The DOI matches its Crossref record; 299 of the 300 references it cites were found in a registry or an index.
Proteasome activation delays aging in vitro and in vivo
Abstract
Aging is a natural biological process that is characterized by a progressive accumulation of macromolecular damage. In the proteome, aging is accompanied by decreased protein homeostasis and function of the major cellular proteolytic systems, leading to the accumulation of unfolded, misfolded, or aggregated proteins. In particular, the proteasome is responsible for the removal of normal as well as damaged or misfolded proteins. Extensive work during the past several years has clearly demonstrated that proteasome activation by either genetic means or use of compounds significantly retards aging. Importantly, this represents a common feature across evolution, thereby suggesting proteasome activation to be an evolutionarily conserved mechanism of aging and longevity regulation. This review article reports on the means of function of these proteasome activators and how they regulate aging in various species.
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“Thus, it should have a positive effect on this system [13, 14, 46].”
From GHK and DNA: Resetting the human genome to health (2014) · cites this paper as [14]
Citations
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Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971
“While proteasomal dysfunction is correlated with age progression and protein aggregation, proteasome activation slows the aging progress down and increases longevity (Chondrogianni et al., 2014).”
BackgroundThe Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
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“Proteasome activation delays aging in vivo and vitro in a variety of laboratory organisms [84].”
BackgroundMolecular and biological hallmarks of ageing
Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 341
Metadata
- Authors
- Chondrogianni, N., Sakellari, M., Lefaki, M., Papaevgeniou, N., & Gonos, E. S.
- Affiliations
- National Hellenic Research Foundation (GR)
- Örebro University (SE)
- Corresponding author
- Chondrogianni, Niki
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 71
- Pages
- 303-320
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2018028939
- Cited by
- 94
- References
- 300
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 10 · 2016: 9 · 2015: 6 · 2014: 5
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation) (submittedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- proteasome activation, aging, longevity, proteostasis, proteasome activator, protein aggregation, protein misfolding, proteasome inhibitors
- MeSH terms
- Aging, Animals, Antioxidants, Drosophila melanogaster, Enzyme Activation, Free Radicals, Humans, Longevity, Nuclear Proteins, Saccharomyces cerevisiae, Caenorhabditis elegans, Proteasome Endopeptidase Complex, Mice, Rats, Proteolysis
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