The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Role of inflammation and oxidative stress in atrial fibrillation
Open accessAbstract
BACKGROUND Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. There is increasing evidence that inflammation and oxidative stress contribute to the pathogenesis of AF, but their role remains poorly defined. Furthermore, it is unclear if inflammation and oxidative stress are associated with particular types of AF. OBJECTIVE The purpose of this study was to define the role of inflammation and oxidative stress in AF. METHODS Using a case-control study design, 305 patients with AF were compared to 150 control patients. AF was categorized into lone and typical AF, and further sub-categorized as paroxysmal, persistent or permanent AF. Serum concentrations of interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1, vascular endothelial growth factor (VEGF) and N-terminal pro-brain natriuretic peptide (NTpBNP) and urinary F2-isoprostanes, a measure of oxidative stress, were measured. RESULTS IL-6, IL-8, IL-10, TNF-α, MCP1, VEGF and NTpBNP concentrations were independently associated with AF (all P values <0.05), but F2-isoprostane excretion was not elevated (P=0.50). There was a graded increase in TNF-α (median [interquartile range (IQR)]: 6.8 [3.4–11.3], 8.0 [5.6–10.9], 10.1 [5.7–12.4] pg/ml, P<0.05) and NTpBNP (170.6 [67.3–481.9], 681.39 [310.3–1439.0], 1179.9 [653.1–2096.0] pg/ml, P<0.001) among the subgroups of paroxysmal, persistent and permanent AF, respectively. CONCLUSIONS This study shows that inflammatory biomarkers were significantly increased in patients with AF, supporting a strong association between inflammation and the arrhythmia. Surprisingly, urinary F2-isoprostanes, a sensitive index of systemic oxidative stress in vivo, were not increased in AF overall, or in different subtypes of AF.
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Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Inflammation as a risk factor for atrial fibrillation
Aviles, R. J., Martin, D. O., Apperson-Hansen, C., Houghtaling, P. L., Rautaharju, P., Kronmal, R. A., Tracy, R. P., Van Wagoner, D. R., Psaty, B. M., Lauer, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103131.70301.4f · Cited by 1,425
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Frustaci, A., Chimenti, C., Bellocci, F., Morgante, E., Russo, M. A., & Maseri, A. (1997) · Circulation · doi:10.1161/01.cir.96.4.1180 · Cited by 1,401
Chung, M. K., Martin, D. O., Sprecher, D., Wazni, O., Kanderian, A., Carnes, C. A., Bauer, J. A., Tchou, P. J., Niebauer, M. J., Natale, A., et al. (2001) · Circulation · doi:10.1161/hc4901.101760 · Cited by 1,375
Isoprostanes: markers and mediators of oxidative stress
Montuschi, P., Barnes, P. J., & Roberts, L. J. (2004) · The FASEB Journal · doi:10.1096/fj.04-2330rev · Cited by 747
Kadiiska, M. B., Gladen, B. C., Baird, D. D., Germolec, D., Graham, L. B., Parker, C. E., Nyska, A., Wachsman, J. T., Ames, B. N., Basu, S., et al. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.017 · Cited by 697
Impaired Myofibrillar Energetics and Oxidative Injury During Human Atrial Fibrillation
Mihm, M. J., Yu, F., Carnes, C. A., Reiser, P. J., McCarthy, P. M., Van Wagoner, D. R., & Bauer, J. A. (2001) · Circulation · doi:10.1161/01.cir.104.2.174 · Cited by 667
Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation
Issac, T. T., Dokainish, H., & Lakkis, N. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.054 · Cited by 524
Carnes, C. A., Chung, M. K., Nakayama, T., Nakayama, H., Baliga, R. S., Piao, S., Kanderian, A., Pavia, S., Hamlin, R. L., McCarthy, P. M., et al. (2001) · Circulation Research · doi:10.1161/hh1801.097644 · Cited by 523
Morrow, J. D. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000152605.64964.c0 · Cited by 453
Cited by
Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes
Staerk, L., Sherer, J. A., Ko, D., Benjamin, E. J., & Helm, R. H. (2017) · Circulation Research · doi:10.1161/circresaha.117.309732 · Cited by 1,201
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J., Cabrera, J. A., Chen, S. A., Chugh, S. S., Corradi, D., D’Avila, A., Dobrev, D., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 771
Brundel, B. J. J. M., Ai, X., Hills, M. T., Kuipers, M. F., Lip, G. Y. H., & de Groot, N. M. S. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00347-9 · Cited by 499
Role of Inflammation in Atrial Fibrillation Pathophysiology and Management
Harada, M., Van Wagoner, D. R., & Nattel, S. (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0138 · Cited by 473
Rochette, L., Lorin, J., Zeller, M., Guilland, J.-C., Lorgis, L., Cottin, Y., & Vergely, C. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.004 · Cited by 456
Metadata
- Authors
- Li, J., Solus, J., Chen, Q., Rho, Y. H., Milne, G., Stein, C. M., & Darbar, D.
- Venue
- Heart Rhythm
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 7
- Issue
- 4
- Pages
- 438-444
- ISSN
- 1547-5271 (ISSN-L)
- OpenAlex
- W2087807225
- Cited by
- 317
- References
- 31
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- green
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