Cited by 230Estrogen and related hormone effectsEffects and risks of endocrine disrupting chemicalsAdipokines, Inflammation, and Metabolic Diseases

The diversity of sex steroid action: regulation of metabolism by estrogen signaling

Open access
Faulds, Malin Hedengran, Zhao, Chunyan, Dahlman-Wright, Karin, Gustafsson, Jan-Åke·2012·Journal of Endocrinology

Abstract

The metabolic syndrome is a complex condition characterized by obesity, insulin resistance, decreased high-density lipoproteins, and hypertension associated with high risk of developing type 2 diabetes and cardiovascular disease. A major increase in the incidence of developing metabolic syndrome and related diseases is observed worldwide in association with a change toward a less active lifestyle and increased food consumption. Estrogen and the estrogen receptors (ERs) are well-known regulators of several aspects of metabolism, including glucose and lipid metabolism, and impaired estrogen signaling is associated with the development of metabolic diseases. This review will describe the key effects of estrogen signaling in metabolic and glucose sensing tissues, including the liver, pancreatic β cells, adipose tissue, and skeletal muscle. The impact on metabolic processes of impaired estrogen signaling and knock out of each ER subtype will also be discussed.

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Crossref · 10.1530/joe-11-0044

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  • Classical genomic ER action typically occurs within hours, leading to activation or repression of target genes; ligand-activated ER binds as a dimer directly to an estrogen response element in target gene promoters.

    “The classical genomic action mechanism of ER action typically occurs within hours, leading to activation or repression of target genes.”

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Authors
Faulds, M. H., Zhao, C., Dahlman-Wright, K., & Gustafsson, J.-Å.
Affiliations
Karolinska Institutet (SE)
Venue
Journal of Endocrinology
Published
2011-04-21
Volume
212
Issue
1
Pages
3-12
ISSN
  • 0022-0795 (ISSN-L)
  • 1479-6805
OpenAlex
W2140387377
Cited by
230
References
105
Citations by year
2026: 3 · 2025: 12 · 2024: 15 · 2023: 14 · 2022: 10 · 2021: 12 · 2020: 18 · 2019: 6 · 2018: 13 · 2017: 17 · 2016: 15 · 2015: 23 · 2014: 24 · 2013: 26 · 2012: 16
FWCI
2.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
estrogen signaling, estrogen receptor, metabolic syndrome, glucose metabolism, lipid metabolism, insulin resistance, obesity, type 2 diabetes, cardiovascular disease, hepatic glucose metabolism, pancreatic beta cells, adipose tissue, skeletal muscle
MeSH terms
Animals, Cholesterol, Estrogens, Glucose, Homeostasis, Humans, Inflammation, Insulin Resistance, Lipolysis, Metabolic Syndrome, Lipogenesis

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