Dietary nitrate supplementation in COPD: An acute, double-blind, randomized, placebo-controlled, crossover trial
Abstract
Background The acute consumption of dietary nitrate has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease. Many COPD patients have reduced exercise capacity. We hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in COPD subjects.Methods Eleven COPD subjects were randomly assigned to consume either a high nitrate or a matched, low nitrate beverage in a double-blind, randomized, placebo-controlled, crossover design. ISWT distance was measured both before and 3 h after the beverage and change was recorded. After a 7-day washout, ISWT distances were re-measured before and 3 h after the alternate beverage and changes were recorded.Results We observed an increase in ISWT distance after consuming the high nitrate juice (25 m) compared with a reduction after the low nitrate juice (14 m) (p < 0.01). This improvement in exercise capacity was associated with significant increases in serum nitrate (p < 0.000005) and nitrite (p < 0.01) levels and a significant lowering of resting blood pressure (<0.05).Conclusions In patients with stable COPD, the acute consumption of dietary nitrate increased serum nitrate/nitrite levels and exercise capacity and was associated with a decrease in resting blood pressure. Nitrate consumption might alter exercise capacity in COPD patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent human studies demonstrated that dietary nitrate (beetroot juice containing approximately 200-400 mg of nitrate) improved exercise performance and reduced blood pressure in COPD patients.
“Recent human studies have demonstrated that dietary nitrate (beetroot juice containing approximately 200–400 mg of nitrate) improved the exercise performance and reduced blood pressure in COPD patients [130,131].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [131]
Cites
Lung volumes and forced ventilatory flows
Quanjer, P. H., Tammeling, G. J., Cotes, J. E., Pedersen, O. F., Peslin, R., & Yernault, J. (1993) · European Respiratory Journal · doi:10.1183/09041950.005s1693 · Cited by 5,484 · see citing works
(1993) · PubMed · Cited by 3,827 · see citing works
ATS/ACCP statement on cardiopulmonary exercise testing
(2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.167.2.211 · Cited by 3,026 · see citing works
ATS/ACCP statement on cardiopulmonary exercise testing.
Ross, R. M. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.167.10.950 · Cited by 2,563 · see citing works
General considerations for lung function testing
Miller, M. R., Crapo, R. O., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R. H., Coates, A. L., Enright, P., van der Grinten, C. P. M., Gustafsson, P., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00034505 · Cited by 2,026 · see citing works
Development of a shuttle walking test of disability in patients with chronic airways obstruction.
Singh, S., Morgan, M. D., Scott, S., Walters, D., & Hardman, A. E. (1992) · Thorax · doi:10.1136/thx.47.12.1019 · Cited by 1,435 · see citing works
Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
Pitta, F., Troosters, T., Spruit, M. A., Probst, V. S., Decramer, M., & Gosselink, R. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-855oc · Cited by 1,256 · see citing works
Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759 · see citing works
Intragastric nitric oxide production in humans: measurements in expelled air.
Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661 · see citing works
Complex chronic comorbidities of COPD
Fabbri, L. M., Luppi, F., Beghé, B., & Rabe, K. F. (2008) · European Respiratory Journal · doi:10.1183/09031936.00114307 · Cited by 660 · see citing works
Bailey, S. J., Fulford, J., Vanhatalo, A., Winyard, P. G., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Benjamin, N., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00046.2010 · Cited by 607 · see citing works
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586 · see citing works
Govoni, M., Jansson, E. Å., Weitzberg, E., & Lundberg, J. O. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.08.003 · Cited by 585 · see citing works
Maltais, F., Simard, A. A., Simard, C., Jobin, J., Desgagnés, P., & Leblanc, P. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.1.8542131 · Cited by 571 · see citing works
Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Pavey, T. G., Wilkerson, D. P., Benjamin, N., Winyard, P. G., & Jones, A. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00206.2010 · Cited by 529 · see citing works
The discovery of nitric oxide as the endogenous nitrovasodilator.
