Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets

Cellular senescence: when bad things happen to good cells

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Remodelling the extracellular matrix in development and disease

Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367

Mechanisms of hepatic stellate cell activation

Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909

Senescence of Activated Stellate Cells Limits Liver Fibrosis

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The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

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Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors

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Mechanisms of hepatic fibrogenesis

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Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.

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Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues

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Inflammation and aging: signaling pathways and intervention therapies

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443

Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

Ezhilarasan, D. (2021) · Toxicology · doi:10.1016/j.tox.2021.152840 · Cited by 196

Ferroptosis and Liver Fibrosis

Pan, Q., Luo, Y., Xia, Q., & He, K. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.62903 · Cited by 155

MicroRNA interplay between hepatic stellate cell quiescence and activation

Ezhilarasan, D. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173507 · Cited by 129

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

Blokland, K. E. C., Pouwels, S. D., Schuliga, M. J., Knight, D. A., & Burgess, J. K. (2020) · Clinical Science · doi:10.1042/cs20190893 · Cited by 132

Human biomimetic liver microphysiology systems in drug development and precision medicine

Gough, A., Soto-Gutierrez, A., Vernetti, L., Ebrahimkhani, M. R., Stern, A. M., & Taylor, D. L. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00386-1 · Cited by 117

Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models

Ezhilarasan, D. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104093 · Cited by 107

Critical role of estrogen in the progression of chronic liver diseases

Ezhilarasan, D. (2020) · Hepatobiliary & Pancreatic Diseases International · doi:10.1016/j.hbpd.2020.03.011 · Cited by 96

Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents

Yan, L., Lu, Y., & Li, X. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2019.1641508 · Cited by 99

Hepatoprotection and hepatotoxicity of Chinese herb Rhubarb (Dahuang): How to properly control the “General (Jiang Jun)” in Chinese medical herb

Zhuang, T., Gu, X., Zhou, N., Ding, L., Yang, L., & Zhou, M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110224 · Cited by 78

Hepatic stellate cells in the injured liver: Perspectives beyond hepatic fibrosis

Ezhilarasan, D. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30582 · Cited by 79

β-Sitosterol attenuates carbon tetrachloride–induced oxidative stress and chronic liver injury in rats

Ezhilarasan, D., Roy, A., Veeraragavan, G. R., Magesh, A., Sleeba, A. V., Arivarasu, L., & Brundha, M. P. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01810-8 · Cited by 72

Extracellular vesicles‐derived miR‐150‐5p secreted by adipose‐derived mesenchymal stem cells inhibits CXCL1 expression to attenuate hepatic fibrosis

Du, Z., Wu, T., Liu, L., Luo, B., & Wei, C. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16119 · Cited by 70

Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases

Lu, C., Jiang, Y., Xu, W., & Bao, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05669-4 · Cited by 80

Liver fibrosis: Extracellular vesicles mediated intercellular communication in perisinusoidal space

Ezhilarasan, D., Perumal, E., Raghunandhakumar, S., & Najimi, M. (2021) · Hepatology · doi:10.1002/hep.32239 · Cited by 66

Anti-fibrotic treatments for chronic liver diseases: The present and the future

Odagiri, N., Matsubara, T., Sato-Matsubara, M., Fujii, H., Enomoto, M., & Kawada, N. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0187 · Cited by 64

Nanotechnology in Drug Delivery for Liver Fibrosis

Gu, L., Zhang, F., Wu, J., & Zhuge, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.804396 · Cited by 61

Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells

Ezhilarasan, D. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220949148 · Cited by 54

Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases

Ezhilarasan, D. (2021) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2021.04.010 · Cited by 46

Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms

Ezhilarasan, D. (2023) · Drug Metabolism Reviews · doi:10.1080/03602532.2023.2215478 · Cited by 47

Rhus chinensis Mill. fruits prevent high-fat/ethanol diet-induced alcoholic fatty liver in rats via AMPK/SREBP-1/FAS signaling pathway

Wu, Z., Ma, Y., Gong, X., Zhang, Y., Zhao, L., Cheng, G., & Cai, S. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103498 · Cited by 43

Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases

Udomsinprasert, W., Sobhonslidsuk, A., Jittikoon, J., Honsawek, S., & Chaikledkaew, U. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1992385 · Cited by 41

H3K18 lactylation accelerates liver fibrosis progression through facilitating SOX9 transcription

Wu, S., Li, J., & Zhan, Y. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114135 · Cited by 43

Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells

Li, Z.-B., Jiang, L., Ni, J., Xu, Y.-H., Liu, F., Liu, W., Wang, S.-G., Liu, Z., & Wang, C.-Y. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01044-9 · Cited by 37

Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2

Ban, D., Hua, S., Zhang, W., Shen, C., Miao, X., & Liu, W. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0179-4 · Cited by 36

The Phenylethanol Glycoside Liposome Inhibits PDGF-Induced HSC Activation via Regulation of the FAK/PI3K/Akt Signaling Pathway

Zhang, S.-L., Ma, L., Zhao, J., You, S., Ma, X., Ye, X., & Liu, T. (2019) · Molecules · doi:10.3390/molecules24183282 · Cited by 35

S100 Proteins in Fatty Liver Disease and Hepatocellular Carcinoma

Delangre, E., Oppliger, E., Berkcan, S., Gjorgjieva, M., de Sousa, M. C., & Foti, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911030 · Cited by 32

Evaluation of Pancreatic Fibrosis Grading by Multiparametric Quantitative Magnetic Resonance Imaging

Liu, C., Shi, Y., Lan, G., Xu, Y., & Yang, F. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27626 · Cited by 33

Sequential delivery for hepatic fibrosis treatment based on carvedilol loaded star-like nanozyme

Lü, Q., Zhou, Y., Xu, M., Liang, X., Jing, H., Wang, X., & Li, N. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.033 · Cited by 32

Therapeutic implications of targeting autophagy and TGF-β crosstalk for the treatment of liver fibrosis

Siapoush, S., Rezaei, R., Alavifard, H., Hatami, B., Zali, M. R., Vosough, M., Lorzadeh, S., Łoś, M., Baghaei, K., & Ghavami, S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121894 · Cited by 34

Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy

Hofschröer, V., Najder, K., Rugi, M., Bouazzi, R., Cozzolino, M., Arcangeli, A., Panyi, G., & Schwab, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.586599 · Cited by 33

Galectin-3 and Severity of Liver Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease

Sotoudeheian, M. (2024) · Protein and Peptide Letters · doi:10.2174/0109298665301698240404061300 · Cited by 32

Sesamol as a potential candidate for the treatment of hepatic fibrosis, based on its regulation of FXR/LXR axis-mediated inhibition of autophagy through crosstalk between hepatic cells and macrophage

Jiang, Y., Hou, L., Dou, J., Xuan, M., Cui, Z., Lian, L., Nan, J., & Wu, Y. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155145 · Cited by 29

Antifibrotic effect of methylated quercetin derivatives on TGFβ-induced hepatic stellate cells

Ganbold, M., Shimamoto, Y., Ferdousi, F., Tominaga, K., & Isoda, H. (2019) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2019.100678 · Cited by 28

Dynamic Changes in Function and Proteomic Composition of Extracellular Vesicles from Hepatic Stellate Cells during Cellular Activation

Li, X., Chen, R., Kemper, S., & Brigstock, D. R. (2020) · Cells · doi:10.3390/cells9020290 · Cited by 28

Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice

Wang, T., Zhou, X., Kuang, G., Jiang, R., Guo, X., Wu, S., Wan, J., & Yin, L. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaa042 · Cited by 28

Comparative analysis of various temporary computer-aided design/computer-aided manufacturing polymethyl methacrylate crown materials based on color stability, flexural strength, and surface roughness: An in vitro study

Shenoy, A. D., Rajaraman, V., & Maiti, S. (2022) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/japtr.japtr_119_22 · Cited by 27

Serum chitinase-3-like protein 1 is a biomarker of liver fibrosis in patients with chronic hepatitis B in China

Jin, X., Fu, B., Wu, Z., Zheng, X., Hu, J., Jin, L., & Tang, L. (2020) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2020.05.009 · Cited by 26

Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4

Sun, C., Shi, C., Duan, X., Zhang, Y., & Wang, B. (2022) · Bioengineered · doi:10.1080/21655979.2021.2023799 · Cited by 25

Bone marrow mesenchymal stem cells inhibit hepatic fibrosis via the AABR07028795.2/rno-miR-667-5p axis

Feng, Y., Li, Y., Xu, M., Meng, H., Dai, C., Yao, Z., & Lin, N. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03069-7 · Cited by 25

Combined carvacrol and cilostazol ameliorate ethanol-induced liver fibrosis in rats: Possible role of SIRT1/Nrf2/HO-1 pathway

