The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
National trends in antidepressant medication treatment among publicly insured pregnant women
Open accessAbstract
Objective The risk of depression in women is greatest at childbearing age. We sought to examine and explain national trends in antidepressant use in pregnant women.Methods This was a cohort study including pregnant women aged 12-55 who were enrolled in Medicaid during 2000-2007. We examined the proportion of women taking antidepressants during pregnancy by patient characteristics (descriptive), by region (mixed-effects model) and over time (interrupted time series).Results We identified 1,106,757 pregnancies in 47 states; mean age was 23 years, and 60% were nonwhite. Nearly 1 in 12 used an antidepressant during pregnancy. Use was higher for older (11.2% for age ≥30 vs. 7.6% for <30) and white (14.4% vs. 4.0% for nonwhite) women. There was a four- to fivefold difference in rate of antidepressant use among states. Of the 5.3% of women taking antidepressants at conception, 33% and 17% were still on treatment 90 and 180 days, respectively, into pregnancy; an additional 4% began use during pregnancy. Labeled pregnancy-related health advisories did not appear to affect antidepressant use.Conclusions Antidepressant use during pregnancy remains high in this population; treatment patterns vary substantially by patient characteristics and region. Comparative safety and effectiveness data to help inform treatment choices are needed in this setting.
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“Although pharmacological treatment is effective and can be safely utilized during pregnancy under medical supervision, only 2–8% of pregnant women are currently estimated to use antidepressants (23–26).”
From Acceptance, experiences, and needs of hospitalized pregnant women toward an electronic mindfulness-based intervention: A pilot mixed-methods study (2022) · cites this paper as [26]
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Cites
Segmented regression analysis of interrupted time series studies in medication use research
Wagner, A. K., Soumerai, S. B., Zhang, F., & Ross-Degnan, D. (2002) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2002.00430.x · Cited by 3,279 · cited 2×
“This number is not based on estimates of power, but has been suggested because it allows the analyst to adequately evaluate seasonal variation [33].”
BackgroundMethodKaufman, D. W., Kelly, J. P., Rosenberg, L., Anderson, T. E., & Mitchell, A. A. (2002) · JAMA · doi:10.1001/jama.287.3.337 · Cited by 1,845
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.7.979 · Cited by 1,485 · cited 1×
“The lifetime risk of depression in women is 10%–25%, twice that in men [1].”
BackgroundCohort study of depressed mood during pregnancy and after childbirth
Evans, J., Heron, J., Francomb, H., Oke, S., & Golding, J. (2001) · BMJ · doi:10.1136/bmj.323.7307.257 · Cited by 1,273
Cohen, L. S. (2006) · JAMA · doi:10.1001/jama.295.5.499 · Cited by 1,031
Neonatal Abstinence Syndrome after Methadone or Buprenorphine Exposure
Jones, H. E., Kaltenbach, K., Heil, S. H., Stine, S. M., Coyle, M. G., Arria, A. M., O'Grady, K. E., Selby, P., Martin, P. R., & Fischer, G. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005359 · Cited by 986
Hirschfeld, R. M. A. (1997) · JAMA · doi:10.1001/jama.277.4.333 · Cited by 896
Selective Serotonin-Reuptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn
Chambers, C., Hernández–Dı́az, S., Marter, L. J. V., Werler, M. M., Louik, C., Jones, K. L., & Mitchell, A. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052744 · Cited by 877
Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008
Mitchell, A. A., Gilboa, S. M., Werler, M. M., Kelley, K. E., Louik, C., & Hernández–Dı́az, S. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.02.029 · Cited by 813
Birth Outcomes in Pregnant Women Taking Fluoxetine
Chambers, C., Johnson, K. A., Dick, L. M., Felix, R. J., & Jones, K. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351402 · Cited by 735
