The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes
Open accessAbstract
Background Induced premature menopause and cardio-toxic therapy increase cardiovascular disease risk in female cancer survivors.Objective To compare the effects of a 12 month aerobic-resistance fitness center intervention to home based physical activity on cardiovascular function and metabolic risk factors.Methods Subjects (N = 154) who had completed primary and/or adjuvant chemotherapy (past 3 years) were randomized to a fitness center intervention or a home based group. The fitness center intervention was a structured thrice weekly aerobic (30 min brisk walking treadmill in target heart range) combined with resistance (30 min of lower body strength training) exercise program, supervised for the first 6 months. The home based group received national guidelines for 30 min moderate intensity exercise most days of the week. Fasting serum samples were collected at baseline, 6 and 12 months for insulin, glucose, lipids and hemoglobin A-1C. A graded exercise stress test was also performed at baseline and 6 months.Results The majority of subjects were white (85.7%), had breast cancer (83.1%) and the average age was 51.9 years. Subjects in the fitness center intervention had significantly improved time on treadmill (p = .039), improved heart rate recovery at 1 min (p = .028), greater MET minutes/week (p ≤ .0001), a trend for improved insulin resistance (p = .067) and stable insulin levels (p = .045) compared to the home based physical activity group.Conclusions Exercise represents a potential cardiac risk reduction intervention for cancer survivors. CLINICAL TRIALS.GOV: NCT01102985.
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Current evidence indicates that exercise under supervision yields better outcomes.
“current evidence indicates that exercise under supervision yields better outcomes.10,43-47”
From Exercise is medicine in oncology: Engaging clinicians to help patients move through cancer (2019) · cites this paper as [43]
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Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580 · see citing works
Heart-rate Recovery Immediately After Exercise as a Predictor of Mortality
Cole, C. R., Blackstone, E. H., Pashkow, F. J., Snader, C. E., & Lauer, M. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910283411804 · Cited by 1,935 · see citing works
Speck, R. M., Courneya, K. S., Mâsse, L. C., Duval, S., & Schmitz, K. H. (2010) · Journal of Cancer Survivorship · doi:10.1007/s11764-009-0110-5 · Cited by 1,352 · see citing works
Cardiovascular Complications of Cancer Therapy
Yeh, E. T. H., & Bickford, C. L. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.050 · Cited by 1,276 · see citing works
Assessment of Physical Activity: An International Perspective
Booth, M. L. (2000) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2000.11082794 · Cited by 1,098 · see citing works
Doyle, C., Kushi, L. H., Byers, T., Courneya, K. S., Demark-Wahnefried, W., Grant, B., McTiernan, A., Rock, C. L., Thompson, C., Gansler, T., et al. (2006) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.56.6.323 · Cited by 950 · see citing works
Cluster-Randomized Trial to Increase Hepatitis B Testing among Koreans in Los Angeles
Bastani, R., Glenn, B. A., & Maxwell, A. E. (2015) · eCite Digital Repository (University of Tasmania) · doi:10.1158/1055-9965 · Cited by 920 · see citing works
Artinian, N. T., Fletcher, G. F., Mozaffarian, D., Kris-Etherton, P., Van Horn, L., Lichtenstein, A. H., Kumanyika, S., Kraus, W. E., Fleg, J. L., Redeker, N. S., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181e8edf1 · Cited by 919 · see citing works
Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment
Volkova, M., & Russell, R. R. (2012) · Current Cardiology Reviews · doi:10.2174/157340311799960645 · Cited by 874 · see citing works
Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study
Goodwin, P. J. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.1.42 · Cited by 867 · see citing works
Physical activity for cancer survivors: meta-analysis of randomised controlled trials
Fong, D. Y. T., Ho, J. W. C., Hui, B. P. H., Lee, A. M., Macfarlane, D. J., Leung, S. S. K., Cerin, E., Chan, W. Y. Y., Leung, I. P. F., Lam, S. H. S., et al. (2012) · BMJ · doi:10.1136/bmj.e70 · Cited by 782 · see citing works
