Skin temperature and core-peripheral temperature gradient as markers of hemodynamic status in critically ill patients: A Review
Abstract
Objective To examine the evidential basis underpinning the monitoring of skin temperature and core-peripheral temperature gradient as elements of hemodynamic assessment in critically ill and adult cardiac surgical patients.Methods Twenty-six studies examining the efficacy of skin temperature or temperature gradient as markers of hemodynamic status were selected as part of an integrative review.Results Evidence pertaining to the efficacy of these parameters as markers of cardiac function is equivocal and has not been well appraised in the adult cardiac surgical population. Skin temperature and systemic vascular resistance are also affected by factors other than cardiac output.Conclusions Skin temperature and core-peripheral temperature gradient should not be considered in isolation from other hemodynamic parameters when assessing cardiac status until they are validated by further large-scale prospective studies.
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Multiple studies have demonstrated a positive correlation between CPTd and systemic vascular resistance, as well as inverse relationships with cardiac output, stroke index, and urine output.
“Multiple studies have demonstrated a positive correlation between CPTd and systemic vascular resistance, as well as inverse relationships with cardiac output, stroke index, and urine output [25,27].”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [25]
Under normal conditions, the central-peripheral temperature difference should be within a 3-4 °C range; however, it can be influenced by ambient temperature and vasoactive drugs.
“Under normal conditions, the central–peripheral temperature difference (CPTd) should be within a 3–4 °C range; however, it can be influenced by ambient temperature and vasoactive drugs [25].”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [25]
A central-peripheral temperature difference > 5 °C has been used as a marker in several studies, showing associations with decreased cardiac output and elevated peripheral vascular resistance.
“Additionally, a central–peripheral temperature difference > 5 °C has been used as a marker in several studies, showing associations with decreased cardiac output and elevated peripheral vascular resistance [25,31].”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [25]
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Bridier, A., Shcherbakova, M., Kawaguchi, A., Poirier, N., Said, C., Noumeir, R., & Jouvet, P. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1083962 · Cited by 6 · see citing works
Song, Y. R., Soh, S., Shim, J., Park, K. U., & Kwak, Y. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184555 · Cited by 5 · see citing works
Atamañuk, A. N., Gandino, I. J., Miranda, M. N., Cardozo, L. M., Escalante, S. E., Villalba, C., Bernal, D. A., Ross, G., Perna, E. R., & Delgado, D. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.101888 · Cited by 4 · see citing works
Zhang, N., Song, X., He, J., Liang, F., Yang, J., & Wang, W. (2025) · Biomedical Optics Express · doi:10.1364/boe.549693 · Cited by 4 · see citing works
“According to the literature and clinical standards, CPTD is typically considered to be within the range of 3 ◦ C to 4 ◦ C to ensure the stability of peripheral circulation in neonates [10].”
Luo, Q., Li, N., Dong, L., & Shu, H. (2025) · Journal of Mountain Science · doi:10.1007/s11629-025-9568-5 · Cited by 3 · see citing works
“Existed research shows that when the peripheral circulation is normal, the foot temperature is 3°C-4°C lower than the core temperature of the body (Schey et al. 2010).”
Hemodynamic monitoring in pediatric cardiac critical care
Kumar, A., & Joshi, R. K. (2025) · JOURNAL OF PEDIATRIC CRITICAL CARE · doi:10.4103/jpcc.jpcc_21_25 · Cited by 2 · see citing works
Magnin, M., Gavet, M., Ngo, T.-T., Louzier, V., Victoni, T., Ayoub, J. Y., Allaouchiche, B., Bonnet‐Garin, J., & Junot, S. (2024) · Microvascular Research · doi:10.1016/j.mvr.2024.104687 · Cited by 2 · see citing works
Predictors of outcomes in infants with gastroschisis treated with a preformed silo
Lee, R., Dassios, T. G., Ade‐Ajayi, N., Davenport, M., Hickey, A., & Greenough, A. (2024) · Pediatric Surgery International · doi:10.1007/s00383-024-05922-7 · Cited by 2 · see citing works
“The toe-core temperature difference is a measure of peripheral perfusion and circulatory adequacy in adult, paediatric and neonatal intensive care settings [29].”
Nedelcu, C., Ionescu, N. S., Bizubac, A. M., Filip, C., & Cirstoveanu, C. (2025) · Life · doi:10.3390/life15101621 · Cited by 2 · see citing works
“Additionally, a central– peripheral temperature difference > 5 ◦ C has been used as a marker in several studies, showing associations with decreased cardiac output and elevated peripheral vascular resistance [25,31].”