Moncada, S., Palmer, R. M. J., & Higgs, E. A. (1988) · Hypertension · doi:10.1161/01.hyp.12.4.365 · Cited by 493 · see citing works
Predictors of Mortality in Patients with Emphysema and Severe Airflow Obstruction
Martínez, F. J., Foster, G. L., Curtis, J. L., Criner, G. J., Weinmann, G. G., Fishman, A. P., DeCamp, M. M., Benditt, J. O., Sciurba, F. C., Make, B. J., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200510-1677oc · Cited by 445 · see citing works
Dietary Nitrate Supplementation and Exercise Performance
Jones, A. M. (2014) · Sports Medicine · doi:10.1007/s40279-014-0149-y · Cited by 442 · see citing works
Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance
LANSLEY, K. E., WINYARD, P. G., BAILEY, S. J., VANHATALO, A., WILKERSON, D. P., BLACKWELL, J. R., GILCHRIST, M., BENJAMIN, N., & JONES, A. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821597b4 · Cited by 388 · see citing works
Singh, S., Morgan, M., Hardman, A., Rowe, C. C., & Bardsley, P. A. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07112016 · Cited by 386 · see citing works
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease
Kenjale, A. A., Ham, K. L., Stabler, T., Robbins, J. L., Johnson, J. L., VanBruggen, M., Privette, G., Yim, E., Kraus, W. E., & Allen, J. D. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00071.2011 · Cited by 316 · see citing works
Minimum clinically important improvement for the incremental shuttle walking test
Singh, S., Jones, P. M., Evans, R. A., & Morgan, M. (2008) · Thorax · doi:10.1136/thx.2007.081208 · Cited by 300 · see citing works
Tsuchiya, M., Asada, A., Kasahara, E., Sato, E. F., Shindo, M., & Inoue, M. (2002) · Circulation · doi:10.1161/hc1002.105935 · Cited by 247 · see citing works
Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia
Vanhatalo, A., Fulford, J., Bailey, S. J., Blackwell, J. R., Winyard, P. G., & Jones, A. M. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.216341 · Cited by 233 · see citing works
Wilkerson, D. P., Hayward, G. M., Bailey, S. J., Vanhatalo, A., Blackwell, J. R., & Jones, A. M. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2397-6 · Cited by 229 · see citing works
Nitric oxide, reactive oxygen species, and skeletal muscle contraction
Reid, M. B. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200103000-00006 · Cited by 198 · see citing works
Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers
Sobko, T., Marcus, C., Govoni, M., & Kamiya, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.007 · Cited by 185 · see citing works
Dietary nitrate improves muscle but not cerebral oxygenation status during exercise in hypoxia
Masschelein, E., Van Thienen, R., Wang, X., Van Schepdael, A., Thomis, M., & Hespel, P. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01253.2011 · Cited by 152 · see citing works
Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise
Casey, D. P., Madery, B. D., Curry, T. B., Eisenach, J. H., Wilkins, B. W., & Joyner, M. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.180489 · Cited by 137 · see citing works
Miller, G. D., Marsh, A. P., Dove, R. W., Beavers, D., Presley, T., Helms, C., Bechtold, E., King, S. B., & Kim-Shapiro, D. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.02.002 · Cited by 84 · see citing works
The incremental shuttle walking test in elderly people with chronic airflow limitation
DYER, C. A. E. (2002) · Thorax · doi:10.1136/thorax.57.1.34 · Cited by 83 · see citing works
Vermeeren, M. A. P., Wouters, E. F. �., Nelissen, L. H., van Lier, A., Hofman, Z., & Schols, A. M. W. J. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.295 · Cited by 80 · see citing works
Basic science of electronic cigarettes: assessment in cell culture and in vivo models