Wolin, K. Y., Carson, K., & Colditz, G. A. (2010) · The Oncologist · doi:10.1634/theoncologist.2009-0285 · Cited by 778 · see citing works
Weight, Weight Gain, and Survival After Breast Cancer Diagnosis
Kroenke, C. H., Chen, W. Y., Rosner, B., & Holmes, M. D. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.079 · Cited by 670 · see citing works
Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study
Goodwin, P. J., Ennis, M., Pritchard, K. I., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.1.42 · Cited by 660 · see citing works
Effect of Obesity on Prognosis After Early-Stage Breast Cancer
Ewertz, M., Jensen, M., Gunnarsdóttir, K. Á., Højris, I., Jakobsen, E. H., Nielsen, D. L., Stenbygaard, L. E., Tange, U. B., & Cold, S. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.29.7614 · Cited by 592 · see citing works
Exercise for women receiving adjuvant therapy for breast cancer
Markes, M., Brockow, T., & Resch, K.-L. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005001.pub2 · Cited by 543 · see citing works
Early Breast Cancer Therapy and Cardiovascular Injury
Jones, L. W., Haykowsky, M. J., Swartz, J. J., Douglas, P. S., & Mackey, J. R. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.037 · Cited by 445 · see citing works
Cardiopulmonary Function and Age-Related Decline Across the Breast Cancer Survivorship Continuum
Jones, L. W., Courneya, K. S., Mackey, J. R., Muss, H. B., Pituskin, E., Scott, J. M., Hornsby, W., Sykes, A. D., Herndon, J. E., Douglas, P. S., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.9014 · Cited by 443 · see citing works
Stacey, F. G., James, E. L., Chapman, K. L., Courneya, K. S., & Lubans, D. R. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-014-0413-z · Cited by 411 · see citing works
Irwin, M. L., McTiernan, A., Baumgartner, R., Baumgartner, K. B., Bernstein, L., Gilliland, F. D., & Ballard-Barbash, R. R. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.036 · Cited by 360 · see citing works
Schmitz, K. H., Ahmed, R. L., Hannan, P. J., & Yee, D. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0736 · Cited by 310 · see citing works
Exercise at the Extremes: The Amount of Exercise to Reduce Cardiovascular Events.
Eijsvogels, T., Molossi, S., Lee, D.-C., Emery, M., & Thompson, P. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.11.034 · Cited by 297 · see citing works
Brown, J. K., Byers, T., Doyle, C., Courneya, K. S., Demark‐Wahnefried, W., Kushi, L. H., McTiernan, A., Rock, C. L., Aziz, N., Bloch, A. S., et al. (2003) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.53.5.268 · Cited by 293 · see citing works
Ligibel, J. A., Campbell, N., Partridge, A. H., Chen, W. Y., Salinardi, T. C., Chen, H., Adloff, K. O., Keshaviah, A. P., & Winer, E. P. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.7357 · Cited by 289 · see citing works
Associations of Insulin Resistance and Adiponectin With Mortality in Women With Breast Cancer
Duggan, C. R., Irwin, M. L., Xiao, L., Henderson, K. D., Smith, A. W., Baumgartner, R., Baumgartner, K. B., Bernstein, L., Ballard-Barbash, R. R., & McTiernan, A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.4473 · Cited by 288 · see citing works
Irwin, M. L., Varma, K., Alvarez-Reeves, M., Cadmus, L. A., Wiley, A., Chung, G. G., DiPietro, L., Mayne, S. T., & Yu, H. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0531 · Cited by 279 · see citing works
Cardiorespiratory fitness as predictor of cancer mortality: a systematic review and meta-analysis
Schmid, D., & Leitzmann, M. F. (2015) · Annals of Oncology · doi:10.1093/annonc/mdu250 · Cited by 276 · see citing works
Practical clinical interventions for diet, physical activity, and weight control in cancer survivors
Demark‐Wahnefried, W., Rogers, L. Q., Alfano, C. M., Thomson, C. A., Courneya, K. S., Meyerhardt, J. A., Stout, N. L., Kvale, E., Ganzer, H., & Ligibel, J. A. (2015) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21265 · Cited by 251 · see citing works
Weaver, K. E., Foraker, R. E., Alfano, C. M., Rowland, J. H., Arora, N., Bellizzi, K. M., Hamilton, A. S., Oakley-Girvan, I. A., Keel, G., & Aziz, N. M. (2013) · Journal of Cancer Survivorship · doi:10.1007/s11764-013-0267-9 · Cited by 251 · see citing works
Cardiovascular Health of Patients With Cancer and Cancer Survivors
Barac, A., Murtagh, G., Carver, J. R., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.04.059 · Cited by 230 · see citing works
