Linking oxidative stress to inflammation: Toll-like receptors

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

Tolerance, Danger, and the Extended Family

Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,996

Approaching the asymptote? Evolution and revolution in immunology.Preprint

Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386

NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125

Baicalein exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF-kB and LOX and AMPK/Nrf2 pathway

Yuan, Y. J., Men, W., Shan, X., Zhai, H., Qiao, X., Geng, L., & Li, C. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00714-6 · Cited by 93

Regulation of Intestinal Inflammation by Dietary Fats

Basson, A. R., Chen, C., Sagl, F., Trotter, A., Bederman, I. R., Gomez-Nguyen, A., Sundrud, M. S., Ilić, S., Cominelli, F., & Rodriguez‐Palacios, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604989 · Cited by 87

Is Neurotoxicity of Metallic Nanoparticles the Cascades of Oxidative Stress?

Song, B., Zhang, Y., Liu, J., Feng, X., Zhou, T., & Shao, L. (2016) · Nanoscale Research Letters · doi:10.1186/s11671-016-1508-4 · Cited by 87

Effects of triclocarban on oxidative stress and innate immune response in zebrafish embryos

Wei, J., Zhou, T., Hu, Z., Li, Y., Yuan, H., Zhao, K., Zhang, H., & Liu, C. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.06.163 · Cited by 87

Contribution of oxidative stress to TiO 2 nanoparticle-induced toxicity

Song, B., Zhou, T., Yang, W., Liu, J., & Shao, L. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.10.013 · Cited by 85

Vildagliptin Attenuates Hepatic Ischemia/Reperfusion Injury via the TLR4/NF‐κB Signaling Pathway

Sherif, I. O., & Al‐Shaalan, N. H. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3509091 · Cited by 87

Toll-like Receptor 4 Deficiency Reduces Oxidative Stress and Macrophage Mediated Inflammation in Hypertensive Kidney

Pushpakumar, S. B., Ren, L., Kundu, S., Gamon, A., Tyagi, S. C., & Sen, U. (2017) · Scientific Reports · doi:10.1038/s41598-017-06484-6 · Cited by 85

Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells

Shi, H., Dong, L., Dang, X., Liu, Y., Jiang, J., Wang, Y., Lu, X., & Guo, X. (2013) · Inflammation Research · doi:10.1007/s00011-013-0610-7 · Cited by 86

TIPE2, a Novel Regulator of Immunity, Protects against Experimental Stroke

Zhang, Y., Wei, X., Liu, L., Liu, S., Wang, Z., Zhang, B., Fan, B., Yang, F., Huang, S., Jiang, F., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.348755 · Cited by 85

The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches

Zhu, H.-Y., Hong, F.-F., & Yang, S.-L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094540 · Cited by 84

Toll-Like Receptor Signaling in Burn Wound Healing and Scarring

D’Arpa, P., & Leung, K. P. (2017) · Advances in Wound Care · doi:10.1089/wound.2017.0733 · Cited by 84

Ameliorative effects of L-theanine on dextran sulfate sodium induced colitis in C57BL/6J mice are associated with the inhibition of inflammatory responses and attenuation of intestinal barrier disruption

Wang, D., Cai, M., Wang, T., Liu, T., Huang, J., Wang, Y., & Granato, D. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109409 · Cited by 82

Toll-like Receptor 4 (TLR4) Antagonist Eritoran Tetrasodium Attenuates Liver Ischemia and Reperfusion Injury through Inhibition of High-Mobility Group Box Protein B1 (HMGB1) Signaling

McDonald, K.-A., Huang, H., Tohme, S. T., Loughran, P., Ferrero, K. M., Billiar, T. R., & Tsung, A. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00076 · Cited by 80

The Effect of miR-132, miR-146a, and miR-155 on MRP8/TLR4-Induced Astrocyte-Related Inflammation

Kong, H., Yin, F., He, F., Omran, A., Li, L., Wu, T., Wang, Y., & Peng, J. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0574-x · Cited by 81

Structure, function and disease relevance of Omega-class glutathione transferases

Philip G. Board, & Menon, D. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1691-1 · Cited by 78

Probiotic cheese attenuates exercise-induced immune suppression in Wistar rats

Lollo, P. C. B., da Cruz, A. G., Morato, P. N., Moura, C. S., de Carvalho-Silva, L. B., de Oliveira, C. A. F., Faria, J. A. F., & Amaya‐Farfán, J. (2012) · Journal of Dairy Science · doi:10.3168/jds.2011-5124 · Cited by 78

