The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model
Open accessAbstract
BACKGROUND: Free radical production and mitochondrial dysfunction during cardiac graft reperfusion is a major factor in post-transplant ischemia-reperfusion (IR) injury, an important underlying cause of primary graft dysfunction. We therefore assessed the efficacy of the mitochondria-targeted anti-oxidant MitoQ in reducing IR injury in a murine heterotopic cardiac transplant model. METHODS: Hearts from C57BL/6 donor mice were flushed with storage solution alone, solution containing the anti-oxidant MitoQ, or solution containing the non-anti-oxidant decyltriphenylphosphonium control and exposed to short (30 minutes) or prolonged (4 hour) cold preservation before transplantation. Grafts were transplanted into C57BL/6 recipients and analyzed for mitochondrial reactive oxygen species production, oxidative damage, serum troponin, beating score, and inflammatory markers 120 minutes or 24 hours post-transplant. RESULTS: MitoQ was taken up by the heart during cold storage. Prolonged cold preservation of donor hearts before IR increased IR injury (troponin I, beating score) and mitochondrial reactive oxygen species, mitochondrial DNA damage, protein carbonyls, and pro-inflammatory cytokine release 24 hours after transplant. Administration of MitoQ to the donor heart in the storage solution protected against this IR injury by blocking graft oxidative damage and dampening the early pro-inflammatory response in the recipient. CONCLUSIONS: IR after heart transplantation results in mitochondrial oxidative damage that is potentiated by cold ischemia. Supplementing donor graft perfusion with the anti-oxidant MitoQ before transplantation should be studied further to reduce IR-related free radical production, the innate immune response to IR injury, and subsequent donor cardiac injury.
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MitoQ has been shown to be protective against ischemia/reperfusion injury, cardiac hypertrophy, and hypertension in animal models.
“MitoQ has been used extensively in animal models of disease and been shown to be protective against ischemia/reperfusion injury, cardiac hypertrophy, and hypertension (210, 211) among other pathologies.”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [211]
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Cites
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works
Mitochondria in innate immune responses
West, A. P., Shadel, G. S., & Ghosh, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2975 · Cited by 1,376 · see citing works
Halestrap, A. P. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00533-9 · Cited by 1,223 · see citing works
Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091 · see citing works
Self-citationKawaguchi, M., Takahashi, M., Hata, T., Kashima, Y., Usui, F., Morimoto, H., Izawa, A., Takahashi, Y., Masumoto, J., Koyama, J., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.982777 · Cited by 884 · see citing works
The mitochondrial permeability transition from<i>in vitro</i>artifact to disease target
Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy‐Dyson, E., Di Lisa, F., & Forte, M. A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05213.x · Cited by 627 · see citing works
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
Adlam, V. J., Harrison, J. C., Porteous, C. M., James, A. M., Smith, R. A. J., Murphy, M. P., & Sammut, I. A. (2005) · The FASEB Journal · doi:10.1096/fj.05-3718com · Cited by 618 · see citing works
Self-citationSnow, B. J., Rolfe, F. L., Lockhart, M. M., Frampton, C. M., O'Sullivan, J. D., Fung, V., Smith, R. A. J., Murphy, M. P., Taylor, K. M., & On behalf of the Protect Study Group (2010) · Movement Disorders · doi:10.1002/mds.23148 · Cited by 606 · see citing works
Self-citationAnimal and human studies with the mitochondria‐targeted antioxidant MitoQ
Smith, R. A. J., & Murphy, M. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05627.x · Cited by 553 · see citing works
Self-citationStehlik, J., Edwards, L. B., Kucheryavaya, A. Y., Aurora, P., Christie, J. D., Kirk, R., Dobbels, F., Rahmel, A. O., & Hertz, M. I. (2010) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2010.08.007 · Cited by 509 · see citing works
