The DOI matches its Crossref record; 67 of the 71 references it cites were found in a registry or an index.
Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets
Abstract
Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of extracellular matrix (ECM) in the perisinusoidal space and it is a major problem in chronic liver diseases. Phenotypic activation of hepatic stellate cells (HSC) plays a central role in the progression of hepatic fibrosis. Retardation of proliferation and clearance of activated HSCs from the injured liver is an appropriate therapeutic strategy for the resolution and treatment of hepatic fibrosis. Clearance of activated HSCs from the injured liver by autophagy inhibitors, proapoptotic agents and senescence inducers with the high affinity toward the activated HSCs may be the novel therapeutic strategy for the treatment of hepatic fibrosis in the near future.
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In the citing paper
“Activated hepatic stellate cells are the major functional population during liver fibrogenesis.154”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [154]
Citations
Cites
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Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909
Senescence of Activated Stellate Cells Limits Liver Fibrosis
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Mechanisms of hepatic fibrogenesis
Lee, U. E., & Friedman, S. L. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.02.005 · Cited by 923
Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870
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Research works printed but not linked: 1
- Ezhilarasan, 2014, Silibinin treatment to hepatic stellate cells: an exploration of apoptosis and cellular senescence, J Pharm Res, 8, 1126
Cited by
Sorted by citations
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443
“Activated hepatic stellate cells are the major functional population during liver fibrogenesis.(154) During senescence, their replication, immunerecruiting signals, and clearance are important for the regulation of liver fibrogenesis.”
BackgroundEzhilarasan, D. (2021) · Toxicology · doi:10.1016/j.tox.2021.152840 · Cited by 196
Self-citationFerroptosis and Liver Fibrosis
Pan, Q., Luo, Y., Xia, Q., & He, K. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.62903 · Cited by 155
MicroRNA interplay between hepatic stellate cell quiescence and activation
Ezhilarasan, D. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173507 · Cited by 129
Self-citationRegulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
Blokland, K. E. C., Pouwels, S. D., Schuliga, M. J., Knight, D. A., & Burgess, J. K. (2020) · Clinical Science · doi:10.1042/cs20190893 · Cited by 132
Metadata
- Authors
- Ezhilarasan, D., Sokal, E., & Najimi, M.
- Affiliations
- Saveetha University (IN)
- UCLouvain (BE)
- Corresponding author
- Ezhilarasan, Devaraj
- Venue
- Hepatobiliary & Pancreatic Diseases International
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 17
- Issue
- 3
- Pages
- 192-197
- ISSN
- 2352-9377 (ISSN-L)
- 1499-3872
- OpenAlex
- W2802633545
- Cited by
- 204
- References
- 71
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 16 · 2023: 27 · 2022: 28 · 2021: 64 · 2020: 32 · 2019: 10
- FWCI
- 16.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatobiliary & pancreatic diseases international (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- liver fibrosis, hepatic stellate cells, hepatic stellate cell activation, extracellular matrix accumulation, chronic liver disease, autophagy inhibitors, cellular senescence, antifibrotic therapy
- MeSH terms
- Animals, Autophagy, Extracellular Matrix, Humans, Liver, Liver Cirrhosis, Phenotype, Signal Transduction, Cellular Senescence, Apoptosis, Cell Proliferation, Hepatic Stellate Cells, Myofibroblasts
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