H-Ferritin Subunit Overexpression in Erythroid Cells Reduces the Oxidative Stress Response and Induces Multidrug Resistance Properties

Epsztejn, Silvina; Glickstein, Hava; Picard, Virginie; Slotki, Itzchak N.; Breuer, William; Beaumont, Carole; Cabantchik, Z. Ioav

doi:10.1182/blood.v94.10.3593.422k26_3593_3603

H-Ferritin Subunit Overexpression in Erythroid Cells Reduces the Oxidative Stress Response and Induces Multidrug Resistance Properties

The labile iron pool (LIP) of animal cells has been implicated in cell iron regulation and as a key component of the oxidative-stress response. A major mechanism commonly implied in the downregulation of LIP has been the induced expression of ferritin (FT), particularly the heavy subunits (H-FT) …