Smith, R. A. J., Hartley, R. C., Cochemé, H. M., & Murphy, M. P. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.010 · Cited by 501 · see citing works
Self-citationRoss, M. F., Kelso, G. F., Blaikie, F. H., James, A. M., Cochemé, H. M., Filipovska, A., Ros, T. D., Hurd, T. R., Smith, R. A. J., & Murphy, M. P. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0104-5 · Cited by 495 · see citing works
Self-citationMitochondria-Targeted Small Molecule Therapeutics and Probes
Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3969 · Cited by 399 · see citing works
Self-citationFurda, A. M., Santos, J. H., Meyer, J. N., & Houten, B. V. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-739-6_31 · Cited by 384 · see citing works
Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A. J., & Murphy, M. P. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02250.x · Cited by 379 · see citing works
Self-citationGraham, D., Huynh, N. N., Hamilton, C. A., Beattie, E., Smith, R. A. J., Cochemé, H. M., Murphy, M. P., & Dominiczak, A. F. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130351 · Cited by 367 · see citing works
Self-citationOxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion
Bulteau, A., Lundberg, K. C., Humphries, K. M., Sadek, H. A., Szweda, P. A., Friguet, B., & Szweda, L. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100142200 · Cited by 354 · see citing works
Reperfusion injury: Experimental evidence and clinical implications
Ambrosio, G., & Tritto, I. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70323-6 · Cited by 337 · see citing works
Cochemé, H. M., Quin, C., McQuaker, S. J., Cabreiro, F., Logan, A., Prime, T. A., Abakumova, I., Patel, J. V., Fearnley, I. M., James, A. M., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.003 · Cited by 313 · see citing works
Self-citationSantos, J. H., Meyer, J. N., Mandavilli, B. S., & Houten, B. V. (2008) · Methods in molecular biology · doi:10.1385/1-59259-973-7:183 · Cited by 289 · see citing works
Land, W. G. (2005) · Transplantation · doi:10.1097/01.tp.0000153160.82975.86 · Cited by 278 · see citing works
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells
Ross, M. F., Prime, T. A., Abakumova, I., James, A. M., Porteous, C. M., Smith, R. A. J., & Murphy, M. P. (2008) · Biochemical Journal · doi:10.1042/bj20080063 · Cited by 206 · see citing works
Self-citationMitochondrial Generation of Oxygen Radicals During Reoxygenation of Ischemic Tissues
Turrens, J. F., Beconi, M., Barilla, J., Chavez, U. B., & McCord, J. M. (1991) · Free Radical Research Communications · doi:10.3109/10715769109145847 · Cited by 177 · see citing works
Mikhalski, D., Wissing, K. M., Ghisdal, L., Broeders, N., Touly, M., Hoang, A.-D., Loi, P., Mboti, F., Donckier, V., Vereerstraeten, P., et al. (2008) · Transplantation · doi:10.1097/tp.0b013e318169c29e · Cited by 175 · see citing works
Kuznetsov, A. V., Schneeberger, S., Seiler, R., Brandacher, G., Mark, W., Steurer, W., Saks, V. A., Usson, Y., Margreiter, R., & Gnaiger, E. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00701.2003 · Cited by 168 · see citing works
Primary Graft Failure after Heart Transplantation
Iyer, A., Kumarasinghe, G., Hicks, M., Watson, A., Gao, L., Doyle, A., KEOGH, A. M., Kotlyar, E., Hayward, C., Dhital, K. K., et al. (2011) · Journal of Transplantation · doi:10.1155/2011/175768 · Cited by 146 · see citing works
Risk factors for early primary graft dysfunction after lung transplantation: a registry study
Kuntz, C. L., Hadjiliadis, D., Ahya, V. N., Kotloff, R. M., Pochettino, A., Lewis, J., & Christie, J. D. (2009) · Clinical Transplantation · doi:10.1111/j.1399-0012.2008.00951.x · Cited by 138 · see citing works
Protein carbonyl measurement by enzyme-linked immunosorbent assay
Winterbourn, C. C., & Buss, I. H. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)00118-4 · Cited by 134 · see citing works
Mukhopadhyay, P., Horváth, B., Zsengellér, Z. K., Bátkai, S., Cao, Z., Kechrid, M., Holovac, E., Erdélyi, K., Tanchian, G., Liaudet, L., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.036 · Cited by 133 · see citing works
Heart transplantation in congenic strains of mice.
