CD31+ T cells, endothelial function and cardiovascular risk
Open accessAbstract
Deficits in endothelial cell repair mechanisms are thought to contribute to the aetiology of endothelial dysfunction and, subsequently, cardiovascular disease (CVD). CD31(+) T cells or so-called "angiogenic T cells" are a newly defined T cell subset that exhibit favourable vascular qualities and show a strong negative relation with atherosclerotic disease severity. Despite growing evidence that CD31(+) T cells are important for vascular homeostasis, it is currently unknown if CD31(+) T cell number and function are related to endothelial function and CVD risk in healthy adults. To address this question, we studied 24 healthy adult men (ages: 21-70). Endothelial function was assessed by the forearm blood flow (FBF) response to intra-arterial infusion of acetylcholine (ACh) and CVD risk was estimated by Framingham Risk Score (FRS). CD31(+) T cell number was determined by fluorescence-activated cell sorting. Magnetic-activated cell sorting was used to isolate CD31(+) T cells for Boyden chamber migration. No relation was observed between CD31(+) T cell number and FBF response to ACh or FRS. However, CD31(+) T cell migration to stromal cell-derived factor (SDF)-1α and vascular endothelial growth factor (VEGF) was positively correlated with FBF response to ACh (r = 0.43 for SDF-1α; r = 0.38 for VEGF; both P<0.05) and inversely related to FRS (r = -0.53 for SDF-1α; r = -0.48 for VEGF; both P<0.05). These findings demonstrate that CD31(+) T cell function, but not number, is associated with in vivo endothelial function and CVD risk in healthy adult men.
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Angiogenic T-cells are reduced in patients with vascular risk factors and in hypertensive patients with small vessel disease.
“Angiogenic T-cells are reduced in patients with vascular risk factors (Hur et al., 2007; Weil et al., 2011), and in hypertensive patients with small vessels disease (Rouhl et al., 2012b).”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Weil et al., 2011
Angiogenic T-cell migration in vitro positively correlates with preserved endothelium-dependent vasodilatation in patients with cardiovascular risk factors.
“Furthermore, angiogenic T-cells migration in vitro is positively correlated with preservation of endothelium-dependent vasodilatation in patients with cardiovascular risk factors (Weil et al., 2011), highlighting their protective role in vascular function.”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Weil et al., 2011
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The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works
“Angiogenic T cells are reduced in patients with vascular risk factors (Hur et al., 2007; Weil et al., 2011), and in hypertensive patients with small vessels disease (Rouhl et al.”
- Authors
- Weil, B. R., Kushner, E. J., Diehl, K. J., Greiner, J. J., Stauffer, B. L., & DeSouza, C. A.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- DeSouza, Christopher A.
- Venue
- Heart, Lung and Circulation
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 20
- Issue
- 10
- Pages
- 659-662
- ISSN
- 1443-9506 (ISSN-L)
- PMC
- PMC3176953
- OpenAlex
- W2059917350
- Cited by
- 18
- References
- 16
- Citations by year
- 2025: 3 · 2024: 3 · 2022: 1 · 2020: 1 · 2019: 4 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Heart Lung and Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL076434, HL-076434, HL-077450, R01HL077450)
- National Center for Research Resources (RR-00051, M01RR000051)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- angiogenic T cells, endothelial function, cardiovascular risk, endothelial dysfunction, atherosclerosis, T cell migration, stromal cell-derived factor-1α, vascular endothelial growth factor, Framingham risk score, healthy adults
- MeSH terms
- Acetylcholine, Adult, Blood Flow Velocity, Cardiovascular Diseases, Endothelium, Vascular, Flow Cytometry, Humans, Male, Middle Aged, Risk Factors, T-Lymphocyte Subsets, Lymphocyte Count, Cholinergic Agonists, Platelet Endothelial Cell Adhesion Molecule-1
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