Hiemstra, P., & Bals, R. (2016) · Respiratory Research · doi:10.1186/s12931-016-0447-z · Cited by 75 · see citing works
Dreißigacker, U., Wendt, M., Wittke, T., Tsikas, D., & Maassen, N. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.05.003 · Cited by 57 · see citing works
Totzeck, M., Hendgen-Cotta, U. B., Rammos, C., Frommke, L.-M., Knackstedt, C., Predel, H.-G., Kelm, M., & Rassaf, T. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.05.003 · Cited by 56 · see citing works
Arnardóttir, R. H., Emtner, M., Hedenström, H., Larsson, K., & Boman, G. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-127 · Cited by 52 · see citing works
Cured meat consumption increases risk of readmission in COPD patients
de Batlle, J., Mendez, M., Romieu, I., Balcells, E., Benet, M., Donaire-Gonzalez, D., Ferrer, J. J., Orozco-Levi, M., Antó, J. M., Garcia-Aymerich, J., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00116911 · Cited by 47 · see citing works
Nitrite reduction to nitric oxide in the vasculature
Lundberg, J. O., & Weitzberg, E. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00611.2008 · Cited by 39 · see citing works
Pulmonary vasodilation by inhaled nitric oxide after endothelial injury
Rimar, S., & Gillis, C. N. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.2179 · Cited by 30 · see citing works
Jones, A. T., & Evans, T. W. (1997) · Thorax · doi:10.1136/thx.52.2008.s16 · Cited by 25 · see citing works
Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2014.16 · Cited by 15 · see citing works
Analytical Techniques for Assaying Nitric Oxide Bioactivity
Jiang, H., Parthasarathy, D. K., Torregrossa, A. C., Mian, A. I., & Bryan, N. S. (2012) · Journal of Visualized Experiments · doi:10.3791/3722 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary nitrate and nitrite: Benefits, risks, and evolving perceptions
Bedale, W. A., Sindelar, J. J., & Milkowski, A. L. (2016) · Meat Science · doi:10.1016/j.meatsci.2016.03.009 · Cited by 285 · see citing works
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248 · see citing works
Domínguez, R., Cuenca, E., Maté-Muñoz, J., García-Fernández, P., Serra-Paya, N., Estevan, M., Herreros, P., & Garnacho-Castaño, M. (2017) · Nutrients · doi:10.3390/nu9010043 · Cited by 227 · see citing works
Whitfield, J., Ludzki, A., Heigenhauser, G. J. F., Senden, J. M. G., Verdijk, L. B., van Loon, L. J. C., Spriet, L. L., & Holloway, G. P. (2016) · The Journal of Physiology · doi:10.1113/jp270844 · Cited by 115 · see citing works
NO-Rich Diet for Lifestyle-Related Diseases
Kobayashi, J., Ohtake, K., & Uchida, H. (2015) · Nutrients · doi:10.3390/nu7064911 · Cited by 94 · see citing works
Exercise limitations in heart failure with reduced and preserved ejection fraction
Poole, D. C., Richardson, R. S., Haykowsky, M. J., Hirai, D. M., & Musch, T. I. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00747.2017 · Cited by 97 · see citing works
Pawlak-Chaouch, M., Boissière, J., Gamelin, F. X., Cuvelier, G., Berthoin, S., & Aucouturier, J. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.01.001 · Cited by 81 · see citing works
Shepherd, A. I., Gilchrist, M., Winyard, P. G., Jones, A. M., Hallmann, E., Kazimierczak, R., Rembialkowska, E., Benjamin, N., Shore, A. C., & Wilkerson, D. P. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.014 · Cited by 69 · see citing works
Hirai, D. M., Zelt, J. T., Jones, J. H., Castanhas, L. G., Bentley, R. F., Earle, W., Staples, P., Tschakovsky, M. E., McCans, J., O’Donnell, D. E., et al. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00263.2016 · Cited by 67 · see citing works
Dietary nitrate and blood pressure: evolution of a new nutrient?