Corry, R. J., Winn, H. J., & Russell, P. S. (1973) · PubMed · Cited by 128 · see citing works
Cochemé, H. M., Logan, A., Prime, T. A., Abakumova, I., Quin, C., McQuaker, S. J., Patel, J. V., Fearnley, I. M., James, A. M., Porteous, C. M., et al. (2012) · Nature Protocols · doi:10.1038/nprot.2012.035 · Cited by 128 · see citing works
Self-citationPorteous, C. M., Logan, A., Evans, C., Ledgerwood, E. C., Menon, D. K., Aigbirhio, F., Smith, R. A. J., & Murphy, M. P. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.06.001 · Cited by 121 · see citing works
Self-citationStahl, J. E., Kreke, J. E., Malek, F. A. A., Schaefer, A. J., & Vacanti, J. P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002468 · Cited by 118 · see citing works
Early Institution of Mechanical Support Improves Outcomes in Primary Cardiac Allograft Failure
Marasco, S., Esmore, D. S., Negri, J. C., Rowland, M. A., Newcomb, A. E., Rosenfeldt, F., Bailey, M., & Richardson, M. (2005) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2005.06.007 · Cited by 110 · see citing works
Critical Role of Proinflammatory Cytokine IL-6 in Allograft Rejection and Tolerance
Zhao, X., Boenisch, O., Yeung, M., Mfarrej, B., Yang, S., Turka, L. A., Sayegh, M. H., Iacomini, J., & Yuan, X. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03770.x · Cited by 104 · see citing works
Mitchell, T., Rotaru, D., Saba, H., Smith, R. A. J., Murphy, M. P., & MacMillan-Crow, L. A. (2011) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.176743 · Cited by 84 · see citing works
Self-citationTanaka, M., Mokhtari, G. K., Terry, R. D., Gunawan, F., Balsam, L. B., Hoyt, G. E., Lee, K., Tsao, P. S., & Robbins, R. C. (2005) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2004.06.007 · Cited by 80 · see citing works
Bcl-xL Gene Transfer Inhibits Bax Translocation and Prolongs Cardiac Cold Preservation Time in Rats
Huang, J., Nakamura, K., Ito, Y., Uzuka, T., Morikawa, M., Hirai, S., Tomihara, K., Tanaka, T., Masuta, Y., Ishii, K., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.535740 · Cited by 58 · see citing works
Determination of Interleukin-6 in Lung Transplantation: Association With Primary Graft Dysfunction
Moreno, I., Vicente, R., Ramos, F., Vicente, J. L., & Barberá, M. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2007.07.056 · Cited by 48 · see citing works
The innate immune system in host mice targets cells with allogenic mitochondrial DNA
Ishikawa, K., Toyama‐Sorimachi, N., Nakada, K., Morimoto, M., Imanishi, H., Yoshizaki, M., Sasawatari, S., Niikura, M., Takenaga, K., Yonekawa, H., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092296 · Cited by 48 · see citing works
Sucher, R., Gehwolf, P., Kaier, T. E., Hermann, M., Maglione, M., Oberhuber, R., Ratschiller, T., Kuznetsov, A. V., Bösch, F., Kozlov, A. V., et al. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00883.x · Cited by 44 · see citing works
Tanaka, M., Terry, R. D., Mokhtari, G. K., Inagaki, K., Koyanagi, T., Kofidis, T., Mochly‐Rosen, D., & Robbins, R. C. (2004) · Circulation · doi:10.1161/01.cir.0000138389.22905.62 · Cited by 43 · see citing works
Evans, P., Tredger, J. M., Dunne, J. B., & Halliwell, B. B. (1996) · Transplantation · doi:10.1097/00007890-199610270-00002 · Cited by 38 · see citing works
Land, W. G. (1994) · PubMed · Cited by 32 · see citing works
Kuznetsov, A. V., Schneeberger, S., Renz, O., Meusburger, H., Saks, V. A., Usson, Y., & Margreiter, R. (2004) · Transplantation · doi:10.1097/01.tp.0000115346.85679.34 · Cited by 27 · see citing works
Porteous, C. M., Menon, D. K., Aigbirhio, F. I., Smith, R. A. J., & Murphy, M. P. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.02.005 · Cited by 25 · see citing works
Self-citationKupiec‐Weglinski, J. W. (2008) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283069d87 · Cited by 7 · see citing works
