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Structure and functional roles of Epac2 (Rapgef4)

Sugawara, Kenji, Shibasaki, Tadao, Takahashi, Harumi, Seino, Susumu·2016·Gene
DOI 10.1016/j.gene.2015.09.029PMC PMC6636354
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  1. Ahren, 2009, Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes, Nat. Rev. Drug Discov., 8, 369, 10.1038/nrd2782 · DOI
  2. Baukrowitz, 1998, PIP2 and PIP as determinants for ATP inhibition of KATP channels, Science, 282, 1141, 10.1126/science.282.5391.1141 · DOI
  3. Beavo, 2002, Cyclic nucleotide research — still expanding after half a century, Nat. Rev. Mol. Cell Biol., 3, 710, 10.1038/nrm911 · DOI
  4. Bers, 2008, Calcium cycling and signaling in cardiac myocytes, Annu. Rev. Physiol., 70, 23, 10.1146/annurev.physiol.70.113006.100455 · DOI
  5. Bos, 2006, Epac proteins: multi-purpose cAMP targets, Trends Biochem. Sci., 31, 680, 10.1016/j.tibs.2006.10.002 · DOI
  6. Bratanova-Tochkova, 2002, Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion, Diabetes, 51, S83, 10.2337/diabetes.51.2007.S83 · DOI
  7. Christensen, 2003, cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension, J. Biol. Chem., 278, 35394, 10.1074/jbc.M302179200 · DOI
  8. Consonni, 2012, cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane, Proc. Natl. Acad. Sci. U. S. A., 109, 3814, 10.1073/pnas.1117599109 · DOI
  9. de Heer, 2008, Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas, Diabetologia, 51, 2263, 10.1007/s00125-008-1149-y · DOI
  10. de Rooij, 2000, Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs, J. Biol. Chem., 275, 20829, 10.1074/jbc.M001113200 · DOI
  11. de Rooij, 1998, Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP, Nature, 396, 474, 10.1038/24884 · DOI
  12. Drucker, 2006, The biology of incretin hormones, Cell Metab., 3, 153, 10.1016/j.cmet.2006.01.004 · DOI · Paper page
  13. Dzhura, 2011, Phospholipase C-epsilon links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans, Islets, 3, 121, 10.4161/isl.3.3.15507 · DOI
  14. El-Armouche, 2009, Beta-adrenergic stimulation and myocardial function in the failing heart, Heart Fail. Rev., 14, 225, 10.1007/s10741-008-9132-8 · DOI
  15. Emery, 2014, Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells, J. Biol. Chem., 289, 10126, 10.1074/jbc.M113.529321 · DOI
  16. Enserink, 2002, A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK, Nat. Cell Biol., 4, 901, 10.1038/ncb874 · DOI · Paper page
  17. Fernandes, 2015, Epac2 mediates cAMP-dependent potentiation of neurotransmission in the hippocampus, J. Neurosci., 35, 6544, 10.1523/JNEUROSCI.0314-14.2015 · DOI
  18. Frische, 2010, Rap1, a mercenary among the Ras-like GTPases, Dev. Biol., 340, 1, 10.1016/j.ydbio.2009.12.043 · DOI
  19. Fu, 2011, Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway, Proc. Natl. Acad. Sci. U. S. A., 108, 1403, 10.1073/pnas.1018376108 · DOI
  20. Fujimoto, 2002, Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis, J. Biol. Chem., 277, 50497, 10.1074/jbc.M210146200 · DOI
  21. Gekel, 2008, Application of an Epac activator enhances neurotransmitter release at excitatory central synapses, J. Neurosci., 28, 7991, 10.1523/JNEUROSCI.0268-08.2008 · DOI
  22. Gelinas, 2008, Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus, Learn. Mem., 15, 403, 10.1101/lm.830008 · DOI
  23. Gloerich, 2011, Regulating Rap small G-proteins in time and space, Trends Cell Biol., 21, 615, 10.1016/j.tcb.2011.07.001 · DOI
  24. Henquin, 2000, Triggering and amplifying pathways of regulation of insulin secretion by glucose, Diabetes, 49, 1751, 10.2337/diabetes.49.11.1751 · DOI · Paper page
  25. Hoivik, 2013, DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms, PLoS One, 8, 10.1371/journal.pone.0067925 · DOI
  26. Holz, 2006, Cell physiology of cAMP sensor Epac, J. Physiol., 577, 5, 10.1113/jphysiol.2006.119644 · DOI
  27. Holz, 1999, cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37), J. Biol. Chem., 274, 14147, 10.1074/jbc.274.20.14147 · DOI · Paper page
  28. Hothi, 2008, Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart, Pflugers Arch., 457, 253, 10.1007/s00424-008-0508-3 · DOI
  29. Kai, 2013, Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop beta-cell dysfunction and metabolic syndrome, FASEB J., 27, 4122, 10.1096/fj.13-230433 · DOI
  30. Kang, 2001, cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells, J. Physiol., 536, 375, 10.1111/j.1469-7793.2001.0375c.xd · DOI
