Nrf2 promotes survival following exposure to ionizing radiation

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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p53 is required for radiation-induced apoptosis in mouse thymocytes

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Reconciling the chemistry and biology of reactive oxygen species

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The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

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Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene

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NRF2 and the Hallmarks of Cancer

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Pathological effects of ionizing radiation: endothelial activation and dysfunction

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Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms

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Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy

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Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin

Zhang, L., & Wang, H. (2015) · Marine Drugs · doi:10.3390/md13074310 · Cited by 202

Redox toxicology of environmental chemicals causing oxidative stress

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Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases

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Oxidative stress responsive transcription factors in cellular signalling transduction mechanisms

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Mechanisms of Normal Tissue Injury From Irradiation

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Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis

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Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review)

Liu, R., Bian, Y., Liu, L., Liu, L., Liu, X., & Ma, S. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5121 · Cited by 125

NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest

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Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA Damage

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Oxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker Perspective

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Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair

Yang, L., Shen, C., Estrada‐Bernal, A., Robb, R. N., Chatterjee, M., Sebastian, N., Webb, A., Mo, X. M., Chen, W., Krishnan, S., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab871 · Cited by 80

What has passed is prolog: new cellular and physiological roles of G6PD

Yang, H., Wu, Y.-H., Liu, H.-Y., Stern, A., & Chiu, D. T.-Y. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1223296 · Cited by 75

Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation

Benesch, M. G. K., MacIntyre, I. M., McMullen, T. P. W., & Brindley, D. N. (2018) · Cancers · doi:10.3390/cancers10030073 · Cited by 70

The Anticancer Effects of Flavonoids through miRNAs Modulations in Triple-Negative Breast Cancer

Adinew, G. M., Taka, E., Mendonca, P., Messeha, S. S., & Soliman, K. F. A. (2021) · Nutrients · doi:10.3390/nu13041212 · Cited by 71

Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair

Qin, S., He, X., Lin, H., Schulte, B. A., Zhao, M., Tew, K. D., & Wang, G. Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.04.006 · Cited by 72

Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

Vaiserman, A. M., Cuttler, J. M., & Socol, Y. (2021) · Biogerontology · doi:10.1007/s10522-020-09908-5 · Cited by 63

Cordycepin sensitizes breast cancer cells toward irradiation through elevating ROS production involving Nrf2

Dong, J., Li, Y., Xiao, H., Luo, D., Zhang, S., Zhu, C., Jiang, M., Cui, M., Lu, L., & Fan, S. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.12.006 · Cited by 58

Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress

Godoy, P. R. D. V., Khavari, A. P., Rizzo, M., Sakamoto‐Hojo, E. T., & Haghdoost, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2534643 · Cited by 57

Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials

Lin, Y., Lin, Y., & Chen, C. (2021) · Cells · doi:10.3390/cells10071629 · Cited by 52

Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis

Zhao, Q., Mao, A., Guo, R., Zhang, L., Yan, J., Sun, C., Tang, J., Ye, Y., Zhang, Y., & Zhang, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16622 · Cited by 51

Resveratrol, 4′ Acetoxy Resveratrol, R-equol, Racemic Equol or S-equol as Cosmeceuticals to Improve Dermal Health

Lephart, E. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061193 · Cited by 50

Targeting of stress response pathways in the prevention and treatment of cancer

Zelenka, J., Koncošová, M., & Ruml, T. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.01.007 · Cited by 50

Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition

Amos, A., Jiang, N., Zong, D., Gu, J., Zhou, J., Li, Y., He, X., Xu, Y., & Wu, L. (2023) · BMC Cancer · doi:10.1186/s12885-022-10465-y · Cited by 52

Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy

Meng, G., Tang, X., Yang, Z., Benesch, M. G. K., Marshall, A., Murray, D. L., Hemmings, D. G., Wuest, F. R., McMullen, T. P. W., & Brindley, D. N. (2017) · The FASEB Journal · doi:10.1096/fj.201700159r · Cited by 48

Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer

Brindley, D. N., Tang, X., Meng, G., & Benesch, M. G. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165938 · Cited by 45

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Lephart, E. (2018) · Cosmetics · doi:10.3390/cosmetics5010016 · Cited by 42

