Proteasome activation delays aging in vitro and in vivo

The Hallmarks of Aging

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Molecular chaperones in protein folding and proteostasis

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The genetics of ageing

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Adapting Proteostasis for Disease Intervention

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

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Proteasome inhibitors: a novel class of potent and effective antitumor agents.

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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The plasticity of aging: insights from long-lived mutants

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

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Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

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Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

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Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

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Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26 S Proteasome

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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

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A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

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Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

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Genetic Analysis of Tissue Aging in Caenorhabditis elegans : A Role for Heat-Shock Factor and Bacterial Proliferation

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BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase

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Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

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Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

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Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

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The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle

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Proteasome subunit Rpn13 is a novel ubiquitin receptor

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DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

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Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and ‘aggresomes’ during oxidative stress, aging, and disease

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Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway

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Proteasomal function is impaired in substantia nigra in Parkinson’s disease

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Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

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Widespread protein aggregation as an inherent part of aging in C. elegans

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During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

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Regulation of CD8 + T Cell Development by Thymus-Specific Proteasomes

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Mechanisms of cross‐talk between the ubiquitin‐proteasome and autophagy‐lysosome systems

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Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

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Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry

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A systematic RNAi screen for longevity genes in C. elegansPreprint

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Genetics of longevity in model organisms: debates and paradigm shifts

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Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

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Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

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Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin

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Protein Homeostasis and Aging: the importance of exquisite quality control

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The Naked Mole-Rat: A New Long-Living Model for Human Aging Research

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Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

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Proteasome subunit Rpn1 binds ubiquitin-like protein domains

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A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

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Multiubiquitin Chain Receptors Define a Layer of Substrate Selectivity in the Ubiquitin-Proteasome System

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RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit

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Genetic links between diet and lifespan: shared mechanisms from yeast to humans

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Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

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RPN-6 determines C. elegans longevity under proteotoxic stress conditions

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The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

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The proteasomal system

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Sir2 Blocks Extreme Life-Span Extension

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Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

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Development of the Proteasome Inhibitor PS-341

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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

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Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors

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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

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&cestflwr; The Hsp90 family of proteins in Arabidopsis thaliana

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Condition‐adapted stress and longevity gene regulation by Caenorhabditis elegans SKN‐1/Nrf

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Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion

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Hybrid Proteasomes

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Proteasomes in immune cells: more than peptide producers?

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Protein degradation and the generation of MHC class I-presented peptides

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Multiple Stressors in Caenorhabditis elegans Induce Stress Hormesis and Extended Longevity

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Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

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Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

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Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

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PA200, a nuclear proteasome activator involved in DNA repair

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Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast

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Higher Respiratory Activity Decreases Mitochondrial Reactive Oxygen Release and Increases Life Span in Saccharomyces cerevisiae

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The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

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Integration of Clearance Mechanisms: The Proteasome and AutophagyPreprint

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Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7

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Ubiquitin Chains Are Remodeled at the Proteasome by Opposing Ubiquitin Ligase and Deubiquitinating Activities

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Subcellular localization of proteasomes and their regulatory complexes in mammalian cells

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Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

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Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules

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Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

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Proteasome Activators

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Protein damage, repair and proteolysis

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