Abu-Risha, S. E.-S., Sokar, S. S., Elbohoty, H. R., & El‐Sisi, A. E. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109750 · Cited by 27

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

Liang, H., Li, Z., Ren, Z., Jia, Q., Guo, L., Li, S., Zhang, H., Hu, S., Zhu, D., Shen, D., et al. (2020) · Nano Research · doi:10.1007/s12274-020-2833-6 · Cited by 25

Irisin Regulates the Functions of Hepatic Stellate Cells

Dong, H. N., Park, S. Y., Le, C. T., Choi, D.-H., & Cho, E.-H. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.658 · Cited by 24

Research progress of natural compounds in anti-liver fibrosis by affecting autophagy of hepatic stellate cells

Shu, Y., Liu, X., Huang, H., Wen, Q., & Shu, J. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06171-w · Cited by 23

MicroRNA-195-3p promotes hepatic stellate cell activation and liver fibrosis by suppressing PTEN expression

Wang, A., Bu, F., Li, J., Zhang, Y., Jia, P., You, H., Wu, S., Wu, Y., Zhu, S., Huang, C. Z., et al. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.11.014 · Cited by 23

Clinical application of deep learning and radiomics in hepatic disease imaging: a systematic scoping review

Wang, L., Zhang, L., Jiang, B., Zhao, K., Zhang, Y., & Xie, X. (2022) · British Journal of Radiology · doi:10.1259/bjr.20211136 · Cited by 23

Advantages and challenges in nanomedicines for chronic liver diseases: A hepatologist's perspectives

Ezhilarasan, D. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173832 · Cited by 24

Interaction of non‑parenchymal hepatocytes in the process of hepatic fibrosis (Review)

Cheng, Q.-N., Yang, X. Y., Wu, J., Ai, W., & Ni, Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12003 · Cited by 22

Possible roles of Golgi protein-73 in liver diseases

Liu, M., Huang, L. H., Wu, J., Zhang, H., Ai, W., & Zhang, R. (2022) · Annals of Hepatology · doi:10.1016/j.aohep.2022.100720 · Cited by 22

Relaxin in hepatic fibrosis: What is known and where to head?

Ezhilarasan, D. (2021) · Biochimie · doi:10.1016/j.biochi.2021.06.001 · Cited by 22

Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice

Buchl, S. C., Hanquier, Z., Haak, A. J., Thomason, Y. M., Huebert, R. C., Shah, V. H., & Maiers, J. L. (2021) · Hepatology Communications · doi:10.1002/hep4.1835 · Cited by 20

α-Lipoic acid modulates liver fibrosis: A cross talk between TGF-β1, autophagy, and apoptosis

El-Maadawy, W. H., Hammam, O. A., el-Din, S. H. S., & El-Lakkany, N. M. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119891212 · Cited by 20

Preclinical liver toxicity models: Advantages, limitations and recommendations

Ezhilarasan, D., Karthikeyan, S., Najimi, M., Paramasivan, V., Bhavani, G., & Rani, M. J. (2024) · Toxicology · doi:10.1016/j.tox.2024.154020 · Cited by 23

Retinoids in Stellate Cells: Development, Repair, and Regeneration

Carmona, R., Barrena, S., & Muñoz‐Chápuli, R. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7020010 · Cited by 19

Vitamin A - modified Betulin polymer micelles with hepatic targeting capability for hepatic fibrosis protection

Liu, X., Li, D., Li, T. Y., Wu, Y., Piao, J. S., & Piao, M. G. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106189 · Cited by 18

Regulation of SIRT1-TLR2/TLR4 pathway in cell communication from macrophages to hepatic stellate cells contribute to alleviates hepatic fibrosis by Luteoloside

Xiu, M.-X., Zhao, Y., Wang, X., Yuan, S., Qin, B.-F., Sun, J., Cui, L., & Song, J. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151989 · Cited by 19

Unraveling the pathophysiologic role of galectin‐3 in chronically injured liver

Ezhilarasan, D. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.30956 · Cited by 18

Vanillic acid alleviates liver fibrosis through inhibiting autophagy in hepatic stellate cells via the MIF/CD74 signaling pathway

Qin, L., Tan, J., Lv, X., & Zhang, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115673 · Cited by 18

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

Bestion, E., Jílková, Z. M., Mège, J., Novello, M., Kurma, K., Pour, S. T. A., Lalmanach, G., Vanderlynden, L., Fizanne, L., Bassissi, F., et al. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320942042 · Cited by 18