Ashworth, A., & Bescós, R. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422417000063 · Cited by 65 · see citing works
Richards, J. C., Racine, M. L., Hearon, C. M., Kunkel, M. J., Luckasen, G. J., Larson, D. G., Allen, J. D., & Dinenno, F. A. (2018) · Physiological Reports · doi:10.14814/phy2.13572 · Cited by 58 · see citing works
Billingsley, H., Rodriguez‐Miguelez, P., Buono, M. G. D., Abbate, A., Lavie, C. J., & Carbone, S. (2019) · Nutrients · doi:10.3390/nu11122849 · Cited by 61 · see citing works
On the mechanism by which dietary nitrate improves human skeletal muscle function
Affourtit, C., Bailey, S. J., Jones, A. M., Smallwood, M. J., & Winyard, P. G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00211 · Cited by 58 · see citing works
Curtis, K., O’Brien, K. A., Tanner, R., Polkey, J., Minnion, M., Feelisch, M., Polkey, M. I., Edwards, L. M., & Hopkinson, N. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144504 · Cited by 55 · see citing works
Mills, C. E., Khatri, J., Maskell, P., Odongerel, C., & Webb, A. J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12918 · Cited by 55 · see citing works
Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes
Shannon, O. M., Clifford, T., Seals, D. R., Craighead, D. H., & Rossman, M. J. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.06.002 · Cited by 51 · see citing works
Leong, P., Basham, J. E., Yong, T., Chazan, A., Finlay, P. N., Barnes, S. L., Bardin, P. G., & Campbell, D. A. (2015) · BMC Pulmonary Medicine · doi:10.1186/s12890-015-0057-4 · Cited by 49 · see citing works
Shannon, O. M., Allen, J. D., Bescós, R., Burke, L. M., Clifford, T., Easton, C., Gonzalez, J. T., JONES, A. M., Jonvik, K. L., Larsen, F. J., et al. (2022) · Sports Medicine · doi:10.1007/s40279-022-01701-3 · Cited by 51 · see citing works
Pavitt, M. J., Tanner, R., Lewis, A. P., Buttery, S. C., Mehta, B., Jefford, H., Curtis, K., BANYA, W. A. S., Husain, S., Satkunam, K., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2019-214278 · Cited by 47 · see citing works
Shepherd, A. I., Costello, J. T., Bailey, S. J., BISHOP, N. C., Wadley, A. J., Young‐Min, S. A., Gilchrist, M., Mayes, H. S., White, D. K., Gorczynski, P. F., et al. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00292.2019 · Cited by 46 · see citing works
Kerley, C. P., Dolan, E., James, P. E., & Cormican, L. J. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518000144 · Cited by 38 · see citing works
Siervo, M., Oggioni, C., Jakovljevic, D. G., Trenell, M., Mathers, J. C., Houghton, D., Celis-Morales, C., Ashor, A. W., Ruddock, A., Ranchordas, M., et al. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.11.004 · Cited by 37 · see citing works
Shepherd, A. I., Wilkerson, D. P., Fulford, J., Winyard, P. G., Benjamin, N., Shore, A. C., & Gilchrist, M. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00203.2016 · Cited by 34 · see citing works
Friis, A. L., Steenholt, C. B., Løkke, A., & Hansen, M. (2017) · International Journal of COPD · doi:10.2147/copd.s135752 · Cited by 34 · see citing works
Beijers, R. J. H. C. G., Huysmans, S., van de Bool, C., Kingma, B., Verdijk, L. B., van Loon, L. J. C., Meex, S. J. R., Gosker, H. R., & Schols, A. M. W. J. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.10.011 · Cited by 33 · see citing works
He, Y., Liu, J., Cai, H., Zhang, J., Jiang, Y., Niu, Y., Xi, H., Peng, X., & Guo, L. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.04.006 · Cited by 32 · see citing works
Kerley, C. P., O’Neill, J. O., Reddy Bijjam, V., Blaine, C., James, P. E., & Cormican, L. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2016.01.018 · Cited by 30 · see citing works
Kerley, C. P., James, P. E., McGowan, A., Faul, J. L., & Cormican, L. J. (2018) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2018.1492521 · Cited by 28 · see citing works
Behnia, M. M., Wheatley, C. M., Avolio, A. P., & Johnson, B. D. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.03.009 · Cited by 27 · see citing works