Use of isotope differential derivatization for simultaneous determination of thiols and oxidized thiols by liquid chromatography tandem mass spectrometry

Huang, Y.-Q., Ruan, G., Liu, J., Gao, Q., & Feng, Y. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.05.020 · Cited by 76

Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll‐like receptor 4

Milanesi, S., Verzola, D., Cappadona, F., Bonino, B., Murugavel, A., Pontremoli, R., Garibotto, G., & Viazzi, F. C. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27929 · Cited by 78

Oxidative Stress: Dual Pathway Induction in Cardiorenal Syndrome Type 1 Pathogenesis

Virzì, G. M., Clementi, A., de Cal, M., Brocca, A., Day, S., Pastori, S., Bolin, C., Vescovo, G., & Ronco, C. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/391790 · Cited by 78

Roles of Toll-Like Receptors in Nitroxidative Stress in Mammals

Li, Y., Deng, S., Lian, Z., & Yu, K. (2019) · Cells · doi:10.3390/cells8060576 · Cited by 78

Glutathione transferase Omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages

Menon, D., Coll, R. C., O'Neill, L. A. J., & Philip G. Board (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.020 · Cited by 77

Propofol: an anesthetic possessing neuroprotective effects.

Fan, W., Zhu, X. M., Wu, L., Wu, Z., Li, D., Huang, F., & He, H. (2015) · PubMed · Cited by 75

TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice

Dasu, M. R., Thangappan, R. K., Bourgette, A., DiPietro, L. A., Isseroff, R., & Jialal, I. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.158 · Cited by 73

Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review

Karanikas, E., Daskalakis, N. P., & Agorastos, A. (2021) · Brain Sciences · doi:10.3390/brainsci11060723 · Cited by 78

A Study on the Pathogenesis of Vascular Cognitive Impairment and Dementia: The Chronic Cerebral Hypoperfusion Hypothesis

Yu, W., Li, Y., Hu, J. P., Wu, J., & Huang, Y. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11164742 · Cited by 75

Genome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue

Devignot, S., Sapet, C., Duong, V., Bergon, A., Rihet, P., Ong, S., Try, P. L., Chroeung, N., Ngeav, S., Tolou, H. J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011671 · Cited by 78

Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review

Rosenblat, J. D., McIntyre, R. S., Alves, G. S., Fountoulakis, K. Ν., & Carvalho, A. F. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150630175044 · Cited by 72

A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury

Thiele, J. R., Zeller, J., Kiefer, J., Braig, D., Kreuzaler, S., Lenz, Y., Potempa, L. A., Grahammer, F., Huber, T. B., Huber-Lang, M. S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00675 · Cited by 71

Regulation of Toll-like Receptor-Mediated Sestrin2 Induction by AP-1, Nrf2, and the Ubiquitin-Proteasome System in Macrophages

Kim, M. G., Yang, J. H., Kim, K. M., Jang, C. H., Jung, J. Y., Cho, I. J., Shin, S. M., & Ki, S. H. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv012 · Cited by 70

Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega‐3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial

Wu, J. H. Y., Marchioli, R., Silletta, M. G., Masson, S., Sellke, F. W., Libby, P., Milne, G. L., Brown, N. J., Lombardi, F., Damiano, R. J., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.001886 · Cited by 71

Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats

Luo, Y., Yang, Y., Liu, J., Li, W.-H., Yang, J., Sui, X. Y., Yuan, X., Nie, Z., Liu, Y., Chen, D., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.008 · Cited by 71

Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats

Tao, X., Sun, X., Xu, L., Yin, L., Han, X., Qi, Y., Xu, Y., Zhao, Y., Wang, C., & Peng, J. (2016) · Nutrients · doi:10.3390/nu8070418 · Cited by 70

Dry Eye Disease: Emerging Approaches to Disease Analysis and Therapy

Heidari, M., Noorizadeh, F., Wu, K. J., Inomata, T., & Mashaghi, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091439 · Cited by 72

Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

Gentile, C., Allegra, M., Angileri, F., Pintaudi, A. M., Livrea, M. A., & Tesoriere, L. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0220-5 · Cited by 69

Comparative study of alleviating effects of GSH, Se and Zn under combined contamination of cadmium and chromium in rice (Oryza sativa)

