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Cited by 42Epigenetics and DNA MethylationNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Epigenetic signature in neural plasticity: the journey so far and journey ahead

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Nayak, Madhusmita, Das, Diptimayee, Pradhan, Jyotsnarani, Ahmed, R.G., Laureano-Melo, Roberto, Dandapat, Jagneshwar·2022·Heliyon
DOI 10.1016/j.heliyon.2022.e12292PMC PMC9798197
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Abstract

Neural plasticity is a remarkable characteristic of the brain which allows neurons to rewire their structure in response to internal and external stimuli. Many external stimuli collectively referred to as 'epigenetic factors' strongly influence structural and functional reorganization of the brain, thereby acting as a potential driver of neural plasticity. DNA methylation and demethylation, histone acetylation, and deacetylation are some of the frontline epigenetic mechanisms behind neural plasticity. Epigenetic signature molecules (mostly proteins) play a pivotal role in epigenetic reprogramming. Though neuro-epigenetics is an incredibly important field of emerging research, the critical role of signature proteins associated with epigenetic alteration and their involvement in neural plasticity needs further attention. This study gives an integrated and systematic overview of the current state of knowledge with a clear idea of types of neural plasticity and the context-dependent role of epigenetic signature molecules and their modulation by some natural bioactive compounds.

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  • At the molecular level, synaptic plasticity processes are supported by glutamatergic signaling through NMDA and AMPA receptors, neurotrophins such as BDNF, intracellular signaling cascades, and dynamic interactions with astrocytes and microglia.

    “At the molecular level, these processes are supported by glutamatergic signaling through N-Methyl-D-aspartic acid (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, neurotrophins such as brain-derived neurotrophic factor (BDNF), intracellular signaling cascades, and dynamic interactions with astrocytes and microglia [82, 83].”

    From Toward a Unified Framework in Molecular Neurobiology of Alzheimer’s Disease: Revisiting the Pathophysiological Hypotheses (2026) · cites this paper as [82]

    The sections on NMDAR-dependent LTP/LTD and BDNF-dependent plasticity support the roles of NMDA and AMPA receptors, BDNF, and intracellular signaling pathways. Our copy does not support the attributed claim about dynamic interactions with astrocytes and microglia; searches for both terms found no relevant passage. The indexed passages provide section labels but no page numbers. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Nayak, M., Das, D., Pradhan, J., Ahmed, R. G., Laureano-Melo, R., & Dandapat, J.
Affiliations
  • Utkal University (IN)
  • Chettinad Academy of Research and Education (IN)
  • Beni-Suef University (EG)
Corresponding author
  • Pradhan, Jyotsnarani
  • Dandapat, Jagneshwar
ORCID
Venue
Heliyon
Publisher
Elsevier BV
Published
2022-12
Volume
8
Issue
12
Pages
e12292
ISSN
2405-8440 (ISSN-L)
DOI
10.1016/j.heliyon.2022.e12292
PMC
PMC9798197
OpenAlex
W4312052775
Cited by
42
References
14
Citations by year
2026: 8 · 2025: 20 · 2024: 10 · 2023: 4
FWCI
0.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Heliyon (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Science and Engineering Research Board
  • Department of Biotechnology, Ministry of Science and Technology, India
  • Department of Science and Technology, Ministry of Science and Technology, India
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
neuroplasticity, epigenetics, neuroepigenetics, DNA methylation, histone acetylation, histone deacetylation, epigenetic reprogramming, natural bioactive compounds, brain reorganization

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