Expression patterns of Yes-associated protein 1 in the developing mouse liver
Abstract
The Hippo signaling pathway regulates many cellular processes, but has been specifically associated with control organ size and tumor growth. Yes-associated protein 1 (YAP1) is a transcriptional cofactor, in the Hippo pathway, that regulates gene expression when localized in the nucleus. Elevated expression of YAP1 in adult mouse liver leads to hepatomegaly and can cause hepatocellular carcinoma; while the loss of function studies reveal its importance in regulating cholangiocyte development. Here, we report the expression of YAP1 in mouse embryonic and postnatal hepatic cells, using AFP-GFP transgenic mice to identify the hepatocyte lineage. At embryonic day (E) 8.5, YAP1 is highly expressed in the endoderm, but is not present in the nucleus. Between E9.5-12.5, hepatic cells display low levels of nuclear and non-nuclear YAP1. The nuclear expression of YAP1 is first detected in a small subset of hepatic cells starting at E13.5 when the hepatoblasts begin to differentiate into hepatocytes and cholangiocytes. At E18.5, nuclear YAP1 is nearly undetectable in hepatoblasts and hepatocytes, but enriched within the nuclei of cholangiocytes. These levels remain similar postnatally, consistent with the role of YAP1 in cholangiocyte specification and maintenance.
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- Authors
- Wei, W., Lotto, J., & Hoodless, P. A.
- Affiliations
- BC Cancer Agency (CA)
- Corresponding author
- Hoodless, Pamela A.
- Venue
- Gene Expression Patterns
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 29
- Pages
- 10-17
- ISSN
- 1567-133X (ISSN-L)
- OpenAlex
- W2795563643
- Semantic Scholar
- 5f9e51d01105cb3a6169d49a57acbf9625e224ea
- Cited by
- 3
- References
- 37
- Citations by year
- 2022: 1 · 2020: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene Expression Patterns (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Society (FRN 21466)
- Canadian Institutes of Health Research (FRN 376243)
- Natural Sciences and Engineering Research Council of Canada (FRN RGPIN-2017-04917, RGPIN-2012-418298)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- YAP, Hippo signaling pathway, liver development, hepatoblast differentiation, nuclear localization, embryonic endoderm, hepatomegaly, hepatocellular carcinoma, mouse embryo
- MeSH terms
- YAP-Signaling Proteins, alpha-Fetoproteins, Animals, Cell Differentiation, Cells, Cultured, Epithelial Cells, Humans, Liver, Mice, Transgenic, Phosphoproteins, Signal Transduction, Gene Expression Regulation, Developmental, Cell Cycle Proteins, Hepatocytes, Adaptor Proteins, Signal Transducing, Cell Proliferation, Green Fluorescent Proteins, Mice
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