  31. Kang, 2006, cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells, J. Physiol., 573, 595, 10.1113/jphysiol.2006.107391 · DOI
  32. Kashima, 2001, Critical role of cAMP-GEFII–Rim2 complex in incretin-potentiated insulin secretion, J. Biol. Chem., 276, 46046, 10.1074/jbc.M108378200 · DOI
  33. Kawasaki, 1998, A family of cAMP-binding proteins that directly activate Rap1, Science, 282, 2275, 10.1126/science.282.5397.2275 · DOI
  34. Kelley, 2001, Phospholipase C(epsilon): a novel Ras effector, EMBO J., 20, 743, 10.1093/emboj/20.4.743 · DOI
  35. Kiermayer, 2005, Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells, Mol. Biol. Cell, 16, 5639, 10.1091/mbc.e05-05-0432 · DOI
  36. Li, 2006, The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane, J. Biol. Chem., 281, 2506, 10.1074/jbc.M508165200 · DOI
  37. Liu, 2008, Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2, Mol. Cell. Biol., 28, 7109, 10.1128/MCB.01060-08 · DOI
  38. Metrich, 2010, Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway, Cell. Signal., 22, 1459, 10.1016/j.cellsig.2010.05.014 · DOI
  39. Metrich, 2008, Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy, Circ. Res., 102, 959, 10.1161/CIRCRESAHA.107.164947 · DOI
  40. Montague, 1972, The mode of action of adenosine 3′:5′-cyclic monophosphate in mammalian islets of Langerhans. Preparation and properties of islet-cell protein phosphokinase, Biochem. J., 129, 551, 10.1042/bj1290551 · DOI
  41. Morel, 2005, cAMP-binding protein Epac induces cardiomyocyte hypertrophy, Circ. Res., 97, 1296, 10.1161/01.RES.0000194325.31359.86 · DOI
  42. Murray, 2008, Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration, Mol. Cell. Neurosci., 38, 578, 10.1016/j.mcn.2008.05.006 · DOI
  43. Nauck, 2009, Unraveling the science of incretin biology, Am. J. Med., 122, S3, 10.1016/j.amjmed.2009.03.012 · DOI
  44. Niimura, 2009, Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function, J. Cell. Physiol., 219, 652, 10.1002/jcp.21709 · DOI · Paper page
  45. Nijholt, 2008, Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation, Cell. Signal., 20, 1715, 10.1016/j.cellsig.2008.05.001 · DOI
  46. Ostroveanu, 2010, Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval, Hippocampus, 20, 1018, 10.1002/hipo.20700 · DOI
  47. Ozaki, 2000, cAMP-GEFII is a direct target of cAMP in regulated exocytosis, Nat. Cell Biol., 2, 805, 10.1038/35041046 · DOI · Paper page
  48. Park, 2012, Glucagon-like peptide-1 enhances glucokinase activity in pancreatic beta-cells through the association of Epac2 with Rim2 and Rab3A, Endocrinology, 153, 574, 10.1210/en.2011-0259 · DOI
  49. Parnell, 2015, The future of EPAC-targeted therapies: agonism versus antagonism, Trends Pharmacol. Sci., 36, 203, 10.1016/j.tips.2015.02.003 · DOI
  50. Penzes, 2011, Epac2-mediated dendritic spine remodeling: implications for disease, Mol. Cell. Neurosci., 46, 368, 10.1016/j.mcn.2010.11.008 · DOI
  51. Pereira, 2013, Epac2 mediates cardiac beta1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia, Circulation, 127, 913, 10.1161/CIRCULATIONAHA.12.148619 · DOI
  52. Pereira, 2015, Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes, Proc. Natl. Acad. Sci. U. S. A., 112, 3991, 10.1073/pnas.1416163112 · DOI
  53. Pereira, 2012, Epac enhances excitation-transcription coupling in cardiac myocytes, J. Mol. Cell. Cardiol., 52, 283, 10.1016/j.yjmcc.2011.10.016 · DOI
  54. Qiao, 2002, Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP, J. Biol. Chem., 277, 26581, 10.1074/jbc.M203571200 · DOI
  55. Quesada, 2008, Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes, J. Endocrinol., 199, 5, 10.1677/JOE-08-0290 · DOI
  56. Rehmann, 2012, Epac2: a sulfonylurea receptor?, Biochem. Soc. Trans., 40, 6, 10.1042/BST20110640 · DOI
  57. Rehmann, 2008, Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B, Nature, 455, 124, 10.1038/nature07187 · DOI
  58. Rehmann, 2006, Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state, Nature, 439, 625, 10.1038/nature04468 · DOI
  59. Renstrom, 1997, Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic β-cells, J. Physiol., 502, 105, 10.1111/j.1469-7793.1997.105bl.x · DOI · Paper page
  60. Roscioni, 2008, Epac: effectors and biological functions, Naunyn Schmiedeberg's Arch. Pharmacol., 377, 345, 10.1007/s00210-007-0246-7 · DOI
  61. Sakaba, 2001, Preferential potentiation of fast-releasing synaptic vesicles by cAMP at the calyx of Held, Proc. Natl. Acad. Sci. U. S. A., 98, 331, 10.1073/pnas.98.1.331 · DOI
