The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
Open accessAbstract
Morphogens act during development to provide graded spatial information that controls patterning and cell lineage specification in the nervous system. The role of morphogen signaling in instructing the expression of downstream effector transcription factors has been well established. However, a key requirement for morphogen signaling is the existence of functional intracellular machinery able to mediate the appropriate response in target cells. Here we suggest that dynamic changes in the temporal responses to Shh in the developing ventral telencephalon occur through alterations in progenitor competence. We suggest these developmental changes in competence are mediated by a transcriptional mechanism that intrinsically integrates information from the distinct signaling pathways that act to pattern the telencephalic neuroepithelium.
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“consistent with a role in MGE fate repression41 and LGE neuron state regulation (Extended Data Fig. 9h,i).”
From Inferring and perturbing cell fate regulomes in human brain organoids (2023) · cites this paper as [41]
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Cites
Hedgehog signaling in animal development: paradigms and principlesPreprint
Ingham, P. W., & McMahon, A. P. (2001) · Genes & Development · doi:10.1101/gad.938601 · Cited by 3,025 · cited 2×
“Studies in the spinal cord have demonstrated that ventral sources of Shh establish a long-range graded signal that controls spatial patterning along the dorsal–ventral axis [3,7,8].”
BackgroundEchelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154 · cited 1×
“5 expression is observed in the preoptic area (POA), the mantle of the MGE and the amygdala region [13,14].”
BackgroundNeuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089 · cited 1×
“Studies in the spinal cord have demonstrated that ventral sources of Shh establish a long-range graded signal that controls spatial patterning along the dorsal–ventral axis [3,7,8].”
BackgroundSussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873
Ericson, J., Brenner‐Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870 · cited 1×
“008 Current Opinion in Genetics & Development 2010, 20:1–9 tion of neuronal identity [9] and its activity triggers the sequential temporal expression of the transcriptional determinants involved in patterning the ventral spinal cord [10 ,11].”
BackgroundMouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
Park, H. L., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C., Nakashima, M., & Joyner, A. L. (2000) · Development · doi:10.1242/dev.127.8.1593 · Cited by 717
Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
Machold, R. P., Hayashi, S., Rutlin, M. L., Muzumdar, M. D., Nery, S. V., Corbin, J. G., Gritli-Linde, A., Dellovade, T., Porter, J. A., Rubin, L. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00561-0 · Cited by 710 · cited 1×
“5 onwards results in a reduction in the number of neural progenitors located in the postnatal subventricular zone but only minor patterning abnormalities [18,19].”
BackgroundSelf-citationYamada, T., Placzek, M., Tanaka, H., Dodd, J., & Jessell, T. M. (1991) · Cell · doi:10.1016/0092-8674(91)90247-v · Cited by 707
Inductive interactions direct early regionalization of the mouse forebrain
Shimamura, K., & Rubenstein, J. L. R. (1997) · Development · doi:10.1242/dev.124.14.2709 · Cited by 659 · cited 1×
“However, during the early stages of development, Pax6 becomes repressed in the ventral telencephalic midline through the action of Shh secreted from the underlying axial mesendoderm (Figure 1) [25,26].”
BackgroundLongitudinal organization of the anterior neural plate and neural tube
Shimamura, K., Hartigan-O’Connor, D. J., Martı́nez, S., Puelles, L., & Rubenstein, J. L. R. (1995) · Development · doi:10.1242/dev.121.12.3923 · Cited by 654
Cited by
Sorted by citations
Gli Proteins in Development and Disease
Hui, C., & Angers, S. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154048 · Cited by 713
“Similar regulatory mechanisms could contribute to the developmental changes in competence to Shh signaling in the developing forebrain (Sousa & Fishell 2010).”
BackgroundA highlight on Sonic hedgehog pathway
Carballo, G. B., Honorato, J. R., de Lopes, G. P. F., & Spohr, T. C. L. D. S. E. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0220-7 · Cited by 460
“velopment, having a mitogenic effect on proliferative cells throughout development [90].”
BackgroundInferring and perturbing cell fate regulomes in human brain organoids
Fleck, J. S., Jansen, S. M. J., Wollny, D., Zenk, F., Seimiya, M., Jain, A., Okamoto, R., Santel, M., He, Z., Camp, J. G., et al. (2023) · Nature · doi:10.1038/s41586-022-05279-8 · Cited by 315
“development by promoting MGE neurogenesis and altering LGE neuronal expression, consistent with a role in MGE fate repression 41 and LGE neuron state regulation (Extended Data Fig.”
A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells
Stein, J. L., de la Torre-Ubieta, L., Tian, Y., Parikshak, N. N., Hernández, I. A., Marchetto, M. C., Baker, D. K., Lu, D., Hinman, C. R., Lowe, J. K., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.035 · Cited by 201
The Role of Organizers in Patterning the Nervous System
Kiecker, C. M., & Lumsden, A. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150543 · Cited by 193
“This telencephalic Shh domain is likely to act as a secondary organizer that refines the DV pattern of the telencephalon (Figure 1d ) (Sousa & Fishell 2010).”
Background
Metadata
- Authors
- Sousa, V. H., & Fishell, G.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Fishell, Gord
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 20
- Issue
- 4
- Pages
- 391-399
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC2991106
- OpenAlex
- W2022089796
- Cited by
- 106
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 10 · 2012: 14
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH068469, R01MH071679, R37MH071679)
- National Institute of Neurological Disorders and Stroke (R01NS032993, R01NS039007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Sonic hedgehog, morphogen signaling, temporal competence, ventral telencephalon, forebrain development, transcriptional regulation, signaling pathway integration, cell lineage specification
- MeSH terms
- Zinc Finger Protein GLI1, Thyroid Nuclear Factor 1, Animals, Cell Differentiation, Fibroblast Growth Factors, Nuclear Proteins, Telencephalon, Transcription Factors, Signal Transduction, Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Developmental, Body Patterning, Mice, Hedgehog Proteins
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