Cited by 553Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathways

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Linking oxidative stress to inflammation: Toll-like receptors

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Gill, Roop, Tsung, Allan, Billiar, Timothy·2010·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2010.01.006PMC PMC3423196

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Abstract

Injury caused by oxidative stress occurs in many clinical scenarios involving ischemia and reperfusion such as organ transplantation, hemorrhagic shock (HS), myocardial infarction, and cerebral vascular accidents. Activation of the immune system as a result of disturbances in the redox state of cells seems to contribute to tissue and organ damage in these conditions. The link between oxidative stress and inflammatory pathways is poorly understood. Recently, Toll-like receptors (TLRs) have been shown to mediate the inflammatory response seen in experimental ischemia and reperfusion (I/R). The TLR family of receptors involved in alerting the innate immune system of danger seems to be activated by damage-associated molecular pattern molecules (DAMPs) that are released during conditions of oxidative stress. In this review, we examine the role of TLRs in various experimental models of oxidative stress such as HS and I/R. We also report on potential DAMPs that may interact with TLRs in mediating injury. Finally, potential mechanisms by which reactive oxygen species from NADPH oxidase can signal the commencement of inflammatory pathways through TLRs are explored.

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Authors: Gill, R., Tsung, A., & Billiar, T.
Affiliations: University of Pittsburgh (US)
Corresponding author: Gill, Roop
ORCID: Tsung, Allan
Billiar, Timothy
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2010-05
Volume: 48
Issue: 9
Pages: 1121-1132
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2010.01.006
PMC: PMC3423196
OpenAlex: W2013742341
Cited by: 553
References: 134
Citations by year: 2026: 21 · 2025: 37 · 2024: 26 · 2023: 41 · 2022: 34 · 2021: 50 · 2020: 42 · 2019: 39 · 2018: 38 · 2017: 33 · 2016: 28 · 2015: 31 · 2014: 35 · 2013: 33 · 2012: 18
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM050441)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: oxidative stress, Toll-like receptors, inflammation, ischemia-reperfusion injury, hemorrhagic shock, damage-associated molecular patterns, reactive oxygen species, NADPH oxidase, innate immunity, organ transplantation, myocardial infarction, stroke
MeSH terms: Animals, Humans, Inflammation, Reperfusion Injury, Oxidative Stress, Toll-Like Receptors

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Linking oxidative stress to inflammation: Toll-like receptors

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