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Mitochondria as a therapeutic target for common pathologies
Murphy, M. P., & Hartley, R. C. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.174 · Cited by 832 · see citing works
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Mitochondria in acute myocardial infarction and cardioprotection
Ramachandra, C. J. A., Hernández‐Reséndiz, S., Crespo-Avilan, G. E., Lin, Y., & Hausenloy, D. J. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102884 · Cited by 345 · see citing works
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Nieuwenhuijs‐Moeke, G. J., Pischke, S. E., Berger, S. P., Sanders, J., Pol, R. A., Struys, M. M. R. F., Ploeg, R. J., & Leuvenink, H. G. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010253 · Cited by 332 · see citing works
Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation
Schlegel, A. A., Muller, X., Mueller, M., Степанова, А., Kron, P., de Rougemont, O., Muiesan, P., Clavien, P., Galkin, A. S., Meierhofer, D., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103014 · Cited by 254 · see citing works
Hu, Q., Ren, J., Li, G., Wu, J., Wu, X., Wang, G., Gu, G., Ren, H., Hong, Z., & Li, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0436-x · Cited by 182 · see citing works
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation
Martin, J. L., Costa, A. S. H., Gruszczyk, A. V., Beach, T. E., Allen, F. M., Prag, H. A., Hinchy, E. C., Mahbubani, K. T. A., Hamed, M. O., Tronci, L., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0115-y · Cited by 166 · see citing works
Self-citationParadies, G., Paradies, V., Ruggiero, F. M., & Petrosillo, G. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00028.2018 · Cited by 143 · see citing works
The mitochondrial permeability transition pore in AD 2016: An update
Biasutto, L., Azzolini, M., Szabó, I., & Zoratti, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.02.012 · Cited by 128 · see citing works
Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123 · see citing works
Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart
Bou‐Teen, D., Kaludercic, N., Weissman, D., Turan, B., Maack, C., Lisa, F. D., & Ruiz‐Meana, M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.043 · Cited by 119 · see citing works
Escribano‐López, I., Díaz‐Morales, N., Rovira‐Llopis, S., Marañón, A., Orden, S., Álvarez, Á., Bañuls, C., Rocha, M., Murphy, M. P., Hernández‐Mijares, A., et al. (2016) · Redox Biology · doi:10.1016/j.redox.2016.10.017 · Cited by 107 · see citing works
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Self-citationMitochondrial Dysfunction in Cardiovascular Diseases: Potential Targets for Treatment
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Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease
Camacho-Encina, M., Booth, L. K., Redgrave, R. E., Folaranmi, O., Spyridopoulos, I., & Richardson, G. D. (2024) · Cells · doi:10.3390/cells13040353 · Cited by 101 · see citing works
Nuzzo, A. M., Camm, E. J., Sferruzzi-Perri, A. N., Ashmore, T. J., Yung, H. W., Cindrová‐Davies, T., Spiroski, A., Sutherland, M. R., Logan, A., Austin‐Williams, S., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.07.027 · Cited by 94 · see citing works
Self-citationMitochondria as Therapeutic Targets in Transplantation
Saeb‐Parsy, K., Martin, J. L., Summers, D. M., Watson, C. J. E., Krieg, T., & Murphy, M. P. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.08.001 · Cited by 88 · see citing works
Self-citationMitochondrial mechanisms and therapeutics in ischaemia reperfusion injury
Martin, J. L., Gruszczyk, A. V., Beach, T. E., Murphy, M. P., & Saeb‐Parsy, K. (2018) · Pediatric Nephrology · doi:10.1007/s00467-018-3984-5 · Cited by 87 · see citing works
Self-citationCui, L., Zhou, Q., Zheng, X., Sun, B., & Zhao, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.09.028 · Cited by 88 · see citing works