Mind the Gap! Core-Peripheral Temperature Gradient and Its Relationship to Mortality in Major Burns
Keohane, N., Driver, J. L., Mullhi, R., Chipp, E., Torlińska, B., & Torliński, T. (2025) · European Burn Journal · doi:10.3390/ebj6010011 · Cited by 1 · see citing works
Watanabe, K., Sato, S., Obara, Y., Kariya, N., Shinba, T., & Matsui, T. (2025) · Sensors · doi:10.3390/s25051582 · Cited by 1 · see citing works
“…at 09:00 in patients with MDD can be attributed to a morning increase in plasma norepinephrine, which induces peripheral vascular contraction [4,12,13]. major depressive disorder (MDD) was signi fi Morning sympathetic surge may occur around 09:00 because the HR of patients with MDD at that time is…”
Teixeira, L. G., Martins, L. R., Schimites, P. I., de Oliveira, R. B., Bonella, J., Campos, R. V., Mangini, L. T., Gasparotto, J. C., & Soares, A. V. (2018) · The Veterinary Journal · doi:10.1016/j.tvjl.2018.09.003 · Cited by 1 · see citing works
“Cool Knees” as a Measure of Systemic Vascular Resistance in Cardiac Patients
Westcott, S. K., Wung, W., Schelegle, A. R., Ganaga, S., & Schaefer, S. (2020) · Cureus · doi:10.7759/cureus.11304 · Cited by 1 · see citing works
“Other studies have concluded that extremity temperatures are a weak indicator of perfusion status, probably due to the inclusion of a broad category of patients (many with distributive shock) and the use of clinical assessments such as knee mottling and “cool extremities” rather than objective knee temperature measure…”
BackgroundVital measurements and shock syndromes in critically ill adults
Booker, K. J., & Andrews, L. K. (2015) · Critical Care Nursing · doi:10.1002/9781118992845.ch2 · Cited by 1 · see citing works
Avaliação de parâmetros perfusionais nas diferentes classes de insuficiência cardíaca em cães
Soares, F. B. (2015) · doi:10.26512/2015.02.d.18436
“…que haja controle da temperatura ambiente em todos os estudos que avaliem gradientes de temperatura, conforme foi realizado no presente trabalho, a qual foi mantida na faixa termoneutra em torno de 24oC, a fim de não influenciar a temperatura periférica (Schey et al., 2009; Schey et al., 2010).”
BackgroundHypothermia and postoperative outcomes: Association or causation?
Gologorsky, E., & Salerno, T. A. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.06.061
Association of Peripheral Perfusion Status and Prognosis of Patients on Mechanical Ventilator
Soumya, C., Thenmozhi, P., & KalaBarathi, S. (2023) · Cardiometry · doi:10.18137/cardiometry.2023.26.7597665
Core to Skin Temperature Gradient in Septic Shock Patients and its Impact on Mortality: A Review
Yadav, P. K., Singh, R. R., Singh, M., Tripathi, S. K., & Verma, A. (2023) · Indian Journal of Forensic Medicine & Toxicology · doi:10.37506/ijfmt.v17i4.19948
- Authors
- Schey, B. M., Williams, D. Y., & Bucknall, T.
- Affiliations
- St Vincent's Hospital Melbourne (AU)
- Deakin University (AU)
- Corresponding author
- Schey, Bernadette M.
- ORCID
- Bucknall, Tracey
- Venue
- Heart & Lung
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 39
- Issue
- 1
- Pages
- 27-40
- ISSN
- 0147-9563 (ISSN-L)
- OpenAlex
- W2013242210
- Cited by
- 40
- References
- 95
- Citations by year
- 2025: 8 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 1 · 2018: 2 · 2017: 4 · 2015: 2 · 2014: 2 · 2012: 1
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Heart & Lung (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Keywords
- skin temperature, hemodynamic monitoring, critically ill patients, cardiac surgery, cardiac output, systemic vascular resistance, cardiac function assessment, non-invasive monitoring
- MeSH terms
- Adult, Body Temperature, Cardiac Output, Heart Diseases, Cardiac Surgical Procedures, Hemodynamics, Humans, Monitoring, Physiologic, Regional Blood Flow, Skin, Skin Temperature, Vasoconstriction, Vasodilation, Critical Illness
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