Proteasome activation delays aging in vitro and in vivo

Nitric oxide inhibits H 2 O 2 -induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway

Kotamraju, S., Tampo, Y., Keszler, Á., Chitambar, C. R., Joseph, J., Haas, A. L., & Kalyanaraman, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1933581100 · Cited by 94

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

Tsakiri, E. N., Sykiotis, G. P., Papassideri, I. S., Gorgoulis, V. G., Bohmann, D., & Trougakos, I. P. (2013) · The FASEB Journal · doi:10.1096/fj.12-221408 · Cited by 94

Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration

Kwak, Y.-D., Wang, B., Li, J. J., Wang, R., Deng, Q., Diao, S., Chen, Y., Xu, R., Masliah, E., Xu, H., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1836-12.2012 · Cited by 93

Rpn4 Is a Physiological Substrate of the Ubr2 Ubiquitin Ligase

Wang, L., Mao, X., Ju, D., & Xie, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410085200 · Cited by 93

Reduced Insulin/Insulin-like Growth Factor-1 Signaling and Dietary Restriction Inhibit Translation but Preserve Muscle Mass in Caenorhabditis elegans

Depuydt, G., Xie, F., Petyuk, V., Shanmugam, N., Smolders, A., Dhondt, I., Brewer, H. M., Camp, D., Smith, R. D., & Braeckman, B. P. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.027383 · Cited by 92

Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier–dependent pathway

Ahner, A., Gong, X., Schmidt, B. Z., Peters, K. W., Rabeh, W. M., Thibodeau, P. H., Lukács, G. L., & Frizzell, R. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-09-0678 · Cited by 91

Age-dependent protein modifications and declining proteasome activity in the human lens

Viteri, G., Carrard, G., Birlouez‐Aragon, I., Silva, E. D., & Friguet, B. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.05.006 · Cited by 91

Immunoproteasome deficiency alters retinal proteasome’s response to stress

Hussong, S. A., Kapphahn, R. J., Phillips, S. L., Maldonado, M., & Ferrington, D. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06688.x · Cited by 91

Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1

Grimm, S., Ott, C., Hörlacher, M., Weber, D., Höhn, A., & Grune, T. (2012) · Biochemical Journal · doi:10.1042/bj20120298 · Cited by 87

Ump1 extends yeast lifespan and enhances viability during oxidative stress: Central role for the proteasome?

Chen, Q., Thorpe, J. A., Dohmen, R. J., Li, F., & Keller, J. N. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.048 · Cited by 87

Ubiquitin-Proteasome System Impairment Caused by a Missense Cardiac Myosin-binding Protein C Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy

Bahrudin, U., Morisaki, H., Morisaki, T., Ninomiya, H., Higaki, K., Nanba, E., Igawa, O., Takashima, S., Mizuta, E., Miake, J., et al. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.09.070 · Cited by 87

Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures

Chondrogianni, N., & Gonos, E. S. (2004) · Biogerontology · doi:10.1023/b:bgen.0000017687.55667.42 · Cited by 86

Immunoproteasomes and immunosenescence

Mishto, M., Santoro, A., Bellavista, E., Bonafè, M., Monti, D., & Franceschi, C. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00030-8 · Cited by 86

Structure, Assembly and Homeostatic Regulation of the 26S Proteasome

Xie, Y. (2010) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq030 · Cited by 85

Parkin Directly Modulates 26S Proteasome Activity

Um, J. W., Im, E., Lee, H. J., Min, B., Yoo, L., Yoo, J., Lübbert, H., Stichel-Gunkel, C. C., Cho, H.-S., Yoon, J. B., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2862-09.2010 · Cited by 83

Implications of Protein Degradation in Aging

Goto, S., Takahashi, R., Kumiyama, A., Radak, Z. O., Hayashi, T., Takenouchi, M., & Abe, R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05635.x · Cited by 83

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

Kuhlbrodt, K., Janiesch, P. C., Kevei, É., Segref, A., Barikbin, R., & Hoppe, T. (2011) · Nature Cell Biology · doi:10.1038/ncb2200 · Cited by 82