Chen, S., Wang, Y., Zhang, H., Chen, R., Lv, F., Li, Z., Jiang, T., Lin, D., Zhang, H., Yang, L., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.30193 · Cited by 84 · see citing works
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Mitochondria and ischemia reperfusion injury
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Zhang, J., Culp, M. L., Craver, J., & Darley-Usmar, V. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14308 · Cited by 73 · see citing works
Covarrubias, A. E., Lecarpentier, É., Lo, A. S., Salahuddin, S., Gray, K. J., Karumanchi, S. A., & Zsengellér, Z. K. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.09.007 · Cited by 73 · see citing works
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Kadlec, A. O., Chabowski, D. S., Ait‐Aissa, K., Hockenberry, J. C., Otterson, M. F., Durand, M. J., Freed, J. K., Beyer, A., & Gutterman, D. D. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09289 · Cited by 49 · see citing works
Lung Ischaemia–Reperfusion Injury: The Role of Reactive Oxygen Species
Pak, O., Sydykov, A. S., Kosanovic, D., SCHERMULY, R. T., Dietrich, A., Schröder, K., Brandes, R. P., Gudermann, T. W., Sommer, N., & Weißmann, N. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_12 · Cited by 51 · see citing works
Oxidative Stress after Surgery on the Immature Heart
Fudulu, D. P., & Angelini, G. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1971452 · Cited by 48 · see citing works
Pros and Cons of Use of Mitochondria-Targeted Antioxidants
Plotnikov, E. Y., & Zorov, D. B. (2019) · Antioxidants · doi:10.3390/antiox8080316 · Cited by 43 · see citing works
Arndt, S., Baeza-Garza, C. D., Logan, A., Rosa, T., Wedmann, R., Prime, T. A., Martin, J. L., Saeb‐Parsy, K., Krieg, T., Filipović, M. R., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784678 · Cited by 38 · see citing works
Self-citationAnti-ageing interventions for the treatment of cardiovascular disease
Abdellatif, M., Schmid, S., Fuerlinger, A., & Kroemer, G. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae177 · Cited by 37 · see citing works
Hamed, M. O., Logan, A., Gruszczyk, A. V., Beach, T. E., James, A. M., Dare, A. J., Barlow, A. D., Martin, J. L., Georgakopoulos, N., Gane, A., et al. (2021) · British journal of surgery · doi:10.1093/bjs/znab108 · Cited by 37 · see citing works
Self-citationDJ-1: A promising therapeutic candidate for ischemia-reperfusion injury
Lazzari, F. D., Prag, H. A., Gruszczyk, A. V., Whitworth, A. J., & Bisaglia, M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101884 · Cited by 36 · see citing works
Toldo, S. A., Quader, M. A., Salloum, F. N., Mezzaroma, E., & Abbate, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060958 · Cited by 37 · see citing works
Yang, M.-Y., Fan, Z., Zhang, Z., & Fan, J. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.10.007 · Cited by 34 · see citing works
Mao, H., Zhang, Y., Xiong, Y., Zhu, Z., Wang, L., & Liu, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2213503 · Cited by 35 · see citing works
Lin, L., Zhou, Y., Li, Y., Wang, L., Sun, L., Zhou, L., Arai, H., Qi, Y., & Yang, X. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.013 · Cited by 33 · see citing works
Yuan, S., Che, Y., Wang, Z., Xing, K., Xie, X., & Chen, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04763-7 · Cited by 31 · see citing works
Key hepatoprotective roles of mitochondria in liver regeneration
Lamanilao, G. G., Doğan, M., Patel, P. S., Azim, S., Patel, D. S., Bhattacharya, S. K., Eason, J. D., Kuscu, C., Kuscu, C., & Bajwa, A. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00220.2022 · Cited by 30 · see citing works
Bao, Y. W., Hu, C., Wang, B., Liu, X., Wu, Q., Xu, D., Shi, Z., & Sun, C. (2025) · Biology · doi:10.3390/biology14091140 · Cited by 29 · see citing works
