Cited by 286Heavy Metal Exposure and ToxicityCancer and biochemical researchToxic Organic Pollutants Impact

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Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

Matés, José M., Segura, Juan A., Alonso, Francisco J., Márquez, Javier·2010·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2010.07.028

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Abstract

Oxidants have critical functions inside healthy and unhealthy cells. Deregulated cell cycle and apoptosis, both regulated by oxidative stress, have been described as hallmarks of mitotic (cancer) and postmitotic (neuronal) cells. This review provides an updated revision of the oxidant effects of some environmental contaminants such as dioxins and the heavy metals cadmium, cobalt, and copper. Dioxins exert their toxic actions by acting on phase I and phase II enzymes, such as cytochromes P450, superoxide dismutase, and glutathione peroxidase, promoting cell proliferation, growth arrest, and apoptosis, affecting cancer homeostasis and neuronal function. Heavy metals manifest cytotoxic effects in various cells and tissues, and tight regulation of metals is essential to the health of organisms. Cadmium modulates gene expression and signal transduction and reduces activities of proteins involved in antioxidant defense, interfering with DNA repair and modifying cancer development and brain function. Cobalt provokes generation of reactive oxygen species and DNA damage in cancer cells and brain tissues, altering proliferation and differentiation and causing apoptosis. Copper is a key metal in cell division processes in both normal and tumor cells. Copper also has been shown to have an important role in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis.

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Authors: Matés, J. M., Segura, J. A., Alonso, F. J., & Márquez, J.
Affiliations: Universidad de Málaga (ES)
Corresponding author: Matés, José M.
ORCID: Matés, José M.
Alonso, Francisco J.
Márquez, Javier
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2010-11
Volume: 49
Issue: 9
Pages: 1328-1341
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2010.07.028
OpenAlex: W2059124139
Cited by: 286
References: 174
Citations by year: 2026: 7 · 2025: 16 · 2024: 14 · 2023: 23 · 2022: 13 · 2021: 18 · 2020: 20 · 2019: 20 · 2018: 11 · 2017: 12 · 2016: 19 · 2015: 21 · 2014: 23 · 2013: 25 · 2012: 25
FWCI: 2.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: dioxins, heavy metals, cadmium, cobalt, copper, reactive oxygen species, oxidative stress, cancer, neurodegenerative diseases, apoptosis, cell cycle, cytochrome P450, superoxide dismutase, glutathione peroxidase, DNA damage, DNA repair, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, environmental pollutants
MeSH terms: Animals, Cell Differentiation, Cell Transformation, Neoplastic, Dioxins, Environmental Pollutants, Humans, Neoplasms, Nervous System Diseases, Reactive Oxygen Species, Oxidative Stress, Metals, Heavy, Cell Proliferation

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Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

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