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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

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Oxidative mechanisms in the toxicity of metal ions

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Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

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Cadmium, Environmental Exposure, and Health Outcomes

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Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein

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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

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Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review)

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Role of oxidative stress in cadmium toxicity and carcinogenesis

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Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease

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Contamination and Health Impact of Heavy Metals

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Ischemic optic neuropathy as a model of neurodegenerative disorder: A review of pathogenic mechanism of axonal degeneration and the role of neuroprotection

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Cobalt-Induced Ototoxicity in Rat Postnatal Cochlear Organotypic Cultures

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DJ-1/park7 protects against neointimal formation via the inhibition of vascular smooth muscle cell growth

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Elevated Adult Neurogenesis in Brain Subventricular Zone Following In vivo Manganese Exposure: Roles of Copper and DMT1

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Transcriptional and translational regulation of COX-2 expression by cadmium in C6 glioma cells

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Autophagy potentially protects against 2,3,7,8-tetrachlorodibenzo-p-Dioxin induced apoptosis in SH-SY5Y cells

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Impact of oral cadmium intoxication on levels of different essential trace elements and oxidative stress measures in mice: a response to dose

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Cyanine and Squaric Acid Metal Sensors

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Current understandings and perspectives of petroleum hydrocarbons in Alzheimer’s disease and Parkinson’s disease: a global concern

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Mechanisms of Hepatocyte Detoxification

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Removal of cadmium and zinc ions from industrial wastewater using nanocomposites of PANI/ZnO and PANI/CoHCF: a comparative study

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Melatonin prevents hypochlorous acid‐mediated cyanocobalamin destruction and cyanogen chloride generation

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Hydrogen-Rich Water Alleviates the Nickel-Induced Toxic Responses (Inflammatory Responses, Oxidative Stress, DNA Damage) and Ameliorates Cocoon Production in Earthworm

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Cigarette smoke extract induces EGFR-TKI resistance via promoting EGFR signaling pathway and ROS generation in NSCLC cell lines

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Probing the bioinorganic chemistry of toxic metals in the mammalian bloodstream to advance human health

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Maternal cadmium exposure and neurobehavior in children: The HOME study

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Arsenic and lead in the indoor residential settings of different socio-economic status; assessment of human health risk via dust exposure

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Ruta graveolens and its active constituent rutin protect against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress

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Aberrant Adult Neurogenesis in the Subventricular Zone-Rostral Migratory Stream-Olfactory Bulb System Following Subchronic Manganese Exposure

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High sensitive mesoporous TiO2-coated love wave device for heavy metal detection

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Nitrogen Regulates the Grain Yield, Antioxidant Attributes, and Nitrogen Metabolism in Fragrant Rice Grown Under Lead-Contaminated Soil

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Mercury specifically induces LINE-1 activity in a human neuroblastoma cell line

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Outpatient toxicology clinic experience of patients with hip implants*

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Sensitivity of neural stem cell survival, differentiation and neurite outgrowth within 3D hydrogels to environmental heavy metals

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Human Health Risk Assessment and Safety Threshold of Harmful Trace Elements in the Soil Environment of the Wulantuga Open-Cast Coal Mine

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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

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Spectroscopic Determination of Metals in Palm Oils from Different Stages of the Technological Process

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Association between heavy metal exposure and poor working memory and possible mediation effect of antioxidant defenses during aging

Souza‐Talarico, J. N., Marcourakis, T., Barbosa, F., Barros, S. B. D. M., Rivelli, D. P., Pompéia, S., Caramelli, P., Plusquellec, P., LUPIEN, S. J., Catucci, R. F., et al. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.09.121 · Cited by 24

Mechanisms of Hepatocyte Detoxification

Messner, D. J., Murray, K. F., & Kowdley, K. V. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00055-5 · Cited by 24

In vitro toxicity evaluation of low doses of pesticides in individual and mixed condition on human keratinocyte cell line

Abhishek, A., Ansari, N. G., Shankhwar, S. N., Jain, A., & Singh, V. (2014) · Bioinformation · doi:10.6026/97320630010716 · Cited by 22

Physiochemical basis of human degenerative disease

Zeliger, H. I., & Lipiński, B. (2015) · Interdisciplinary Toxicology · doi:10.1515/intox-2015-0003 · Cited by 22

The iron component of particulate matter is antiapoptotic: A clue to the development of lung cancer after exposure to atmospheric pollutants?