Melittin restores proteasome function in an animal model of ALS

Yang, E. J., Kim, S. H., Yang, S. C., Lee, S. M., & Choi, S. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-69 · Cited by 82

Crystal Structures of the Rhodococcus Proteasome with and without its Pro-peptides: Implications for the Role of the Pro-peptide in Proteasome Assembly

Kwon, Y. D., Nagy, I., Adams, P. D., Baumeister, W. P., & Jap, B. K. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.08.029 · Cited by 81

Enhancing protein disaggregation restores proteasome activity in aged cells

Andersson, V., Hanzén, S., Liu, B., Molin, M., & Nyström, T. (2013) · Aging · doi:10.18632/aging.100613 · Cited by 80

Myocardial Ischemic Preconditioning Preserves Postischemic Function of the 26S Proteasome Through Diminished Oxidative Damage to 19S Regulatory Particle Subunits

Divald, A., Kivity, S., Wang, P., Hochhauser, E., Roberts, B., Teichberg, S., Gomes, A. V., & Powell, S. R. (2010) · Circulation Research · doi:10.1161/circresaha.110.219485 · Cited by 78

Degrade to create: developmental requirements for ubiquitin-mediated proteolysis during earlyC. elegansembryogenesis

Bowerman, B. A., & Kurz, T. (2006) · Development · doi:10.1242/dev.02276 · Cited by 77

Transformation of the proteasome with age‐related macular degeneration

Ethen, C. M., Hussong, S. A., Reilly, C., Feng, X., Olsen, T. W., & Ferrington, D. A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.061 · Cited by 76

Incorporation of the Rpn12 Subunit Couples Completion of Proteasome Regulatory Particle Lid Assembly to Lid-Base Joining

Tomko, R. J., & Hochstrasser, M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.11.020 · Cited by 76

FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis

Watanabe, T., Hikichi, Y., Willuweit, A., Shintani, Y., & Horiguchi, T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5659-11.2012 · Cited by 76

Duplicated Proteasome Subunit Genes in Drosophila melanogaster Encoding Testes-Specific Isoforms

Yuan, X. Q., Miller, M. E., & Belote, J. M. (1996) · Genetics · doi:10.1093/genetics/144.1.147 · Cited by 75

An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity

Du, Y., Yang, D., Liang, L., Luo, G., Li, T., Fan, X., Wang, Q., Zhang, X., Wang, Y., & Le, W. (2009) · Autophagy · doi:10.4161/auto.5.5.8377 · Cited by 75

Overexpression of hUMP1/POMP proteasome accessory protein enhances proteasome-mediated antioxidant defence

Chondrogianni, N., & Gonos, E. S. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.012 · Cited by 74

Yeast Colonies: A Model for Studies of Aging, Environmental Adaptation, and Longevity

Váchová, L., Čáp, M., & Palková, Z. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/601836 · Cited by 74

Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism

Stout, G. J., Stigter, E. C. A., Essers, P., Mulder, K. W., Kolkman, A., Snijders, D. S., van den Broek, N. J. F., Betist, M. C., Korswagen, H. C., MacInnes, A. W., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.35 · Cited by 74

Immunoproteasome responds to injury in the retina and brain

Ferrington, D. A., Hussong, S. A., Roehrich, H., Kapphahn, R. J., Kavanaugh, S. M., Heuss, N. D., & Gregerson, D. S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05345.x · Cited by 73

Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster

Fredriksson, Å., Krogh, E. J., Hernebring, M., Pettersson, E., Javadi, A., Almstedt, A., & Nyström, T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00823.x · Cited by 71

Insulin/IGF-1 Signaling Regulates Proteasome Activity through the Deubiquitinating Enzyme UBH-4

Matilainen, O., Arpalahti, L., Rantanen, V., Hautaniemi, S., & Holmberg, C. I. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.012 · Cited by 70

LPS-Induced Formation of Immunoproteasomes: TNF-α and Nitric Oxide Production are Regulated by Altered Composition of Proteasome-Active Sites