Cao, F., Wang, N., Zhang, M., Dai, H., Dawood, M., Zhang, G., & Wu, F. (2013) · BioMetals · doi:10.1007/s10534-013-9611-9 · Cited by 69

Curcumin protects against Aflatoxin B1-induced liver injury in broilers via the modulation of long non-coding RNA expression

Li, S., Liu, R., Wei, G., Guo, G., Yu, H., Zhang, Y., Ishfaq, M., Fazilani, S. A., & Zhang, X. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111725 · Cited by 70

GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway

Menon, D., Coll, R. C., O'Neill, L. A. J., & Philip G. Board (2015) · Journal of Cell Science · doi:10.1242/jcs.167858 · Cited by 66

The anti-inflamm-aging and hepatoprotective effects of huperzine A in d-galactose-treated rats

Ruan, Q., Liu, F., Gao, Z., Kong, D., Hu, X., Shi, D., Bao, Z., & Yu, Z. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.12.005 · Cited by 65

Ameliorative effect of supercritical fluid extract of Chrysanthemum indicum Linnén against D-galactose induced brain and liver injury in senescent mice via suppression of oxidative stress, inflammation and apoptosis

Zhang, X., Wu, J., Lin, Z., Yuan, Q., Li, Y., Liang, J.-L., Zhan, J. Y.-X., Xie, Y., Su, Z., & Liu, Y. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.12.050 · Cited by 65

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity

Menon, D., Innes, A., Oakley, A. J., Dahlstrom, J. E., Jensen, L. M., Brüstle, A., Tummala, P., Rooke, M., Casarotto, M. G., Baell, J. B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17861-6 · Cited by 64

Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways

Ismail, R., Habib, H. A., Anter, A. F., Amin, A., & Heeba, G. H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1528978 · Cited by 63

Sitagliptin attenuated brain damage and cognitive impairment in mice with chronic cerebral hypo-perfusion through suppressing oxidative stress and inflammatory reaction

Tsai, T., Sun, C., Su, C.-H., Sung, P., Chua, S. O., Zhen, Y., Leu, S., Chang, H., Yang, J., & Yip, H. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000529 · Cited by 66

MicroRNAs and the metabolic hallmarks of aging

Victoria, B., López, Y. O. N., & Masternak, M. M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.021 · Cited by 64

The Mechanism of Contrast-Induced Acute Kidney Injury and Its Association with Diabetes Mellitus

Li, Y., & Ren, K. (2020) · Contrast Media & Molecular Imaging · doi:10.1155/2020/3295176 · Cited by 65

Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota

Peng, X., Hao, M., Zhao, Y., Cai, Y., Chen, X., Chen, H., Zhang, Y., Dong, L., Liu, X., Ding, C., et al. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153772 · Cited by 62

IFPA Award in Placentology Lecture: Preeclampsia, the decidual battleground and future maternal cardiovascular disease

Staff, A. C., & Redman, C. W. G. (2013) · Placenta · doi:10.1016/j.placenta.2013.12.003 · Cited by 61

Oxidative Stress Mechanisms in the Pathogenesis of Environmental Lung Diseases

Thimmulappa, R. K., Chattopadhyay, I., & Rajasekaran, S. (2019) · Springer eBooks · doi:10.1007/978-981-32-9366-3_5 · Cited by 63

Hemorrhagic Shock and the Microvasculature

Filho, I. P. T. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170006 · Cited by 63

Polysaccharides from Dendrobium officinale ameliorate colitis-induced lung injury via inhibiting inflammation and oxidative stress

Wen, Y., Xiao, H., Liu, Y., Yang, Y., Wang, Y., Xu, S., Huang, S. M., Hou, S., & Liang, J. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109615 · Cited by 58

Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults

Agrawal, S., & Schneider, J. A. (2022) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2022.100148 · Cited by 61

Immune response associated with ischemia and reperfusion injury during organ transplantation

Tang, Q., Dong, C., & Sun, Q. (2022) · Inflammation Research · doi:10.1007/s00011-022-01651-6 · Cited by 59

In vivo effect of bone marrow-derived mesenchymal stem cells in a rat kidney transplantation model with prolonged cold ischemia

Hara, Y., Stolk, M., Ringe, J., Dehne, T., Ladhoff, J., Kotsch, K., Reutzel‐Selke, A., Reinke, P., Volk, H., & Seifert, M. (2011) · Transplant International · doi:10.1111/j.1432-2277.2011.01328.x · Cited by 58

Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling?

