Cited by 169T-cell and B-cell ImmunologyCancer Immunotherapy and BiomarkersTGF-β signaling in diseases

Foxp3 expressing CD4+ CD25+ and CD8+CD28− T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma

Meloni, Federica, Morosini, Monica, Solari, Nadia, Passadore, Ileana, Nascimbene, Caterina, Novo, Monique, Ferrari, Marco, Cosentino, Marco +3 more·2006·Human Immunology

Abstract

The role of T regulatory (Treg) cells in human cancer has not yet been clarified. We assessed the presence and function of CD4+ and CD8+ Treg cell subsets in the peripheral blood of patients with lung cancer (LC) and pleural mesothelioma (PM). We found a low but significant increase in the number of CD4+ T cells with phenotype and functional features of Treg cells in LC patients compared to normal healthy controls (NHC). Furthermore, total CD4+ T cells from LC patients proliferated less than cells from controls, suggesting that the increase in the CD4+ Treg cell pool has functional importance. LC patients also showed an expansion of the CD8+CD28- T cell subset and these cells expressed Foxp3 mRNA, as recently observed in alloantigen-specific CD8+CD28- T suppressor cells. No variation of peripheral Treg cell subsets was found in patients with PM, a disease with a predominantly localized nature. However, the lack of correlation between cancer stage and the number or the function of peripheral Treg cells in LC patients refuted the hypothesis that these cells are involved in tumor spreading. A possible involvement of the peripheral Treg cell pool in cancer development and/or in inducing systemic immunosuppression in LC patients can be hypothesized.

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Crossref · 10.1016/j.humimm.2005.11.005

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Authors
Meloni, F., Morosini, M., Solari, N., Passadore, I., Nascimbene, C., Novo, M., Ferrari, M., Cosentino, M., Marino, F., Pozzi, E., & Fietta, A. M.
Affiliations
  • University of Pavia (IT)
  • University of Insubria (IT)
Corresponding author
Fietta, Anna M.
Venue
Human Immunology
Publisher
Elsevier BV
Published
2006-01
Volume
67
Issue
1-2
Pages
1-12
ISSN
0198-8859 (ISSN-L)
OpenAlex
W1974252673
Cited by
169
References
56
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 9 · 2021: 17 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 16 · 2012: 11
FWCI
4.17
Type
journal article
Language
en
Open access
closed
Locations
  • Human Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
regulatory T cells, Foxp3, CD4+CD25+ T cells, CD8+CD28- T cells, lung cancer, pleural mesothelioma, peripheral blood, T cell proliferation, systemic immunosuppression, tumor stage, tumor immunology
MeSH terms
Aged, Female, Humans, Immune Tolerance, Lung Neoplasms, Male, Mesothelioma, Middle Aged, Pleural Neoplasms, Receptors, Interleukin-2, CD4 Antigens, T-Lymphocyte Subsets, CD8 Antigens, CD28 Antigens, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Forkhead Transcription Factors

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