Prenatal exposure to maternal depression and cortisol influences infant temperament
DAVIS, E. P., GLYNN, L. M., SCHETTER, C. D., HOBEL, C., CHICZ-DEMET, A., & SANDMAN, C. A. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318047b775 · Cited by 628
Prenatal depression effects on the fetus and newborn: a review
Field, T., Diego, M., & Hernandez-Reif, M. (2006) · Infant Behavior and Development · doi:10.1016/j.infbeh.2006.03.003 · Cited by 592
Oberlander, T. F., Warburton, W., Misri, S., Aghajanian, J., & Hertzman, C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.898 · Cited by 551
Perinatal Risks of Untreated Depression during Pregnancy
Bonari, L., Pinto, N., Ahn, E., Einarson, A., Steiner, M. S., & Koren, G. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404901103 · Cited by 534
First-Trimester Use of Selective Serotonin-Reuptake Inhibitors and the Risk of Birth Defects
Louik, C., Lin, A. E., Werler, M. M., Hernández–Dı́az, S., & Mitchell, A. A. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067407 · Cited by 500
Use of Selective Serotonin-Reuptake Inhibitors in Pregnancy and the Risk of Birth Defects
Alwan, S., Reefhuis, J., Rasmussen, S. A., Olney, R. S., & Friedman, J. M. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066584 · Cited by 495
(2003) · PubMed · Cited by 490
Yonkers, K. A., Wisner, K. L., Stewart, D. E., Oberlander, T. F., Dell, D. L., Stotland, N., Ramin, S., Chaudron, L., & Lockwood, C. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.04.003 · Cited by 469
Increasing use of antidepressants in pregnancy
Cooper, W. O., Willy, M. E., Pont, S. J., & Ray, W. A. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.01.033 · Cited by 458
Use of antidepressant medications during pregnancy: a multisite study
Andrade, S. E., Raebel, M. A., Brown, J., Lane, K., Livingston, J., Boudreau, D., Rolnick, S. J., Roblin, D., Smith, D. H., Willy, M. E., et al. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.07.036 · Cited by 403
Recall Accuracy for Prescription Medications: Self-report Compared with Database Information
West, S. L., Savitz, D. A., Koch, G. G., Strom, B. L., Guess, H. A., & Hartzema, A. G. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117563 · Cited by 354
Dietz, P. M., Williams, S. B., Callaghan, W. M., Bachman, D. J., Whitlock, E. P., & Hornbrook, M. C. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111893 · Cited by 350
Neonate Characteristics After Maternal Use of Antidepressants in Late Pregnancy
Källén, B. A. J. (2004) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.158.4.312 · Cited by 296
Bérard, A., Ramos, É., Rey, É., Blais, L., St‐André, M., & Oraichi, D. (2006) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20099 · Cited by 274
Perinatal Outcome Following Third Trimester Exposure to Paroxetine
Costei, A. M., Kozer, E., Ho, T., Ito, S., & Koren, G. (2002) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.156.11.1129 · Cited by 270
Selective serotonin reuptake inhibitors and adverse pregnancy outcomes
Wen, S. W., Yang, Q., Garner, P. R., Fraser, W. D., Olatunbosun, O. A., Nimrod, C. A., & WALKER, M. C. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.02.019 · Cited by 235
Davis, R. L., Rubanowice, D. M., McPhillips, H. A., Raebel, M. A., Andrade, S. E., Smith, D. H., Yood, M. U., & Platt, R. G. (2007) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1462 · Cited by 203
Stewart, D. E. (2011) · New England Journal of Medicine · doi:10.1056/nejmcp1102730 · Cited by 196
Maternal Use of Selective Serotonin Reuptake Inhibitors and Risk of Congenital Malformations
Wogelius, P., Nørgaard, M., Gislum, M., Pedersen, L. H., Munk, E. M., Mortensen, P. B., Lipworth, L., & Sørensen, H. T. (2006) · Epidemiology · doi:10.1097/01.ede.0000239581.76793.ae · Cited by 184
Paroxetine in the first trimester and the prevalence of congenital malformations
Cole, J. A., Ephross, S. A., Cosmatos, I. S., & Walker, A. M. (2007) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1463 · Cited by 163
