Cited by 682Memory and Neural MechanismsHistone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Histone acetylation: molecular mnemonics on the chromatin

Open access
Gräff, Johannes, Tsai, Li-Huei·2013·Nature Reviews Neuroscience

Abstract

Long-lasting memories require specific gene expression programmes that are, in part, orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in cognitive processes, histone acetylation has spurred considerable interest. Whereas increments in histone acetylation have consistently been shown to favour learning and memory, a lack thereof has been causally implicated in cognitive impairments in neurodevelopmental disorders, neurodegeneration and ageing. As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.

Integrity signals

Registry

Crossref · 10.1038/nrn3427

Cites

183 of 183 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Learning and long-term memory formation are improved by enhanced histone acetylation, which could be improved by HDAC inhibitors.

    “The synthesis of new proteins is necessary for long-term changes in synaptic plasticity and learning (132–134). In this context, learning and long-term memory formation are improved by enhanced histone acetylation (135), which could be improved by HDAC inhibitors (HDACi).”

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Gräff, J., & Tsai, L.-H.
Affiliations
Broad Institute (US)
Corresponding author
Tsai, Li-Huei
Venue
Nature Reviews Neuroscience
Published
2013-01-17
Volume
14
Issue
2
Pages
97-111
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2072106835
Cited by
680
References
183
Citations by year
2026: 41 · 2025: 47 · 2024: 57 · 2023: 48 · 2022: 72 · 2021: 68 · 2020: 36 · 2019: 47 · 2018: 40 · 2017: 48 · 2016: 53 · 2015: 36 · 2014: 61 · 2013: 26
FWCI
4.99
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Neurological Disorders and Stroke (NS078839, R01NS078839, NS51874, R01NS051874)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
histone acetylation, histone deacetylase inhibitors, memory, learning, epigenetic mechanisms, chromatin, cognitive frailty, neurodegeneration, aging, neurodevelopmental disorders, cognitive impairment, gene expression
MeSH terms
Acetylation, Aging, Animals, Chromatin, Cognition Disorders, Histone Deacetylases, Histones, Humans, Memory, Neuronal Plasticity, Epigenesis, Genetic, Histone Deacetylase 2, Histone Deacetylase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review