The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Dietary flavonoids: Role of (−)-epicatechin and related procyanidins in cell signaling
Open accessAbstract
Plant polyphenols are among the most abundant phytochemicals present in human diets. Increasing evidence supports the health-promoting effects of certain polyphenols, including flavonoids. This review discusses current knowledge of the capacity of monomeric flavanols, i.e., (-)-epicatechin and (+)-catechin, and their derived procyanidins to modulate cell signaling and the associations of these actions with better health. Flavanols and procyanidins can regulate cell signaling through different mechanisms of action. Monomers and dimeric procyanidins can be transported inside cells and directly interact and modulate the activity of signaling proteins and/or prevent oxidation. Larger and nonabsorbable procyanidins can regulate cell signaling by interacting with cell membrane proteins and lipids, inducing changes in membrane biophysics, and by modulating oxidant production. All these actions would be limited by the bioavailability of flavanols at the target tissue. The protection from cardiac and vascular disease and from cancer that is associated with a high consumption of fruit and vegetables could be in part explained by the capacity of flavanols and related procyanidins to modulate proinflammatory and oncogenic signals.
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Cited by
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Flavonoids as Antioxidants and Developmental Regulators: Relative Significance in Plants and Humans
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Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease
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Research trends in flavonoids and health
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Self-citation
Metadata
- Authors
- Fraga, C. G., & Oteiza, P. I.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 51
- Issue
- 4
- Pages
- 813-823
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2164675156
- Cited by
- 257
- References
- 123
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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