CoChat
Sign Up
Cited by 1,561Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsRNA Interference and Gene Delivery

The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.

Liposomes: structure, composition, types, and clinical applications

Open access
Nsairat, Hamdi, Khater, Dima, Sayed, Usama, Odeh, Fadwa, Al Bawab, Abeer, Alshaer, Walhan·2022·Heliyon
DOI 10.1016/j.heliyon.2022.e09394PMC PMC9118483
Open this paper in CoChat — free accountOpen PDF

Abstract

Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity. Liposomes also proved to enhance drug solubility and controlled distribution, as well as their capacity for surface modifications for targeted, prolonged, and sustained release. Based on the composition, liposomes can be considered to have evolved from conventional, long-circulating, targeted, and immune-liposomes to stimuli-responsive and actively targeted liposomes. Many liposomal-based drug delivery systems are currently clinically approved to treat several diseases, such as cancer, fungal and viral infections; more liposomes have reached advanced phases in clinical trials. This review describes liposomes structure, composition, preparation methods, and clinical applications.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.heliyon.2022.e09394

Cites

219 of 219 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

1 retracted

Items 201–219 of 219

Flagged first, then by citations

Research works printed but not linked: 8

  1. Sahoo, 2003, Nanotech approaches to drug delivery and imaging, Drug Discov. Today, 8, 1112, 10.1016/S1359-6446(03)02903-9 · DOI
  2. Bulbake, 2017, Liposomal formulations in clinical use: an updated review, Pharmaceutics, 9, 12, 10.3390/pharmaceutics9020012 · DOI
  3. Tadokoro, 2016, 39, 446
  4. Bozzuto, 2015, Liposomes as nanomedical devices, Int. J. Nanomed., 10, 975, 10.2147/IJN.S68861 · DOI
  5. Gonzalez-Rodriguez, 2011, Charged liposomes as carriers to enhance the permeation through the skin, Expet Opin. Drug Deliv., 8, 857, 10.1517/17425247.2011.574610 · DOI
  6. He, 2018, Safety of novel liposomal drugs for cancer treatment, Adv. Prosp., 295, 13
  7. Bigazzi, 2019, Supercritical fluid methods: an alternative to conventional methods to prepare liposomes, Chem. Eng. J., 383, 123106
  8. Immordino, 2006, Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential, Int. J. Nanomed., 1, 297

Cited by

Sorted by citations

See all 1,561

Related

See all

Metadata

Authors
Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W.
Affiliations
  • Al-Ahliyya Amman University (JO)
  • Applied Science Private University (JO)
  • University of Jordan (JO)
Corresponding author
Alshaer, Walhan
ORCID
Venue
Heliyon
Publisher
Elsevier BV
Published
2022-05
Volume
8
Issue
5
Pages
e09394
ISSN
2405-8440 (ISSN-L)
DOI
10.1016/j.heliyon.2022.e09394
PMC
PMC9118483
OpenAlex
W4280621631
Cited by
1,561
References
219
Citations by year
2026: 366 · 2025: 601 · 2024: 405 · 2023: 179 · 2022: 10
FWCI
20.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Heliyon (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
liposomes, liposomal drug delivery, nanocarriers, liposome structure, liposome composition, liposome preparation, targeted liposomes, long-circulating liposomes, stimuli-responsive liposomes, sustained drug release, drug solubility enhancement, biocompatibility, clinical application, cancer therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review