Leroux, M., Crobeddu, B., Kassis, N., PETIT, P. X., Janel, N., Baeza‐Squiban, A., & Andréau, K. (2015) · Biochimie · doi:10.1016/j.biochi.2015.09.030 · Cited by 20

New insights into the effects of the herbicide imazethapyr on Cu(II) ecotoxicity to the aquatic unicellular alga Scenedesmus obliquus

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Cadmium induces alterations in the human spinal cord morphogenesis

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Esculetin modulates cytotoxicity induced by oxidants in NB4 human leukemia cells

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Adverse effects of low occupational cadmium exposure on renal and oxidative stress biomarkers in solderers

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The contents of essential and toxic metals in coffee beans and soil in Dale Woreda, Sidama Regional State, Southern Ethiopia

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The mechanism of antioxidant activity of IRFI005 as a synthetic hydrophilic analogue of vitamin E

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Copper accumulation in the brain causes the elevation of oxidative stress and less anxious behavior in Ts1Cje mice, a model of Down syndrome

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The morphotropic phase boundary based BCST ferroelectric system for water remediation through Bi-catalytic activity

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Styrofoam modified paper as a low-cost platform for qualitative and semi-quantitative determination of Ni 2+ ions in wastewater

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Cellular Redox, Epigenetics and Diseases

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Associations between PFAS concentrations and the oxidative status in a free-living songbird (Parus major) near a fluorochemical facility

Buytaert, J. A. N., Eens, M., AbdElgawad, H., Bervoets, L., Beemster, G. T. S., & Groffen, T. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122304 · Cited by 15

Comparative Cytotoxicity Study of PM2.5 and TSP Collected from Urban Areas

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Phytotoxic effects of ımidacloprid and its nano-form on the cucumber plants under greenhouse condition and their toxicity on HepG2 cell line

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Mortality analysis on wastewater exposure in Shijiazhuang, Hebei, China, from 2007 to 2011

Massaquoi, L. D., Li, M., Wang, J., Ma, J., Yuan, M., & Liu, D. (2014) · International Journal of Environmental Health Research · doi:10.1080/09603123.2014.915022 · Cited by 14

General Template for the FMEA Applications in Primary Food Processing

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Role of liver fatty acid binding protein in hepatocellular injury: Effect of CrPic treatment

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Toxic Metal -Mediated Neurodegradation: A Focus on Glutathione and GST Gene Variants.

Gasmi, A., Noor, S., Piscopo, S., & Menzel, A. (2022) · PubMed · doi:10.22092/ari.2021.356279.1816 · Cited by 15

Catalpol protects against 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐induced cytotoxicity in osteoblastic MC3T3‐E1 cells

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Analysis of chromosome damage by sister chromatid exchange (SCE) and redox homeostasis characterization on sheep flocks from Sardinian pasturelands

Genualdo, V., Perucatti, A., Pauciullo, A., Iannuzzi, A., Incarnato, D., Spagnuolo, M. S., Solinas, N., Bullitta, S., & Iannuzzi, L. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.05.021 · Cited by 12

Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens

Deferme, L., Wolters, J. E. J., Claessen, S. M. H., Briedé, J. J., & Kleinjans, J. C. S. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00222 · Cited by 12

Capillary and Electrodynamic Forces-Driven Separation Detection of Metal Ions Using a Disposable Microfluidic Sensor with a Composite Electrode

Hossain, M. M., Karim, M. M., Seo, K., Park, D., & Shim, Y. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03518 · Cited by 11

Insufficient evidence to link human exposure to heavy metals with biomarkers of glioma

Xie, M., Huang, G., Lin, Z., Sun, X.-F., Wu, C.-C., Liu, Y., Liu, L., & Zeng, E. Y. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.130779 · Cited by 11

Accumulation of metals in cancerous and healthy tissues of patients with lung cancer in Southern Poland

Binkowski, Ł. J., Rogoziński, P., Roychoudhury, S., Bruliński, K., Kucharzewski, M., Łaciak, T., Massányi, P., & Stawarz, R. (2014) · Journal of Environmental Science and Health Part A · doi:10.1080/10934529.2015.964597 · Cited by 11

Changes of three organic acids in the process of Cd and Pb phytoextraction by Helianthus annuus L.