Ding, S., Kim, Y., Huang, K., Um, D. J., Jung, Y., & Kong, H. (2024) · Nano Convergence · doi:10.1186/s40580-024-00423-8 · Cited by 28 · see citing works
Chullo, G., Rosello, A. P., Marquez, N., Colmenero, J., Brunet, M., Pera-Román, M., Roselló‐Catafau, J., Bataller, R. A., García‐Valdecasas, J. C., & Fundora, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021117 · Cited by 26 · see citing works
Mitochondria-Targeted Antioxidants for the Treatment of Cardiovascular Disorders
Kim, H. K., & Han, J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_32 · Cited by 27 · see citing works
Renal Mitochondrial Response to Low Temperature in Non-Hibernating and Hibernating Species
Dugbartey, G. J., Hardenberg, M. C., Kok, W. F., Boerema, A. S., Carey, H. V., Staples, J. F., Henning, R. H., & Bouma, H. R. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6705 · Cited by 25 · see citing works
Paillard, M., Abdellatif, M., Andreadou, I., Bär, C., Bertrand, L., Brundel, B. J. J. M., Chiva‐Blanch, G., Davidson, S. M., Dawson, D. K., Lisa, F. D., et al. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.3674 · Cited by 28 · see citing works
Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury
Rozich, E., Ozkurede, U., Pakkiriswami, S., Gemilere, R., Azarin, S. M., & Liu, J. C. (2025) · The Journal of Physiology · doi:10.1113/jp287770 · Cited by 27 · see citing works
Advances in Mitochondrial Dysfunction and Its Role in Cardiovascular Diseases
Qiu, Y. J., Chang, S., Zeng, Y., & Wang, X. (2025) · Cells · doi:10.3390/cells14201621 · Cited by 24 · see citing works
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia
Szibor, M., Schreckenberg, R., Gizatullina, Z. Z., Dufour, É., Wiesnet, M., Dhandapani, P. K., Dębska–Vielhaber, G., Heidler, J., Wittig, I., Nyman, T. A., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15043 · Cited by 24 · see citing works
Self-citationZhou, P., Liu, H., Liu, X., Ling, X., Xiao, Z., Zhu, P., Zhu, Y., Lu, J., & Zheng, S. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02114-7 · Cited by 24 · see citing works
Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets
Doležalová, N., Gruszczyk, A. V., Barkan, K., Gamble, J. A., Galvin, S. G., Moreth, T., O’Holleran, K., Mahbubani, K. T. A., Higgins, J., Gribble, F. M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89853-6 · Cited by 20 · see citing works
Self-citationXenotopic expression of alternative oxidase (AOX) to study mechanisms of mitochondrial disease
Viscomi, C. F., Moore, A. L., Zeviani, M., & Szibor, M. (2022) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2022.148947 · Cited by 18 · see citing works
Endothelial Cells and Mitochondria: Two Key Players in Liver Transplantation
Parente, A., Carvalho, M. F., & Schlegel, A. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210091 · Cited by 20 · see citing works
Tao, L., Xue, Y.-F., Sun, F., He, X., Wang, H., Tong, C.-C., Zhang, C., Xu, D., & Chen, X. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116914 · Cited by 20 · see citing works
Enhanced Mitochondrial DNA Repair Resuscitates Transplantable Lungs Donated After Circulatory Death
Tan, Y. B., Pastukh, V. M., Gorodnya, O. M., Mulekar, M. S., Simmons, J. D., Machuca, T., Beaver, T. M., Wilson, G. L., & Gillespie, M. N. (2019) · Journal of Surgical Research · doi:10.1016/j.jss.2019.07.057 · Cited by 20 · see citing works
Sanz, M., Farine, E., Niederberger, P., Méndez‐Carmona, N., Wyss, R. K., Arnold, M., Gulac, P., Fiedler, M., Gressette, M., Garnier, A., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.15024 · Cited by 19 · see citing works
Gouda, E., & Babiker, F. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-22097-0 · Cited by 18 · see citing works
Punetha, M., Saini, S., Chaudhary, S., Bala, R., Sharma, M., Kumar, P., Kumar, D., & Yadav, P. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102067 · Cited by 20 · see citing works