Kerley, C. P., Dolan, E., & Cormican, L. J. (2017) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-016-1551-2 · Cited by 25 · see citing works
Eglin, C., Costello, J. T., Bailey, S. J., Gilchrist, M., Massey, H. C., & Shepherd, A. I. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.09.005 · Cited by 25 · see citing works
Marín-Hinojosa, C., Eraso, C. C., Sánchez‐López, V., Hernández, L. C., Otero, R., & López-Campos, J. L. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab267 · Cited by 24 · see citing works
Timpani, C. A., Hayes, A., & Rybalka, E. (2017) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-017-0652-y · Cited by 23 · see citing works
Burnley-Hall, N., Abdul, F. B., Androshchuk, V., Morris, K., Ossei‐Gerning, N., Anderson, R. A., Rees, A., & James, P. E. (2018) · Thrombosis and Haemostasis · doi:10.1160/th17-06-0394 · Cited by 19 · see citing works
McNarry, M. A., Harrison, N. K., Withers, T. M., Chinnappa, N. B. R., & Lewis, M. J. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-017-0364-z · Cited by 18 · see citing works
Cumpstey, A. F., Hennis, P. J., Gilbert-Kawai, E. T., Fernandez, B. O., Poudevigne, M., Cobb, A., Meale, P., Mitchell, K., Moyses, H. E., Pöhnl, H., et al. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.10.005 · Cited by 16 · see citing works
Physiological Effects of Beetroot in Athletes and Patients
Olsson, H., Al‐Saadi, J., Oehler, D., Pergolizzi, J. V., & Magnusson, P. (2019) · Cureus · doi:10.7759/cureus.6355 · Cited by 16 · see citing works
Woessner, M. N., Levinger, I., Allen, J. D., McIlvenna, L. C., & Neil, C. (2020) · Nutrients · doi:10.3390/nu12072132 · Cited by 15 · see citing works
Ramick, M. G., Kirkman, D. L., Stock, J. M., Muth, B. J., Farquhar, W. B., Chirinos, J. A., Doulias, P.-T., Ischiropoulos, H., & Edwards, D. G. (2021) · Nitric Oxide · doi:10.1016/j.niox.2020.10.002 · Cited by 14 · see citing works
Nitric Oxide Formation From Inorganic Nitrate
Lundberg, J. O., & Weitzberg, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00012-0 · Cited by 12 · see citing works
Alsulayyim, A. S., Alasmari, A., Alghamdi, S. M., Polkey, M. I., & Hopkinson, N. S. (2021) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2021-000948 · Cited by 11 · see citing works
Proctor, D. N., Neely, K. A., Mookerjee, S., Tucker, J., Somani, Y. B., Flanagan, M., Kim‐Shapiro, D. B., Basu, S., Muller, M. D., & Kim, D. J.-K. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.02.004 · Cited by 11 · see citing works
Dietary nitrate as modulator of physical performance and cardiovascular health
Kerley, C. P. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000414 · Cited by 10 · see citing works
Lee, E., Park, H., Kim, S.-W., Sun, Y., Choi, J.-H., Seo, J., Jung, Y. P., Kim, A.-J., Kim, J., & Lim, K. (2023) · Nutrients · doi:10.3390/nu15153324 · Cited by 11 · see citing works
Dietary Beetroot Juice – Effects in Patients with COPD: A Review
Chen, M., Chang, S., Xu, Y., Parke, H. G., & Liu, J. (2024) · International Journal of COPD · doi:10.2147/copd.s473397 · Cited by 8 · see citing works
Wouters, E. F. �. (2021) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2021.725534 · Cited by 10 · see citing works
Giuriato, G., Paneroni, M., Venturelli, M., & Layec, G. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.08.004 · Cited by 6 · see citing works
Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model
Sonoda, K., Ohtake, K., Tagiri, M., Hirata, M., Tamada, H., Uchida, H., Ito, J., & Kobayashi, J. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00512 · Cited by 6 · see citing works
Chapman, C. L., Schlader, Z. J., Reed, E. L., Worley, M. L., & Johnson, B. D. (2021) · Nutrients · doi:10.3390/nu13061986 · Cited by 6 · see citing works
A randomized pilot study of nitrate supplementation with beetroot juice in acute respiratory failure