Niu, Z., Li, X., Sun, L., & Sun, T. (2012) · Plant Soil and Environment · doi:10.17221/230/2012-pse · Cited by 11

Characterization of a Decapentapletic Gene (AccDpp) from Apis cerana cerana and Its Possible Involvement in Development and Response to Oxidative Stress

Li, G., Zhao, H., Wang, H., Guo, X., Guo, X., Sun, Q., & Xu, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149117 · Cited by 11

Co-morditities of environmental diseases: A common cause

Zeliger, H. I. (2014) · Interdisciplinary Toxicology · doi:10.2478/intox-2014-0016 · Cited by 12

Protective effects of ginger (Zingiber officinale Roscoe) against cadmium chloride-induced oxidative stress in the blood of rats

Attia, A., Ibrahim, F. A., El-Latif, N. A. A., Aziz, S. W., & Sherif, A. A. M. (2014) · Journal of Medicinal Plants Research · doi:10.5897/jmpr2014.5531 · Cited by 11

Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations

Mafe, A. N., & Büsselberg, D. (2025) · Journal of Xenobiotics · doi:10.3390/jox16010002 · Cited by 11

Magnetic Polymer Nanocomposites for Removal of Dyes and Metals From Wastewater

Harun‐Ur‐Rashid, M., Imran, A. B., & Susan, M. A. B. H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95486-0.00008-9 · Cited by 10

Dietary interventions in mitigating the impact of environmental pollutants on Alzheimer’s disease – A review

Khandayataray, P., & Murthy, M. K. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.020 · Cited by 11

Natural Compound 2-Chloro-1,3-dimethoxy-5-methylbenzene, Isolated from Hericium Erinaceus, Inhibits Fungal Growth by Disrupting Membranes and Triggering Apoptosis

Zhang, Q., Zhang, M., Wang, Y., Tingting, Z., Roujuan, W., Shuhong, W., Du, Y., Ruirui, Y., Peng, Y., Yifan, S., et al. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01417 · Cited by 10

The effect of substituents on the response of 3,4-dihydro-3-(2-oxo-2-phenylethylidene)-quinoxalin-2(1H)-one derivatives toward binding of Cu2+

Korin, E., Cohen, B., Bai, Y., Zeng, C., & Becker, J. Y. (2012) · Tetrahedron · doi:10.1016/j.tet.2012.06.071 · Cited by 9

To study the relationship between cadmium, zinc and mtDNA copy number in North Indian patients suffering from prostate cancer: A case control study

Abhishek, A., Singh, V., Sinha, R. J., Ansari, N. G., Siddiqe, M. K. J., Verma, M., & Kumar, M. (2016) · African Journal of Urology · doi:10.1016/j.afju.2016.05.011 · Cited by 10

Aspects of Cadmium Neurotoxicity

Carageorgiou, H., & Katramadou, M. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9663-3_33 · Cited by 10

Combined incubation of Cadmium, docosahexaenoic and eicosapentaenoic acid results in increased uptake of cadmium and elevated docosapentaenoic acid content in Hepatocytes in vitro

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Assessing the Association Between Lead Pollution and Risk of Alzheimer’s Disease by Integrating Multigenomics

Li, C., Zhang, Y., Liang, J., Wu, C., & Zou, X. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.880105 · Cited by 9

Protective role of seleno-amino acid against IBD via ferroptosis inhibition in enteral nutrition therapy

Huangfu, S., Zheng, J., He, J., Liao, J., Jiang, H., Zhou, H., & Pan, J. (2024) · iScience · doi:10.1016/j.isci.2024.110494 · Cited by 9

