Cited by 110Genomics, phytochemicals, and oxidative stressEffects of Radiation ExposureRedox biology and oxidative stress

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Nrf2 promotes survival following exposure to ionizing radiation

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Sekhar, Konjeti R., Freeman, Michael L.·2015·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2015.04.035PMC PMC4628893

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Abstract

Nrf2 is a transcription factor that promotes antioxidant and drug-metabolizing gene expression. It also regulates the transcription of genes involved in carbohydrate and lipid metabolism, NADPH regeneration, and heme and iron metabolism, as well as proteasome metabolism. Emerging research has identified Nrf2 as a critical factor for promoting survival of mammalian cells subjected to ionizing radiation. At a mechanistic level, Nrf2 promotes the repair of DNA damage and drives detoxification of superoxide that is generated hours to days after irradiation. This review summarizes research in these areas and discusses targeting of Nrf2 in radiation-resistant cancer and Nrf2׳s role in mitigating acute radiation syndrome.

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Authors: Sekhar, K. R., & Freeman, M. L.
Affiliations: Vanderbilt University (US)
Corresponding author: Freeman, Michael L.
ORCID: Sekhar, Konjeti R.
Freeman, Michael L.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2015-11
Volume: 88
Issue: Pt B
Pages: 268-274
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2015.04.035
PMC: PMC4628893
OpenAlex: W767415338
Cited by: 109
References: 91
Citations by year: 2026: 5 · 2025: 14 · 2024: 9 · 2023: 12 · 2022: 6 · 2021: 15 · 2020: 16 · 2019: 3 · 2018: 10 · 2017: 12 · 2016: 4 · 2015: 3
FWCI: 0.94
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH/NHLBI (RO1HL112286)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: Nrf2, ionizing radiation, radioresistance (biology), DNA repair, superoxide detoxification, antioxidant gene expression, radiation sickness, cell survival
MeSH terms: Animals, Cell Survival, DNA Repair, Humans, Radiation Tolerance, Radiation, Ionizing, NF-E2-Related Factor 2

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Nrf2 promotes survival following exposure to ionizing radiation

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