Cited by 395Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

The BCM theory of synapse modification at 30: interaction of theory with experiment

Cooper, Leon N, Bear, Mark F.·2012·Nature Reviews Neuroscience

Abstract

Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro's 'Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.

Integrity signals

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Crossref · 10.1038/nrn3353

Cites

193 of 194 references verified0 citation errors · 0 not checkable

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  • If the contribution of CaMKII to synaptic transmission were a net gain that simply adds onto the preexisting excitatory drive of the cell, the system would be unstable and quickly saturate.

    “If this were the case, it has been argued that the system would be unstable and quickly saturate (366–371).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [366]

  • The existence of LTD avoids the problem of saturation, which could be essential for a mnemonic device.

    “The existence of LTD avoids the problem of saturation, which could be essential for a mnemonic device (366–371).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [366]

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Research works printed but not linked: 1

  1. Ezzell, C. Neuroscientists manic about long-term depression studies. J. NIH Res. 5, 27–29 (1993).

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Authors
Cooper, L. N., & Bear, M. F.
Affiliations
  • Brown University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
  • Cooper, Leon N
  • Bear, Mark F.
Venue
Nature Reviews Neuroscience
Published
2012-10-19
Volume
13
Issue
11
Pages
798-810
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2045432657
Cited by
395
References
194
Citations by year
2026: 26 · 2025: 29 · 2024: 31 · 2023: 34 · 2022: 31 · 2021: 34 · 2020: 32 · 2019: 34 · 2018: 32 · 2017: 32 · 2016: 25 · 2015: 22 · 2014: 16 · 2013: 17
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • Dana Foundation
  • Ittleson Foundation
  • U.S. Air Force
  • Office of Naval Research
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
synaptic plasticity, Hebbian learning, learning and memory, orientation specificity, visual cortex, binocular interaction
MeSH terms
Animals, Humans, Models, Neurological, Neuronal Plasticity, Photic Stimulation, Synapses, Time Factors, Visual Cortex

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