The prognosis of bodily distress syndrome: a cohort study in primary care
Open accessAbstract
OBJECTIVE: Bodily distress syndrome (BDS) is a newly proposed diagnosis for functional disorders. The diagnosis is based on empirical research, but little is known about the course of the disease. We aimed to study the prognosis in terms of diagnosis stability over time. METHOD: A longitudinal study of 1356 primary care patients with 2-year follow-up was conducted in the Central Denmark Region. Data were obtained from family physician registration forms, patient questionnaires (including a BDS checklist) and nationwide registries. Complete data were available for 1001 patients (73.8%). RESULTS: Overall, 146 persons [14.6%, 95% confidence interval (CI): 12.5-16.9] fulfilled the criteria for BDS at baseline and 142 persons (14.2%, CI: 12.1-16.5) at follow-up. Among study participants with BDS at baseline, 56.8% (CI: 48.4-65.0) also had BDS at follow-up. Multiorgan BDS tended to be more persistent (81.8%, CI: 48.2-97.7) than single-organ BDS (54.8%, CI: 46.0-63.4). Patients with BDS had fewer socioeconomic resources, experienced more emotional distress, and used more opioids and medical services. CONCLUSIONS: BDS is a common clinical condition being prone to chronicity; one in seven primary care patients met the criteria for BDS, and more than half of these patients still suffered from BDS 2 years later.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
The Danish Civil Registration System
Pedersen, C. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810387965 · Cited by 4,713 · see citing works
The Danish National Patient Register
Lynge, E., Sandegaard, J. L., & Rebolj, M. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811401482 · Cited by 3,968 · see citing works
The Danish National Prescription Registry
Wallach‐Kildemoes, H., Sørensen, H. T., & Hallas, J. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810394717 · Cited by 2,470 · see citing works
The Danish Psychiatric Central Research Register
Mors, O., Perto, G. P., & Mortensen, P. B. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810395825 · Cited by 1,589 · see citing works
Thygesen, L. C., Daasnes, C., Thaulow, I., & Brønnum‐Hansen, H. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811399956 · Cited by 1,089 · see citing works
BARSKY, A. J., Orav, E. J., & Bates, D. W. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.8.903 · Cited by 912 · see citing works
International Classification of Primary Care
Bentsen, B. G. (1986) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813438609013970 · Cited by 900 · see citing works
The Danish National Health Service Register
Andersen, J. S., Olivarius, N. D. F., & Krasnik, A. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810394718 · Cited by 892 · see citing works
The epidemiology of irritable bowel syndrome
Card, T., Canavan, C., & West, J. (2014) · Clinical Epidemiology · doi:10.2147/clep.s40245 · Cited by 889 · see citing works
Fink, P., & Schröder, A. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.02.004 · Cited by 334 · see citing works
Self-citationFink, P., Toft, T., Hansen, M. S., Ørnbøl, E., & Olesen, F. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31802e46eb · Cited by 314 · see citing works
Resource Utilization of Patients With Hypochondriacal Health Anxiety and Somatization
Barsky, A. J., Ettner, S. L., Horsky, J., & Bates, D. W. (2001) · Medical Care · doi:10.1097/00005650-200107000-00007 · Cited by 309 · see citing works
The prognosis of chronic fatigue and chronic fatigue syndrome: a systematic review
Joyce, J. (1997) · QJM · doi:10.1093/qjmed/90.3.223 · Cited by 302 · see citing works
Toft, T., Fink, P., Oernboel, E., Christensen, K., Frostholm, L., & Olesen, F. (2005) · Psychological Medicine · doi:10.1017/s0033291705004459 · Cited by 253 · see citing works
A brief case-finding questionnaire for common mental disorders: the CMDQ
Christensen, K. S., Fink, P., Toft, T., Frostholm, L., Ørnbøl, E., & Olesen, F. (2005) · Family Practice · doi:10.1093/fampra/cmi025 · Cited by 181 · see citing works
Self-citationChronic widespread pain in the population: a seven year follow up study
Papageorgiou, A. C., Silman, A. J., & Macfarlane, G. J. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.12.1071 · Cited by 164 · see citing works
Lieb, R., Zimmermann, P., Friis, R. H., Höfler, M., Tholen, S., & Wïttchen, H. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00686-7 · Cited by 135 · see citing works
Epidemiology of irritable bowel syndrome
Schmulson, M. J., & López‐Colombo, A. (2013) · doi:10.2217/ebo.13.462 · Cited by 130 · see citing works
A new questionnaire to identify bodily distress in primary care: the 'BDS checklist
Budtz-Lilly, A., Fink, P., Ørnbøl, E., Vestergaard, M., Moth, G., Christensen, K. S., & Rosendal, M. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.03.006 · Cited by 129 · see citing works
The natural history of chronic pain in the community: a better prognosis than in the clinic?
