal Medicine

Advanced Glycation End Products researchImmune Response and Inflammation

Cited by 187

Nitric oxide, a protective molecule in the cardiovascular system

Lei, J., Vodovotz, Y., Tzeng, E., & Billiar, T. R. (2013) · Nitric Oxide

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 184

Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells

Xiang, M., Shi, X., Li, Y., Xu, J., Yin, L., Xiao, G., Scott, M. J., Billiar, T. R., Wilson, M. A., & Fan, J. (2011) · The Journal of Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 155

Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS

Bayır, H., Kagan, V. E., Borisenko, G. G., Tyurina, Y. Y., Janesko, K. L., Vagni, V. A., Billiar, T. R., Williams, D. L., & Kochanek, P. M. (2005) · Journal of Cerebral Blood Flow & Metabolism

Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research

Cited by 138

Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock

Meng, Z. H., Dyer, K., Billiar, T. R., & Tweardy, D. J. (2001) · American Journal of Physiology-Cell Physiology

Trauma, Hemostasis, Coagulopathy, ResuscitationSepsis Diagnosis and Treatment

Cited by 131

Human transcriptome array for high-throughput clinical studies

Xu, W., Seok, J., Mindrinos, M. N., Schweitzer, A. C., Jiang, H., Wilhelmy, J., Clark, T. A., Kapur, K., Xing, Y., Faham, M., et al. (2011) · Proceedings of the National Academy of Sciences

Gene expression and cancer classificationGenomics and Phylogenetic Studies

Cited by 124