Whole-genome analysis of Drosophila gastrulation
Abstract
Microarray assays and bioinformatics methods have identified many of the genes and associated regulatory DNAs that control the early phases of gastrulation in Drosophila. The localized activities of these genes are coordinated by a nuclear gradient of the maternal regulatory factor, Dorsal, that is established shortly after fertilization. At least half of the Dorsal target genes encode transcription factors or signaling components that lead to the restricted activation of FGF, EGF, and TGF-beta signaling pathways in the mesoderm, neurogenic ectoderm and dorsal ectoderm, respectively. Recent work has yielded insights into how these signaling pathways control gastrulation, particularly in the context of the Dorsal-mediated gene regulation network
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The gradient of nuclear-localized Dorsal regulates a number of genes in a concentration-dependent manner.
“The gradient of nuclear-localized Dorsal regulates a number of genes in a concentrationdependent manner”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Stathopoulos and Levine 2004
Classical genetic screens identified 10 genes that function in the early embryo to control dorsoventral patterning: sna, twi, single-minded, m8, brinker, rho, sog, tld, zen, and dpp.
“Classical genetic screens identified 10 genes that function in the early embryo to control DV patterning (sna, twi, single-minded [sim], m8, brinker [brk], rho, sog, tld, zen, and dpp)”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Stathopoulos and Levine, 2004
Based on their expression patterns along the dorsoventral axis, the first set of 25 cis-regulatory sequences were categorized into four classes: ventral (Type I), ventrolateral (Type II), broad lateral (Type III+), and dorsal (Type III-) domains.
“Based on their expression patterns along the DV axis, this first set of 25 cis-regulatory sequences were categorized into four classes: ventral (Type I), ventrolateral (Type II), broad lateral (Type IIIþ), and dorsal (Type III2) domains”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Stathopoulos and Levine 2004
Roughly half of the estimated Dorsal target genes encode signaling molecules.
“Roughly half of the estimated Dorsal target genes encode signaling molecules.”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Stathopoulos and Levine 2004
These genes are essential for the localized activation of FGF, EGFR, and TGF-b signaling pathways in the mesoderm, neurogenic ectoderm, and dorsal ectoderm of pregastrula embryos, respectively.
“These genes are essential for the localized activation of FGF (fibroblast growth factor), EGFR, and TGF (transforming growth factor)-b signaling pathways in the mesoderm, neurogenic ectoderm, and dorsal ectoderm of pregastrula embryos, respectively”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Stathopoulos and Levine 2004
Dorsal target genes also include components of Notch, Insulin-like, TNF, and Wnt pathways.
“Dorsal target genes also include components of Notch, Insulin-like, TNF, and Wnt (not shown) pathways.”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Stathopoulos and Levine 2004
In addition to FGF signaling, TGF-b signaling is required to induce mesoderm cells that reach the dorsal-most regions of the ectoderm to adopt cardial and dorsal somatic mesoderm lineage choices.
“For instance, in addition to FGF signaling, TGF-b signaling is also required to induce mesoderm cells that reach the dorsal-most regions of the ectoderm to adopt cardial and dorsal somatic mesoderm lineage choices (Fig. 4B).”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Stathopoulos and Levine 2004
Dorsal regulates the activation of the TGF-b, EGFR, and FGF signaling pathways by spatial regulation of pathway components.
“Dorsal regulates the activation of the TGF-b, EGFR, and FGF signaling pathways by spatial regulation of pathway components.”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Stathopoulos and Levine 2004
Cites
Weiss, J. B., Von Ohlen, T., Mellerick, D. M., Dressler, G., Doe, C. Q., & Scott, M. P. (1998) · Genes & Development · doi:10.1101/gad.12.22.3591 · Cited by 250 · see citing works
A regulatory code for neurogenic gene expression in the<i>Drosophila</i>embryo
Markstein, M., Zinzen, R., Markstein, P., Yee, K.-P., Erives, A., Stathopoulos, A., & Levine, M. (2004) · Development · doi:10.1242/dev.01124 · Cited by 165 · see citing works
Self-citationThe origin of dorsoventral polarity in <i>Drosophila</i>
Roth, S. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2003.1325 · Cited by 87 · see citing works
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How the Dorsal gradient works: Insights from postgenome technologies
Hong, J.-W., Hendrix, D. A., Papatsenko, D., & Levine, M. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806476105 · Cited by 137 · see citing works
Self-citationGraded dorsal and differential gene regulation in the Drosophila embryo.
Reeves, G. T., & Stathopoulos, A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000836 · Cited by 119 · see citing works
Self-citationModeling the dynamics of transcriptional gene regulatory networks for animal development
Ben-Tabou de-Leon, S., & Davidson, E. H. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.043 · Cited by 99 · see citing works
Design flexibility in cis-regulatory control of gene expression: Synthetic and comparative evidence
Liberman, L. M., & Stathopoulos, A. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.12.020 · Cited by 76 · see citing works
Self-citationBiemar, F., Nix, D. A., Piel, J., Peterson, B., Ronshaugen, M., Sementchenko, V., Bell, I., Manak, J. R., & Levine, M. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604484103 · Cited by 53 · see citing works
Self-citation
- Authors
- Stathopoulos, A., & Levine, M.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Levine, Michael
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 14
- Issue
- 5
- Pages
- 477-484
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W2080071785
- Cited by
- 71
- References
- 3
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- Drosophila gastrulation, Dorsal, nuclear gradients, transcription factors, FGF signaling, EGF signaling, TGF-beta signaling, mesoderm, dorsal ectoderm, gene regulatory networks, early embryonic development
- MeSH terms
- Animals, Drosophila, Fibroblast Growth Factors, Gastrula, Signal Transduction, Genome, Gene Expression Regulation, Developmental
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