Macfarlane, G. J., Thomas, E., Papageorgiou, A. C., Schollum, J. B. W., Croft, P. R., & Silman, A. J. (1996) · PubMed · Cited by 123 · see citing works
Medically Unexplained Symptoms, Somatisation and Bodily Distress
(2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511977862 · Cited by 111 · see citing works
Latent class analysis of functional somatic symptoms in a population-based sample of twins
Kato, K., Sullivan, P. F., & Pedersen, N. L. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.01.010 · Cited by 95 · see citing works
Cognitive–behavioural group treatment for a range of functional somatic syndromes: Randomised trial
Schröder, A., Rehfeld, E., Ørnbøl, E., Sharpe, M., Licht, R. W., & Fink, P. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.098681 · Cited by 95 · see citing works
Self-citationReasons for encounter and disease patterns in Danish primary care: Changes over 16 years
Moth, G., Olesen, F., & Vedsted, P. (2012) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2012.679230 · Cited by 89 · see citing works
Detecting mental disorders in general hospitals by the SCL-8 scale
Fink, P., Ørnbøl, E., Hansen, M. S., Søndergaard, L., & De Jonge, P. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00071-0 · Cited by 66 · see citing works
Course and prediction of somatoform disorder and medically unexplained symptoms in primary care
Steinbrecher, N., & Hiller, W. (2011) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2011.05.002 · Cited by 59 · see citing works
Lam, T. P., Goldberg, D. P., Dowell, A. C., Fortes, S., Mbatia, J. K., Minhas, F. A., & Klinkman, M. S. (2013) · Family Practice · doi:10.1093/fampra/cms037 · Cited by 59 · see citing works
Budtz-Lilly, A., Vestergaard, M., Fink, P., Carlsen, A. H., & Rosendal, M. (2015) · British Journal of General Practice · doi:10.3399/bjgp15x686545 · Cited by 51 · see citing works
Course and predictors of medically unexplained pain symptoms in the general population
Leiknes, K. A., Finset, A., Moum, T., & Sandanger, I. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.08.009 · Cited by 48 · see citing works
Rosendal, M., Vedsted, P., Christensen, K. S., & Moth, G. (2013) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2012.751688 · Cited by 43 · see citing works
Current state of management and organisation of care
Fink, P., Burton, C., De Bie, J., Söllner, W., & Fritzsche, K. (2011) · Medically Unexplained Symptoms, Somatisation and Bodily Distress · doi:10.1017/cbo9780511977862.005 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Petersen, M. W., Schröder, A., Jørgensen, T., Ørnbøl, E., Meinertz Dantoft, T., Eliasen, M., Benros, M. E., & Fink, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-60318-6 · Cited by 170 · see citing works
Rosendal, M., Olde Hartman, T. C., Aamland, A., van der Horst, H., Lucassen, P., Budtz-Lilly, A., & Burton, C. (2017) · BMC Family Practice · doi:10.1186/s12875-017-0592-6 · Cited by 129 · see citing works
Bodily distress syndrome: a new diagnosis for functional disorders in primary care?