Metabolic Alterations in Spheroid-Cultured Hepatic Stellate Cells

Fujisawa, K., Takami, T., Sasai, N., Matsumoto, T., Yamamoto, N., & Sakaida, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103451 · Cited by 18

Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver

Ezhilarasan, D., & Najimi, M. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103902 · Cited by 18

Nanoparticle formulation of mycophenolate mofetil achieves enhanced efficacy against hepatocellular carcinoma by targeting tumour‐associated fibroblast

Yang, Z., Zhang, L., Zhu, H. H., Zhou, K., Wang, H., Wang, Y., Su, R., Guo, D., Zhou, L., Xu, X., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16434 · Cited by 17

Hepatocellular Interactions of Potential Nutraceuticals in the Management of Inflammatory NAFLD

Ezhilarasan, D., & Kulanthaivel, L. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4112 · Cited by 17

Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway

Abdolahi, A., Vahabzadeh, Z., Izadpanah, E., & Moloudi, M. R. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00852-7 · Cited by 17

Adoptive transfer of regulatory T cells stimulated by Allogeneic Hepatic Stellate Cells mitigates liver injury in mice with concanavalin A-induced autoimmune hepatitis

Huang, H., & Deng, Z. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.147 · Cited by 16

Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis

Zhang, Y., Cai, B., Li, Y., Xu, Y. J., Wang, Y., Zheng, L., Zheng, X., Yin, L., Chen, G., Wang, Y., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1098463 · Cited by 15

Role of sirtuins in liver diseases

Ezhilarasan, D., & Najimi, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00005-7 · Cited by 15

Tripartite motif protein 52 (TRIM52) promoted fibrosis in LX‐2 cells through PPM1A‐mediated Smad2/3 pathway

Zhou, J., Lan, Q., Li, W., Yang, L., You, J., Zhang, Y., & Ni, W. (2019) · Cell Biology International · doi:10.1002/cbin.11206 · Cited by 15

Effects of autophagy inhibition by chloroquine on hepatic stellate cell activation in CCl4‐induced acute liver injury mouse model

Le, T. V., Dinh, N. B. T., Dang, T. M., Phan, N. L.-C., Dang, L. T. T., Grassi, G., Holterman, A., Le, H. M., & Truong, N. H. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15726 · Cited by 14

Estrogen receptor 1 signaling in hepatic stellate cells designates resistance to liver fibrosis

Li, T., Wang, G., Zhao, H., Liu, F., Deng, Z., Chen, D., Zhou, X., Cao, Y., Fu, W., Zhang, H., et al. (2025) · Cell Discovery · doi:10.1038/s41421-025-00783-3 · Cited by 14

Unlocking the potential of Mesenchymal stem cells in liver Fibrosis: Insights into the impact of autophagy and aging

Tao, H., Liu, Q., Zeng, A., & Song, L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110497 · Cited by 13

Stress and Liver Fibrogenesis

Hanquier, Z., Misra, J., Baxter, R., & Maiers, J. L. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.06.006 · Cited by 15

Flavonoids-based nanomedicines for the treatment of liver fibrosis: A recent progress

Harini, K. S., & Ezhilarasan, D. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105467 · Cited by 14

DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 pathway

Ding, R., Zheng, J., Li, N., Cheng, Q., Zhu, M., Wang, Y., Zhou, X., Zhang, Z., & Shi, G. (2021) · PeerJ · doi:10.7717/peerj.11374 · Cited by 13

Role of ferroptosis in fibrosis diseases

Sun, Z., Zou, X., Bao, M., Huang, Z., Lou, Y., Zhang, Y., & Huang, P. C. (2023) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2023.04.024 · Cited by 14

Discovery and evaluation of phenacrylanilide derivatives as novel potential anti-liver fibrosis agents

Lin, Y., Xue, T., Su, X., Liu, Z., Liu, H., Tan, Z., Gan, C., Xie, Y., & Ye, T. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114685 · Cited by 12

CaM/CaMKII mediates activation and proliferation of hepatic stellate cells regulated by ASIC1a

Liu, H., Lu, W., Hong, H.-Q., Li, M., Ye, M.-P., Rao, Q.-F., Kong, J.-L., Luan, S., Huang, Y., Hu, Q., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.996667 · Cited by 13