Moretti, R., & Caruso, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031095 · Cited by 62

Effects of feed fat level on growth performance, body composition and serum biochemical indices of hybrid grouper (Epinephelus fuscoguttatus × Epinephelus polyphekadion)

Xie, R., Amenyogbe, E., Chen, G., & Huang, J. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735813 · Cited by 58

The Heart-Brain Connection: A Multidisciplinary Approach Targeting a Missing Link in the Pathophysiology of Vascular Cognitive Impairment

van Buchem, M. A., Biessels, G. J., Rocca, H. B., de Craen, A. J. M., van der Flier, W. M., Ikram, M. A., Kappelle, L. J., Koudstaal, P. J., Mooijaart, S. P., Niessen, W. J., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141542 · Cited by 57

ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes

Wang, G., Wang, H., Singh, S., Zhou, P., Yang, S., Wang, Y., Zhu, Z., Zhang, J., Chen, A., Billiar, T. R., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.08.002 · Cited by 55

Monoammonium glycyrrhizinate inhibited the inflammation of LPS-induced acute lung injury in mice

Shi, J., Mao, L., Jiang, R., Qian, Y., Tang, H., & Chen, J. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.07.004 · Cited by 55

Impacts of replacement of dietary fish oil by vegetable oils on growth performance, anti-oxidative capacity, and inflammatory response in large yellow croaker Larimichthys crocea

Mu, H., Wei, C., Zhang, Y., Zhou, H., Pan, Y. J., Chen, J., Zhang, W., & Mai, K. (2019) · Fish Physiology and Biochemistry · doi:10.1007/s10695-019-00712-8 · Cited by 55

Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

Labarrere, C. A., & Kassab, G. S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.979719 · Cited by 56

Vascular cognitive impairment: pathophysiological mechanisms, insights into structural basis, and perspectives in specific treatments

Parfenov, V. A., Ostroumova, O. D., Оstroumova, Т. М., Кочетков, А. И., Fateeva, V. V., Khacheva, K. K., Khakimova, G. R., & Epstein, O. I. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s197032 · Cited by 56

Pathological changes in neurovascular units: Lessons from cases of vascular dementia

Li, C., Wang, Y., Yan, X., Guo, Z., & Yang, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13572 · Cited by 51

A Perspective on the Role of Extracellular Hemoglobin on the Innate Immune System

Lee, S. K., & Ding, J. L. (2013) · DNA and Cell Biology · doi:10.1089/dna.2012.1897 · Cited by 52

The inflammatory footprints of alcohol-induced oxidative damage in neurovascular components

Alikunju, S., Muneer, P. M. A., Zhang, Y., Szlachetka, A. M., & Haorah, J. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.007 · Cited by 53

The TRIPS (Toll-like receptors in immuno-inflammatory pathogenesis) Hypothesis: a novel postulate to understand schizophrenia

Venkatasubramanian, G., & Debnath, M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.001 · Cited by 56

Tetrastigma hemsleyanum tubers polysaccharide ameliorates LPS-induced inflammation in macrophages and Caenorhabditis elegans

Chu, Q., Jia, R., Chen, M., Li, Y., Yu, X., Wang, Y., Chen, W., Ye, X., Liu, Y., Jiang, Y., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.09.039 · Cited by 53

The Neurovascular Protective Effects of Huperzine A on D-Galactose-Induced Inflammatory Damage in the Rat Hippocampus

Ruan, Q., Hu, X., Ao, H., Ma, H., Gao, Z., Liu, F., Kong, D., Bao, Z., & Yu, Z. (2014) · Gerontology · doi:10.1159/000358235 · Cited by 52

Abasic sites preferentially form at regions undergoing DNA replication

Chastain, P. D., Nakamura, J., Rao, S., Chu, H., Ibrahim, J. G., Swenberg, J. A., & Kaufman, D. G. (2010) · The FASEB Journal · doi:10.1096/fj.09-145276 · Cited by 52

Identification of the HSPB4/TLR2/NF‐κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea

Oh, J. Y., Choi, H., Lee, R. H., Roddy, G. W., Ylöstalo, J., Wawrousek, E. F., & Prockop, D. J. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200221 · Cited by 51

Involvement of the TLR4 (Toll-like receptor4) signaling pathway in palmitate-induced INS-1 beta cell death

