Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis
Open accessAbstract
Malignant tumors develop through multiple steps of initiation and progression, and tumor initiation is of singular importance in tumor prevention, diagnosis, and treatment. However, the molecular mechanism whereby a signaling network of interacting pathways restrains proliferation in normal cells and prevents tumor initiation is still poorly understood. Here, we have reported that the Hippo, Wnt/β-catenin, and Notch pathways form an interacting network to maintain liver size and suppress hepatocellular carcinoma (HCC). Ablation of the mammalian Hippo kinases Mst1 and Mst2 in liver led to rapid HCC formation and activated Yes-associated protein/WW domain containing transcription regulator 1 (YAP/TAZ), STAT3, Wnt/β-catenin, and Notch signaling. Previous work has shown that abnormal activation of these downstream pathways can lead to HCC. Rigorous genetic experiments revealed that Notch signaling forms a positive feedback loop with the Hippo signaling effector YAP/TAZ to promote severe hepatomegaly and rapid HCC initiation and progression. Surprisingly, we found that Wnt/β-catenin signaling activation suppressed HCC formation by inhibiting the positive feedback loop between YAP/TAZ and Notch signaling. Furthermore, we found that STAT3 in hepatocytes is dispensable for HCC formation when mammalian sterile 20-like kinase 1 and 2 (Mst1 and Mst2) were removed. The molecular network we have identified provides insights into HCC molecular classifications and therapeutic developments for the treatment of liver tumors caused by distinct genetic mutations.
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Notch signaling is a mediator of the Hippo/YAP pathway; YAP activation increases Notch receptor expression, triggering Notch signaling and translocation of the Notch intracellular domain into the nucleus.
“Notch signaling is also considered a mediator of the Hippo/YAP (Yes-Associated Protein) pathway. The activation of YAP leads to an increase in Notch receptor expression, which in turn triggers Notch signaling and translocation of Notch intracellular domain into the nucleus[57].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [57]
The Results (page not provided) report that YAP or TAZ overexpression increased JAG1 expression and Notch signaling activity, supporting the link between Hippo/YAP and Notch. But JAG1 is the ligand, not a Notch receptor; the cited passages also do not establish that YAP activation causes NICD to translocate into the nucleus. (LLM, conf=0.88)
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- Authors
- Kim, W., Khan, S. K., Gvozdenovic-Jeremic, J., Kim, Y., Dahlman, J., Kim, H., Park, O., Ishitani, T., Jho, E.-H., Gao, B., & Yang, Y.
- Affiliations
- National Institutes of Health (US)
- University of Seoul (KR)
- Kyushu University (JP)
- Venue
- Journal of Clinical Investigation
- Published
- 2016-11-21
- Volume
- 127
- Issue
- 1
- Pages
- 137-152
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC5199712
- OpenAlex
- W2556760701
- Cited by
- 244
- References
- 82
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 23 · 2023: 31 · 2022: 29 · 2021: 37 · 2020: 34 · 2019: 22 · 2018: 26 · 2017: 9
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Human Genome Research Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- Hippo signaling pathway, Wnt/β-catenin signaling, Notch signaling, hepatocellular carcinoma, hepatocarcinogenesis, YAP/TAZ, STAT3, MST1, MST2, hepatomegaly, tumor initiation, signaling networks
- MeSH terms
- Hippo Signaling Pathway, Serine-Threonine Kinase 3, YAP-Signaling Proteins, Hippo Kinases, Animals, Carcinoma, Hepatocellular, Liver Neoplasms, Experimental, Phosphoproteins, Proto-Oncogene Proteins, Hepatocyte Growth Factor, Protein Serine-Threonine Kinases, Mice, Knockout, Cell Cycle Proteins, Adaptor Proteins, Signal Transducing, STAT3 Transcription Factor, beta Catenin, Mice, Receptors, Notch, Wnt Signaling Pathway
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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