Foxp3 expressing CD4+ CD25+ and CD8+CD28− T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma
Abstract
The role of T regulatory (Treg) cells in human cancer has not yet been clarified. We assessed the presence and function of CD4+ and CD8+ Treg cell subsets in the peripheral blood of patients with lung cancer (LC) and pleural mesothelioma (PM). We found a low but significant increase in the number of CD4+ T cells with phenotype and functional features of Treg cells in LC patients compared to normal healthy controls (NHC). Furthermore, total CD4+ T cells from LC patients proliferated less than cells from controls, suggesting that the increase in the CD4+ Treg cell pool has functional importance. LC patients also showed an expansion of the CD8+CD28- T cell subset and these cells expressed Foxp3 mRNA, as recently observed in alloantigen-specific CD8+CD28- T suppressor cells. No variation of peripheral Treg cell subsets was found in patients with PM, a disease with a predominantly localized nature. However, the lack of correlation between cancer stage and the number or the function of peripheral Treg cells in LC patients refuted the hypothesis that these cells are involved in tumor spreading. A possible involvement of the peripheral Treg cell pool in cancer development and/or in inducing systemic immunosuppression in LC patients can be hypothesized.
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Senescent CD28−/dim CD8+ T cells are observed in patients with lung cancer and head and neck cancer.
“Phenotypically, senescent CD28−/dimCD8+T cells are observed in patients with lung cancers [57], head and neck cancer [58].”
From T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment (2013) · cites this paper as [57]
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- Authors
- Meloni, F., Morosini, M., Solari, N., Passadore, I., Nascimbene, C., Novo, M., Ferrari, M., Cosentino, M., Marino, F., Pozzi, E., & Fietta, A. M.
- Affiliations
- University of Pavia (IT)
- University of Insubria (IT)
- Corresponding author
- Fietta, Anna M.
- Venue
- Human Immunology
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 67
- Issue
- 1-2
- Pages
- 1-12
- ISSN
- 0198-8859 (ISSN-L)
- OpenAlex
- W1974252673
- Cited by
- 169
- References
- 56
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 9 · 2021: 17 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 10 · 2014: 5 · 2013: 16 · 2012: 11
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Immunology (publishedVersion)
- PubMed (publishedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- regulatory T cells, Foxp3, CD4+CD25+ T cells, CD8+CD28- T cells, lung cancer, pleural mesothelioma, peripheral blood, T cell proliferation, systemic immunosuppression, tumor stage, tumor immunology
- MeSH terms
- Aged, Female, Humans, Immune Tolerance, Lung Neoplasms, Male, Mesothelioma, Middle Aged, Pleural Neoplasms, Receptors, Interleukin-2, CD4 Antigens, T-Lymphocyte Subsets, CD8 Antigens, CD28 Antigens, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Forkhead Transcription Factors
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