Lee, S.-M., Choi, S., Lee, J., Lee, J., Jung, I., Lee, S., Lee, K. W., & KANG, Y. Y. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0820-7 · Cited by 51

Maternal exposure to silver nanoparticles are associated with behavioral abnormalities in adulthood: Role of mitochondria and innate immunity in developmental toxicity

Amiri, S., Yousefi‐Ahmadipour, A., Hosseini, M., Haj‐Mirzaian, A., Momeny, M., Hosseini-Chegeni, H., Mokhtari, T., Kharrazi, S., Hassanzadeh, G., Amini, S. M., et al. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.03.006 · Cited by 50

Rebamipide potentially mitigates methotrexate‐induced nephrotoxicity via inhibition of oxidative stress and inflammation: A molecular and histochemical study

Elmansy, R. A., Seleem, H. S., Mahmoud, A. R., Hassanein, E. H. M., & Ali, F. E. M. (2020) · The Anatomical Record · doi:10.1002/ar.24482 · Cited by 54

Cognitive Dysfunction after Heart Disease: A Manifestation of the Heart‐Brain Axis

Xu, C., Tao, X., Ma, X., Zhao, R., & Cao, Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4899688 · Cited by 53

Quercetin inhibits NF-kB and JAK/STAT signaling via modulating TLR in thymocytes and splenocytes during MSG-induced immunotoxicity: an in vitro approach

Das, D., Banerjee, A., Mukherjee, S., & Maji, B. K. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09245-7 · Cited by 51

The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue

Lucas, K., Morris, G., Anderson, G., & Maes, M. H. J. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150317224645 · Cited by 50

Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models

Chung, T. D., Linville, R. M., Guo, Z., Ye, R., Jha, R., Grifno, G. N., & Searson, P. C. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00327-x · Cited by 51

Apios americana Medikus tuber polysaccharide exerts anti-inflammatory effects by activating autophagy

Chu, Q., Zhang, S., Yu, L., Li, Y., Liu, Y., Ye, X., & Zheng, X. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.012 · Cited by 48

Early Detection Is the Best Prevention—Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System

Rajlic, S., Treede, H., Münzel, T. F., Daiber, A., & Duerr, G. D. (2023) · Cells · doi:10.3390/cells12040583 · Cited by 51

The Hemodynamic and Nonhemodynamic Crosstalk in Cardiorenal Syndrome Type 1

Virzì, G. M., Clementi, A., Brocca, A., de Cal, M., Vescovo, G., Granata, A. R. M., & Ronco, C. (2014) · Cardiorenal Medicine · doi:10.1159/000362650 · Cited by 47

ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells

Hojo, T., Maishi, N., Towfik, A. M., Akiyama, K., Ohga, N., Shindoh, M., Hida, Y., Minowa, K., Fujisawa, T., & Hida, K. (2017) · Oncotarget · doi:10.18632/oncotarget.17567 · Cited by 47

Immunopathology of Recurrent Vulvovaginal Infections: New Aspects and Research Directions

Kalia, N., Singh, J., & Kaur, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02034 · Cited by 51

Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus

Lindsay, C. B., Zolezzi, J. M., Rivera, D. S., Cisternas, P., Bozinovic, F., & Inestrosa, N. C. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01784-6 · Cited by 48

Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays

Roth, A. D., & Lee, M. (2017) · BioMed Research International · doi:10.1155/2017/9176937 · Cited by 49

The Heart Is at Risk: Understanding Stroke-Heart-Brain Interactions with Focus on Neurogenic Stress Cardiomyopathy—A Review

Ziaka, M., & Exadaktylos, A. K. (2023) · Journal of Stroke · doi:10.5853/jos.2022.02173 · Cited by 47

Novel Therapeutic Approaches to Liver Fibrosis Based on Targeting Oxidative Stress

Blas‐García, A., & Apostolova, N. (2023) · Antioxidants · doi:10.3390/antiox12081567 · Cited by 51

Toll-Like Receptor 4–Mediated Nuclear Factor Kappa B Activation Is Essential for Sensing Exogenous Oxidants to Propagate and Maintain Oxidative/Nitrosative Cellular Stress

Karki, R., & Igwe, O. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073840 · Cited by 47

The heart-brain connection: mechanistic insights and models

Ritz, K., van Buchem, M. A., & Daemen, M. J. A. P. (2012) · Netherlands Heart Journal · doi:10.1007/s12471-012-0348-9 · Cited by 46

