The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease
Abstract
Periodontal and cardiovascular disease are both major health issues. Poor oral health has long been associated with the development of systemic diseases, with the typical example being the risk of endocarditis posterior to dental procedures. Through the years, the association of periodontal disease with other non-infectious systemic diseases has been brought to attention. One of the most interesting associations is the one that exists with the development of cardiovascular disease. Many studies, including systematic reviews and meta-analyses, suggest an important association between periodontal disease and ischaemic heart disease, cerebrovascular disease, heart failure, atrial fibrillation and peripheral artery disease. Among the proposed mechanisms of this relationship, systemic inflammation appears to play a major role. Evidence suggests that periodontal inflammation triggers a systemic inflammatory state that, added to the damage mediated by antibodies that cross react between periodontal pathogens and components of the intimal wall, and the direct lesion of the intima by bacteria entering the circulation, promotes atheroma plaque development and progression. There are other studies that show a clear relationship between periodontal disease severity, elevations of inflammatory markers, and the presence of atherosclerosis. Here, we give a review of the available evidence supporting this association, and the possible mechanisms involved.
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Cited by
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485
Periodontal Inflammation and Systemic Diseases: An Overview
Martínez-García, M., & Hernández-Lemus, E. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.709438 · Cited by 512
Pediatric obesity—Long‐term consequences and effect of weight loss
Marcus, C., Danielsson, P., & Hagman, E. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13547 · Cited by 267
Barbe, A. G., Küpeli, L. S., Hamacher, S., & Noack, M. J. (2020) · International Journal of Dental Hygiene · doi:10.1111/idh.12439 · Cited by 39
Metadata
- Authors
- Carrizales-Sepúlveda, E. F., Ordaz-Farías, A., Vera-Pineda, R., & Flores-Ramírez, R.
- Venue
- Heart, Lung and Circulation
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 27
- Issue
- 11
- Pages
- 1327-1334
- ISSN
- 1443-9506 (ISSN-L)
- OpenAlex
- W2807006992
- Cited by
- 398
- References
- 76
- FWCI
- 30.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carrizales-Sepúlveda, E. F., Ordaz-Farías, A., Vera-Pineda, R., & Flores-Ramírez, R. (2018). Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease. Heart, Lung and Circulation. https://doi.org/10.1016/j.hlc.2018.05.102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