Reis, J. C., Guan, X. Q., Kisselev, A. F., Papasian, C. J., Qureshi, A. A., Morrison, D. C., Way, C. W. V., Vogel, S. N., & Qureshi, N. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9182-8 · Cited by 70

Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats

Selsby, J. T., Judge, A. R., Yimlamai, T., Leeuwenburgh, C., & DODD, S. L. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.012 · Cited by 69

Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver

Dasuri, K., Zhang, L., Ebenezer, P. J., Liu, Y., Fernandez‐Kim, S. O., & Keller, J. N. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.10.003 · Cited by 69

Protein homeostasis and aging: Role of ubiquitin protein ligases

Jana, N. R. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.02.009 · Cited by 67

Age‐related increase in the immunoproteasome content in rat hippocampus: molecular and functional aspects

Gavilán, M. P., Castaño, A., Torres, M., Portavella, M., Caballero, C., Jiménez, S., García‐Martínez, A., Parrado, J., Vitórica, J., & Ruano, D. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05762.x · Cited by 67

Proteasome (multicatalytic proteinase) of sea urchin sperm and its possible participation in the acrosome reaction

Matsumura, K., & Aketa, K. (1991) · Molecular Reproduction and Development · doi:10.1002/mrd.1080290215 · Cited by 66

Non-neuronal induction of immunoproteasome subunits in an ALS model: Possible mediation by cytokines

Puttaparthi, K., & Elliott, J. L. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.027 · Cited by 66

Proteasome malfunction activates macroautophagy in the heart.

Zheng, Q., Su, H., Tian, Z., & Wang, X. (2011) · PubMed Central · Cited by 65

Functional Interplay between Mitochondrial and Proteasome Activity in Skin Aging

Kozieł, R., Greussing, R., Maier, A. B., Declercq, L., & Jansen‐Dürr, P. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.383 · Cited by 65

Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function

Dohmen, R. J., Willers, I. M., & Marques, A. J. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.05.015 · Cited by 65

Proteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms: a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28γ-Dependent Mechanism

Suzuki, R., Moriishi, K., Fukuda, K., Shirakura, M., Ishii, K., Shoji, I., Wakita, T., Miyamura, T., Matsuura, Y., & Suzuki, T. (2008) · Journal of Virology · doi:10.1128/jvi.01690-08 · Cited by 65

Subcomplexes of PA700, the 19 S Regulator of the 26 S Proteasome, Reveal Relative Roles of AAA Subunits in 26 S Proteasome Assembly and Activation and ATPase Activity*

Thompson, D., Hakala, K. W., & DeMartino, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023218 · Cited by 62

Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population

Mishto, M., Bellavista, E., Ligorio, C., Textoris‐Taube, K., Santoro, A., Giordano, M., D’Alfonso, S., Listı̀, F., Nacmias, B., Cellini, E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009287 · Cited by 62

Blm10 binds to pre‐activated proteasome core particles with open gate conformation

Lehmann, A. D., Jechow, K., & Enenkel, C. (2008) · EMBO Reports · doi:10.1038/embor.2008.190 · Cited by 61

Emerging roles of insulin-like growth factor-I in the adult brain

Fernández, S., Fernandez, A. M., López-López, C., & Torres‐Alemán, I. (2007) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2007.01.006 · Cited by 61

AIP-1 ameliorates β-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model

Hassan, W. M., Merin, D. A., Fonte, V. G., & Link, C. D. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp209 · Cited by 59

Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation

Vechio, F. D., Cerqueira, F. M., Augusto, O., Lopes, R., & Demasi, M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.017 · Cited by 58

Interactions of the Proteasomal System with Chaperones

Kästle, M., & Grune, T. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397863-9.00004-3 · Cited by 56

Diversity of proteasomal missions: fine tuning of the immune response

Borissenko, L. V., & Groll, M. (2007) · Biological Chemistry · doi:10.1515/bc.2007.109 · Cited by 56

Algae Extract-Mediated Stimulation and Protection of Proteasome Activity Within Human Keratinocytes Exposed to UVA and UVB Irradiation