Extra domain A-positive fibronectin-positive feedback loops and their association with cutaneous inflammatory disease

McFadden, J. P., Basketter, D. A., Dearman, R. J., & Kimber, I. (2011) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2010.11.003 · Cited by 44

CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms

Subramanian, K., Du, R., Tan, N. S., Ho, B., & Ding, J. L. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202648 · Cited by 44

Pharmahuasca and DMT rescue ROS production and differentially expressed genes observed after predator and psychosocial stress: Relevance to human PTSD

Kelley, D. P., Venable, K., Destouni, A., Billac, G., Ebenezer, P., Stadler, K., Nichols, C., Barker, S., & Francis, J. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00660 · Cited by 42

Coriander‐Derived Exosome‐Like Nanovesicles Laden Hydrogel with Antioxidant Property Accelerates Wound Healing

Wang, T., Li, Y., Hao, L., Liu, Y., Liu, D., Zhang, C., Yi, H., & Zhang, J. (2025) · Macromolecular Bioscience · doi:10.1002/mabi.202400640 · Cited by 43

Immunomodulatory effects of 4-hydroxynonenal

Ioannidis, M., Tjepkema, J., Uitbeijerse, M. R. P., & van den Bogaart, G. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103719 · Cited by 46

TLR2, TLR3, and TLR4 activation specifically alters the oxidative status of intestinal epithelial cells

Latorre, E., Mendoza, C., Layunta, E., Alcalde, A. I., & Mesonero, J. E. (2013) · Cell Stress and Chaperones · doi:10.1007/s12192-013-0461-8 · Cited by 43

Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts

Kim, K., Jung, N., Lee, K., Choi, J.-W., Kim, S., Jun, J. H., Kim, E., & Kim, D. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2012.11.026 · Cited by 43

Reduced Formation of Oxidative Stress Biomarkers and Migration of Mononuclear Phagocytes in the Cochleae of Chinchilla after Antioxidant Treatment in Acute Acoustic Trauma

Du, X., Choi, C.-H., Chen, K., Cheng, W., Floyd, R. A., & Kopke, R. D. (2011) · International Journal of Otolaryngology · doi:10.1155/2011/612690 · Cited by 43

Depressive disorders: Processes leading to neurogeneration and potential novel treatments

Brown, G. M., McIntyre, R. S., Rosenblat, J. D., & Hardeland, R. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.023 · Cited by 44

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease

Sfyri, P., & Matsakas, A. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0346-8 · Cited by 44

Effects of dietary baicalin supplementation on growth performance, antioxidative status and protection against oxidative stress-induced liver injury in GIFT tilapia (Oreochromis niloticus)

Jia, R., Du, J., Cao, L., Feng, W., Xu, P., & Yin, G. (2020) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2020.108914 · Cited by 43

Protective Mechanism of Anethole on Hepatic Ischemia/Reperfusion Injury in Mice

Cho, H., Kim, K., Kwak, J. H., Lee, S. K., & Lee, S. (2013) · Journal of Natural Products · doi:10.1021/np4004323 · Cited by 42

Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells

Paimela, T., Hyttinen, J. M. T., Viiri, J., Ryhänen, T., Karjalainen, R., Salminen, A., & Kaarniranta, K. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.05.027 · Cited by 42

Toll-like receptor 4 signaling: A common pathway for interactions between prooxidants and extracellular disulfide high mobility group box 1 (HMGB1) protein-coupled activation

Zhang, Y., Karki, R., & Igwe, O. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.08.109 · Cited by 42

Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation

Evankovich, J. W., Billiar, T. R., & Tsung, A. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/537263 · Cited by 37

doi:10.1155/2010/537263 Review Article

Receptors, T.-L., Evankovich, J., Billiar, T., & Tsung, A. (2010)

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

Li, P., & Chang, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147688 · Cited by 143

The role of oxidative stress during inflammatory processes

Lugrin, J., Rosenblatt‐Velin, N., Parapanov, R., & Liaudet, L. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0241 · Cited by 766

Toll-like receptor 4 mediated injury after hepatic ischemia-reperfusion involves reactive oxygen species

Tsung, A., Klune, J. R., Nakao, A., Critchlow, N. D., Chan, M., Billiar, T. R., & Geller, D. A. (2006) · Journal of Surgical Research · doi:10.1016/j.jss.2005.11.036