Air Pollution and Its Effects in the Respiratory System

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Impact of Heavy Metals on Glioma Tumorigenesis

Caruso, G., Nanni, A., Curcio, A., Lombardi, G., Somma, T., Minutoli, L., & Caffo, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015432 · Cited by 9

Esculetin Neutralises Cytotoxicity oft-BHP but Not of H2O2on Human Leukaemia NB4 Cells

Rubio, V., Garcia-Perez, A. I., Tejedor, M. C., Herráez, Á., & Diez, J. C. (2017) · BioMed Research International · doi:10.1155/2017/9491045 · Cited by 9

Microdroplet anodic stripping voltammetry at the in situ preparing antimony‐modified rotating disk electrode for determination of Cd(II) and Pb(II)

Huo, R., Liu, L., Chanthasa, C., Okazaki, T., Sazawa, K., Sugawara, K., & Kuramitz, H. (2023) · Electroanalysis · doi:10.1002/elan.202200528 · Cited by 9

Metal Species in Biology: Bottom-Up and Top-Down LC Approaches in Applied Toxicological Research

Gailer, J. (2013) · ISRN Chromatography · doi:10.1155/2013/801840 · Cited by 9

Do metals that translocate to the brain exacerbate traumatic brain injury?

Kalinich, J. F., & Kasper, C. E. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.02.011 · Cited by 9

Hip implants and systemic cobalt toxicity: a comprehensive review with case studies

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Heavy metal detection by nanotechnology-based sensors

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Guardians under Siege: Exploring Pollution’s Effects on Human Immunity

Drago, G., Aloi, N., Ruggieri, S., Longo, A., Contrino, M. L., Contarino, F. M., Cibella, F., Colombo, P., & Longo, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147788 · Cited by 10

Volatile Organic Compounds (VOCs) in Neurodegenerative Diseases (NDDs): Diagnostic Potential and Analytical Approaches

Palmisani, J., Aresta, A. M., Vergaro, V., Mancini, G., Mazzola, M. C., Nisi, M., Pastore, L., Pizzillo, V., Vietro, N. D., Boncristiani, C., et al. (2025) · Molecules · doi:10.3390/molecules30194028 · Cited by 8

Assessment of quality and safety of meats from various animal species in the Shuchinsk-Burabay resort zone, Kazakhstan

Maikanov, B. S., ISMAGULOVA, G. T., Auteleyeva, L., Kemeshov, Z., & Zhanabayeva, D. K. (2021) · Veterinary World · doi:10.14202/vetworld.2021.1615-1621 · Cited by 8

Risk of neurodegeneration among residents of electronic waste recycling areas

Zhu, X., Li, Z., Guo, C., Wang, Z., Wang, Z., Li, X., Qian, Y., & Wei, Y. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.113132 · Cited by 8

Titanium alloys with varying surface micro-area potential differences have antibacterial abilities and a favorable cellular response

Wang, C., Hou, Y., Fu, S., Zhang, E., Zhang, Z., & Bai, B. (2023) · Clinical Oral Investigations · doi:10.1007/s00784-023-05115-x · Cited by 9

Analysis of plasma indices of redox homeostasis in dairy cows reared in polluted areas of Piedmont (northern Italy)

Spagnuolo, M. S., Cigliano, L., Nebbia, C., Rossetti, C., Grazioli, G., & Iannuzzi, L. (2012) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2012.06.100 · Cited by 8

Copper Ion Detection Using Green Precursor-Derived Carbon Dots in Aqueous Media

Chen, C.-S., Lin, M. F., & Wan, C. (2026) · Chemosensors · doi:10.3390/chemosensors14010021 · Cited by 7

The Developmental and Physiological Interactions between Free Radicals and Antioxidant Defense System: Effect of Environmental Pollutants

Ahmed, R. G., Incerpi, S., Ahmed, F., & Gaber, A. (2013) · Journals & Books Hosting (International Knowledge Sharing Platform) · Cited by 7