Predictors and correlates of high levels of depression and anxiety symptoms among children at age 10
Leech, S. L., Larkby, C. A., Day, R., & Day, N. L. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000184930.18552.4d · Cited by 144
A Life Course Perspective on Depressive Symptoms in Mid-Pregnancy
Holzman, C., Eyster, J. T., Tiedje, L. B., Roman, L. A., Seagull, E. A. W., & Rahbar, M. H. (2006) · Maternal and Child Health Journal · doi:10.1007/s10995-005-0044-0 · Cited by 114
West, S. L., Strom, B. L., Freundlich, B., Normand, E. H., Koch, G. G., & Savitz, D. A. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90021-3 · Cited by 79
Noyes, K., Liu, H., Lyness, J. M., & Friedman, B. (2011) · Psychiatric Services · doi:10.1176/ps.62.10.pss6210_1159 · Cited by 76
Toh, S., Mitchell, A. A., Werler, M. M., & Hernández–Dı́az, S. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm367 · Cited by 69
McKenzie, D. A., Semradek, J. A., McFarland, B. H., Mullooly, J. P., & McCamant, L. E. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00259-6 · Cited by 61
Stewart, D. E. (2012) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e31824b6f88 · Cited by 47
Diagnosis of Depression and Use of Antidepressant Pharmacotherapy Among Adults in the United States
Sclar, D. A., Robison, L. M., Schmidt, J. M., Bowen, K. A., Castillo, L. V., & Oganov, A. M. (2012) · Clinical Drug Investigation · doi:10.2165/11598950-000000000-00000 · Cited by 40
Flagged first, then by citations
Research works printed but not linked: 2
- Palmsten, 2011, Medicaid Analytic eXtract for studies of drug safety during pregnancy, Pharmacoepidemiol Drug Saf, 20, S266
- Margulis, 2010, A claims-based algorithm to estimate the date of the last menstrual period, Pharmacoepidemiol Drug Saf, 19, s300
Cited by
Sorted by citations
Jarde, A., Morais, M., Kingston, D., Giallo, R., MacQueen, G. M., Giglia, L., Beyene, J., Wang, Y., & McDonald, S. D. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0934 · Cited by 616
Jandoc, R., Burden, A. M., Mamdani, M., Lévesque, L. E., & Cadarette, S. M. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2014.12.018 · Cited by 474
Antidepressant Use in Pregnancy and the Risk of Cardiac Defects
Huybrechts, K. F., Palmsten, K. K., Avorn, J., Cohen, L. S., Holmes, L. B., Franklin, J. M., Mogun, H., Levin, R., Kowal, M. K., Setoguchi, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312828 · Cited by 415
Rosenfeld, C. S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24603 · Cited by 280
Malm, H., Brown, A. S., Gissler, M., Gyllenberg, D., Hinkka-Yli-Salomäki, S., McKeague, I. W., Weissman, M., Wickramaratne, P., Artama, M., Gingrich, J. A., et al. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.02.013 · Cited by 206
Metadata
- Authors
- Huybrechts, K. F., Palmsten, K., Mogun, H., Kowal, M., Avorn, J., Setoguchi-Iwata, S., & Hernández-Díaz, S.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Duke University (US)
- Corresponding author
- Huybrechts, Krista F.
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 35
- Issue
- 3
- Pages
- 265-271
- ISSN
- 0163-8343 (ISSN-L)
- PMC
- PMC4077674
- OpenAlex
- W2114602840
- Cited by
- 161
- References
- 38
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 13 · 2020: 19 · 2019: 16 · 2018: 16 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 3
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Child Health and Human Development
- National Institutes of Health
- Agency for Healthcare Research and Quality (T32HD060454, R01 HSO18533)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- antidepressant use in pregnancy, maternal depression, Medicaid, regional variation in treatment, racial disparities, temporal trends
- MeSH terms
- Adolescent, Adult, Antidepressive Agents, Child, Depressive Disorder, Female, Humans, Medicaid, Middle Aged, Pregnancy, Pregnancy Complications, United States, Cohort Studies, Young Adult
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