Tan, Y., Nie, Y., Lei, Z., & Zheng, Z. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00573b · Cited by 17 · see citing works
Westhofen, S., Jelinek, M., Dreher, L., Biermann, D., Martin, J. L., Vitzthum, H., Reichenspurner, H. C., Ehmke, H., & Schwoerer, A. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214513 · Cited by 16 · see citing works
Das, J., Sah, A. K., Choudhary, R. K., Elshaikh, R. H., Bhui, U., Chowdhury, S., Abbas, A. M., Shalabi, M. G., Siddique, N. A., Alshammari, R. R., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13071532 · Cited by 18 · see citing works
Lo, S., Blaszak, R. T., & Parajuli, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103506 · Cited by 15 · see citing works
Azan, N. I. N., Karim, N. A., Sulaiman, N. S., Ng, M. H., Najib, A. M., Hassan, H., & Alias, E. (2026) · Biomedicines · doi:10.3390/biomedicines14010100 · Cited by 15 · see citing works
Pintye, D., Sziva, R. E., Mastyugin, M., Török, M., Jacas, S., Lo, A. S., Salahuddin, S., & Zsengellér, Z. K. (2023) · Antioxidants · doi:10.3390/antiox12081578 · Cited by 14 · see citing works
Alotaibi, K., Arulkumaran, N., Dyson, A., & Singer, M. (2025) · Clinical Science · doi:10.1042/cs20242074 · Cited by 13 · see citing works
Salahi, E., Amidi, F., Zahiri, Z., Aghahosseini, M., Mashayekhi, F., Abkenari, S. A., Hosseinishenatal, S., & Sobhani, A. (2021) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-021-06230-4 · Cited by 12 · see citing works
Li, J., Wu, B., Teng, D., Sun, X.-Y., Li, J., Li, J., Zhang, G., & Cai, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8384 · Cited by 11 · see citing works
Du, T., Su, H., Cao, D., Meng, Q., Zhang, M., Liu, Z., & Li, H. (2024) · European journal of medical research · doi:10.1186/s40001-024-02181-z · Cited by 10 · see citing works
Wu, Z., Miao, X., Jiang, Y., Kong, D., Liu, H., Xie, W., Shi, B., & Gong, W. (2023) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2023.03.005 · Cited by 10 · see citing works
Gouda, E., & Babiker, F. A. (2020) · All Life · doi:10.1080/26895293.2020.1832921 · Cited by 10 · see citing works
Mitochondrial Targeted Interventions for AgingPreprint
Liu, S. Z., Chiao, Y. A., Rabinovitch, P. S., & Marcinek, D. J. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041199 · Cited by 10 · see citing works
Xing, Y., Xie, S.-Y., Deng, W., & Tang, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116936 · Cited by 9 · see citing works
Haxhikadrija, P., Wu, J. M. F., Hübner, S., Grün, K., Kretzschmar, T., Müller, T., Gräler, M. H., Backsch, C., Weise, A., Klein, E., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04340-3 · Cited by 8 · see citing works
Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion
Hu, S., Tang, X., Zhu, F., Chen, L., Wang, S., Wang, H., Li, P., & Li, Y. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101282 · Cited by 7 · see citing works
Cairns, A. G., McQuaker, S. J., Murphy, M. P., & Hartley, R. C. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1262-0_6 · Cited by 6 · see citing works
Self-citationCheng, C., Meng, Y., Pan, Y., Zhang, Y., He, S.-Y. R., Baral, K., & Zhao, M. (2025) · Transplantation · doi:10.1097/tp.0000000000005432 · Cited by 5 · see citing works
Li, G., Chen, J., Wang, Z., Fu, Q., Tian, Z., Liu, Y., Ai, X., Wang, C., Wang, J., Yang, H., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123494 · Cited by 5 · see citing works
Asl, M. M., Rahbarghazi, R., Beheshti, R., Alihemmati, A., Aliparasti, M. R., & Abedelahi, A. (2021) · Europe PMC (PubMed Central) · doi:10.22074/cellj.2021.6877 · Cited by 5 · see citing works
Han, X., Lang, Z., Lv, X., Xing, Y., Hou, M., Tan, Z., Zhang, T., & Leng, Y. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10894-5 · Cited by 4 · see citing works
