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Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
Open accessAbstract
Morphogens act during development to provide graded spatial information that controls patterning and cell lineage specification in the nervous system. The role of morphogen signaling in instructing the expression of downstream effector transcription factors has been well established. However, a key requirement for morphogen signaling is the existence of functional intracellular machinery able to mediate the appropriate response in target cells. Here we suggest that dynamic changes in the temporal responses to Shh in the developing ventral telencephalon occur through alterations in progenitor competence. We suggest these developmental changes in competence are mediated by a transcriptional mechanism that intrinsically integrates information from the distinct signaling pathways that act to pattern the telencephalic neuroepithelium.
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“consistent with a role in MGE fate repression41 and LGE neuron state regulation (Extended Data Fig. 9h,i).”
From Inferring and perturbing cell fate regulomes in human brain organoids (2023) · cites this paper as [41]
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“Recent findings promise to clarify the temporal and spatial development of the CGE [36–38].”
BackgroundDynamic Domains of Gene Expression in the Early Avian Forebrain
Bell, E. J. D. H., Ensini, M., Gulisano, M., & Lumsden, A. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0301 · Cited by 44 · cited 5×
“5 in a ventral domain and results in the formation of a sharp boundary with the dorsal Pax6 domain (Figure 2a) [15].”
Influential
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Gli Proteins in Development and Disease
Hui, C., & Angers, S. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154048 · Cited by 713
“Similar regulatory mechanisms could contribute to the developmental changes in competence to Shh signaling in the developing forebrain (Sousa & Fishell 2010).”
BackgroundA highlight on Sonic hedgehog pathway
Carballo, G. B., Honorato, J. R., de Lopes, G. P. F., & Spohr, T. C. L. D. S. E. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0220-7 · Cited by 460
“velopment, having a mitogenic effect on proliferative cells throughout development [90].”
BackgroundInferring and perturbing cell fate regulomes in human brain organoids
Fleck, J. S., Jansen, S. M. J., Wollny, D., Zenk, F., Seimiya, M., Jain, A., Okamoto, R., Santel, M., He, Z., Camp, J. G., et al. (2023) · Nature · doi:10.1038/s41586-022-05279-8 · Cited by 315
“development by promoting MGE neurogenesis and altering LGE neuronal expression, consistent with a role in MGE fate repression 41 and LGE neuron state regulation (Extended Data Fig.”
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The Role of Organizers in Patterning the Nervous System
Kiecker, C. M., & Lumsden, A. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150543 · Cited by 193
“This telencephalic Shh domain is likely to act as a secondary organizer that refines the DV pattern of the telencephalon (Figure 1d ) (Sousa & Fishell 2010).”
Background
Metadata
- Authors
- Sousa, V. H., & Fishell, G.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Fishell, Gord
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 20
- Issue
- 4
- Pages
- 391-399
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC2991106
- OpenAlex
- W2022089796
- Cited by
- 106
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 10 · 2012: 14
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH068469, R01MH071679, R37MH071679)
- National Institute of Neurological Disorders and Stroke (R01NS032993, R01NS039007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Sonic hedgehog, morphogen signaling, temporal competence, ventral telencephalon, forebrain development, transcriptional regulation, signaling pathway integration, cell lineage specification
- MeSH terms
- Zinc Finger Protein GLI1, Thyroid Nuclear Factor 1, Animals, Cell Differentiation, Fibroblast Growth Factors, Nuclear Proteins, Telencephalon, Transcription Factors, Signal Transduction, Oncogene Proteins, Trans-Activators, Gene Expression Regulation, Developmental, Body Patterning, Mice, Hedgehog Proteins
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