Histone acetylation: molecular mnemonics on the chromatin
Open accessAbstract
Long-lasting memories require specific gene expression programmes that are, in part, orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in cognitive processes, histone acetylation has spurred considerable interest. Whereas increments in histone acetylation have consistently been shown to favour learning and memory, a lack thereof has been causally implicated in cognitive impairments in neurodevelopmental disorders, neurodegeneration and ageing. As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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Learning and long-term memory formation are improved by enhanced histone acetylation, which could be improved by HDAC inhibitors.
“The synthesis of new proteins is necessary for long-term changes in synaptic plasticity and learning (132–134). In this context, learning and long-term memory formation are improved by enhanced histone acetylation (135), which could be improved by HDAC inhibitors (HDACi).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [135]
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- Authors
- Gräff, J., & Tsai, L.-H.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Tsai, Li-Huei
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-01-17
- Volume
- 14
- Issue
- 2
- Pages
- 97-111
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2072106835
- Cited by
- 680
- References
- 183
- Citations by year
- 2026: 41 · 2025: 47 · 2024: 57 · 2023: 48 · 2022: 72 · 2021: 68 · 2020: 36 · 2019: 47 · 2018: 40 · 2017: 48 · 2016: 53 · 2015: 36 · 2014: 61 · 2013: 26
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (NS078839, R01NS078839, NS51874, R01NS051874)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- histone acetylation, histone deacetylase inhibitors, memory, learning, epigenetic mechanisms, chromatin, cognitive frailty, neurodegeneration, aging, neurodevelopmental disorders, cognitive impairment, gene expression
- MeSH terms
- Acetylation, Aging, Animals, Chromatin, Cognition Disorders, Histone Deacetylases, Histones, Humans, Memory, Neuronal Plasticity, Epigenesis, Genetic, Histone Deacetylase 2, Histone Deacetylase Inhibitors
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