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The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Hematopoietic stem cell self-renewal

Akala, Omobolaji O, Clarke, Michael F·2006·Current Opinion in Genetics & Development
DOI 10.1016/j.gde.2006.08.011
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Abstract

Recent studies have begun to elucidate the mechanisms controlling hematopoietic stem cell (HSC) self-renewal. Self-renewal requires the integration of survival signals and proliferation controls with the maintenance of an undifferentiated state. This demands a complex crosstalk between extrinsic signals from the microenvironment and the cell-intrinsic regulators of self-renewal. The Polycomb protein Bmi1 is absolutely required for the maintenance of both adult HSCs and neural stem cells. Evidence from studies in murine and human embryonic stem cells indicates that Polycomb group proteins play a dynamic role in concert with master transcriptional regulators in actively maintaining an undifferentiated state, suggesting that this mechanism applies to multiple types of stem cell. Recently, various new players that regulate HSC maintenance (e.g. Mcl1, Tel/Etv6, Gfi1, Pten and Stat5) have been identified. In order to better understand HSC self-renewal, we need to understand how these pathways are coordinated.

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Research works printed but not linked: 37

  1. Domen, 1998, Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation, Blood, 91, 2272, 10.1182/blood.V91.7.2272 · DOI
  2. Domen, 2000, The role of apoptosis in the regulation of hematopoietic stem cells: overexpression of BCL-2 increases both their number and repopulation potential, J Exp Med, 191, 253, 10.1084/jem.191.2.253 · DOI
  3. Opferman, 2005, Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells, Science, 307, 1101, 10.1126/science.1106114 · DOI
  4. Hock, 2004, Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival, Genes Dev, 18, 2336, 10.1101/gad.1239604 · DOI
  5. Antonchuk, 2002, Related Articles: HOXB4-induced expansion of adult hematopoietic stem cells ex vivo, Cell, 109, 39, 10.1016/S0092-8674(02)00697-9 · DOI
  6. Sauvageau, 1995, Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo, Genes Dev, 9, 1753, 10.1101/gad.9.14.1753 · DOI
  7. Krosl, 2003, In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein, Nat Med, 9, 1428, 10.1038/nm951 · DOI
  8. Miyake, 2006, HOXB4-induced self-renewal of hematopoietic stem cells is significantly enhanced by p21 deficiency, Stem Cells, 24, 653, 10.1634/stemcells.2005-0328 · DOI
  9. Brun, 2004, Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells, Blood, 103, 4126, 10.1182/blood-2003-10-3557 · DOI
  10. Bijl, 2006, Analysis of HSC activity and compensatory Hox gene expression profile in HoxB cluster mutant fetal liver cells, Blood, 108, 116, 10.1182/blood-2005-06-2245 · DOI
  11. Zeng, 2004, Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells, Embo J, 23, 4116, 10.1038/sj.emboj.7600419 · DOI
  12. Cheng, 2000, Hematopoietic stem cell quiescence maintained by p21CIP1/WAF1, Science, 287, 1804, 10.1126/science.287.5459.1804 · DOI · Paper page
  13. Yuan, 2004, In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C, Nat Cell Biol, 6, 436, 10.1038/ncb1126 · DOI
  14. Yu, 2006, Hematopoietic stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners, Blood, 107, 1200, 10.1182/blood-2005-02-0685 · DOI · Paper page
  15. Yu, 2004, The STATs of cancer — new molecular targets come of age, Nat Rev Cancer, 4, 97, 10.1038/nrc1275 · DOI · Paper page
  16. Kato, 2005, Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis, J Exp Med, 202, 169, 10.1084/jem.20042541 · DOI
  17. Snow, 2002, STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells, Blood, 99, 95, 10.1182/blood.V99.1.95 · DOI
  18. Yilmaz, 2006, Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells, Nature, 441, 475, 10.1038/nature04703 · DOI · Paper page
  19. Molofsky, 2003, Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation, Nature, 425, 962, 10.1038/nature02060 · DOI
  20. Iwama, 2004, Enhanced self-renewal of hematopoietic stem cells mediated by the Polycomb gene product Bmi-1, Immunity, 21, 843, 10.1016/j.immuni.2004.11.004 · DOI · Paper page
  21. van der Lugt, 1996, The Polycombgroup homolog Bmi-1 is a regulator of murine Hox gene expression, Mech Dev, 58, 153, 10.1016/S0925-4773(96)00570-9 · DOI
  22. Kajiume, 2004, Polycomb group gene Mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells, Exp Hematol, 32, 571, 10.1016/j.exphem.2004.03.001 · DOI
  23. Kim, 2004, Defective long-term repopulating ability in hematopoietic stem cells lacking the Polycomb-group gene Rae28, Eur J Haematol, 73, 75, 10.1111/j.1600-0609.2004.00268.x · DOI
  24. Ohta, 2002, Polycomb group gene Rae28 is required for sustaining activity of hematopoietic stem cells, J Exp Med, 195, 759, 10.1084/jem.20011911 · DOI
  25. Boyer, 2006, Polycomb complexes repress developmental regulators in murine embryonic stem cells, Nature, 441, 349, 10.1038/nature04733 · DOI
  26. Lee, 2006, Control of developmental regulators by Polycomb in human embryonic stem cells, Cell, 125, 301, 10.1016/j.cell.2006.02.043 · DOI
  27. Boyer, 2005, Core transcriptional regulatory circuitry in human embryonic stem cells, Cell, 122, 947, 10.1016/j.cell.2005.08.020 · DOI · Paper page
  28. Li, 2005, Stem cell niche: structure and function, Annu Rev Cell Dev Biol, 21, 605, 10.1146/annurev.cellbio.21.012704.131525 · DOI
  29. Calvi, 2003, Osteoblastic cells regulate the haematopoietic stem cell niche, Nature, 425, 841, 10.1038/nature02040 · DOI
  30. Zhang, 2003, Identification of the haematopoietic stem cell niche and control of the niche size, Nature, 425, 836, 10.1038/nature02041 · DOI
  31. Arai, 2004, Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche, Cell, 118, 149, 10.1016/j.cell.2004.07.004 · DOI
  32. Duncan, 2005, Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance, Nat Immunol, 6, 314, 10.1038/ni1164 · DOI
  33. Stier, 2002, Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome, Blood, 99, 2369, 10.1182/blood.V99.7.2369 · DOI
  34. Ye, 2004, Expression of constitutively active Notch4 (Int-3) modulates myeloid proliferation and differentiation and promotes expansion of hematopoietic progenitors, Leukemia, 18, 777, 10.1038/sj.leu.2403291 · DOI
  35. Mancini, 2005, Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation, Blood, 105, 2340, 10.1182/blood-2004-08-3207 · DOI
  36. Cobas, 2004, β-catenin is dispensable for hematopoiesis and lymphopoiesis, J Exp Med, 199, 221, 10.1084/jem.20031615 · DOI
  37. Bhardwaj, 2001, Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation, Nat Immunol, 2, 172, 10.1038/84282 · DOI

Cited by

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Metadata

Authors
Akala, O. O., & Clarke, M. F.
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2006-10
Volume
16
Issue
5
Pages
496-501
ISSN
0959-437X
DOI
10.1016/j.gde.2006.08.011
Cited by
75
References
8
Language
en
Licence

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CoChat. (2026). Citation check: Hematopoietic stem cell self-renewal. https://app.cochat.ai/papers/10.1016/j.gde.2006.08.011
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Akala, O. O., & Clarke, M. F. (2006). Hematopoietic stem cell self-renewal. Current Opinion in Genetics & Development. https://doi.org/10.1016/j.gde.2006.08.011