Bulteau, A., Moreau, M., Saunois, A., Nizard, C., & Friguet, B. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.136 · Cited by 55

Parkin interacts with the proteasome subunit α4

Dächsel, J. C., Lücking, C. B., Deeg, S., Schultz, E., Lalowski, M. M., Casademunt, E., Corti, O., Hampe, C., Patenge, N., Vaupel, K., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.06.003 · Cited by 52

Proteasome synthesis and assembly are required for survival during stationary phase

Chen, Q., Thorpe, J. A., Ding, Q., El-Amouri, I. S., & Keller, J. N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.025 · Cited by 51

Increased aerobic metabolism is essential for the beneficial effects of caloric restriction on yeast life span

de Oliveira, G. A., Tahara, E. B., Gombert, A. K., de Barros, M. H., & Kowaltowski, A. J. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9159-5 · Cited by 51

Proteasome response to interferon‐γ is altered in senescent human fibroblasts

Stratford, F. L. L., Chondrogianni, N., Trougakos, I. P., Gonos, E. S., & Rivett, A. J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.029 · Cited by 50

Kinetic mechanism of activation by cardiolipin (diphosphatidylglycerol) of the rat liver multicatalytic proteinase

de Mena, I. R., Mahillo, E., Arribas, J., & Castaño, J. G. (1993) · Biochemical Journal · doi:10.1042/bj2960093 · Cited by 49

Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics

Burnett, B. G., Andrews, J., Ranganathan, S., Fischbeck, K. H., & Prospero, N. A. D. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.02.007 · Cited by 48

Aging and calorie restriction modulate yeast redox state, oxidized protein removal, and the ubiquitin–proteasome system

da Cunha, F. M., Demasi, M., & Kowaltowski, A. J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.035 · Cited by 47

Ubiquitination and the Ubiquitin–Proteasome System as regulators of transcription and transcription factorsin epithelial mesenchymal transition of cancer

Voutsadakis, I. A. (2012) · Tumor Biology · doi:10.1007/s13277-012-0355-x · Cited by 46

Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells.

Liu, Y., Liu, X., Zhang, T., Luna, C., Liton, P. B., & González, P. (2007) · PubMed Central · Cited by 42

Unfolded Protein Response and Activated Degradative Pathways Regulation in GNE Myopathy

Li, H., Chen, Q., Liu, F., Zhang, X., Li, W., Liu, S., Zhao, Y., Gong, Y., & Yan, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058116 · Cited by 41

Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin–proteasome system and autophagy

Ohnishi, K., Nakahata, E., Irie, K., & Murakami, A. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.104 · Cited by 41

Structural analysis of the 26S proteasome by cryoelectron tomography

Nickell, S., Mihalache, O., Beck, F., Hegerl, R., Korinek, A., & Baumeister, W. P. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.141 · Cited by 40

Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion

Chen, L., Ai, X., Portaliou, A. G., Minetti, C. A. S. A., Remeta, D. P., Economou, A., & Kalodimos, C. G. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.025 · Cited by 40

Postnatal Proteasome Inhibition Induces Neurodegeneration and Cognitive Deficiencies in Adult Mice: A New Model of Neurodevelopment Syndrome

Romero‐Granados, R., Fontán‐Lozano, Á., Aguilar-Montilla, F. J., & Carrión, Á. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028927 · Cited by 39

Activation of 20S Proteasomes from Spinach Leaves by Fatty Acids

Watanabe, N., & Yamada, S. (1996) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a028925 · Cited by 39

Genome-Wide Analysis Identifies MYND-Domain Protein Mub1 as an Essential Factor for Rpn4 Ubiquitylation

Ju, D., Wang, X., Xu, H., & Xie, Y. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01787-07 · Cited by 38

Synthetic peptide-based activators of the proteasome

Wilk, S., & Chen, W. (1997) · Molecular Biology Reports · doi:10.1023/a:1006851428691 · Cited by 37

Chaperone-driven proteasome assembly

Rosenzweig, R., & Glickman, M. H. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360807 · Cited by 37

Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction

Dasuri, K., Nguyen, A., Zhang, L., Fernandez-Kim, O. S., Bruce‐Keller, A. J., Blalock, B., de Cabo, R., & Keller, J. N. (2008) · Free Radical Research · doi:10.1080/10715760802534812 · Cited by 36

Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status

Chondrogianni, N., Trougakos, I. P., Kletsas, D., Chen, Q. M., & Gonos, E. S. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00425.x · Cited by 36

REGγ proteasome mediates degradation of the ubiquitin ligase Smurf1

Nie, J., Wu, M., Wang, J., Xing, G., He, F., & Zhang, L. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.05.034 · Cited by 34

Low-level caloric restriction rescues proteasome activity and Hsc70 level in liver of aged rats

Bonelli, M. A., Desenzani, S., Cavallini, G., Donati, A., Romani, A. A., Bergamini, E., & Borghetti, A. F. (2007) · Biogerontology · doi:10.1007/s10522-007-9111-9 · Cited by 34

Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: Enhanced activity for degradation of abnormal protein

Kwak, M.-K., Huang, B., Chang, H., Kim, J., & Kensler, T. W. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.04.014 · Cited by 33

Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress

Dasuri, K., Zhang, L., Ebenezer, P. J., Fernandez‐Kim, S. O., Bruce‐Keller, A. J., Szweda, L. I., & Keller, J. N. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.001 · Cited by 33

Nutrient restriction differentially modulates the mammalian target of rapamycin signaling and the ubiquitin-proteasome system in skeletal muscle of cows and their fetuses1

Du, ‬., Zhu, M. J., Means, W. J., Hess, B. W., & Ford, S. P. (2005) · Journal of Animal Science · doi:10.2527/2005.831117x · Cited by 32

Role of the Ubiquitin–Proteasome in Protein Quality Control and Signaling

Shang, F., & Taylor, A. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397863-9.00010-9 · Cited by 29

Poly-Ub-Substrate-Degradative Activity of 26S Proteasome Is Not Impaired in the Aging Rat Brain

Giannini, C., Kloß, A., Gohlke, S., Mishto, M., Nicholson, T. P., Sheppard, P. W., Kloetzel, P., & Dahlmann, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064042 · Cited by 29

MURF2B, a Novel LC3-Binding Protein, Participates with MURF2A in the Switch between Autophagy and Ubiquitin Proteasome System during Differentiation of C2C12 Muscle Cells

Pizon, V., Rybina, S., Gerbal, F., Delort, F., Vicart, P., Baldacci, G., & Karsenti, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076140 · Cited by 27

Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen

Zhang, L., Li, F., Dimayuga, E. R., Craddock, J., & Keller, J. N. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.054 · Cited by 27

Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1

Nakajima, M., Shimizu, T., & Shirasawa, T. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20001015)62:2 · Cited by 27

Activation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain

Crowe, E. P., Sell, C., Thomas, J. D., Johannes, G. J., & Torres, C. A. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.10.005 · Cited by 26

Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression

Lu, L., Song, H., Wei, J.-L., Liu, X., Song, W.-H., Yan, B.-Y., Yang, G.-J., Li, A., & Yang, W. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.113 · Cited by 26

Human erythrocyte multicatalytic proteinase: Activation and binding to sulfated galacto- and lactosylceramides

Ohkubo, I., Gasa, S., Namikawa, C., Makita, A., & Sasaki, M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91538-n · Cited by 25

skn - 1 -Dependent and -Independent Regulation of aip - 1 Expression following Metabolic Stress in Caenorhabditis elegans

Ferguson, A. A., Springer, M. G., & Fisher, A. L. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01340-09 · Cited by 24

Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities

Gohlke, S., Mishto, M., Textoris‐Taube, K., Keller, C., Giannini, C., Vasuri, F., Capizzi, E., D’Errico, A., Kloetzel, P., & Dahlmann, B. (2013) · AGE · doi:10.1007/s11357-013-9543-x · Cited by 24