Ischaemia–Reperfusion Injury in Organ Transplantation: Role of Coenzyme Q10
Mantle, D., Cufflin, N., Purcell, T. T., & Hargreaves, I. P. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14186486 · Cited by 4 · see citing works
Beyond Static Cold Storage: Toward the Next Generation of Tailored Organ Preservation Solutions
Fernandes, F. W., Yildirim, F. S., Horie, H., Karakaya, O. F., Jiao, C., Crasta, G. S., Eshraghi, N., Takase, K., Diwan, T., Oliveira, L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199515 · Cited by 4 · see citing works
Lu, C., Meng, Z., Tang, S., Wei, H., Hu, Y., Chen, D., Liu, D., Wen, H. M., Dong, K., Na, N., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.02.014 · Cited by 4 · see citing works
Zsengellér, Z. K., Mastyugin, M., Fusco, A. R., Vlocskó, R. B., Costa, M., Ferguson, C., Pintye, D., Sziva, R. E., Salahuddin, S., Young, B. C., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090680 · Cited by 4 · see citing works
Mitochondrial translational control in cardiovascular diseases: from mechanisms to therapies
Deng, Y., Guo, N., Li, D., & Zh, W. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104143 · Cited by 3 · see citing works
Organ Preservation: Cryobiology and Beyond
Woods, E. J., & Mullen, S. F. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0042-8 · Cited by 3 · see citing works
Yang, Z., Zhao, D., Huang, Y., Han, C., Chen, M., Wang, F., Yang, S., Wang, C., & Zhang, S. (2026) · Transplantation · doi:10.1097/tp.0000000000005622 · Cited by 2 · see citing works
Mitochondrial DNA regulation of hepatic ischemia-reperfusion injury and intervention strategies
Shen, R., An, P., Chen, M., Lu, P., Yang, J., Wu, L., & Wang, R. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08155-5 · Cited by 2 · see citing works
Antioxidant Therapy in CVD: Hope or Hype
Nasser, S. A., & Dent, G. (2024) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-031-62131-4_6 · Cited by 2 · see citing works
Oxidative Stress and Antioxidant Strategies in Human Diseases
Yuan, K., & Zhang, Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-0522-2_1 · Cited by 1 · see citing works
Надеев, А. П., Евгеньевич, К. В., Волков, А. М., Фомичев, А. В., Sirota, D. A., Zhulkov, M. O., Kliver, E. E., Volchek, A. V., Kazanskaya, G. M., & Aidagulova, S. V. (2024) · Russian Journal of Archive of Pathology · doi:10.17116/patol20248605133 · Cited by 1 · see citing works
- Authors
- Dare, A. J., Logan, A., Prime, T. A., Rogatti, S., Goddard, M., Bolton, E. M., Bradley, J. A., Pettigrew, G. J., Murphy, M. P., & Saeb-Parsy, K.
- Affiliations
- University of Cambridge (GB)
- National Health Service (GB)
- Corresponding author
- Murphy, Michael P.
- ORCID
- Venue
- The Journal of Heart and Lung Transplantation
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 34
- Issue
- 11
- Pages
- 1471-1480
- ISSN
- 1053-2498 (ISSN-L)
- PMC
- PMC4626443
- OpenAlex
- W1788023720
- Cited by
- 119
- References
- 48
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 13 · 2023: 8 · 2022: 7 · 2021: 14 · 2020: 13 · 2019: 7 · 2018: 11 · 2017: 8 · 2016: 9
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Heart and Lung Transplantation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- MitoQ, mitochondria-targeted antioxidants, ischemia-reperfusion injury, heart transplantation, primary graft dysfunction, oxidative stress, mitochondrial reactive oxygen species, cold ischemia, donor heart preservation, mitochondrial DNA damage, inflammatory cytokines
- MeSH terms
- Animals, Antioxidants, Disease Models, Animal, Female, Male, Mice, Inbred C57BL, Mitochondria, Heart, Organ Preservation, Organophosphorus Compounds, Ubiquinone, Reperfusion Injury, Heart Transplantation, Free Radical Scavengers, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Micronutrients, Mice, Rats, Primary Graft Dysfunction
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