Kelley, G. A., Kelley, K. S., & Tran, Z. V. (2004) · Journal of Women's Health · doi:10.1089/jwh.2004.13.1148 · Cited by 225 · see citing works
Fairey, A., Courneya, K. S., Field, C. J., Bell, G. J., Jones, L. W., & Mackey, J. R. (2003) · PubMed · Cited by 225 · see citing works
Sparano, J. A., Wang, M., Zhao, F., Stearns, V., Martino, S., Ligibel, J. A., Perez, E. A., Saphner, T., Wolff, A. C., Sledge, G. W., et al. (2012) · Cancer · doi:10.1002/cncr.27527 · Cited by 206 · see citing works
Herceptin and the Heart — A Molecular Modifier of Cardiac Failure
Chien, K. R. (2006) · New England Journal of Medicine · doi:10.1056/nejmp058315 · Cited by 201 · see citing works
Donnelly, J., JACOBSEN, D. J., Heelan, K., Seip, R. L., & Smith, S. R. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801198 · Cited by 199 · see citing works
Goodwin, P. J., Ennis, M., Pritchard, K. I., Trudeau, M., Koo, J., Taylor, S. K., & Hood, N. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.2723 · Cited by 194 · see citing works
Frank, L. L., Sorensen, B. E., Yasui, Y., Tworoger, S. S., Schwartz, R. S., Ulrich, C. M., Irwin, M. L., Rudolph, R. E., Rajan, K. B., Stanczyk, F. Z., et al. (2005) · Obesity Research · doi:10.1038/oby.2005.66 · Cited by 187 · see citing works
Harrigan, M., Cartmel, B., Loftfield, E., Sanft, T. B., Chagpar, A. B., Zhou, Y., Playdon, M. C., Li, F., & Irwin, M. L. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.61.6375 · Cited by 186 · see citing works
Chapman, J.-A., Meng, D., Shepherd, L. E., Parulekar, W. R., Ingle, J. N., Muss, H. B., Palmer, M., Yu, C., & Goss, P. E. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn014 · Cited by 175 · see citing works
Makari‐Judson, G., Judson, C. H., & Mertens, W. C. (2007) · The Breast Journal · doi:10.1111/j.1524-4741.2007.00419.x · Cited by 137 · see citing works
Exercise Stress Testing in Women
Kohli, P., & Gulati, M. (2010) · Circulation · doi:10.1161/circulationaha.109.914754 · Cited by 129 · see citing works
A Longitudinal Study of Weight and the Menopause Transition
Crawford, S. L., Casey, V. A., Avis, N. E., et al. (2000) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200007020-00005 · Cited by 126 · see citing works
Exercise, Lipids, and Lipoproteins in Older Adults: A Meta‐Analysis
Kelley, G. A., Kelley, K. S., & Tran, Z. V. (2005) · Preventive Cardiology · doi:10.1111/j.0197-3118.2005.03769.x · Cited by 118 · see citing works
Jones, L. W., Haykowsky, M. J., Peddle‐McIntyre, C. J., Joy, A. A., Pituskin, E., Tkachuk, L., Courneya, K. S., Slamon, D. J., & Mackey, J. R. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0870 · Cited by 112 · see citing works
Gilchrist, S. C., Jones, L. W., Krone, R. J., Stein, P. K., & Scott, J. M. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.05.014 · Cited by 100 · see citing works
Obesity and the outcome of young breast cancer patients in the UK: the POSH study
Copson, E., Cutress, R., Maishman, T., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu509 · Cited by 99 · see citing works
Ewer, M. S., & Glück, S. (2009) · Cancer · doi:10.1002/cncr.24219 · Cited by 91 · see citing works
McInnes, J. A., & Knobf, M. T. (2001) · PubMed · Cited by 86 · see citing works
Self-citationA Meta-Analysis of Aerobic Exercise Interventions for Women With Breast Cancer
Kim, C., Kang, D.-H., & Park, J.-W. (2009) · Western Journal of Nursing Research · doi:10.1177/0193945908328473 · Cited by 83 · see citing works
Khakoo, A. Y., & Yeh, E. T. H. (2008) · Nature Clinical Practice Oncology · doi:10.1038/ncponc1225 · Cited by 79 · see citing works
Esteva, F. J., & Hortobágyi, G. N. (2005) · The Breast · doi:10.1016/j.breast.2005.08.033 · Cited by 72 · see citing works
Insulin Breast Cancer Connection: Confirmatory Data Set the Stage for Better Care
DeCensi, A., & Gennari, A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.3022 · Cited by 45 · see citing works
McInnis, K. J., BALADY, G. J., Weiner, D. A., et al. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90680-w · Cited by 43 · see citing works
Survivorship: Nutrition and Weight Management, Version 2.2014
Denlinger, C. S., Ligibel, J. A., Are, M., Baker, K. S., Demark‐Wahnefried, W., Dizon, D. S., Friedman, D. L., Goldman, M. E., Jones, L. W., King, A. A., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0137 · Cited by 40 · see citing works