Autophagy-independent enhancing effects of Beclin 1 on cytotoxicity of ovarian cancer cells mediated by proteasome inhibitors

Liu, C., Xu, Y., Wang, H., Gao, Y., Liu, J., Hu, Z., Liu, D., Gao, J., & Lin, B. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-622 · Cited by 24

Preconditioning stimulus of proteasome inhibitor enhances aggresome formation and autophagy in differentiated SH-SY5Y cells

Bang, Y., Kang, B. Y., & Choi, H. J. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.02.056 · Cited by 23

Short-Term Feed Deprivation Rapidly Induces the Protein Degradation Pathway in Skeletal Muscles of Young Mice

Shavlakadze, T., Soffe, Z., Anwari, T., Cozens, G. S., & Grounds, M. D. (2013) · Journal of Nutrition · doi:10.3945/jn.112.171967 · Cited by 23

Zinc supplementation in the elderly subjects: Effect on oxidized protein degradation and repair systems in peripheral blood lymphocytes

Cabreiro, F., Perichon, M., Jatje, J., Malavolta, M., Mocchegiani, E., Friguet, B., & Petropoulos, I. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.007 · Cited by 23

Characterization of a REG/PA28 Proteasome Activator Homolog in Dictyostelium discoideum Indicates that the Ubiquitin- and ATP-Independent REGγ Proteasome Is an Ancient Nuclear Protease

Masson, P., Lundin, D., Söderbom, F., & Young, P. (2009) · Eukaryotic Cell · doi:10.1128/ec.00165-08 · Cited by 22

Knockdown of PSMB7 Induces Autophagy in Cardiomyocyte Cultures: Possible Role in Endoplasmic Reticulum Stress

Kyrychenko, V. O., Nagibin, V. S., Tumanovska, L. V., Pashevin, D. O., Gurianova, V. L., Moibenko, A. A., Dosenko, V., & Klionsky, D. J. (2013) · Pathobiology · doi:10.1159/000350704 · Cited by 19

Synthesis and proteasome inhibition of lithocholic acid derivatives

Dang, Z., Lin, A., Ho, P., Soroka, D. N., Lee, K., Huang, L., & Chen, C. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.02.041 · Cited by 18

A regulator of ubiquitin-proteasome activity, 2-hexyldecanol, suppresses melanin synthesis and the appearance of facial hyperpigmented spots

Hakozaki, T., Laughlin, T. L., Zhao, S., Wang, J., Deng, D., Jewell-Motz, E. A., & Elstun, L. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12364 · Cited by 18

Proteasome and Neurodegeneratıve Diseases

Catalgol, B., & Grune, T. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397863-9.00011-0 · Cited by 13

Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death

Droggiti, A., Ho, C. C., Stefanis, L., Dauer, W. T., & Rideout, H. J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07444.x · Cited by 8

[Mechanisms of cardiac hystiocyte's aging and death under noncoronary cardiac diseases].

Vg, T. (2012) · PubMed · Cited by 2

Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases

Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., & Salvioli, S. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00061 · Cited by 945

Regulation of proteasome assembly and activity in health and disease

Rousseau, A., & Bertolotti, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0040-z · Cited by 510

The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks

Aunan, J. R., Cho, W. C. S., & Søreide, K. (2017) · Aging and Disease · doi:10.14336/ad.2017.0103 · Cited by 389

Molecular and biological hallmarks of ageing

Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 341

Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases

Chondrogianni, N., Voutetakis, K., Καπετάνου, Μ., Delitsikou, V., Papaevgeniou, N., Sakellari, M., Lefaki, M., Filippopoulou, K., & Gonos, E. S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.003 · Cited by 115

Proteasome activatοrs as diet constituents: a promising strategy against aging and aggregation

Chondrogianni, N. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.050

Proteasome activation as a novel anti-aging strategy

Gonos, E. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.114

The pivotal role of proteasome enhancement in ageing, longevity and proteostasis across species

Chondrogianni, N. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.052

Proteasome dysfunction in mammalian aging: Steps and factors involved

Chondrogianni, N., & Gonos, E. S. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.004 · Cited by 143