Cited by 204Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Diseases and Immunity

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Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets

Ezhilarasan, Devaraj, Sokal, Etienne, Najimi, Mustapha·2018·Hepatobiliary & Pancreatic Diseases International

DOI 10.1016/j.hbpd.2018.04.003

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Abstract

Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of extracellular matrix (ECM) in the perisinusoidal space and it is a major problem in chronic liver diseases. Phenotypic activation of hepatic stellate cells (HSC) plays a central role in the progression of hepatic fibrosis. Retardation of proliferation and clearance of activated HSCs from the injured liver is an appropriate therapeutic strategy for the resolution and treatment of hepatic fibrosis. Clearance of activated HSCs from the injured liver by autophagy inhibitors, proapoptotic agents and senescence inducers with the high affinity toward the activated HSCs may be the novel therapeutic strategy for the treatment of hepatic fibrosis in the near future.

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Authors: Ezhilarasan, D., Sokal, E., & Najimi, M.
Affiliations: Saveetha University (IN)
UCLouvain (BE)
Corresponding author: Ezhilarasan, Devaraj
ORCID: Ezhilarasan, Devaraj
Sokal, Etienne
Najimi, Mustapha
Venue: Hepatobiliary & Pancreatic Diseases International
Publisher: Elsevier BV
Published: 2018-06
Volume: 17
Issue: 3
Pages: 192-197
ISSN: 2352-9377 (ISSN-L)
1499-3872
DOI: 10.1016/j.hbpd.2018.04.003
OpenAlex: W2802633545
Cited by: 204
References: 71
Citations by year: 2026: 6 · 2025: 20 · 2024: 16 · 2023: 27 · 2022: 28 · 2021: 64 · 2020: 32 · 2019: 10
FWCI: 16.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hepatobiliary & pancreatic diseases international (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords: liver fibrosis, hepatic stellate cells, hepatic stellate cell activation, extracellular matrix accumulation, chronic liver disease, autophagy inhibitors, cellular senescence, antifibrotic therapy
MeSH terms: Animals, Autophagy, Extracellular Matrix, Humans, Liver, Liver Cirrhosis, Phenotype, Signal Transduction, Cellular Senescence, Apoptosis, Cell Proliferation, Hepatic Stellate Cells, Myofibroblasts

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Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets

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