Knobf, M. T., Jeon, S., Smith, B. A., Harris, L. N., Kerstetter, J. E., Thompson, A. S., & Insogna, K. L. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3693-3 · Cited by 32 · see citing works
Self-citationFeliciano, E. M. C., Kwan, M. L., Kushi, L. H., Weltzien, E. K., Castillo, A., & Caan, B. J. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4133-8 · Cited by 28 · see citing works
Anthracyclines and Cardiotoxicity
Birtle, A. J. (2000) · Clinical Oncology · doi:10.1053/clon.2000.9141 · Cited by 26 · see citing works
Sturgeon, K. M., Dean, L. T., Héroux, M., Kane, J., Bauer, T., Palmer, E., Long, J., Lynch, S. M., Jacobs, L. A., Sarwer, D. B., et al. (2016) · Journal of Cancer Survivorship · doi:10.1007/s11764-016-0582-z · Cited by 23 · see citing works
Lifestyle Interventions for Cardiovascular Risk Reduction in Women with Breast Cancer
Knobf, M. T., & Coviello, J. S. (2012) · Current Cardiology Reviews · doi:10.2174/157340311799960627 · Cited by 22 · see citing works
Self-citationDeterminants of newly diagnosed comorbidities among breast cancer survivors
Obi, N., Gornyk, D., Heinz, J., Vrieling, A., Seibold, P., Chang-Claude, J. C., & Flesch‐Janys, D. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-013-0338-y · Cited by 22 · see citing works
Obesity and Breast Cancer Outcome: Adding to the Evidence
Chlebowski, R. T. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.39.7877 · Cited by 22 · see citing works
Exercise training improves heart rate recovery in women with breast cancer
Giallauria, F., Maresca, L., Vitelli, A., de Magistris, M. S., Chiodini, P., Mattiello, A., Gentile, M., Mancini, M. E., Grieco, A., Russo, A., et al. (2015) · SpringerPlus · doi:10.1186/s40064-015-1179-0 · Cited by 21 · see citing works
Lemay, A., Turcot, L., Déchêne, F., Dodin, S., & Forest, J.-C. (2010) · Menopause · doi:10.1097/gme.0b013e3181b7c521 · Cited by 17 · see citing works
Anthracyclines and Cardiotoxicity
Birtle, A. J. (2000) · Clinical Oncology · doi:10.1007/s001740070057 · Cited by 11 · see citing works
Nuclear Cardiology, The Basics
(2007) · Humana Press eBooks · doi:10.1007/978-1-59745-262-5 · Cited by 6 · see citing works
Nuclear Cardiology: The Basics
Wackers, F. J. T., Bruni, W., & Zaret, B. L. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-426-9 · Cited by 3 · see citing works
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Exercise is medicine in oncology: Engaging clinicians to help patients move through cancer
Schmitz, K. H., Campbell, A. M., Stuiver, M. M., Pinto, B. M., Schwartz, A. L., Morris, G. S., Ligibel, J. A., Cheville, A., Galvão, D. A., Alfano, C. M., et al. (2019) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21579 · Cited by 789 · see citing works
Lynch, B. M., Nguyen, N. H., Moore, M. M., Reeves, M. M., Rosenberg, D. E., Boyle, T., Vallance, J. K., Milton, S., Friedenreich, C. M., & English, D. R. (2019) · Cancer · doi:10.1002/cncr.32143 · Cited by 171 · see citing works
- Authors
- Knobf, M. T., Jeon, S., Smith, B., Harris, L., Thompson, S., Stacy, M. R., Insogna, K., & Sinusas, A. J.
- Affiliations
- Yale University (US)
- Michigan State University (US)
- National Institutes of Health (US)
- Corresponding author
- Knobf, M. Tish
- Jeon, Sangchoon
- Smith, Barbara
- Harris, Lyndsay
- Thompson, Siobhan
- Stacy, Mitchel R.
- Insogna, Karl
- Sinusas, Albert J.
- ORCID
- Venue
- Heart & Lung
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 46
- Issue
- 5
- Pages
- 375-381
- ISSN
- 0147-9563 (ISSN-L)
- PMC
- PMC6129386
- OpenAlex
- W2744960472
- Cited by
- 26
- References
- 68
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Heart & Lung (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NCI (R01CA122658)
- NIH/NHLBI (5T32HL098069-07)
- Yale CTSA (UL1TR000142)
- National Center for Advancing Translational Science (NCATS)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- female cancer survivors, exercise intervention, concurrent training, home-based physical activity, cardiovascular function, heart rate recovery, treadmill exercise capacity, insulin resistance, metabolic risk factors, breast cancer, cardio-oncology
- MeSH terms
- Aged, Cardiovascular Diseases, Exercise Therapy, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasms, Physical Fitness, Risk Factors, Time Factors, United States, Exercise, Prevalence, Survival Rate, Walking, Survivors
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