Phytochemical analysis and differential in vitro cytotoxicity assessment of root extracts of Inula racemosa

Mohan, S. V., & Gupta, D. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.053 · Cited by 41

Roles of NRF2 in DNA damage repair

Li, J., Xu, C. S., & Liu, Q. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00834-5 · Cited by 36

Hydrogen‐Rich Water Ameliorates Total Body Irradiation‐Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical

Zhang, J., Xue, X., Han, X., Li, Y., Lu, L., Li, D., & Fan, S. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8241678 · Cited by 34

Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity

Shrishrimal, S., Chatterjee, A., Kosmacek, E. A., Davis, P. J., McDonald, J. T., & Oberley‐Deegan, R. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.014 · Cited by 35

Introduction to Special Issue on ‘Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine

Mann, G. E., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.002 · Cited by 34

Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography

Greenwood, H. E., Barber, A. R., Edwards, R. S., Tyrrell, W. E., George, M. E., dos Santos, S. N., Baark, F., Tanç, M., Khalil, E., Falzone, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54852-4 · Cited by 35

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae

Benesch, M. G. K., Tang, X., & Brindley, D. N. (2020) · Cancers · doi:10.3390/cancers12020374 · Cited by 33

Protective effect of total flavonoids of Engelhardia roxburghiana Wall. leaves against radiation-induced intestinal injury in mice and its mechanism

Wu, S., Chen, T., Tu, Z., Guo, J., Xu, F., Qin, W., Chang, H., Wang, Z., Hu, T., Sun, X. J., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116428 · Cited by 34

Decoding lysophosphatidic acid signaling in physiology and disease: mapping the multimodal and multinodal signaling networks

Nadhan, R., Nath, K., Basu, S., Isidoro, C., Song, Y. S., & Dhanasekaran, D. N. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02423-4 · Cited by 39

HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

Da, C., Pu, J., Liu, Z., Wei, J., Qu, Y., Wu, Y., Shi, B., Yang, J., He, N., & Hou, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00793-z · Cited by 30

A Salidroside‐Based Radiosensitizer Regulates the Nrf2/ROS Pathway for X‐Ray Activated Synergistic Cancer Precise Therapy

Li, Q., Chen, Q., Xiao, S., Wang, S., Ge, X., Wang, Q., Zheng, L., Wei, Q., Du, W., Shen, W., et al. (2025) · Advanced Materials · doi:10.1002/adma.202413226 · Cited by 29

Defenses against Pro-oxidant Forces - Maintenance of Cellular and Genomic Integrity and Longevity

Murray, D. L., Mirzayans, R., & McBride, W. H. (2018) · Radiation Research · doi:10.1667/rr15101.1 · Cited by 28

Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40

Chen, L., Ran, Q., Xiang, Y., Xiang, L., Chen, L., Li, F., Wu, J., Wu, C. T., & Li, Z. (2017) · Theranostics · doi:10.7150/thno.17853 · Cited by 27

A mitohormetic response to pro-oxidant exposure in the house mouse

Zhang, Y., Humes, F., Almond, G. T., Kavazis, A. N., & Hood, W. R. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00176.2017 · Cited by 27

Nrf2 alleviates radiation-induced rectal injury by inhibiting of necroptosis

Xu, Y., Tu, W., Sun, D., Chen, X., Ge, Y., Yao, S., Li, B., Zhang, Z., & Liu, Y. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.004 · Cited by 27

Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2

Sun, X., Dong, M., Gao, Y., Wang, Y., Du, L., Liu, Y., Wang, Q., Ji, K., He, N., Wang, J., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114981 · Cited by 26

Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?