  62. Schmidt, 2013, Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions, Pharmacol. Rev., 65, 670, 10.1124/pr.110.003707 · DOI
  63. Schmidt, 2001, A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase, Nat. Cell Biol., 3, 1020, 10.1038/ncb1101-1020 · DOI
  64. Schwede, 2015, Structure-guided design of selective Epac1 and Epac2 agonists, PLoS Biol., 13, 10.1371/journal.pbio.1002038 · DOI
  65. Seino, 2011, Dynamics of insulin secretion and the clinical implications for obesity and diabetes, J. Clin. Invest., 121, 2118, 10.1172/JCI45680 · DOI · Paper page
  66. Seino, 2010, GIP and GLP-1, the two incretin hormones: similarities and differences, J. Diabetes Investig., 1, 8, 10.1111/j.2040-1124.2010.00022.x · DOI · Paper page
  67. Shibasaki, 2004, Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis, J. Biol. Chem., 279, 7956, 10.1074/jbc.M309068200 · DOI
  68. Shibasaki, 2007, Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP, Proc. Natl. Acad. Sci. U. S. A., 104, 19333, 10.1073/pnas.0707054104 · DOI · Paper page
  69. Song, 2002, Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon, Oncogene, 21, 8105, 10.1038/sj.onc.1206003 · DOI
  70. Srivastava, 2012, Social, communication, and cortical structural impairments in Epac2-deficient mice, J. Neurosci., 32, 11864, 10.1523/JNEUROSCI.1349-12.2012 · DOI
  71. Srivastava, 2012, An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice, PLoS Biol., 10, 10.1371/journal.pbio.1001350 · DOI
  72. Ster, 2009, Epac mediates PACAP-dependent long-term depression in the hippocampus, J. Physiol., 587, 101, 10.1113/jphysiol.2008.157461 · DOI
  73. Takahashi, 2015, Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion, Diabetes, 64, 1262, 10.2337/db14-0576 · DOI
  74. Takahashi, 2013, Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A, Sci. Signal., 6, 10.1126/scisignal.2004581 · DOI
  75. Thorens, 1992, Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1, Proc. Natl. Acad. Sci. U. S. A., 89, 8641, 10.1073/pnas.89.18.8641 · DOI · Paper page
  76. Tsalkova, 2011, Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs, Assay Drug Dev. Technol., 9, 88, 10.1089/adt.2010.0338 · DOI
  77. Tsuboi, 2003, Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells, Biochem. J., 369, 287, 10.1042/bj20021288 · DOI
  78. Uenishi, 2013, Actin dynamics regulated by the balance of neuronal Wiskott–Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion, J. Biol. Chem., 288, 25851, 10.1074/jbc.M113.464420 · DOI
  79. Ueno, 2001, Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform, Genomics, 78, 91, 10.1006/geno.2001.6641 · DOI · Paper page
  80. Ulucan, 2007, Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy, Am. J. Physiol. Heart Circ. Physiol., 293, H1662, 10.1152/ajpheart.00159.2007 · DOI
  81. Usdin, 1993, Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain, Endocrinology, 133, 2861, 10.1210/endo.133.6.8243312 · DOI · Paper page
  82. Vliem, 2008, 8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue, Chembiochem, 9, 2052, 10.1002/cbic.200800216 · DOI
  83. Wang, 2007, Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion, J. Biol. Chem., 282, 9536, 10.1074/jbc.M610553200 · DOI · Paper page
  84. Yamada, 1995, Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA, Genomics, 29, 773, 10.1006/geno.1995.9937 · DOI
  85. Yang, 2012, EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation, Neuron, 73, 774, 10.1016/j.neuron.2012.02.003 · DOI
  86. Yasuda, 2010, Rim2alpha determines docking and priming states in insulin granule exocytosis, Cell Metab., 12, 117, 10.1016/j.cmet.2010.05.017 · DOI · Paper page
  87. Zhang, 2009, The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs, Science, 325, 607, 10.1126/science.1172256 · DOI
  88. Zhong, 2005, cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction, J. Neurosci., 25, 208, 10.1523/JNEUROSCI.3703-04.2005 · DOI

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Metadata

Authors
Sugawara, K., Shibasaki, T., Takahashi, H., & Seino, S.
Venue
Gene
Publisher
Elsevier BV
Published
2016-01
Volume
575
Issue
2
Pages
577-583
ISSN
0378-1119
DOI
10.1016/j.gene.2015.09.029
PMC
PMC6636354
Cited by
59
References
10
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Institutes of Health (GM089820, GM114833)
  • Ministry of Education, Culture, Sport, Science and Technology (24229007)

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