Using Latent Class Modeling to Jointly Characterize Economic Stress and Multipollutant Exposure

Larsen, A., Kolpacoff, V., McCormack, K., Seewaldt, V. L., & Hyslop, T. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-1365 · Cited by 8

Efectos sobre la salud del agua contaminada por metales pesados

Aguilar, P. O., & Olmos-Palma, D. A. (2022) · Herreriana · doi:10.29057/h.v4i1.8630 · Cited by 7

Biochemical hazards associated with unsafe disposal of electrical and electronic items

Korla, K., & Mitra, C. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817030-4.00001-2 · Cited by 7

Inhibition Properties of Arylsulfatase and β‑Glucuronidase by Hydrogen Peroxide, Hypochlorite, and Peracetic Acid

Zhong, S., Zhang, J., Liu, Z., Dang, Z., & Liu, Y. (2021) · ACS Omega · doi:10.1021/acsomega.0c06060 · Cited by 7

The effect of bicarbonate on menadione-induced redox cycling and cytotoxicity: potential involvement of the carbonate radical

Aljuhani, N., Michail, K., Karapetyan, Z., & Siraki, A. G. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0254 · Cited by 7

Combined Effects of Metals, PCBs, Dioxins, and Furans on Cardiovascular Dysfunction

Akinyemi, B., & Obeng-Gyasi, E. (2025) · Journal of Xenobiotics · doi:10.3390/jox15030094 · Cited by 6

A near-infrared fluorescent probe for detecting Cu 2+ and its versatile applications

Li, P., Yang, J., & Yan, L. (2025) · Analytical Methods · doi:10.1039/d5ay00580a · Cited by 6

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5

Du, T., Caragounis, A., Parker, S. J., Meyerowitz, J., Fontaine, S. L., Kanninen, K. M., Perreau, V. M., Crouch, P. J., & White, A. R. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.006 · Cited by 7

The protective role of Diosmin, Hesperidine combination against heavy metals toxicity in Wistar albino rats: Biochemical, Immunohistochemical and Molecular Studies

Sarhan, H., Saleh, A., Hammam, O. A., Atta, A. H., & El-Nahrery, E. M. A. (2021) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2021.83002.4078 · Cited by 6

Review of Antioxidant-rich Natural Dietary Products as Protective and Therapeutic Factors against Cadmium Toxicity in Living Organisms

Quddus, A., Yimer, N., Basit, M., Khan, S., & Amir, M. (2021) · Pertanika journal of tropical agricultural science · doi:10.47836/pjtas.44.1.05 · Cited by 6

Development of an Electrochemical Bioassay Based on the Alkaline Phosphatase Activity of to Assess the Toxicity of Heavy Metals

Jiang, H., Islam, M. S., Sazawa, K., Hata, N., Taguchi, S., Nakamura, S., Sugawara, K., & Kuramitz, H. (2016) · International Journal of Electrochemical Science · doi:10.20964/2016.06.65 · Cited by 6

Xanthohumol ameliorates 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin–induced cellular toxicity in cultured MC3T3‐E1 osteoblastic cells

Suh, K. S., Choi, E. M., Kim, H., Park, S. Y., Chin, S. O., Rhee, S. Y., Pak, Y. K., Choe, W., Ha, J., & Chon, S. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3613 · Cited by 6

Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: a review.

Buzard, G. S., & Kasprzak, K. S. (2000) · PubMed · Cited by 87

Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage

Nuran Ercal, B. S. P., Hande Gurer-Orhan, B. S. P., & Nukhet Aykin-Burns, B. S. P. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394831 · Cited by 1,944

Metallotoxicant-driven cellular dysregulation: Redox pathways in stress signalling and death program execution

Das, S., Alavala, S., Santaki, S., Yadav, P., Jamalpur, R. P., & Challa, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44299-5.00016-x

Heavy metals and free radical-induced cell death mechanisms

Madkour, L. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-822481-6.00006-2 · Cited by 8

Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

Paithankar, J. G., Saini, S., Dwivedi, S., Sharma, A., & Chowdhuri, D. K. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128350 · Cited by 611