Budtz-Lilly, A., Schröder, A., Rask, M. T., Fink, P., Vestergaard, M., & Rosendal, M. (2015) · BMC Family Practice · doi:10.1186/s12875-015-0393-8 · Cited by 115 · see citing works
Roenneberg, C., Sattel, H., Schaefert, R., Henningsen, P., & Hausteiner-Wiehle, C. (2019) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2019.0553 · Cited by 111 · see citing works
Duration of untreated illness in patients with somatoform disorders
Herzog, A., Mora, M. C. S., Jordan, P., & Löwe, B. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.01.011 · Cited by 54 · see citing works
Dessel, N. C.-V., van der Wouden, J. C., Hoekstra, T., Dekker, J., & van der Horst, H. E. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.11.012 · Cited by 34 · see citing works
van der Sluijs, J. F. V. E., ten Have, M., de Graaf, R., Rijnders, C. A. T., van Marwijk, H., & Feltz-Cornelis, C. M. V. D. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00613 · Cited by 70 · see citing works
Limburg, K., Sattel, H. C., Dinkel, A., Radziej, K., Becker‐Bense, S., & Lahmann, C. (2017) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2017.05.003 · Cited by 32 · see citing works
Eliasen, M., Schröder, A., Fink, P., Kreiner, S., Dantoft, T. M., Poulsen, C. H., Petersen, M. W., Eplov, L. F., Skovbjerg, S., & Jørgensen, T. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.03.002 · Cited by 29 · see citing works
Female sex and femininity independently associate with common somatic symptom trajectories
Ballering, A., Wardenaar, K. J., Hartman, T. O., & Rosmalen, J. G. M. (2020) · Psychological Medicine · doi:10.1017/s0033291720004043 · Cited by 29 · see citing works
Schumacher, S., Rief, W., Klaus, K., Brähler, E., & Mewes, R. (2017) · Psychological Medicine · doi:10.1017/s0033291717000149 · Cited by 28 · see citing works
Schröder, A., Ørnbøl, E., Jensen, J. S., Sharpe, M., & Fink, P. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.01.005 · Cited by 25 · see citing works
Pedersen, H. F., Agger, J. L., Frostholm, L., Jensen, J. S., Ørnbøl, E., Fink, P., & Schröder, A. (2019) · Psychological Medicine · doi:10.1017/s0033291718001666 · Cited by 24 · see citing works
Münker, L., Rimvall, M. K., Frostholm, L., Ørnbøl, E., Wellnitz, K. B., Rosmalen, J. G. M., & Rask, C. U. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.111064 · Cited by 16 · see citing works
Is psychotherapy for functional somatic syndromes harmful? A mixed methods study on negative effects
Holsting, A. F., Pedersen, H. F., Rask, M. T., Frostholm, L., & Schröder, A. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.05.010 · Cited by 13 · see citing works
Petersen, M. W., Skovenborg, E. L., Rask, C. U., Høeg, M. D., Ørnbøl, E., & Schröder, A. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.11.005 · Cited by 13 · see citing works
Rasmussen, S., Jensen, C. T., Rosendal, M., Vægter, H. B., Søndergaard, J., & Jarbøl, D. E. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.109941 · Cited by 13 · see citing works
Hennemann, S., Böhme, K., Baumeister, H., Bendig, E., Kleinstäuber, M., Ebert, D. D., & Witthöft, M. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-024929 · Cited by 12 · see citing works
Adibi, P., Ani, A., Vaez, A., Hadizadeh, F., Snieder, H., & Roohafza, H. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-048941 · Cited by 11 · see citing works
Non-Cardiac Chest Pain as a Persistent Physical Symptom: Psychological Distress and Workability
Flóvenz, S. Ó., Salkovskis, P. M., Svansdóttir, E., Karlsson, H. D., Andersen, K. K., & Sigurðsson, J. F. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20032521 · Cited by 9 · see citing works
„Funktionelle Körperbeschwerden“: Klinisch relevante Leitlinien-Empfehlungen
Roenneberg, C., Hausteiner‐Wiehle, C., & Henningsen, P. (2020) · PSYCH up2date · doi:10.1055/a-0901-5103 · Cited by 7 · see citing works
Raasthøj, I., Rasmussen, S., Carstensen, T. B. W., Wehberg, S., Rosendal, M., & Jarbøl, D. E. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.111140 · Cited by 7 · see citing works
Madsen, M. M., Trolle, C., Fynne, L. V., Ørnbøl, E., Fink, P., & Gormsen, L. K. (2024) · PLoS ONE · doi:10.1371/journal.pone.0307057 · Cited by 5 · see citing works
Barends, H., van der Horst, H. E., van der Wouden, J. C., Dessel, N. C.-V., Dekker, J., & Hoekstra, T. (2025) · BMJ Open · doi:10.1136/bmjopen-2023-083276 · Cited by 5 · see citing works
Raasthøj, I., Jarbøl, D. E., Rasmussen, S., Wehberg, S., Sætre, L. M. S., Rosendal, M., & Carstensen, T. B. W. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.111832 · Cited by 5 · see citing works
Flóvenz, S. Ó., Broddadóttir, E., Brynjólfsson, S., Agnarsdóttir, A. S., Primary Health Care of the Capital area, I., Salkovskis, P. M., & Sigurðsson, J. F. (2021) · Læknablaðið · doi:10.17992/lbl.2021.02.620 · Cited by 5 · see citing works
Pedersen, H. F., Lamm, T. T., Fink, P., Ørnbøl, E., & Frostholm, L. (2023) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2023.101069 · Cited by 4 · see citing works
“2 reduced quality of life and is associated with substantial socioeconomic costs, involving expensive diagnostic examinations, sick leave, and long-term disability [2,13,14].”