Roxarsone inhibits hepatic stellate cell activation and ameliorates liver fibrosis by blocking TGF-β1/Smad signaling pathway

Li, T., Su, X., Chen, L.-L., Zhang, W., Zhang, J., Wang, Y., & Xu, W. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109527 · Cited by 12

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

Setyawati, D. R., Sekaringtyas, F. C., Pratiwi, R. D., Rosyidah, A., Azhar, R., Gustini, N., Syahputra, G., Rosidah, I., Mardliyati, E., Tarwadi, et al. (2024) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.15.89 · Cited by 14

Lead compounds with the potentials for the treatment of chronic liver diseases

Ezhilarasan, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817890-4.00012-3 · Cited by 12

Nanomedicine for Hepatic Fibrosis

Ezhilarasan, D., & Rajeshkumar, S. (2020) · Springer eBooks · doi:10.1007/978-981-15-0391-7_2 · Cited by 12

IOX1 protects from TGF‑β induced fibrosis in LX‑2 cells via the regulation of extracellular matrix protein expression

Tian, T., Xie, R., Ding, K., Han, B., Yang, Q., & Yang, X. Y. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9611 · Cited by 11

Hsp47 acts as a bridge between NLRP3 inflammasome and hepatic stellate cells activation in arsenic-induced liver fibrosis

Yuan, W., Qiu, T., Yao, X., Wu, C., Shi, Y., Wang, N., Zhang, J., Jiang, L., Liu, X., Yang, G., et al. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.07.816 · Cited by 12

UEG Week 2019 Poster Presentations

Jaeger, M.-C., Guiraud, L., Rolland, C., Rolland, C., Belot, A., Sebbag, M., Bermúdez‐Humarán, L. G., Langella, P., Vergnolle, N., & Deraison, C. (2019) · United European Gastroenterology Journal · doi:10.1177/2050640619854671 · Cited by 11

The effect of vitamin D supplementation on the progression of fibrosis in patients with chronic liver disease

Chen, T., Zuo, X., Wang, S., Yu, P., Yuan, J., Wei, S., Chen, J., Sun, Y., Gao, Y., & Li, X. (2020) · Medicine · doi:10.1097/md.0000000000020296 · Cited by 9

Anti-fibrotic effect of intravenous umbilical cord-derived mesenchymal stem cells (UC-MSCs) injection in experimental rats induced liver fibrosis

Sungkar, T., Putra, A. B., Lindarto, D., & Sembiring, R. J. (2020) · Medicinski Glasnik · doi:10.17392/1211-21 · Cited by 9

Lagerstroemia speciosa (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats

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11β‑hydroxysteroid dehydrogenase‑1 is associated with the activation of hepatic stellate cells in the development of hepatic fibrosis

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miR-654-5p Contributes to the Activation and Proliferation of Hepatic Stellate Cells by Targeting RXRα

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Extraction, characterization, and anticancer potential of extracellular polymeric substances from marine actinobacteria of Streptomyces species

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The potential health benefits and mechanisms of sesame lignans in age-related diseases

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Advances in antituberculosis drug-induced liver injury: Molecular mechanisms, genetic insights, and emerging animal-free prediction models

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Ginsenoside AD-2 Ameliorating Lipopolysaccharide-Induced Activation in HSC-T6 Cells and Carbon Tetrachloride-Induced Hepatic Fibrosis in Mice via Regulation of VD-VDR Axis

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Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway

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A meritorious integrated medical regimen for hepatic fibrosis and its complications via the systematic review and meta-analysis for Dahuang Zhechong pill-based therapy

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HO‐1: An emerging target in fibrosis

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New advances of nanozymes for the diagnosis and treatment of digestive system diseases (Review)

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FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism

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Periplaneta americana extract attenuates hepatic fibrosis progression by inhibiting collagen synthesis and regulating the TGF-β1/Smad signaling pathway

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Deciphering the toxicological role of Porphyromonas gingivalis derived endotoxins in liver diseases

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Clearance of activated stellate cells for hepatic fibrosis regression: Molecular basis and translational potential

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Hepatic Stellate Cells as a Target for the Treatment of Liver Fibrosis

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The progression for the therapy of liver fibrosis targeting to hepatic stellate cells

Zhang, X. (2003) · Zhongguo yaolixue tongbao

Hepatic stellate cells: a target for the treatment of liver fibrosis

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Modulating hepatic stellate cell senescence: A promising therapeutic strategy for liver fibrosis

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