Elgohary, S., Elkhodiry, A. A., Amin, N. S., Stein, U., & Tayebi, H. M. E. (2021) · Cells · doi:10.3390/cells10020302 · Cited by 25

Polysaccharides extracted fromRheum tanguticumameliorate radiation-induced enteritis via activation of Nrf2/HO-1

Zhang, T., Shi, L., Li, Y., Mu, W., Zhang, H., Li, Y., Wang, X., Zhao, W., Qi, Y., & Liu, L. (2020) · Journal of Radiation Research · doi:10.1093/jrr/rraa093 · Cited by 24

DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway

Chu, X., Zhong, L., Dan, W., Wang, X., Zhang, Z., Liu, Z., Lu, Y., Shao, X., Zhou, Z., Chen, S., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00978-1 · Cited by 24

Autophagy gene Atg7 regulates the development of radiation‐induced skin injury and fibrosis of skin

Chen, X., Qin, W., Wang, L., Jin, Y., Tu, J., & Yuan, X. (2023) · Skin Research and Technology · doi:10.1111/srt.13337 · Cited by 23

Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis

Schmidlin, C. J., de la Vega, M. R., Perer, J., Zhang, D. D., & Wondrak, G. T. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101714 · Cited by 24

Crosstalk between NRF2 and Dicer through metastasis regulating MicroRNAs; mir-34a, mir-200 family and mir-103/107 family

Nabih, H. K. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108326 · Cited by 22

Methylene Blue Induces Antioxidant Defense and Reparation of Mitochondrial DNA in a Nrf2-Dependent Manner during Cisplatin-Induced Renal Toxicity

Samoylova, N. A., Gureev, A. P., & Popov, V. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076118 · Cited by 21

NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch

O'Cathail, S. M., Wu, C., Thomas, R. J., Hawkins, M., Maughan, T., & Lewis, A. (2021) · Antioxidants · doi:10.3390/antiox10091380 · Cited by 19

Vam3 ameliorates total body irradiation-induced hematopoietic system injury partly by regulating the expression of Nrf2-targeted genes

Zhang, J., Xue, X., Han, X., Yao, C., Lu, L., Li, D., Hou, Q., Miao, W., Meng, A., & Fan, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.501 · Cited by 19

Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments

Wei, Y., Gong, Y., Wei, S., Chen, Y., Cui, J. T., Lin, X., Yu, Y., Yan, H., Qin, H., & Yi, L. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01400-7 · Cited by 18

Loss of Nrf2 aggravates ionizing radiation-induced intestinal injury by activating the cGAS/STING pathway via Pirin

Xu, Y., Wang, L., Liao, H. H., Li, X., Zhang, Y., Chen, X., Xu, B., Liu, Y., Tu, W., & Liu, Y. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217218 · Cited by 18

Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential

Helen, H., Gunawan, M. C., Halim, P., Dinata, M. R., Ahmed, A., Dalimunthe, A., Marianne, M., Ribeiro, R. I. M. D. A., Hasibuan, P. A. Z., Nurkolis, F., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117347 · Cited by 18

Dose-Dependent Increase of Nrf2 Target Gene Expression in Mice Exposed to Ionizing Radiation

Miura, S., Yamaguchi, M., Yoshino, H., Nakai, Y., & Kashiwakura, I. (2018) · Radiation Research · doi:10.1667/rr15203.1 · Cited by 18

Mesenchymal Stem Cells Early Response to Low-Dose Ionizing Radiation

Konkova, M. S., Abramova, M. S., Кальянов, А. А., Ershova, E. S., Dolgikh, O. А., Umriukhin, P. E., Izhevskaya, V. L., Kutsev, S. I., Veiko, N. N., & Kostyuk, S. V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.584497 · Cited by 18

Nuclear factor (erythroid‐derived 2)‐like 2 antioxidative response mitigates cytoplasmic radiation‐induced DNA double‐strand breaks

Wang, J., & Konishi, T. (2018) · Cancer Science · doi:10.1111/cas.13916 · Cited by 17

Nrf-2 as a novel target in radiation induced lung injury

Chen, Y., Wang, M., Zuo, C., Mao, M.-X., Peng, X., & Cai, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29492 · Cited by 18

Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion

Hansel, C., Hlouschek, J., Xiang, K., Melnikova, M., Thomale, J., Helleday, T., Jendrossek, V., & Matschke, J. (2021) · Cells · doi:10.3390/cells10113040 · Cited by 15

The Delivery of Biologically Active Agents into the Nuclei of Target Cells for the Purposes of Translational Medicine

Sobolev, A. S. (2020) · Acta Naturae · doi:10.32607/actanaturae.11049 · Cited by 14