Files, D. C., Heinrich, T. M., Shields, K. L., Love, N. J., Brailer, C., Bakhru, R. N., Purcell, L. D., Flores, L. S., Gibbs, K. W., Miller, G. D., et al. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.10.009 · Cited by 6 · see citing works
Yang, H., He, S., Chen, F., Liang, L., & Pan, J. (2022) · Medicine · doi:10.1097/md.0000000000028578 · Cited by 5 · see citing works
Long, G., Giourdas, A. D., Fisher, A. J., Lahm, T., Coggan, A. R., & Brown, M. B. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00037.2025 · Cited by 4 · see citing works
Wang, J., Feng, F., Zhao, Y., Bai, L., Xu, Y., Wei, Y., He, H., & Zhou, X. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107498 · Cited by 4 · see citing works
Dietary nitrate decreased blood pressure in obstructive sleep apnoea syndrome
Kerley, C. P., Dolan, E., & Cormican, L. J. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000858 · Cited by 3 · see citing works
Allen, J. D. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.05.005 · Cited by 3 · see citing works
Nitrate and Exercise Performance
Bailey, S. J., Vanhatalo, A., & JONES, A. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_20 · Cited by 2 · see citing works
Nutrition in Pulmonary Rehabilitation
Schols, A. M. W. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-65888-9_11 · Cited by 2 · see citing works
Renji, R., Robinson, S. M., & Witham, M. D. (2024) · JCSM Communications · doi:10.1002/rco2.105 · Cited by 1 · see citing works
Derella, C. C., Anderson, K. C., Woessner, M. N., Paterson, C. A., & Allen, J. D. (2024) · Nutrients · doi:10.3390/nu16223832 · Cited by 1 · see citing works
Curtis, K. (2016) · Spiral (Imperial College London) · doi:10.25560/44728 · Cited by 1 · see citing works
Shepherd, A. I., Wilkerson, D. P., Dobson, L., Kelly, J., Winyard, P. G., Jones, A. M., Benjamin, N., Shore, A. C., & Gilchrist, M. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.01.002 · Cited by 88 · see citing works
Nitrite and Nitrate as a Treatment for Hypertension
Kapil, V. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_17
Kerley, C. P., Reddy, V., Neill, J. O., & Cormican, L. J. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115003146
EFFECTS OF DIETARY NITRATE FROM VEGETABLES ON BLOOD PRESSURE IN HEALTHY HUMANS
ASHWORTH, E. (2019) · PEARL (University of Plymouth) · doi:10.24382/892
Woessner, M. N. (2019) · Victoria University Research Repository (Victoria University)
Zeng, Y., He, T., Ma, X., Guo, Q., & Zhang, J. (2025) · International Journal of COPD · doi:10.2147/copd.s517252 · Cited by 1 · see citing works
Efficacy and Limitations of Nutritional Supplements Containing Nitrates as Their Main Component
Qu, X. (2025) · Springer eBooks · doi:10.1007/978-981-95-2824-0_11
Chiappa, G. R., Filho, A. S. S., Sá, J., Duarte, A. G., Ferrari, G., Chiappa, A. M. G., Morais, L. D. A., Müller, P. D. T., Puente‐Maestu, L., Santos, F. V., et al. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuag013
- Authors
- Kerley, C. P., Cahill, K., Bolger, K., McGowan, A., Burke, C., Faul, J., & Cormican, L.
- Affiliations
- University College Dublin (IE)
- Connolly Hospital Blanchardstown (IE)
- Corresponding author
- Kerley, Conor P.
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 44
- Pages
- 105-111
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W2032897320
- Cited by
- 69
- References
- 42
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 15 · 2016: 9 · 2015: 9
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Funders
- Irish Thoracic Society
- Asthma Society of Ireland
- Irish Lung Foundation
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- dietary nitrate, chronic obstructive pulmonary disease, exercise capacity, incremental shuttle walk test, serum nitrate, serum nitrite, resting blood pressure
- MeSH terms
- Aged, Aged, 80 and over, Blood Pressure, Double-Blind Method, Exercise Test, Female, Hemodynamics, Humans, Male, Middle Aged, Nitrates, Nitric Oxide, Nitrites, Walking, Cross-Over Studies, Pulmonary Disease, Chronic Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
