Dietary nitrate increases exercise tolerance in patients with non-ischemic, dilated cardiomyopathy-a double-blind, randomized, placebo-controlled, crossover trial
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In heart failure and cardiomyopathy, dietary nitrate improves left ventricular function in mice and overall cardiac contractility and exercise performance in humans.
“Additionally, in the setting of heart failure and cardiomyopathy, dietary nitrate improves left ventricular function in mice[133] and overall cardiac contractility and exercise performance in humans[134–137]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [136]
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- Authors
- Kerley, C. P., O’Neill, J. O., Reddy Bijjam, V., Blaine, C., James, P. E., & Cormican, L.
- Affiliations
- University College Dublin (IE)
- Connolly Hospital Blanchardstown (IE)
- Cardiff University (GB)
- Venue
- The Journal of Heart and Lung Transplantation
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 35
- Issue
- 7
- Pages
- 922-926
- ISSN
- 1053-2498 (ISSN-L)
- OpenAlex
- W2255261813
- Cited by
- 30
- References
- 7
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 3
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- green
- arrow.tudublin.ie
- Licence
- Locations
- The Journal of Heart and Lung Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Arrow - TU Dublin (Technological University Dublin) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- dietary nitrate, exercise tolerance, non-ischemic dilated cardiomyopathy, left ventricular dysfunction, peak oxygen uptake, heart failure, dietary supplementation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cardiomyopathy, Dilated, Exercise Test, Female, Humans, Male, Middle Aged, Nitrates, Oxygen Consumption, Prognosis, Randomized Controlled Trials as Topic, Exercise Tolerance, Dietary Supplements
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