Increase in the radioresistance of normal skin fibroblasts but not tumor cells by mechanical injury

Chen, Z., Wang, X., Jin, T., Wang, Y., Hong, C. S., Tan, L., Dai, T., Wu, L., Zhuang, Z., & Shi, C. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.416 · Cited by 14

Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis

Meng, G., Wuest, M., Tang, X., Dufour, J. H., McMullen, T. P. W., Wuest, F. R., Murray, D. L., & Brindley, D. N. (2020) · Cancers · doi:10.3390/cancers12040999 · Cited by 14

Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate

Du, J., Carroll, R. S., Steers, G. J., Wagner, B. A., O’Leary, B. R., Jensen, C. S., Buettner, G. R., & Cullen, J. J. (2021) · Antioxidants · doi:10.3390/antiox10040614 · Cited by 13

The combination of calreticulin-targeting L-ASNase and anti-PD-L1 antibody modulates the tumor immune microenvironment to synergistically enhance the antitumor efficacy of radiotherapy

Zhang, Y., Akhil, V., Seo, H. S., Park, H., Kim, S. H., You, S.-H., Liu, Z., Kim, S., Sultonova, R. D., Min, J., et al. (2024) · Theranostics · doi:10.7150/thno.90376 · Cited by 12

Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment

Ravari, N. R., Sadri, F., Mahdiabadi, M. A., Mohammadi, Y., Ourang, Z., & Rezaei, Z. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1522873 · Cited by 14

Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery

Wuputra, K., Tsai, M.-H., Kato, K., Ku, C., Pan, J.-B., Yang, Y.-H., Saito, S., Wu, C., Lin, Y., Cheng, K., et al. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00290-6 · Cited by 13

NRF2-driven redox metabolism takes center stage in cancer metabolism from an outside-in perspective

Choi, E.-J., & Jeon, S. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01224-3 · Cited by 10

Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome

Galal, S. M., Abdel-Rafei, M. K., & Hasan, H. F. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0578 · Cited by 10

Laminin-dystroglycan mediated ferroptosis in hemorrhagic shock and reperfusion induced-cognitive impairment through AMPK/Nrf2

Xu, A., Yuan, K., Xue, S., Lü, W., Wu, X., Liu, W., Xue, Q., Liu, L., Hu, J., Guo, L., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.01.046 · Cited by 9

Retinoic acid downregulates thiol antioxidant defences and homologous recombination while promotes A549 cells sensitization to cisplatin

Ramos, V. D. M., Gasparotto, J., Figueiró, F., Dias, A. D. F., Rostirolla, D. C., Somensi, N., da Rosa, H. T., Grün, L. K., Barbé‐Tuana, F. M., Gelain, D. P., et al. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109356 · Cited by 9

18β-glycyrrhetinic acid alleviates radiation-induced skin injury by activating the Nrf2/HO-1 signaling pathway

Wang, Z., Chen, R., Chen, J., & Su, L. (2024) · Biological Chemistry · doi:10.1515/hsz-2023-0200 · Cited by 8

Trans-resveratrol alleviates hepatic and renal injury in γ-irradiated rats

Bakary, N. M. E., Abdel-Rafei, M. K., Maarouf, R. E., Mansour, S. Z., & Thabet, N. M. (2022) · Human & Experimental Toxicology · doi:10.1177/09603271221142817 · Cited by 8

Radiomodulators as Agents of Biological Protection against Oxidative Stress under the Influence of Ionizing Radiation

Васин, М. В., & Ушаков, И. Б. (2020) · Biology Bulletin Reviews · doi:10.1134/s2079086420040106 · Cited by 9

Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) as a Biomarker for Radiation Dosimetry and Health Risk Assessment: A Review

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Polyphenols as Potential Antioxidants for the Treatment of Intervertebral Disc Degeneration

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A recombinant plasmid encoding human hepatocyte growth factor promotes healing of combined radiation-trauma skin injury involved in regulating Nrf2 pathway in mice

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NRF2 Mediates Cellular Resistance to Transformation, Radiation, and Inflammation in Mice

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Nrf2 is a potential therapeutic target in radioresistance in human cancer

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