BackgroundLi, L., Zhang, Y., Feng, S., Cao, Y., Li, H., Li, X., Ji, Y., Sun, H., Mao, X., Zhou, B., et al. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.03.014 · Cited by 4 · see citing works
Fluctuation of functional somatic disorders in a population-based cohort. The DanFunD study
Schovsbo, S. U., Kårhus, L. L., Bjerregaard, A. A., Petersen, M. W., Frostholm, L., Fink, P., Carstensen, T. B. W., Eplov, L. F., Benros, M. E., Brix, S., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0312031 · Cited by 4 · see citing works
Lipid metabolism and functional somatic disorders in the general population. The DanFunD study
Jørgensen, T., Jacobsen, R. K., Sæbye, D., Petersen, M. W., Fink, P., Gormsen, L. K., Linneberg, A. R., Bjerregaard, A. A., Schovsbo, S. U., Benros, M. E., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0296799 · Cited by 4 · see citing works
Jespersen, C. P., Pedersen, H. F., Kleinstäuber, M., Fink, P., Wellnitz, K. B., Ørnbøl, E., Schröder, A., Agger, J. L., Vase, L., Finnerup, N. B., et al. (2024) · Contemporary Clinical Trials · doi:10.1016/j.cct.2024.107524 · Cited by 2 · see citing works
Raasthøj, I., Jarbøl, D. E., Rasmussen, S., Carstensen, T. B. W., & Rosendal, M. (2024) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2024.10.005 · Cited by 2 · see citing works
Somatoforme Störungen - der Körper spiegelt die Last der Seele
Kunzel, H. E. (2022) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-022-1802-2 · Cited by 2 · see citing works
Agger, J. L., Schröder, A., Ørnbøl, E., Jensen, J. S., Pedersen, H. F., Fink, P., & Gormsen, L. K. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114474 · Cited by 1 · see citing works
Brund, R. B. K., Jensen, L. S., Gladvind, K. M., & Fonager, K. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111561 · Cited by 1 · see citing works
Astenia funcional o síndrome de fatiga crónica
Kachaner, A., & Ranque, B. (2021) · EMC - Tratado de Medicina · doi:10.1016/s1636-5410(21)45104-4
Unerklärte Körperbeschwerden und somatoforme Störungen
Kleinstäuber, M., Thomas, P., Witthöft, M., & Hiller, W. F. A. (2017) · Springer eBooks · doi:10.1007/978-3-662-54664-2_1
Medically Unexplained Symptoms
Dowrick, C. F., & Rosendal, M. (2018) · Cambridge University Press eBooks · doi:10.1017/9781911623038.011
Ballering, A. (2024) · doi:10.33612/diss.902736104
Persistent Somatic Symptoms, Somatoform Disorders, and Somatic Symptom Disorders
Kleinstäuber, M., Thomas, P., Witthöft, M., & Hiller, W. (2025) · Springer eBooks · doi:10.1007/978-3-662-69726-9_1
Landmark, L., Sunde, H. F., Fors, E. A., Kennair, L. E. O., & Rème, S. E. (2026) · European Journal of Pain · doi:10.1002/ejp.70212
- Authors
- Budtz-Lilly, A., Vestergaard, M., Fink, P., Carlsen, A. H., & Rosendal, M.
- Affiliations
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Corresponding author
- Budtz-Lilly, Anna
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 37
- Issue
- 6
- Pages
- 560-566
- ISSN
- 0163-8343 (ISSN-L)
- OpenAlex
- W2127479911
- Cited by
- 41
- References
- 31
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 8 · 2015: 1
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- pure.au.dk
- Licence
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Danish Research Foundation for General Practice
- Committee for Quality Improvement and Continuing Medical Education in the Central Denmark Region
- Primary Health Care Foundation of the Central Denmark Region
- Health Research Fund of the Central Denmark Region
- TrygFonden
- Lundbeck Foundation (R155-2012-11280)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- bodily distress syndrome, prognosis, functional disorders, chronicity, primary care patients, socioeconomic resources, emotional distress, opioid use, health care utilization
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Denmark, Female, Humans, Longitudinal Studies, Male, Middle Aged, Primary Health Care, Prognosis, Surveys and Questionnaires, Somatoform Disorders, Young Adult, Checklist
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review